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Article: [Analysis of the effect of gene mutations on the efficacy of ruxolitinib in patients with myelofibrosis based on second-generation sequencing technology].

Tan, Y X / Luo, J / Huang, J X / Luo, D M / Liang, H Y / Zhou, X / Liu, X L / Xu, N

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2022 Volume 43, Issue 4, Page(s) 323–329

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Mutation ; Nitriles ; Primary Myelofibrosis/drug therapy ; Primary Myelofibrosis/genetics ; Pyrazoles ; Pyrimidines ; Retrospective Studies ; Technology ; Transcription Factors/genetics
Chemical Substances	Nitriles ; Pyrazoles ; Pyrimidines ; Transcription Factors ; ruxolitinib (82S8X8XX8H)
Language	Chinese
Publishing date	2022-06-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2022.04.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development, validity and reproducibility of a whole grain food frequency questionnaire in Malaysian children.

Koo, H C / Lim, G P / Kaur, Satvinder / Chan, K Q / Florence Tan, Y X / Pang, X J / Tang, L Y

Nutrition journal

2020 Volume 19, Issue 1, Page(s) 73

Abstract: Background: To date, there is no validated whole grain assessment tool for children in any Southeast Asian countries. Hence, there is a need for a valid tool to assess whole grain intake among Malaysian children. This study aimed to develop, validate ... ...

Abstract	Background: To date, there is no validated whole grain assessment tool for children in any Southeast Asian countries. Hence, there is a need for a valid tool to assess whole grain intake among Malaysian children. This study aimed to develop, validate and test the reproducibility of a food frequency questionnaire (FFQ) in estimating whole grain intake among Malaysian children. Methods: A total of 392 children participated in the FFQ development and 112 children aged 9-12 years participated in the validation phase; with a subsample of 50 children participating in the reproducibility phase. Three-day diet record (3DR) as the reference method in validation phase. Spearman correlations, mean difference, Bland-Altman plot and cross-classification analyses were used to assess validity. The reproducibility was tested through a repeat administration of the FFQ, with 1 month time interval. Reproducibility analyses involved intra-class correlation coefficient (ICC), Cronbach's alpha and cross-classification analyses. Results: The FFQ consisted of 156 whole grain food items from six food groups. Mean intake of whole grain in FFQ1 and 3DR were correlated well (r = 0.732), demonstrated good acceptance of the FFQ. Bland Altman plots showed relatively good agreement for both the dietary methods. Cross-classification of whole grain intake between the two methods showed that < 9.9% of children were grossly misclassified. Outcomes from ICC (0.989) and Cronbach's alpha (0.995) demonstrated excellent reliability. All the children were classified in the same or adjacent quartile of whole grain intake. Conclusions: Overall, the findings support the validity of the developed FFQ to appropriately estimate the whole grain intake in Malaysian children. This validated FFQ will be a valuable tool for future studies, to analyses the impact of whole grain consumption with disease relationship among Malaysian schoolchildren.
MeSH term(s)	Child ; Diet ; Diet Records ; Diet Surveys ; Edible Grain ; Energy Intake ; Humans ; Reproducibility of Results ; Surveys and Questionnaires ; Whole Grains
Language	English
Publishing date	2020-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1475-2891
ISSN (online)	1475-2891
DOI	10.1186/s12937-020-00588-y
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Article: Development, validity and reproducibility of a whole grain food frequency questionnaire in Malaysian children

Koo, H. C / Lim, G. P / Kaur, Satvinder / Chan, K. Q / Florence Tan, Y. X / Pang, X. J / Tang, L. Y

Nutrition journal. 2020 Dec., v. 19, no. 1

2020

Abstract: BACKGROUND: To date, there is no validated whole grain assessment tool for children in any Southeast Asian countries. Hence, there is a need for a valid tool to assess whole grain intake among Malaysian children. This study aimed to develop, validate and ...

Abstract	BACKGROUND: To date, there is no validated whole grain assessment tool for children in any Southeast Asian countries. Hence, there is a need for a valid tool to assess whole grain intake among Malaysian children. This study aimed to develop, validate and test the reproducibility of a food frequency questionnaire (FFQ) in estimating whole grain intake among Malaysian children. METHODS: A total of 392 children participated in the FFQ development and 112 children aged 9–12 years participated in the validation phase; with a subsample of 50 children participating in the reproducibility phase. Three-day diet record (3DR) as the reference method in validation phase. Spearman correlations, mean difference, Bland-Altman plot and cross-classification analyses were used to assess validity. The reproducibility was tested through a repeat administration of the FFQ, with 1 month time interval. Reproducibility analyses involved intra-class correlation coefficient (ICC), Cronbach’s alpha and cross-classification analyses. RESULTS: The FFQ consisted of 156 whole grain food items from six food groups. Mean intake of whole grain in FFQ1 and 3DR were correlated well (r = 0.732), demonstrated good acceptance of the FFQ. Bland Altman plots showed relatively good agreement for both the dietary methods. Cross-classification of whole grain intake between the two methods showed that < 9.9% of children were grossly misclassified. Outcomes from ICC (0.989) and Cronbach’s alpha (0.995) demonstrated excellent reliability. All the children were classified in the same or adjacent quartile of whole grain intake. CONCLUSIONS: Overall, the findings support the validity of the developed FFQ to appropriately estimate the whole grain intake in Malaysian children. This validated FFQ will be a valuable tool for future studies, to analyses the impact of whole grain consumption with disease relationship among Malaysian schoolchildren.
Keywords	correlation ; food frequency questionnaires ; food groups ; grain consumption ; reliability ; reproducibility ; school children ; validity ; whole grain foods ; South East Asia
Language	English
Dates of publication	2020-12
Size	p. 73.
Publishing place	BioMed Central
Document type	Article
Note	NAL-light
ISSN	1475-2891
DOI	10.1186/s12937-020-00588-y
Database	NAL-Catalogue (AGRICOLA)

