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Article ; Online: Ratiometric electrochemical immunoassay based on 2D Co/Fe MOF decorated with toluidine blue and Fc-labeled Schiff base for accurate assay of alpha-fetoprotein in clinical serum.

Sun, He-Nan / Wang, Miao / Tan, Hong-Sheng / Liu, Hui-Ping / Liu, Mingjun / Li, Shan-Shan

2024 Volume 273, Page(s) 125876

Abstract: The high level of alpha-fetoprotein (AFP) expression is closely related to hepatocellular carcinoma (HCC). Herein, a dual signal ratiometric electrochemical immunosensor based on chitosan-ferrocenecarboxaldehyde-spindle gold (Chit-Fc-SAu) and Co/Fe metal- ...

Abstract	The high level of alpha-fetoprotein (AFP) expression is closely related to hepatocellular carcinoma (HCC). Herein, a dual signal ratiometric electrochemical immunosensor based on chitosan-ferrocenecarboxaldehyde-spindle gold (Chit-Fc-SAu) and Co/Fe metal-organic framework-toluidine blue/polydopamine (Co/Fe MOF-TB/PDA) was proposed for quantitative analysis of AFP. Specifically, Chit-Fc-SAu worked as a substrate to trap more primary antibodies (Ab
MeSH term(s)	Humans ; alpha-Fetoproteins/analysis ; Tolonium Chloride/chemistry ; Carcinoma, Hepatocellular ; Biosensing Techniques/methods ; Reproducibility of Results ; Schiff Bases ; Immunoassay/methods ; Liver Neoplasms ; Antibodies/chemistry ; Electrochemical Techniques/methods ; Metal Nanoparticles/chemistry ; Limit of Detection ; Gold/chemistry
Chemical Substances	alpha-Fetoproteins ; Tolonium Chloride (15XUH0X66N) ; Schiff Bases ; Antibodies ; Gold (7440-57-5)
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125876
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Article ; Online: Fluorescent metal nanoclusters: From luminescence mechanism to applications in enzyme activity assays.

Wang, Tong / Tan, Hong-Sheng / Wang, Ai-Jun / Li, Shan-Shan / Feng, Jiu-Ju

Biosensors & bioelectronics

2024 Volume 257, Page(s) 116323

Abstract: Metal nanoclusters (MNCs) have outstanding fluorescence property and biocompatibility, which show widespread applications in biological analysis. Particularly, evaluation of enzyme activity with the fluorescent MNCs has been developed rapidly within the ... ...

Abstract	Metal nanoclusters (MNCs) have outstanding fluorescence property and biocompatibility, which show widespread applications in biological analysis. Particularly, evaluation of enzyme activity with the fluorescent MNCs has been developed rapidly within the past several years. In this review, we first introduced the fluorescent mechanism of mono- and bi-metallic nanoclusters, respectively, whose interesting luminescence properties are mainly resulted from electron transfer between the lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) energy levels. Meanwhile, the charge migration within the structure occurs through ligand-metal charge transfer (LMCT) or ligand-metal-metal charge transfer (LMMCT). On such foundation, diverse enzyme activities were rigorously evaluated, including three transferases and nine hydrolases, in turn harvesting rapid research progresses within past 5 years. Finally, we summarized the design strategies for evaluating enzyme activity with the MNCs, presented the major issues and challenges remained in the relevant research, coupled by showing some improvement measures. This review will attract researchers dedicated to the studies of the MNCs and provide some constructive insights for their further applications in enzyme analysis.
MeSH term(s)	Biosensing Techniques/methods ; Enzyme Assays/methods ; Metal Nanoparticles/chemistry ; Humans ; Fluorescent Dyes/chemistry ; Luminescence ; Fluorescence
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116323
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Article: Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats

Wang, Yu / Jiang, Jia-Ming / Tan, Hong-Sheng / Tang, Li-Ming / Xu, Hong-Xi / Zhang, Hong / Zheng, Dan

Phytomedicine. 2019 May, v. 58

2019

Abstract: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, ... ...

