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  1. Book ; Online: Ensemble-based Hybrid Optimization of Bayesian Neural Networks and Traditional Machine Learning Algorithms

    Tan, Peiwen

    2023  

    Abstract: This research introduces a novel methodology for optimizing Bayesian Neural Networks (BNNs) by synergistically integrating them with traditional machine learning algorithms such as Random Forests (RF), Gradient Boosting (GB), and Support Vector Machines ( ...

    Abstract This research introduces a novel methodology for optimizing Bayesian Neural Networks (BNNs) by synergistically integrating them with traditional machine learning algorithms such as Random Forests (RF), Gradient Boosting (GB), and Support Vector Machines (SVM). Feature integration solidifies these results by emphasizing the second-order conditions for optimality, including stationarity and positive definiteness of the Hessian matrix. Conversely, hyperparameter tuning indicates a subdued impact in improving Expected Improvement (EI), represented by EI(x). Overall, the ensemble method stands out as a robust, algorithmically optimized approach.
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Publishing date 2023-10-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: AI-Based Decadal Predictive Analysis of Twenty Infectious Diseases in China with an Improved BSTS-MCMC Model

    Tan, Peiwen

    2023  

    Abstract: This study embarks on a comprehensive exploration of the decadal trends and future trajectories of twenty distinct infectious diseases in China from 1998 to 2021. A refined Hybrid Bayesian Structural Time Series (BSTS)-Markov Chain Monte Carlo (MCMC) ... ...

    Abstract This study embarks on a comprehensive exploration of the decadal trends and future trajectories of twenty distinct infectious diseases in China from 1998 to 2021. A refined Hybrid Bayesian Structural Time Series (BSTS)-Markov Chain Monte Carlo (MCMC) model is employed, intertwining with Long Short-Term Memory (LSTM) networks to dissect intricate relationships amidst population demographics, economic indices, and the evolution of infectious diseases. The findings reveal the persistent prevalence of high incidence diseases in future 10 years, like AIDS, Gonorrhea, and Syphilis, and stable occurrences of middle incidence rate diseases such as Brucellosis and Scarlet Fever, while also foretelling the potential disappearance of lower incidence rate diseases like Cholera, Encephalitis B, and Measles. The study particularly underscores the transformative impact of the COVID-19 pandemic, showcasing its extensive implications on the incidences and management of a plethora of diseases, urging a deeper probe into the nuanced alterations in disease transmission, testing, and reporting modalities amidst global health crises. This research accentuates the critical role of advanced predictive analytics in fostering global preparedness and response mechanisms, and in fortifying the resilience and adaptability of China public health framework against burgeoning infectious disease threats.
    Keywords Quantitative Biology - Populations and Evolution
    Publishing date 2023-10-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Inconsistent idealizations and inferentialism about scientific representation.

    Tan, Peter

    Studies in history and philosophy of science

    2021  Volume 89, Page(s) 11–18

    Abstract: Inferentialists about scientific representation hold that an apparatus's representing a target system consists in the apparatus allowing "surrogative inferences" about the target. I argue that a serious problem for inferentialism arises from the fact ... ...

    Abstract Inferentialists about scientific representation hold that an apparatus's representing a target system consists in the apparatus allowing "surrogative inferences" about the target. I argue that a serious problem for inferentialism arises from the fact that many scientific theories and models contain internal inconsistencies. Inferentialism, left unamended, implies that inconsistent scientific models have unlimited representational power, since an inconsistency permits any conclusion to be inferred. I consider a number of ways that inferentialists can respond to this challenge before suggesting my own solution. I develop an analogy to exploitable glitches in a game. Even though inconsistent representational apparatuses may in some sense allow for contradictions to be generated within them, doing so violates the intended function of the apparatus's parts and hence violates representational "gameplay".
    Language English
    Publishing date 2021-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 202358-1
    ISSN 1879-2510 ; 0039-3681
    ISSN (online) 1879-2510
    ISSN 0039-3681
    DOI 10.1016/j.shpsa.2021.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intrinsic statistical separation of subpopulations in heterogeneous collective motion via dimensionality reduction.

