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Article ; Online: Cementoplasty to cryoablation: review and current status.

Tan, Jin Rong / Yan, Yet Yen / Sheikh, Adnan / Ouellette, Hugue / Mallinson, Paul / Munk, Peter L

BJR open

2024 Volume 6, Issue 1, Page(s) tzae007

Abstract: Recent advances in percutaneous image-guided techniques have empowered interventional radiologists with diverse treatment options for the management of musculoskeletal lesions. Of note, there is growing utility for cementoplasty procedures, with ... ...

Abstract	Recent advances in percutaneous image-guided techniques have empowered interventional radiologists with diverse treatment options for the management of musculoskeletal lesions. Of note, there is growing utility for cementoplasty procedures, with indications ranging from stabilization of bone metastases to treatment of painful vertebral compression fractures. Likewise, cryoablation has emerged as a viable adjunct in the treatment of both primary and secondary bone and soft tissue neoplasms. These treatment options have been progressively incorporated into the multidisciplinary approach to holistic care of patients, alongside conventional radiotherapy, systemic therapy, surgery, and analgesia. This review article serves to outline the indications, technical considerations, latest developments, and evidence for the burgeoning role of cementoplasty and cryoablation in the musculoskeletal system, with an emphasis on pain palliation and tumour control.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article ; Review
ISSN	2513-9878
ISSN (online)	2513-9878
DOI	10.1093/bjro/tzae007
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Article: S-acylation of YKT61 modulates its unconventional participation in the formation of SNARE complexes in Arabidopsis.

Ma, Ting / Tan, Jun-Ru / Lu, Jin-Yu / Li, Sha / Zhang, Yan

Journal of genetics and genomics = Yi chuan xue bao

2024

Abstract: Hetero-tetrameric soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) complexes are critical for vesicle-target membrane fusion within the endomembrane system of eukaryotic cells. SNARE assembly involves four different SNARE ... ...

Abstract	Hetero-tetrameric soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) complexes are critical for vesicle-target membrane fusion within the endomembrane system of eukaryotic cells. SNARE assembly involves four different SNARE motifs, Qa, Qb, Qc, and R, provided by three or four SNARE proteins. YKT6 is an atypical R-SNARE that lacks a transmembrane domain and is involved in multiple vesicle-target membrane fusions. Although YKT6 is evolutionarily conserved and essential, its function and regulation in different phyla seem distinct. Arabidopsis YKT61, the yeast and metazoan YKT6 homolog, is essential for gametophytic development, plays a critical role in sporophytic cells, and mediates multiple vesicle-target membrane fusion. However, its molecular regulation is unclear. We report here that YKT61 is S-acylated. Abolishing its S-acylation by a C195S mutation dissociates YKT61 from endomembrane structures and causes its functional loss. Although interacting with various SNARE proteins, YKT61 functions not as a canonical R-SNARE but coordinates with other R-SNAREs to participates in the formation of SNARE complexes. Phylum-specific molecular regulation of YKT6 may be evolved to allow more efficient SNARE-assembly in different eukaryotic cells.
Language	English
Publishing date	2024-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2374568-X
ISSN	1873-5533 ; 1673-8527
ISSN (online)	1873-5533
ISSN	1673-8527
DOI	10.1016/j.jgg.2024.04.007
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Article ; Online: R-SNARE protein YKT61 mediates root apical meristem cell division via BRASSINOSTEROID-INSENSITIVE1 recycling.

Ma, Ting / Tan, Jun-Ru / Zhang, Yan / Li, Sha

Plant physiology

2023 Volume 194, Issue 3, Page(s) 1467–1480

Abstract: Root growth is sustained by cell division and differentiation of the root apical meristem (RAM), in which brassinosteroid (BR) signaling mediated via the dynamic targeting of BRASSINOSTEROID-INSENSITIVE1 (BRI1) plays complex roles. BRI1 is constitutively ...