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Article: [Targeted next-generation sequencing for the molecular diagnosis of patients with chronic myeloid leukemia with resistance or intolerance to tyrosine kinase inhibitor].

Wu, W E / Zhou, X / Xu, N / Huang, J X / Liu, L / Tan, Y X / Luo, J / Qin, J Y / Yin, C X / Zhou, L L / Liu, X L

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2020 Volume 41, Issue 10, Page(s) 848–852

MeSH term(s)	Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mutation/drug effects ; Protein Kinase Inhibitors/pharmacology
Chemical Substances	Protein Kinase Inhibitors
Language	Chinese
Publishing date	2020-11-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2020.10.010
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Article: [Application of carbon nanoparticles mapping lymph nodes in curative resection for colorectal carcinoma].

Cai, J W / Li, X L / Chen, X / Rong, Y M / Tan, Y X / Weng, J R / Xiao, Q / Lin, X T / Zou, Y F

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2020 Volume 23, Issue 10, Page(s) 990–995

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Biocompatible Materials ; Carbon ; Case-Control Studies ; Colorectal Neoplasms/surgery ; Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Nanoparticles ; Neoplasm Recurrence, Local ; Retrospective Studies
Chemical Substances	Biocompatible Materials ; Carbon (7440-44-0)
Language	Chinese
Publishing date	2020-10-12
Publishing country	China
Document type	Journal Article
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.cn.441530-20200728-00447
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Article: [Analysis of gene mutations and clinic features in 108 patients with myeloproliferative neoplasm].

Tan, Y X / Xu, N / Huang, J X / Wu, W E / Liu, L / Zhou, L L / Liu, X L / Yin, C X / Xu, D / Zhou, X

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2020 Volume 41, Issue 7, Page(s) 576–582

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Calreticulin ; Humans ; Janus Kinase 2 ; Mutation ; Myeloproliferative Disorders/genetics ; Polycythemia Vera
Chemical Substances	Calreticulin ; Janus Kinase 2 (EC 2.7.10.2)
Language	Chinese
Publishing date	2020-08-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2020.07.008
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Article ; Online: Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.

Goggi, J L / Tan, Y X / Hartimath, S V / Jieu, B / Hwang, Y Y / Jiang, L / Boominathan, R / Cheng, P / Yuen, T Y / Chin, H X / Tang, J R / Larbi, A / Chacko, A M / Renia, L / Johannes, C / Robins, Edward G

Molecular imaging and biology

2020 Volume 22, Issue 5, Page(s) 1392–1402

Abstract: Purpose: Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understood ... ...

Abstract	Purpose: Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understood and may increase the likelihood of immune-mediated adverse events. Accurate stratification of ICI response by non-invasive PET imaging may help ensure safe therapy management across a wide number of cancer phenotypes. Procedures: We have assessed the ability of a fluorine-labelled peptide, [ Results: [ Conclusions: [
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Line, Tumor ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Granzymes/metabolism ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Leukocytes/pathology ; Magnetic Resonance Imaging ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Peptides/chemistry ; Phenotype ; Positron-Emission Tomography ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Immune Checkpoint Inhibitors ; Peptides ; Granzymes (EC 3.4.21.-)
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-020-01519-3
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Zs.A 6468: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Dynamic variations of c-Fos expression in the spinal cord exposed to intramuscular hypertonic saline-induced muscle nociception.

Chen, Y-K / Lei, J / Jin, L / Tan, Y-X / You, H-J

European journal of pain (London, England)

2013 Volume 17, Issue 3, Page(s) 336–346

Abstract: Background: Numerous studies focus on intramuscular (i.m.) injection of hypertonic saline-induced muscle pain and nociception. The spatio-temporal characteristics and dynamic variation of spinal neuronal activities elicited by i.m. hypertonic saline ... ...

