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  1. Book ; Conference proceedings: Lu xun yu "zuo lian"

    Tan, Guilin / Wu, Kang

    zhong guo lu xun yan jiu hui li shi hui 2010 nian nian hui lun wen ji

    2011  

    Title variant Zhong guo lu xun yan jiu hui li shi hui 2010 nian nian hui lun wen ji ; 中国鲁迅研究会理事会2010年年会论文集
    Institution Lu Xun yu zuo lian xue shu yan tao hui :
    Zhongguo zuo yi zuo jia lian meng
    Event/congress Lu Xun yu zuo lian xue shu yan tao hui (2010, ChangshaChina)
    Author's details Tan gui lin, wu kang zhu bian
    Keywords Authors, Chinese ; Chinese literature/History and criticism
    Language Chinese
    Size 2, 357 p., [1] p. of plates, ill, 24 cm
    Edition Di 1 ban
    Publisher Hu nan shi fan da xue chu ban she
    Publishing place Chang sha
    Document type Book ; Conference proceedings
    Note Includes bibliographical references
    ISBN 7564805420 ; 9787564805425
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Er shi shi ji zhong guo wen xue de zhong xi zhi zheng

    Tan, Guilin

    (20 shi ji zhong guo xue shu lun bian shu xi ; 二十世纪中国学朮论辩书系$文学卷)

    2006  

    Title variant 20 shi ji Zhongguo wen xue de zhong xi zhi zheng
    Author's details Tan gui lin deng zhu
    Series title 20 shi ji zhong guo xue shu lun bian shu xi
    二十世纪中国学朮论辩书系$文学卷
    Keywords Chinese literature/History and criticism
    Language Chinese
    Size 4, 5, 4, 282 p, 21 cm
    Edition Di 1 ban
    Publisher Bai hua zhou wen yi chu ban she
    Publishing place Nan chang
    Document type Book
    Note Includes bibliographical references
    ISBN 7807421916 ; 9787807421917
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Genipin-Crosslinked Donor Sclera for Posterior Scleral Contraction/Reinforcement to Fight Progressive Myopia.

    Xue, Anquan / Zheng, Linyan / Tan, Guilin / Wu, Shaoqun / Wu, Yue / Cheng, Lingyun / Qu, Jia

    Investigative ophthalmology & visual science

    2018  Volume 59, Issue 8, Page(s) 3564–3573

    Abstract: Purpose: Myopia has become a global public health problem, particularly in East Asia where myopic retinopathy has become one of the leading causes of blindness and visual impairment in the elderly population. The purpose of this study was to evaluate ... ...

    Abstract Purpose: Myopia has become a global public health problem, particularly in East Asia where myopic retinopathy has become one of the leading causes of blindness and visual impairment in the elderly population. The purpose of this study was to evaluate the efficacy of posterior scleral contraction/reinforcement (PSCR) surgery on controlling the progressive elongation of axial length of highly myopic eyes in young patients.
    Methods: This is a prospective self-controlled interventional case series. Forty young patients (<18-years old) with progressive high myopia received PSCR with a genipin-crosslinked donor scleral strip for one eye and the fellow eye served as concurrent control without surgery. The main outcome measurement was the change of axial length over 2 to 3 years of follow-up.
    Results: Immediately after the surgery, axial length was shortened and subsequently increased by 0.32 mm over the follow-up period. In contrast, axial length of the fellow eyes increased by 0.82 mm over the same period (P < 0.001, paired t-test). PSCR delayed axial elongation in eyes with or without staphyloma. No significant change of visual acuity, cornea refractive power, or retina thickness was noted between the surgery and fellow eyes. None of the patients lost visual acuity compared with the baseline. The procedure was well tolerated with only temporary corneal refractive axis shifts that recovered by the 6-month postsurgical visit.
    Conclusions: PSCR with genipin-crosslinked sclera is safe and effective to restrain eye globe elongation in young patients within a 2- to 3-year follow-up period.
    MeSH term(s) Adolescent ; Aged ; Axial Length, Eye/physiopathology ; Child ; Child, Preschool ; Cholagogues and Choleretics/pharmacology ; Cross-Linking Reagents ; Female ; Humans ; Intraocular Pressure/physiology ; Iridoids/pharmacology ; Male ; Myopia, Degenerative/complications ; Myopia, Degenerative/physiopathology ; Ophthalmologic Surgical Procedures ; Prospective Studies ; Retinal Detachment/physiopathology ; Retinal Detachment/prevention & control ; Sclera/drug effects ; Sclera/transplantation ; Scleral Diseases/etiology ; Scleral Diseases/physiopathology ; Scleral Diseases/surgery ; Tensile Strength ; Tissue Donors ; Tomography, Optical Coherence ; Visual Acuity/physiology
    Chemical Substances Cholagogues and Choleretics ; Cross-Linking Reagents ; Iridoids ; genipin (A3V2NE52YG)
    Language English
    Publishing date 2018-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.17-23707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Research on the relation of EEG signal chaos characteristics with high-level intelligence activity of human brain.