Abstract	Root growth is sustained by cell division and differentiation of the root apical meristem (RAM), in which brassinosteroid (BR) signaling mediated via the dynamic targeting of BRASSINOSTEROID-INSENSITIVE1 (BRI1) plays complex roles. BRI1 is constitutively secreted to the plasma membrane (PM), internalized, and recycled or delivered into vacuoles, whose PM abundance is critical for BR signaling. Vesicle-target membrane fusion is regulated by heterotetrameric SNARE complexes. SNARE proteins have been implicated in BRI1 targeting, but how SNAREs affect RAM development is unclear. We report that Arabidopsis (Arabidopsis thaliana) YKT61, an atypical R-SNARE protein, is critical for BR-controlled RAM development through the dynamic targeting of BRI1. Functional loss of YKT61 is lethal for both male and female gametophytes. By using weak mutant alleles of YKT61, ykt61-partially complemented (ykt61-pc), we show that YKT61 knockdown results in a reduction of RAM length due to reduced cell division, similar to that in bri1-116. YKT61 physically interacts with BRI1 and is critical for the dynamic recycling of BRI1 to the PM. We further determine that YKT61 is critical for the dynamic biogenesis of vacuoles, for the maintenance of Golgi morphology, and for endocytosis, which may have a broad effect on development. Endomembrane compartments connected via vesicular machinery, such as SNAREs, influence nuclear-controlled cellular activities such as division and differentiation by affecting the dynamic targeting of membrane proteins, supporting a retro-signaling pathway from the endomembrane system to the nucleus.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Brassinosteroids ; Cell Division ; Meristem/genetics ; R-SNARE Proteins/genetics ; SNARE Proteins
Chemical Substances	Arabidopsis Proteins ; Brassinosteroids ; R-SNARE Proteins ; SNARE Proteins ; YKT61 protein, Arabidopsis ; BRI1 protein, Arabidopsis (EC 2.7.11.1)
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiad634
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Article ; Online: Spontaneous colonic perforation and abdominal wall extrusion of an orally ingested fork handle.

Tan, J R / Buckley, K / Guy, R

Annals of the Royal College of Surgeons of England

2022 Volume 105, Issue 6, Page(s) 585–588

Abstract: Most ingested foreign bodies pass through the gastrointestinal tract spontaneously, but a small number of cases lead to complications and necessitate surgical intervention. We present a rare case of an ingested fork handle that perforated silently ... ...

Abstract	Most ingested foreign bodies pass through the gastrointestinal tract spontaneously, but a small number of cases lead to complications and necessitate surgical intervention. We present a rare case of an ingested fork handle that perforated silently through the colon and fistulated through the abdominal wall. This case highlights the importance of balancing the risks and benefits of surgical intervention and the multidisciplinary approach to complex situations.
MeSH term(s)	Humans ; Abdominal Wall/surgery ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Foreign Bodies/complications ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Colonic Diseases/diagnostic imaging ; Colonic Diseases/etiology ; Colonic Diseases/surgery
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2022.0139
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Article ; Online: Association of adipokines with severity of knee osteoarthritis assessed clinically and on magnetic resonance imaging.

Chong, Timothy Kit Yeong / Tan, Jin-Rong / Ma, Cheryl Ann / Wong, Steven Bak Siew / Leung, Ying-Ying

Osteoarthritis and cartilage open

2023 Volume 5, Issue 4, Page(s) 100405

Abstract: Objectives: We aimed to evaluate the association between the adipokines: Leptin, Adiponectin, Resistin, and high sensitive-C-reactive protein (hs-CRP) with clinical, radiographical and magnetic resonance imaging (MRI) assessment of knee osteoarthritis ( ... ...