Abstract	Background: Numerous studies focus on intramuscular (i.m.) injection of hypertonic saline-induced muscle pain and nociception. The spatio-temporal characteristics and dynamic variation of spinal neuronal activities elicited by i.m. hypertonic saline remain unknown. Methods: The spatio-temporal variations of c-Fos expression in the lumbar spinal cord exposed to i.m. injection of 5.8% saline were investigated in male rats. Results: After a unilateral i.m. 5.8% saline injection, c-Fos expression in dorsal horn of spinal L4-6 segments was significantly enhanced bilaterally (p < 0.05 and p < 0.001). These 5.8% saline-induced bilateral spinal Fos expression occurred rapidly 0.5 h following the i.m. injection, and reached the peak levels within 1 h, which declined gradually and returned to the control levels within 8 h. Compared with intact rats without i.m. insults, no significant influence of the spinalization on spinal c-Fos expression was found. However, the 5.8% saline-induced increases in Fos expression in intact and spinalized rats differed significantly. During muscle nociception, the c-Fos expression within the superficial layer (laminae I-II) and the deep layer (laminae V-VI) in spinalized rats were significantly lower and higher than that of in intact rats (p < 0.05 and p < 0.001). Fentanyl (20 μg/kg, intraperitoneal) completely attenuated the 5.8% saline intramuscularly induced increases in c-Fos expression in laminae III-VI (p < 0.001), but not laminae I-II. Conclusions: It is suggested that spinal nociceptive neuronal activities in superficial and deep layers may differently be modulated by endogenous descending facilitation and inhibition, respectively.
MeSH term(s)	Analgesics, Opioid/pharmacology ; Animals ; Fentanyl/pharmacology ; Functional Laterality/physiology ; Gene Expression/drug effects ; Genes, fos/drug effects ; Genes, fos/physiology ; Immunohistochemistry ; Injections, Intramuscular ; Male ; Musculoskeletal Pain/chemically induced ; Musculoskeletal Pain/genetics ; Nociception/drug effects ; Rats ; Rats, Sprague-Dawley ; Saline Solution, Hypertonic ; Spinal Cord/drug effects ; Spinal Cord/metabolism
Chemical Substances	Analgesics, Opioid ; Saline Solution, Hypertonic ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2013-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/j.1532-2149.2012.00207.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5194: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: [Short-term energy and protein support in mechanically ventilated patients with acute exacerbation of cor pulmonale].

Tan, Y X / Zhong, N S

Zhonghua nei ke za zhi

1994 Volume 33, Issue 8, Page(s) 527–530

Abstract: Twenty-one mechanically ventilated patients with acute exacerbation of cor pulmonale had received home made "Nutritient" via nasal gastric tube as energy and protein support for four weeks (energy supplement 37-45 kcal.kg-1.d-1, protein 1.40-1.67 g.kg-1 ... ...

Abstract	Twenty-one mechanically ventilated patients with acute exacerbation of cor pulmonale had received home made "Nutritient" via nasal gastric tube as energy and protein support for four weeks (energy supplement 37-45 kcal.kg-1.d-1, protein 1.40-1.67 g.kg-1.d-1). Anthropometry, serum albumin, serum prealbumin were measured on the 1st day and at the end of the 1st, 2nd, 4th week of ventilation. The results were compared with those in 15 age-matched ventilated patients who received routine hospital nasal gastric feeding (energy 24-29 kcal.kg-1.d-1, protein: 0.92-1.09 g.kg-1.d-1). All patients were in protein deficient type malnutrition. At the end of the 1st week of ventilation, serum albumin dropped significantly in both groups, resulting in a status of mixed type malnutrition. At the end of the 2nd week, however, serum prealbumin in the experimental group (24.31 +/- 4.80 mg/dl) returned nearly to normal level, being significantly higher than that in the control group (15.10 +/- 3.10 mg/dl, P < 0.01). At the end of the 4th week, both serum albumin (3.90 +/- 0.31 g/dl) and prealbumin (27.33 +/- 3.30 mg/dl) in experimental group returned to normal, being also significantly higher than those in the control group (3.00 +/- 0.23 g/dl, P < 0.05; 17.11 +/- 3.22 mg/dl, P < 0.01). Anthropometry showed no significant change between the two groups during ventilation. It is shown that nasal tube administration of "Nutritient" provides much higher energy and protein as compared with routine nasal feeding, and enables the patient to overcome protein deficiency and to reach positive nitrogen balance earlier.
MeSH term(s)	Aged ; Enteral Nutrition ; Female ; Food, Formulated ; Humans ; Male ; Middle Aged ; Pulmonary Heart Disease/blood ; Pulmonary Heart Disease/therapy ; Respiration, Artificial ; Serum Albumin/metabolism
Chemical Substances	Serum Albumin
Language	Chinese
Publishing date	1994-08
Publishing country	China
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1620: Show issues

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Article ; Audio / Video: Diterpenoids from the Roots of Suregada glomerulata

Yan, R.Y / Tan, Y.X / Cui, X.Q / Chen, R.Y / Yu, D.Q

Journal of natural products. 2008 Feb., v. 71, no. 2

2008

Keywords	Euphorbiaceae ; roots ; diterpenoids ; chemical structure ; spectral analysis ; stereochemistry ; cytotoxicity ; anticarcinogenic activity ; cultured cells ; humans ; China
Language	English
Dates of publication	2008-02
Size	p. 195-198.
Document type	Article ; Audio / Video
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np0705211
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1144: Show issues

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