Abstract	The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, less is known about its potential toxicity on multiple organs.This study aims to determine the multiorgan toxicity of EtOH extract of FP (EEFP) and to investigate the underlying mechanisms through a systematic evaluation in Wistar rats.Wistar rats were orally administered with the EEFP at doses of 1.5, 1.0 and 0.5 g/kg for 28 days. Histopathologic and clinicopathologic analyses were performed, and the hormone levels in serum and the mRNA levels of enzymes related to the production of steroid hormones in adrenal glands were detected. The area of each band of adrenal glands and the steroid levels in the adrenal glands were also measured.After the treatment, both the histopathologic and clinicopathologic examination showed that EEFP caused liver, prostate, seminal vesicle and adrenal gland damage. Among the enzymes involved in the regulation of adrenal steroid hormone production, NET, VMAT2, and CYP11B1 were upregulated, while CYP17A1 was downregulated. Among the adrenal steroid hormones, COR and NE were upregulated, while levels of DHT and serum ACRH and CRH decreased.Our results indicated that adrenal gland, prostate, and seminal vesicles could also be the target organs of FP-induced toxicity. Abnormal enzyme and hormone production related to the hypothalamic pituitary adrenal (HPA) axis caused by the EEFP may be the potential toxic mechanism for changes in the adrenal gland and secondary sex organs of male rats.
Keywords	adrenal glands ; blood serum ; Cullen corylifolium ; enzymes ; ethanol ; fruits ; hepatotoxicity ; histopathology ; laboratory animals ; liver ; males ; messenger RNA ; oral administration ; osteoporosis ; rats ; reproductive toxicology ; seminal vesicles ; steroid hormones
Language	English
Dates of publication	2019-05
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2019.152874
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Article: [Research progress of chemistry and anti-cancer activities of natural products from Chinese Garcinia plants].

Fu, Wen-Wei / Tan, Hong-Sheng / Xu, Hong-Xi

Yao xue xue bao = Acta pharmaceutica Sinica

2014 Volume 49, Issue 2, Page(s) 166–174

Abstract: Garcinia plants are one of the rich sources of natural xanthones and benzophenones which have attracted a great deal of attention from the scientists in the fields of chemistry and pharmacology. Recently, many structurally unique constituents with ... ...

Abstract	Garcinia plants are one of the rich sources of natural xanthones and benzophenones which have attracted a great deal of attention from the scientists in the fields of chemistry and pharmacology. Recently, many structurally unique constituents with various bioactivities, especially anti-tumor activity, have been isolated from Garcinia plants. This concise review focused on the anti-cancer activity natural products isolated from Chinese Garcinia plants, and the research finding by authors and collaborators over the past several years were cited.
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Benzophenones/chemistry ; Benzophenones/isolation & purification ; Benzophenones/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Garcinia/chemistry ; Garcinia/classification ; Humans ; Inhibitory Concentration 50 ; Molecular Structure ; Plants, Medicinal/chemistry ; Plants, Medicinal/classification ; Structure-Activity Relationship ; Terpenes/chemistry ; Terpenes/isolation & purification ; Terpenes/pharmacology ; Xanthones/chemistry ; Xanthones/isolation & purification ; Xanthones/pharmacology
Chemical Substances	Antineoplastic Agents, Phytogenic ; Benzophenones ; Drugs, Chinese Herbal ; Terpenes ; Xanthones ; oblongifolin C ; gambogic acid (8N585K83U2)
Language	Chinese
Publishing date	2014-02
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
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Article: Synthesis and Cytotoxicities of Royleanone Derivatives

Li, Cheng-Ji / Xia, Fan / Wu, Rong / Tan, Hong-Sheng / Xu, Hong-Xi / Xu, Gang / Qin, Hong-Bo

Natural products and bioprospecting. 2018 Dec., v. 8, no. 6

2018

Abstract: Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and ... ...

