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  1. Article ; Online: Race and Antibiotic Use for Children Hospitalized With Acute Respiratory Infections.

    Tan, Jenna H / McGrath, Caitlin L / Brothers, Adam W / Fatemi, Yasaman / Konold, Victoria / Pak, Daniel / Weissman, Scott J / Zerr, Danielle M / Kronman, Matthew P

    Journal of the Pediatric Infectious Diseases Society

    2024  Volume 13, Issue 4, Page(s) 237–241

    Abstract: We sought to evaluate whether children hospitalized with acute respiratory infections experienced differences in antibiotic use by race and ethnicity. We found that likelihood of broad-spectrum antibiotic receipt differed across racial and ethnic groups. ...

    Abstract We sought to evaluate whether children hospitalized with acute respiratory infections experienced differences in antibiotic use by race and ethnicity. We found that likelihood of broad-spectrum antibiotic receipt differed across racial and ethnic groups. Future work should confirm this finding, evaluate causes, and ensure equitable antibiotic use.
    MeSH term(s) Humans ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/ethnology ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Hospitalization/statistics & numerical data ; Infant ; Male ; Female ; Acute Disease ; Adolescent ; Racial Groups ; Ethnicity
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piae021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.

    Benjamin, Daniel I / Brett, Jamie O / Both, Pieter / Benjamin, Joel S / Ishak, Heather L / Kang, Jengmin / Kim, Soochi / Chung, Mingyu / Arjona, Marina / Nutter, Christopher W / Tan, Jenna H / Krishnan, Ananya K / Dulay, Hunter / Louie, Sharon M / de Morree, Antoine / Nomura, Daniel K / Rando, Thomas A

    Cell metabolism

    2023  Volume 35, Issue 3, Page(s) 472–486.e6

    Abstract: With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and with increased death, leading to defective muscle repair. To explore the molecular underpinnings of these defects, we combined multiomics, single-cell measurements, ... ...

    Abstract With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and with increased death, leading to defective muscle repair. To explore the molecular underpinnings of these defects, we combined multiomics, single-cell measurements, and functional testing of MuSCs from young and old mice. The multiomics approach allowed us to assess which changes are causal, which are compensatory, and which are simply correlative. We identified glutathione (GSH) metabolism as perturbed in old MuSCs, with both causal and compensatory components. Contrary to young MuSCs, old MuSCs exhibit a population dichotomy composed of GSH
    MeSH term(s) Mice ; Animals ; Muscle, Skeletal/metabolism ; Multiomics ; Stem Cells/metabolism ; Cellular Senescence ; Aging/physiology
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling.

    Benjamin, Daniel I / Both, Pieter / Benjamin, Joel S / Nutter, Christopher W / Tan, Jenna H / Kang, Jengmin / Machado, Leo A / Klein, Julian D D / de Morree, Antoine / Kim, Soochi / Liu, Ling / Dulay, Hunter / Feraboli, Ludovica / Louie, Sharon M / Nomura, Daniel K / Rando, Thomas A

    Cell metabolism

    2022  Volume 34, Issue 6, Page(s) 902–918.e6

    Abstract: Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown. Here, we report that fasting slows muscle repair both immediately after the conclusion of fasting ... ...

    Abstract Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown. Here, we report that fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding. We show that ketosis, either endogenously produced during fasting or a ketogenic diet or exogenously administered, promotes a deep quiescent state in muscle stem cells (MuSCs). Although deep quiescent MuSCs are less poised to activate, slowing muscle regeneration, they have markedly improved survival when facing sources of cellular stress. Furthermore, we show that ketone bodies, specifically β-hydroxybutyrate, directly promote MuSC deep quiescence via a nonmetabolic mechanism. We show that β-hydroxybutyrate functions as an HDAC inhibitor within MuSCs, leading to acetylation and activation of an HDAC1 target protein p53. Finally, we demonstrate that p53 activation contributes to the deep quiescence and enhanced resilience observed during fasting.
    MeSH term(s) 3-Hydroxybutyric Acid ; Fasting/physiology ; Muscles ; Myoblasts ; Tumor Suppressor Protein p53
    Chemical Substances Tumor Suppressor Protein p53 ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
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  4. Article ; Online: An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice.

    Chen, Tzu-Chieh / Lee, Rebecca A / Tsai, Sam L / Kanamaluru, Deepthi / Gray, Nora E / Yiv, Nicholas / Cheang, Rachel T / Tan, Jenna H / Lee, Justin Y / Fitch, Mark D / Hellerstein, Marc K / Wang, Jen-Chywan

    The Journal of biological chemistry

    2019  Volume 294, Issue 23, Page(s) 9213–9224

    Abstract: Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ... ...

    Abstract Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for hypertriglyceridemia and hepatic steatosis induced by the synthetic glucocorticoid dexamethasone. Angptl4 has also been shown to be required for dexamethasone-induced hepatic ceramide production. Here, we further examined the role of ceramide-mediated signaling in hepatic dyslipidemia caused by chronic glucocorticoid exposure. Using a stable isotope-labeling technique, we found that dexamethasone treatment induced the rate of hepatic
    MeSH term(s) Angiopoietin-like 4 Protein/deficiency ; Angiopoietin-like 4 Protein/genetics ; Angiopoietin-like 4 Protein/metabolism ; Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Ceramides/metabolism ; Dexamethasone/toxicity ; Fatty Acid Synthase, Type I/genetics ; Fatty Acid Synthase, Type I/metabolism ; Fatty Acids, Monounsaturated/pharmacology ; Fatty Liver/etiology ; Fatty Liver/metabolism ; Hypertriglyceridemia/etiology ; Hypertriglyceridemia/metabolism ; Lipogenesis/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Phosphatase 2/antagonists & inhibitors ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Serine C-Palmitoyltransferase/antagonists & inhibitors ; Serine C-Palmitoyltransferase/genetics ; Serine C-Palmitoyltransferase/metabolism ; Triglycerides/blood ; Triglycerides/metabolism
    Chemical Substances Angiopoietin-like 4 Protein ; Angptl4 protein, mouse ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Ceramides ; Fatty Acids, Monounsaturated ; Mlxipl protein, mouse ; RNA, Small Interfering ; Triglycerides ; Dexamethasone (7S5I7G3JQL) ; Serine C-Palmitoyltransferase (EC 2.3.1.50) ; Sptlc1 protein, mouse (EC 2.3.1.50) ; Fasn protein, mouse (EC 2.3.1.85) ; Fatty Acid Synthase, Type I (EC 2.3.1.85) ; protein kinase C zeta (EC 2.7.11.1) ; Protein Kinase C (EC 2.7.11.13) ; Protein Phosphatase 2 (EC 3.1.3.16) ; thermozymocidin (YRM4E8R9ST)
    Language English
    Publishing date 2019-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA118.006259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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