    Tan, Pei / Miles, Christopher E

    Physical review. E

    2024  Volume 109, Issue 1-1, Page(s) 14403

    Abstract: Collective motion of locally interacting agents is found ubiquitously throughout nature. The inability to probe individuals has driven longstanding interest in the development of methods for inferring the underlying interactions. In the context of ... ...

    Abstract Collective motion of locally interacting agents is found ubiquitously throughout nature. The inability to probe individuals has driven longstanding interest in the development of methods for inferring the underlying interactions. In the context of heterogeneous collectives, where the population consists of individuals driven by different interactions, existing approaches require some knowledge about the heterogeneities or underlying interactions. Here, we investigate the feasibility of identifying the identities in a heterogeneous collective without such prior knowledge. We numerically explore the behavior of a heterogeneous Vicsek model and find sufficiently long trajectories intrinsically cluster in a principal component analysis-based dimensionally reduced model-agnostic description of the data. We identify how heterogeneities in each parameter in the model (interaction radius, noise, population proportions) dictate this clustering. Finally, we show the generality of this phenomenon by finding similar behavior in a heterogeneous D'Orsogna model. Altogether, our results establish and quantify the intrinsic model-agnostic statistical disentanglement of identities in heterogeneous collectives.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.014403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: "Bubble-Diode" Breathable Electrodes for Fast Gas Transport.

    He, Yi / Tan, Peng

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 11, Page(s) e202303477

    Abstract: Bubbles arising from wild gas evolution commonly exist in electrochemical systems, particularly in water electrolysis and rechargeable aqueous batteries (e. g., Zn-air batteries). Substantial energy dissipation occurs due to the obstruction of active ... ...

    Abstract Bubbles arising from wild gas evolution commonly exist in electrochemical systems, particularly in water electrolysis and rechargeable aqueous batteries (e. g., Zn-air batteries). Substantial energy dissipation occurs due to the obstruction of active sites and ion-conducting pathways by evolving bubbles. Efforts are made to elucidate effective strategies for fast gas transport, most of which focus on minimizing bubble size and facilitating their timely detachment through complex techniques such as constructing super-hydrophilic nano-structure electrodes, flowing electrolytes, and ultrasonic oscillation. Recently, an innovative, facile, and highly efficient method utilizing a breathable electrode design to promote gaseous molecules to the external environment emerges as a promising approach since it avoids remarkable bubble accumulation while remaining free of additional accessories. This paper highlights the origin and evolution of this promising design. Starting with introducing the basic concept of traditional breathable electrodes based on hydrophobic polymer networks and discussing the current progress made in underlying mechanisms, a detailed description of the advanced design inspired by a "bubble-diode" concept with superior breathability follows. This Concept aims to contribute to a deep understanding of this technology and paves the way for further advancements in this renewable energy era.
    Language English
    Publishing date 2024-01-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A tough act to swallow: Streptococcusanginosus and gastric cancer.

    Wong, Sunny / Tan, Patrick

    Cell host & microbe

    2024  Volume 32, Issue 3, Page(s) 291–293

    Abstract: Gastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric ... ...

    Abstract Gastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.
    MeSH term(s) Humans ; Stomach Neoplasms/microbiology ; Helicobacter Infections/complications ; Helicobacter Infections/microbiology ; Helicobacter pylori ; Mouth/microbiology
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microstructural, Micromechanical Atlas of the Temporomandibular Joint Disc.

    Jiang, N / Tan, P / Sun, Y / Zhou, J / Ren, R / Li, Z / Zhu, S

    Journal of dental research

    2024  Volume 103, Issue 5, Page(s) 555–564

    Abstract: The temporomandibular joint (TMJ) disc is mainly composed of collagen, with its arrangement responding to efficient stress distribution. However, microstructural and micromechanical transformations of the TMJ disc under resting, functional, and ... ...