Abstract	Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
Keywords	cytotoxicity ; humans ; neoplasms ; quinones ; toxicity testing
Language	English
Dates of publication	2018-12
Size	p. 453-456.
Publishing place	Springer Singapore
Document type	Article
ISSN	2192-2195
DOI	10.1007/s13659-018-0173-y
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Article ; Online: Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats.

Wang, Yu / Zhang, Hong / Jiang, Jia-Ming / Zheng, Dan / Tan, Hong-Sheng / Tang, Li-Ming / Xu, Hong-Xi

Phytomedicine : international journal of phytotherapy and phytopharmacology

2019 Volume 58, Page(s) 152874

Abstract: Background: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive ... ...

Abstract	Background: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, less is known about its potential toxicity on multiple organs. Purpose: This study aims to determine the multiorgan toxicity of EtOH extract of FP (EEFP) and to investigate the underlying mechanisms through a systematic evaluation in Wistar rats. Study design and methods: Wistar rats were orally administered with the EEFP at doses of 1.5, 1.0 and 0.5 g/kg for 28 days. Histopathologic and clinicopathologic analyses were performed, and the hormone levels in serum and the mRNA levels of enzymes related to the production of steroid hormones in adrenal glands were detected. The area of each band of adrenal glands and the steroid levels in the adrenal glands were also measured. Results: After the treatment, both the histopathologic and clinicopathologic examination showed that EEFP caused liver, prostate, seminal vesicle and adrenal gland damage. Among the enzymes involved in the regulation of adrenal steroid hormone production, NET, VMAT2, and CYP11B1 were upregulated, while CYP17A1 was downregulated. Among the adrenal steroid hormones, COR and NE were upregulated, while levels of DHT and serum ACRH and CRH decreased. Conclusion: Our results indicated that adrenal gland, prostate, and seminal vesicles could also be the target organs of FP-induced toxicity. Abnormal enzyme and hormone production related to the hypothalamic pituitary adrenal (HPA) axis caused by the EEFP may be the potential toxic mechanism for changes in the adrenal gland and secondary sex organs of male rats.
MeSH term(s)	Administration, Oral ; Adrenal Glands/drug effects ; Adrenal Glands/metabolism ; Adrenal Glands/pathology ; Animals ; Enzymes/genetics ; Enzymes/metabolism ; Ethanol/chemistry ; Female ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Liver/drug effects ; Liver/pathology ; Male ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/metabolism ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/toxicity ; Prostate/drug effects ; Prostate/pathology ; Rats, Wistar ; Steroids/metabolism ; Toxicity Tests/methods
Chemical Substances	Enzymes ; Fructus psoraleae extract ; Plant Extracts ; Steroids ; Ethanol (3K9958V90M)
Language	English
Publishing date	2019-02-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2019.152874
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Zs.A 4115: Show issues

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Article ; Online: UPLC-PDA-QTOFMS-guided isolation of prenylated xanthones and benzoylphloroglucinols from the leaves of Garcinia oblongifolia and their migration-inhibitory activity.

Zhang, Hong / Dan, Zheng / Ding, Zhi-Jie / Lao, Yuan-Zhi / Tan, Hong-Sheng / Xu, Hong-Xi

Scientific reports

2016 Volume 6, Page(s) 35789

Abstract: A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia. As a result, two new prenylated xanthones, oblongixanthones D and E (1-2), six new prenylated benzoylphloroglucinol ... ...

