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  1. Article: Assessing local people's perceptions of ecosystem services to support land management plans in arid desert regions, northwest China.

    Tan, Qi / A, Siru / Lang, Wenying

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25302

    Abstract: Deserts play a significant role in terrestrial ecosystems, but their importance is often underestimated in research due to the undervaluation of ecosystem services (ES), particularly the absence of environmental stakeholder perspectives. This study ... ...

    Abstract Deserts play a significant role in terrestrial ecosystems, but their importance is often underestimated in research due to the undervaluation of ecosystem services (ES), particularly the absence of environmental stakeholder perspectives. This study utilized the social science research methodology to investigate the identification and perceptions of desert ES, and the perceived changes in the significance and accessibility of these services following land use alteration among two groups with distinct livelihood strategies in the arid desert region of Northwest China. The study identified 28 ES; with water being the top priority for all; herbs, water and fodder were considered significantly reduced by 78.69 %, 55.74 % and 50.82 % of the PPG, while 62.69 %, 37.31 % and 32.84 % of the APG considered herbs, sense of belonging and link to ancestors to be significantly decreased. The research also explored the potential of social science research methods for assessing ES and contributing to understanding environmental stakeholders' needs and perceptions. It is recommended that future ecological conservation and land project development prioritizes the livelihoods, emotional well-being, and cultural needs of residents. This approach will contribute to the long-term sustainability of both the environment and the project, while also safeguarding the well-being of residents.
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects and mechanisms of prussian blue nanozymes with multiple enzyme activities on nasopharyngeal carcinoma cells.

    Pan, Ya / Wang, Xiaofeng / Tan, Qi / Wang, Liping

    Tissue & cell

    2024  Volume 87, Page(s) 102316

    Abstract: Prussian blue nanozymes (PBNs) with multiple enzyme activities are prepared and their activities of antitumor in nasopharyngeal carcinoma cells (CEN2) are also explored in this research. On the one hand, it shows that PBNs can exert the catalase-like ( ... ...

    Abstract Prussian blue nanozymes (PBNs) with multiple enzyme activities are prepared and their activities of antitumor in nasopharyngeal carcinoma cells (CEN2) are also explored in this research. On the one hand, it shows that PBNs can exert the catalase-like (CAT-like) activity to decompose hydrogen peroxide (H
    MeSH term(s) Humans ; Oxidation-Reduction ; Hydrogen Peroxide ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms ; Ferrocyanides
    Chemical Substances ferric ferrocyanide (TLE294X33A) ; Hydrogen Peroxide (BBX060AN9V) ; Ferrocyanides
    Language English
    Publishing date 2024-01-28
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2024.102316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Defining signals that promote human alveolar type I differentiation.

    Li, Yong / Prakash, Y S / Tan, Qi / Tschumperlin, Daniel

    American journal of physiology. Lung cellular and molecular physiology

    2024  Volume 326, Issue 4, Page(s) L409–L418

    Abstract: Alveolar type I (ATI) cells cover >95% of the lung's distal surface and facilitate gas exchange through their exceptionally thin shape. ATI cells in vivo are replenished by alveolar type II cell division and differentiation, but a detailed understanding ... ...

    Abstract Alveolar type I (ATI) cells cover >95% of the lung's distal surface and facilitate gas exchange through their exceptionally thin shape. ATI cells in vivo are replenished by alveolar type II cell division and differentiation, but a detailed understanding of ATI biology has been hampered by the challenges in direct isolation of these cells due to their fragility and incomplete understanding of the signaling interactions that promote differentiation of ATII to ATI cells. Here, we explored the signals that maintain ATII versus promote ATI fates in three-dimensional (3-D) organoid cultures and developed a human alveolar type I differentiation medium (hATIDM) suitable for generating ATI cells from either mixed distal human lung cells or purified ATII cells. This media adds bone morphogenetic protein 4 (BMP4) and removes epidermal growth factor (EGF), Wnt agonist CHIR99021, and transforming growth factor-beta (TGF-β) inhibitor SB431542 from previously developed alveolar organoid culture media. We demonstrate that BMP4 promotes expression of the ATI marker gene
    MeSH term(s) Humans ; Pulmonary Alveoli/metabolism ; Cells, Cultured ; Alveolar Epithelial Cells/metabolism ; Lung ; Cell Differentiation ; Transforming Growth Factor beta/metabolism ; Benzamides ; Dioxoles
    Chemical Substances 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide ; Transforming Growth Factor beta ; Benzamides ; Dioxoles
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00191.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Integrated block-wise neural network with auto-learning search framework for finger gesture recognition using sEMG signals.