    Abstract The temporomandibular joint (TMJ) disc is mainly composed of collagen, with its arrangement responding to efficient stress distribution. However, microstructural and micromechanical transformations of the TMJ disc under resting, functional, and pathological conditions remain unclear. To address this, our study presents a high-resolution microstructural and mechanical atlas of the porcine TMJ disc. First, the naive microstructure and mechanical properties were investigated in porcine TMJ discs (resting and functional conditions). Subsequently, the perforation and tear models (pathological conditions) were compared. Following this, a rabbit model of anterior disc displacement (abnormal stress) was studied. Results show diverse microstructures and mechanical properties at the nanometer to micrometer scale. In the functional state, gradual unfolding of the crimping cycle in secondary and tertiary structures leads to D-cycle prolongation in the primary structure, causing tissue failure. Pathological conditions lead to stress concentration near the injury site due to collagen interfibrillar traffic patterns, resulting in earlier damage manifestation. Additionally, the abnormal stress model shows collagen damage initiating at the primary structure and extending to the superstructure over time. These findings highlight collagen's various roles in different pathophysiological states. Our study offers valuable insights into TMJ disc function and dysfunction, aiding the development of diagnostic and therapeutic strategies for TMJ disorders, as well as providing guidance for the design of structural biomimetic materials.
    MeSH term(s) Animals ; Temporomandibular Joint Disc/physiopathology ; Rabbits ; Swine ; Biomechanical Phenomena ; Collagen ; Stress, Mechanical ; Disease Models, Animal ; Temporomandibular Joint Disorders/physiopathology ; Temporomandibular Joint Disorders/pathology
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345241227822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Single-cell profiling of gastric cardia adenocarcinoma reveals drivers of cancer stemness and therapeutic targets.

    Tan, Patrick / Chu, Yunqiang

    Gut

    2023  Volume 73, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Cardia/pathology ; Stomach Neoplasms/pathology ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Esophageal Neoplasms/pathology
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Full-Color-Adjustable Nanophotonic Device Adopting Electrochromic Poly(3,4-ethylenedioxythiophene) Thin Films.

    Tan, Peiyu / Ren, Dengfeng / Han, Yuge

    ACS applied materials & interfaces

    2024  Volume 16, Issue 2, Page(s) 2614–2623

    Abstract: Intercalation-based organic polymers that shift their colors during ion insertion and extraction provide a significant basis for existing electrochromic technology. Nevertheless, the complexity of modifying the structure in the skeleton or combining ... ...

    Abstract Intercalation-based organic polymers that shift their colors during ion insertion and extraction provide a significant basis for existing electrochromic technology. Nevertheless, the complexity of modifying the structure in the skeleton or combining several diverse polymers to produce a full-color range has restricted the practical applications of electrochromic materials. Herein, we demonstrate two configurations of the poly(3,4-ethylenedioxythiophene) (PEDOT) Fabry-Perot (F-P) nanocavity-type electrochromic devices fabricated by spray coating lossless PEDOT on the F-P metasurfaces (Cr/ITO/Ag/Cr), which allows full-color response by simply controlling the thickness of dielectric layer indium tin oxide (ITO). However, the reflected light from the PEDOT F-P nanocavity-type electrode can be modulated by electrically controllable optical absorption of PEDOT. Besides, the subtle brightness regulation could be obtained in our F-P nanocavity electrochromic devices via altering the PEDOT thickness. Overall, our results offer a novel perspective for versatile color control of PEDOT.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c14665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Seeing inside a body in motion.

    Tan, Philip / Lu, Nanshu

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6605, Page(s) 466–467

    Abstract: Adhesive ultrasound patches can provide medical imaging for patients on the go. ...

    Abstract Adhesive ultrasound patches can provide medical imaging for patients on the go.
    MeSH term(s) Adhesives ; Humans ; Movement ; Transdermal Patch ; Ultrasonography/methods
    Chemical Substances Adhesives
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adc8732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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