Abstract	Objectives: We aimed to evaluate the association between the adipokines: Leptin, Adiponectin, Resistin, and high sensitive-C-reactive protein (hs-CRP) with clinical, radiographical and magnetic resonance imaging (MRI) assessment of knee osteoarthritis (OA) severity. Design: We performed a cross-sectional study in participants with earlier knee OA. Demographics, clinical (WOMAC), radiographical and MRI (BLOKS scoring) severity of knee OA were assessed. Serum leptin, adiponectin, resistin and hs-CRP were measured. Association of adipokines and hs-CRP with clinical, radiographic and MRI severity outcomes were evaluated using regression models with adjustment with age, sex, and body mass index (BMI). Results: 137 participants with earlier knee OA (82% women, mean ± SD age: 55.5 ± 7.8 years) were included. Participants had moderate knee OA symptoms, mean WOMAC pain and function were 30.6 ± 18.0, and 31.7 ± 19.8 respectively. Mean BMI was 27.0 ± 5.9 kg/m Conclusion: Serum adipokines, particularly leptin was associated with severity of various structural defects of the knee joint on MRI beyond age, sex and BMI in earlier knee OA.
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Journal Article
ISSN	2665-9131
ISSN (online)	2665-9131
DOI	10.1016/j.ocarto.2023.100405
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Article: Clinics in diagnostic imaging (208). Right knee patellar clunk syndrome.

Tan, Jin Rong / Lau, Adrian Cheng Kiang / Tan, Tien Jin

Singapore medical journal

2020 Volume 61, Issue 9, Page(s) 453–459

MeSH term(s)	Arthroplasty, Replacement, Knee ; Diagnostic Imaging ; Humans ; Patella/diagnostic imaging
Language	English
Publishing date	2020-10-11
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	604319-7
ISSN	0037-5675
ISSN	0037-5675
DOI	10.11622/smedj.2020129
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Article ; Online: Squaraine probes for the bimodal staining of lipid droplets and endoplasmic reticulum imaging in live cells.

Ferdinandus / Tan, Jie Ren / Lim, Jin Heng / Arai, Satoshi / Sou, Keitaro / Lee, Chi-Lik Ken

The Analyst

2022 Volume 147, Issue 15, Page(s) 3570–3577

Abstract: Lipid droplets (LDs) have emerged as a hot target for cancer therapeutics in recent years owing to findings that have shown them to be key organelles involved in maintaining cellular stability and regulating inter-organelle communication through ... ...

Abstract	Lipid droplets (LDs) have emerged as a hot target for cancer therapeutics in recent years owing to findings that have shown them to be key organelles involved in maintaining cellular stability and regulating inter-organelle communication through molecular trafficking. LDs emerge from the endoplasmic reticulum (ER) as a form of cellular homeostasis control. We herein report the study of a library of asymmetric squaraines as superior fluorescence probes to track and image LDs in their native state and environment within cancer cells. The probes are highly selective towards LDs and displayed prominent bright fluorescence with just 1 μM probe concentration. They also possess bimodal LD and ER staining capability
MeSH term(s)	Cell Survival ; Cyclobutanes ; Endoplasmic Reticulum/metabolism ; Lipid Droplets/metabolism ; Molecular Imaging ; Phenols ; Staining and Labeling
Chemical Substances	Cyclobutanes ; Phenols ; squaraine
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an00803c
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Article: NRTPredictor: identifying rice root cell state in single-cell RNA-seq via ensemble learning.

Wang, Hao / Lin, Yu-Nan / Yan, Shen / Hong, Jing-Peng / Tan, Jia-Rui / Chen, Yan-Qing / Cao, Yong-Sheng / Fang, Wei

Plant methods

2023 Volume 19, Issue 1, Page(s) 119

Abstract: Background: Single-cell RNA sequencing (scRNA-seq) measurements of gene expression show great promise for studying the cellular heterogeneity of rice roots. How precisely annotating cell identity is a major unresolved problem in plant scRNA-seq analysis ...

Abstract	Background: Single-cell RNA sequencing (scRNA-seq) measurements of gene expression show great promise for studying the cellular heterogeneity of rice roots. How precisely annotating cell identity is a major unresolved problem in plant scRNA-seq analysis due to the inherent high dimensionality and sparsity. Results: To address this challenge, we present NRTPredictor, an ensemble-learning system, to predict rice root cell stage and mine biomarkers through complete model interpretability. The performance of NRTPredictor was evaluated using a test dataset, with 98.01% accuracy and 95.45% recall. With the power of interpretability provided by NRTPredictor, our model recognizes 110 marker genes partially involved in phenylpropanoid biosynthesis. Expression patterns of rice root could be mapped by the above-mentioned candidate genes, showing the superiority of NRTPredictor. Integrated analysis of scRNA and bulk RNA-seq data revealed aberrant expression of Epidermis cell subpopulations in flooding, Pi, and salt stresses. Conclusion: Taken together, our results demonstrate that NRTPredictor is a useful tool for automated prediction of rice root cell stage and provides a valuable resource for deciphering the rice root cellular heterogeneity and the molecular mechanisms of flooding, Pi, and salt stresses. Based on the proposed model, a free webserver has been established, which is available at https://www.cgris.net/nrtp .
Language	English
Publishing date	2023-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2203723-8
ISSN	1746-4811
ISSN	1746-4811
DOI	10.1186/s13007-023-01092-0
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Article ; Online: Face-to-Face Versus Video Assessment of Facial Paralysis: Implications for Telemedicine.