    Wang, Shurun / Tang, Hao / Chen, Feng / Tan, Qi / Jiang, Qi

    Artificial intelligence in medicine

    2024  Volume 149, Page(s) 102777

    Abstract: Accurate finger gesture recognition with surface electromyography (sEMG) is essential and long-challenge in the muscle-computer interface, and many high-performance deep learning models have been developed to predict gestures. For these models, problem- ... ...

    Abstract Accurate finger gesture recognition with surface electromyography (sEMG) is essential and long-challenge in the muscle-computer interface, and many high-performance deep learning models have been developed to predict gestures. For these models, problem-specific tuning of network architecture is essential for improving the performance, yet it requires substantial knowledge of network architecture design and commitment of time and effort. This process thus imposes a major obstacle to the widespread and flexible application of modern deep learning. To address this issue, we present an auto-learning search framework (ALSF) to generate the integrated block-wised neural network (IBWNN) for sEMG-based gesture recognition. IBWNN contains several feature extraction blocks and dimensional reduction layers, and each feature extraction block integrates two sub-blocks (i.e., multi-branch convolutional block and triplet attention block). Meanwhile, ALSF generates optimal models for gesture recognition through the reinforcement learning method. The results show that the generated models yield state-of-the-art results compared to the modern popular networks on the open dataset Ninapro DB5. Moreover, compared to other networks, the generated models have fewer parameters and can be deployed in practical applications with less resource consumption.
    MeSH term(s) Electromyography/methods ; Gestures ; Neural Networks, Computer ; Recognition, Psychology ; Attention ; Algorithms
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 645179-2
    ISSN 1873-2860 ; 0933-3657
    ISSN (online) 1873-2860
    ISSN 0933-3657
    DOI 10.1016/j.artmed.2024.102777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vulval superficial myofibroblastoma with lymphocytic and eosinophilic infiltrate.

    Tan, Qi Ting / Morgan, Tania / Scurry, James Patrick

    BMJ case reports

    2023  Volume 16, Issue 11

    Abstract: We present the case of a vulval superficial myofibroblastoma with a lymphocytic and eosinophilic rim in a woman in her late 20s. The tumour presented in pregnancy as a cystic lesion with pain and increasing size. While the histopathology of superficial ... ...

    Abstract We present the case of a vulval superficial myofibroblastoma with a lymphocytic and eosinophilic rim in a woman in her late 20s. The tumour presented in pregnancy as a cystic lesion with pain and increasing size. While the histopathology of superficial myofibroblastomas has been well defined in the literature, to our knowledge, there has been no documentation of the presence of an inflammatory infiltrate of lymphocytes and eosinophils surrounding and within the tumour. This may potentially act as a diagnostic or prognostic reference.
    MeSH term(s) Female ; Humans ; Eosinophilia/pathology ; Eosinophils/pathology ; Lymphocytes/pathology ; Neoplasms, Muscle Tissue/diagnosis ; Neoplasms, Muscle Tissue/surgery ; Neoplasms, Muscle Tissue/pathology ; Vulvar Neoplasms/diagnosis ; Vulvar Neoplasms/surgery ; Vulvar Neoplasms/pathology ; Adult
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-248800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Multi-kernel driven 3D convolutional neural network for automated detection of lung nodules in chest CT scans.

    Wu, Ruoyu / Liang, Changyu / Zhang, Jiuquan / Tan, QiJuan / Huang, Hong

    Biomedical optics express

    2024  Volume 15, Issue 2, Page(s) 1195–1218

    Abstract: The accurate position detection of lung nodules is crucial in early chest computed tomography (CT)-based lung cancer screening, which helps to improve the survival rate of patients. Deep learning methodologies have shown impressive feature extraction ... ...