    Wang, Xingyuan / Meng, Juan / Tan, Guilin / Zou, Lixian

    Nonlinear biomedical physics

    2010  Volume 4, Issue 1, Page(s) 2

    Abstract: Using phase space reconstruct technique from one-dimensional and multi-dimensional time series and the quantitative criterion rule of system chaos, and combining the neural network; analyses, computations and sort are conducted on electroencephalogram ( ... ...

    Abstract Using phase space reconstruct technique from one-dimensional and multi-dimensional time series and the quantitative criterion rule of system chaos, and combining the neural network; analyses, computations and sort are conducted on electroencephalogram (EEG) signals of five kinds of human consciousness activities (relaxation, mental arithmetic of multiplication, mental composition of a letter, visualizing a 3-dimensional object being revolved about an axis, and visualizing numbers being written or erased on a blackboard). Through comparative studies on the determinacy, the phase graph, the power spectra, the approximate entropy, the correlation dimension and the Lyapunov exponent of EEG signals of 5 kinds of consciousness activities, the following conclusions are shown: (1) The statistic results of the deterministic computation indicate that chaos characteristic may lie in human consciousness activities, and central tendency measure (CTM) is consistent with phase graph, so it can be used as a division way of EEG attractor. (2) The analyses of power spectra show that ideology of single subject is almost identical but the frequency channels of different consciousness activities have slight difference. (3) The approximate entropy between different subjects exist discrepancy. Under the same conditions, the larger the approximate entropy of subject is, the better the subject's innovation is. (4) The results of the correlation dimension and the Lyapunov exponent indicate that activities of human brain exist in attractors with fractional dimensions. (5) Nonlinear quantitative criterion rule, which unites the neural network, can classify different kinds of consciousness activities well. In this paper, the results of classification indicate that the consciousness activity of arithmetic has better differentiation degree than that of abstract.
    Language English
    Publishing date 2010-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2380068-9
    ISSN 1753-4631 ; 1753-4631
    ISSN (online) 1753-4631
    ISSN 1753-4631
    DOI 10.1186/1753-4631-4-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation.

    Chen, Mei / Hou, Jiangping / Tan, Guilin / Xie, Peng / Freeman, William R / Beadle, James R / Hostetler, Karl Y / Cheng, Lingyun

    Drug delivery

    2017  Volume 24, Issue 1, Page(s) 1703–1712

    Abstract: Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high- ... ...

    Abstract Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high-risk time window for PVR to develop. Lipid prodrug of PMEG, hexadecyloxypropyl 9-[(2-phosphonomethoxy)ethyl]guanine (HDP-PMEG), was prepared and was evaluated as a pharmacological adjuvant to surgical management of PVR. A dose-escalation study determined that the highest nontoxic dose for intravitreal use in pigmented rabbits was 3 µg per eye. The genotoxicity of HDP-PMEG was harnessed as a perioperative preventative measure against PVR in a rabbit eye model while the sustained intravitreal pharmacological effect was evaluated on a laser-induced fibrovascular model in rat eye. After intravitreal 3 µg, HDP-PMEG particles in the rabbit vitreous was visible for at least 6 weeks. A single 50-min intravitreal infusion of HDP-PMEG demonstrated significant inhibition of PVR formation when compared with the eyes infused with only BSS (BSS vs. HDP-PMEG: estimate = 1.14, OR = 3.1, p = .027). A single intravitreal 104 ng (equivalent to 3 µg for rabbit eye) of HDP-PMEG significantly inhibit laser-induced fibrovascular proliferation in rat eye by 55% (least square mean pixel, BSS = 4763569.5 vs. HDP-PMEG = 2148129.7, p < .0001, generalized estimating equation [GEE]). Retinal fluorescein angiography showed the odds for BSS intervened eyes to have higher-rated FA leaking grades were 38.5 times compared with HDP-PMEG treated eyes (p < .0001, GEE). Our study results indicate that single intravitreal HDP-PMEG may be a promising ocular drug delivery as a perioperative intervention to prevent PVR reoccurrence following primary surgical management.
    MeSH term(s) Animals ; Cell Proliferation/drug effects ; Delayed-Action Preparations/pharmacology ; Disease Models, Animal ; Drug Delivery Systems/methods ; Guanine/analogs & derivatives ; Guanine/pharmacology ; Lipids/pharmacology ; Organophosphorus Compounds/pharmacology ; Prodrugs/pharmacology ; Rabbits ; Rats ; Rats, Inbred BN ; Vitreoretinopathy, Proliferative/drug therapy ; Vitreous Body/drug effects
    Chemical Substances Delayed-Action Preparations ; Lipids ; Organophosphorus Compounds ; Prodrugs ; 9-((2-phosphonylmethoxy)ethyl)guanine (114088-58-3) ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2017-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2017.1399303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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