Abstract	A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia. As a result, two new prenylated xanthones, oblongixanthones D and E (1-2), six new prenylated benzoylphloroglucinol derivatives, oblongifolins V-Z (3-7) and oblongifolin AA (8), as well as a known compound oblongifolin L (9), were isolated from the EtOAc-soluble fraction of an acetone extract of the leaves of Garcinia oblongifolia guided by UPLC-PDA-QTOFMS analysis. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD spectra were used to determine the absolute configurations. The results of wound healing and transwell migration assay showed that oblongixanthones D (1), E (2), and oblongifolin L (9) have the ability to inhibit cancer cell migration in lower cytotoxic concentrations. Western blotting results showed that these compounds exhibited an anti-metastasis effect mainly through downregulating RAF protein levels. In addition, 2 and 9 could inhibit phospho-MEK and phospho-ERK at downstream. Moreover, 1, 2, and 9 could inhibit snail protein level, suggesting that they could regulate the EMT pathway.
Language	English
Publishing date	2016-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep35789
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Article ; Online: Corrigendum: UPLC-PDA-QTOFMS-guided isolation of prenylated xanthones and benzoylphloroglucinols from the leaves of Garcinia oblongifolia and their migration-inhibitory activity.

Zhang, Hong / Zheng, Dan / Ding, Zhi-Jie / Lao, Yuan-Zhi / Tan, Hong-Sheng / Xu, Hong-Xi

Scientific reports

2016 Volume 6, Page(s) 39369

Language	English
Publishing date	2016-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep39369
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Article ; Online: Diagnostic filtering to screen polycyclic polyprenylated acylphloroglucinols from Garcinia oblongifolia by ultrahigh performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry.

Zhang, Hong / Zheng, Dan / Li, Hao-Hao / Wang, Hui / Tan, Hong-Sheng / Xu, Hong-Xi

Analytica chimica acta

2016 Volume 912, Page(s) 85–96

Abstract: A novel multistage MS approach, insource collision-induced dissociation (CID) combined with Time Aligned Parallel (TAP) fragmentation, was established to study the fragmentation behavior of polycyclic polyprenylated acylphloroglucinols (PPAPs), which ... ...

Abstract	A novel multistage MS approach, insource collision-induced dissociation (CID) combined with Time Aligned Parallel (TAP) fragmentation, was established to study the fragmentation behavior of polycyclic polyprenylated acylphloroglucinols (PPAPs), which could provide a more reliable fragmentation relationship between precursor and daughter ions. The diagnostic ions for different subtypes of PPAPs and their fragmentation behaviors have been summarized. Moreover, a new and reliable multidimensional analytical workflow that combines ultrahigh performance liquid chromatography (UHPLC), data-independent mass spectrometry (MS(E)), and tandem MS with ion mobility (IM) has been optimized and established for the analysis of PPAPs in the plant Garcinia oblongifolia by diagnostic filtering. Diagnostic fragment ions were used to selectively screen PPAPs from extracts, whereas IM coupled to MS was used to maximize the peak capacity. Under the optimized UHPLC-IM-MS(E) and UHPLC-IM-MS/MS method, 140 PPAPs were detected from the crude extract of G. oblongifolia, and 10 of them were unambiguously identified by comparing them to the reference compounds. Among those PPAPs, 7 pairs of coeluting isobaric PPAPs that were indistinguishable by conventional UHPLC-HRMS alone, were further resolved using UHPLC-IM-MS. It is anticipated that the proposed method will be extended to the rapid screening and characterization of the other targeted or untargeted compounds, especially these coeluting isomers in complex samples.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Garcinia/chemistry ; Phloroglucinol/analysis ; Tandem Mass Spectrometry/methods
Chemical Substances	Phloroglucinol (DHD7FFG6YS)
Language	English
Publishing date	2016-03-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2016.01.039
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Article: Synthesis and Cytotoxicities of Royleanone Derivatives.

Li, Cheng-Ji / Xia, Fan / Wu, Rong / Tan, Hong-Sheng / Xu, Hong-Xi / Xu, Gang / Qin, Hong-Bo

Natural products and bioprospecting

2018 Volume 8, Issue 6, Page(s) 453–456

Abstract: Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and ... ...

Abstract	Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
Language	English
Publishing date	2018-06-16
Publishing country	Germany
Document type	Journal Article
ISSN	2192-2195
ISSN	2192-2195
DOI	10.1007/s13659-018-0173-y
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