    Abstract The accurate position detection of lung nodules is crucial in early chest computed tomography (CT)-based lung cancer screening, which helps to improve the survival rate of patients. Deep learning methodologies have shown impressive feature extraction ability in the CT image analysis task, but it is still a challenge to develop a robust nodule detection model due to the salient morphological heterogeneity of nodules and complex surrounding environment. In this study, a multi-kernel driven 3D convolutional neural network (MK-3DCNN) is proposed for computerized nodule detection in CT scans. In the MK-3DCNN, a residual learning-based encoder-decoder architecture is introduced to employ the multi-layer features of the deep model. Considering the various nodule sizes and shapes, a multi-kernel joint learning block is developed to capture 3D multi-scale spatial information of nodule CT images, and this is conducive to improving nodule detection performance. Furthermore, a multi-mode mixed pooling strategy is designed to replace the conventional single-mode pooling manner, and it reasonably integrates the max pooling, average pooling, and center cropping pooling operations to obtain more comprehensive nodule descriptions from complicated CT images. Experimental results on the public dataset LUNA16 illustrate that the proposed MK-3DCNN method achieves more competitive nodule detection performance compared to some state-of-the-art algorithms. The results on our constructed clinical dataset CQUCH-LND indicate that the MK-3DCNN has a good prospect in clinical practice.
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.504875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of a chemiluminescence assay for tissue plasminogen activator inhibitor complex and its applicability to gastric cancer.

    Ji, Yu / Qin, Yan / Tan, Qi / Qiu, Yanru / Han, Shuang / Qi, Xiaowei

    BMC biotechnology

    2024  Volume 24, Issue 1, Page(s) 30

    Abstract: Background: Venous thromboembolism (VTE), is a noteworthy complication in individuals with gastric cancer, but the current diagnosis and treatment methods lack accuracy. In this study, we developed a t-PAIC chemiluminescence kit and employed ... ...

    Abstract Background: Venous thromboembolism (VTE), is a noteworthy complication in individuals with gastric cancer, but the current diagnosis and treatment methods lack accuracy. In this study, we developed a t-PAIC chemiluminescence kit and employed chemiluminescence to detect the tissue plasminogen activator inhibitor complex (t-PAIC), thrombin-antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC) and thrombomodulin (TM), combined with D-dimer and fibrin degradation products (FDP), to investigate their diagnostic potential for venous thrombosis in gastric cancer patients. The study assessed variations in six indicators among gastric cancer patients at different stages.
    Results: The t-PAIC reagent showed LOD is 1.2 ng/mL and a linear factor R greater than 0.99. The reagents demonstrated accurate results, with all accuracy deviations being within 5%. The intra-batch and inter-batch CVs for the t-PAIC reagent were both within 8%. The correlation coefficient R between this method and Sysmex was 0.979. Gastric cancer patients exhibited elevated levels of TAT, PIC, TM, D-D, FDP compared to the healthy population, while no significant difference was observed in t-PAIC. In the staging of gastric cancer, patients in III-IV stages exhibit higher levels of the six markers compared to those in I-II stages. The ROC curve indicates an enhancement in sensitivity and specificity of the combined diagnosis of four or six indicators.
    Conclusion: Our chemiluminescence assay performs comparably to Sysmex's method and at a reduced cost. The use of multiple markers, including t-PAIC, TM, TAT, PIC, D-D, and FDP, is superior to the use of single markers for diagnosing VTE in patients with malignant tumors. Gastric cancer patients should be screened for the six markers to facilitate proactive prophylaxis, determine the most appropriate treatment timing, ameliorate their prognosis, decrease the occurrence of venous thrombosis and mortality, and extend their survival.
    MeSH term(s) Humans ; Stomach Neoplasms/diagnosis ; Male ; Middle Aged ; Luminescent Measurements/methods ; Female ; Aged ; Antithrombin III/metabolism ; Antithrombin III/analysis ; Thrombomodulin/blood ; Fibrin Fibrinogen Degradation Products/analysis ; Fibrin Fibrinogen Degradation Products/metabolism ; alpha-2-Antiplasmin/metabolism ; alpha-2-Antiplasmin/analysis ; Adult ; Fibrinolysin/metabolism ; Fibrinolysin/analysis ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/blood ; Peptide Hydrolases
    Chemical Substances Antithrombin III (9000-94-6) ; antithrombin III-protease complex ; Thrombomodulin ; Fibrin Fibrinogen Degradation Products ; plasmin-plasmin inhibitor complex ; alpha-2-Antiplasmin ; Fibrinolysin (EC 3.4.21.7) ; fibrin fragment D ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052746-9
    ISSN 1472-6750 ; 1472-6750
    ISSN (online) 1472-6750
    ISSN 1472-6750
    DOI 10.1186/s12896-024-00850-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function.