Tan, Jian Rong / Coulson, Susan / Keep, Melanie

Journal of medical Internet research

2019 Volume 21, Issue 4, Page(s) e11109

Abstract: Background: Patients with facial nerve paralysis (FNP) experience challenges in accessing health care that could potentially be overcome by telemedicine. However, the reliability of telemedicine has yet to be established in this field.: Objective: ... ...

Abstract	Background: Patients with facial nerve paralysis (FNP) experience challenges in accessing health care that could potentially be overcome by telemedicine. However, the reliability of telemedicine has yet to be established in this field. Objective: This study aimed to investigate the consistency between face-to-face and video assessments of patients with FNP by experienced clinicians. Methods: A repeated-measures design was used. A total of 7 clinicians assessed the FNP of 28 patients in a face-to-face clinic using standardized grading systems (the House-Brackmann, Sydney, and Sunnybrook facial grading systems). After 3 months, the same grading systems were used to assess facial palsy in video recordings of the same patients. Results: The House-Brackmann system in video assessment had excellent reliability and agreement (intraclass correlation coefficient [ICC]=0.780; principal component analysis [PCA]=87.5%), similar to face-to-face assessment (ICC=0.686; PCA=79.2%). Reliability of the Sydney system was good to excellent, with excellent agreement face-to-face (ICC=0.633 to 0.834; PCA=81.0%-95.2%). However, video assessment of the cervical branch and synkinesis had fair reliability and good agreement (ICC=0.437 to 0.597; PCA=71.4%), whereas that of other branches had good to excellent reliability and excellent agreement (ICC=0.625 to 0.862; PCA=85.7%-100.0%). Reliability of the Sunnybrook system was poor to fair for resting symmetry (ICC=0.195 to 0.498; PCA=91.3%-100.0%) and synkinesis (ICC=-0.037 to 0.637; PCA=69.6%-87.0%) but was good to excellent for voluntary movement (ICC=0.601 to 0.906; PCA=56.5%-91.3%) in face-to-face and video assessments. Bland-Altman plots indicated normal limits of agreement within ±1 between face-to-face and video-assessed scores only for the temporal and buccal branches of the Sydney system and for resting symmetry in the Sunnybrook system. Conclusions: Video assessment of FNP with the House-Brackmann and Sunnybrook systems was as reliable as face-to-face but with insufficient agreement, especially in the assessment of synkinesis. However, video assessment does not account for the impact of real-time interactions that occur during tele-assessment sessions.
MeSH term(s)	Adult ; Facial Paralysis/diagnosis ; Female ; Humans ; Male ; Reproducibility of Results ; Telemedicine/methods ; Video Recording/methods
Language	English
Publishing date	2019-04-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/11109
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Article: [Efficacy, safety and compliance of immunotherapy in the treatment of allergic rhinitis: a Meta-analysis].

Ji, D X / Tan, J R / Yu, H W

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2019 Volume 54, Issue 12, Page(s) 894–901

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Administration, Sublingual ; Allergens ; Desensitization, Immunologic ; Humans ; Injections, Subcutaneous ; Patient Compliance ; Research Design ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy ; Sublingual Immunotherapy/adverse effects ; Sublingual Immunotherapy/methods
Chemical Substances	Allergens
Language	Chinese
Publishing date	2019-12-30
Publishing country	China
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.issn.1673-0860.2019.12.003
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