    Peng, Ze / Zeng, Yan / Tan, Qi / He, Qifeng / Wang, Shang / Wang, Jianwei

    Biochemical and biophysical research communications

    2024  Volume 708, Page(s) 149786

    Abstract: Ectopic lipid deposition (ELD) and mitochondrial dysfunction are common causes of metabolic disorders in humans. Consuming too much fructose can result in mitochondrial dysfunction and metabolic disorders. 6-Gingerol, the main component of ginger ( ... ...

    Abstract Ectopic lipid deposition (ELD) and mitochondrial dysfunction are common causes of metabolic disorders in humans. Consuming too much fructose can result in mitochondrial dysfunction and metabolic disorders. 6-Gingerol, the main component of ginger (Zingiber officinale Roscoe), has been proven to alleviate metabolic disorders. This study seeks to examine the effects of 6-gingerol on metabolic disorders caused by fructose and uncover the underlying molecular mechanisms. In this study, the results showed that 6-Gingerol ameliorated high-fructose-induced metabolic disorders. Moreover, it inhibited CD36 membrane translocation, increased CD36 expression in the mitochondria, and decreased the O-GlcNAc modification of CD36 and OGT expression in vitro and vivo. In addition, 6-Gingerol enhanced the performance of mitochondria in the skeletal muscle and boosted the respiratory capability of L6 myotubes. This study provides a theoretical basis and new insights for the development of lipid-lowering drugs in clinical practice.
    MeSH term(s) Humans ; Muscle, Skeletal/metabolism ; Mitochondria/metabolism ; Fatty Alcohols/pharmacology ; Fatty Alcohols/metabolism ; Catechols/pharmacology ; Fructose/metabolism ; Metabolic Diseases/metabolism ; Mitochondrial Diseases/metabolism
    Chemical Substances gingerol (925QK2Z900) ; Fatty Alcohols ; Catechols ; Fructose (30237-26-4)
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recent Advances in Molecule Synthesis Involving C-C Bond Cleavage of Ketoxime Esters.

    Chen, Pu / Huang, Huawen / Tan, Qi / Ji, Xiaochen / Zhao, Feng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: The synthetic strategies of oxime derivatives participating in radical-type reactions have been rapidly developed in the last few decades. Among them, the N-O bond cleavage of oxime esters leading to formation of nitrogen-centered radicals triggers ... ...

    Abstract The synthetic strategies of oxime derivatives participating in radical-type reactions have been rapidly developed in the last few decades. Among them, the N-O bond cleavage of oxime esters leading to formation of nitrogen-centered radicals triggers adjacent C-C bond cleavage to produce carbon-centered free radicals, which has been virtually used in organic synthesis in recent years. Herein, we summarized the radical reactions involving oxime N-O bond and C-C bond cleavage through this special reaction form, including those from acyl oxime ester derivatives and cyclic ketoxime ester derivatives. These contents were systematically classified according to different reaction types. In this review, the free radical reactions involving acyl oxime esters and cyclic ketoxime esters after 2021 were included, with emphasis on the substrate scope and reaction mechanism.
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062667
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  10. Article ; Online: Engineered extracellular vesicles: potentials in cancer combination therapy.

    Chen, Jiangbin / Tan, Qi / Yang, Zimo / Jin, Yang

    Journal of nanobiotechnology

    2022  Volume 20, Issue 1, Page(s) 132

    Abstract: Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility ... ...

    Abstract Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with other nanocarriers. With the development of this field, multiple ingenious modification methods have been developed to obtain engineered EVs with desired performance. Application of engineered EVs in cancer therapy has gradually shifted from monotherapy to combinational therapy to fight against heterogeneous cancer cells and complex tumor microenvironment. In addition, the strong plasticity and load capacity of engineered EV make it potential to achieve various combinations of cancer treatment methods. In this review, we summarize the existing schemes of cancer combination therapy realized by engineered EVs, highlight the mechanisms and representative examples of these schemes and provide guidance for the future application of engineered EVs to design more effective cancer combination treatment plans.
    MeSH term(s) Cell Communication ; Combined Modality Therapy ; Drug Delivery Systems/methods ; Extracellular Vesicles ; Humans ; Neoplasms/drug therapy ; Tumor Microenvironment
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-022-01330-y
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