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Article: Efficacy and safety of Gegen Qinlian decoction in the treatment of type II diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials.

Tan, YiMei / Liu, ShuangHua / Huang, MengHe / Cheng, Hui / Xu, BinBin / Luo, HongSheng / Tang, QiZhi

2024 Volume 14, Page(s) 1316269

Abstract: Aim: The study aims to systematically assess the efficacy and safety of Gegen Qinlian decoction in the treatment of type 2 diabetes mellitus.: Methods: We systematically searched a total of nine databases from the time of creation to 20 March 2023. ... ...

Abstract	Aim: The study aims to systematically assess the efficacy and safety of Gegen Qinlian decoction in the treatment of type 2 diabetes mellitus. Methods: We systematically searched a total of nine databases from the time of creation to 20 March 2023. The quality of the literature was assessed using the risk of bias assessment tool in the Cochrane Handbook. RevMan 5. 3 and Stata 14.0 were applied to conduct meta-analysis. Results: A total of 17 studies, encompassing 1,476 patients, were included in the study. Gegen Qinlian decoction combined with conventional treatment was found to significantly reduce FBG (MD = -0.69 mmol/L, 95% CI -0.84 to -0.55, p < 0.01; I Conclusion: Gegen Qinlian Decoction has certain efficacy and safety in enhancing glycolipid metabolism and alleviating insulin resistance, potentially serving as a complementary therapy for type 2 diabetes mellitus. Rigorous, large-sample, multicenter RCTs are needed to verify this. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023413758, PROSPERO CRD42023413758.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Drugs, Chinese Herbal/adverse effects ; Glucose/metabolism ; Insulin Resistance ; Randomized Controlled Trials as Topic
Chemical Substances	Drugs, Chinese Herbal ; gegenqinlian ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1316269
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Article: The role and safety of UVA and UVB in UV-induced skin erythema.

Yang, Jing-Wen / Fan, Guo-Biao / Tan, Fei / Kong, Hai-Mei / Liu, Qing / Zou, Ying / Tan, Yi-Mei

Frontiers in medicine

2023 Volume 10, Page(s) 1163697

Abstract: Background: Different wavelengths of ultraviolet (UV) light cause skin damage through different mechanisms. Minimal erythema dose (MED) is usually used to clinically evaluate skin sensitivity to ultraviolet radiation by inducing skin erythema using ... ...

Abstract	Background: Different wavelengths of ultraviolet (UV) light cause skin damage through different mechanisms. Minimal erythema dose (MED) is usually used to clinically evaluate skin sensitivity to ultraviolet radiation by inducing skin erythema using ultraviolet B (UVB) or ultraviolet A (UVA) + UVB. Aims: In this study, we detected changes in the blood flow at the MED erythema caused by UVB and UVA + UVB radiation through optical coherence tomography (OCT) to explain the role of different bands of ultraviolet rays in erythema induction. Methods: Two MED irradiation areas on the subjects' back were irradiated with UVB alone or UVA + UVB (UVA: UVB = 8:1). The absolute energy of UVB remained the same in UVB and UVA+UVB. At 24 h after the irradiation, the changes in the blood flow in the MED area were detected using OCT. Results: Compared with the blank control, the maximum blood flow depth, blood flow peak, and total blood flow of UVB-MED and UVA+UVB-MED were significantly increased. Notably, the maximum blood flow depth and blood flow peak of UVB-MED were higher than UVA+UVB-MED. There was no significant difference in total blood perfusion between UVA+UVB-MED and UVB-MED. Under the same UVB energy, the skin erythema caused by UVA + UVB was weaker than UVB alone. Conclusions: The analysis of local blood flow by OCT showed that the peak and maximum depth of local blood flow caused by UVB alone were significantly higher than UVA + UVB.
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1163697
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Article ; Online: Cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis: A meta-analysis and systematic review.

Liu, ShuangHua / Tan, YiMei / Huang, WeiDong / Luo, HongSheng / Pan, BingCheng / Wu, Shuan

Seminars in arthritis and rheumatism

2023 Volume 64, Page(s) 152304

Abstract: Purpose: Osteoporosis is intimately linked to cardiovascular disease and it has been uncertain that zoledronic acid is not correlated with cardiovascular disease. We intended to assess the cardiovascular safety of zoledronic acid in the treatment of ... ...

Abstract	Purpose: Osteoporosis is intimately linked to cardiovascular disease and it has been uncertain that zoledronic acid is not correlated with cardiovascular disease. We intended to assess the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. Methods: We included only randomized controlled trials (RCTs) of patients with osteoporosis receiving zoledronic acid or a placebo. We systematically searched PubMed, Embase, Web of Science, Cochrane CENTRAL, Scopus, the Chinese National Knowledge Infrastructure, ClinicalTrials.gov, and ICTRP from the time of database creation to April 5, 2023. Two investigators extracted data independently on study characteristics, outcomes of interest, and risk of bias based on PRISMA guidelines. Results: As of April 5, 2023, our search identified 32,361 records, and after excluding these records, 9 RCTs were included in the meta-analysis. The overall risk ratio for cardiovascular events with zoledronic acid for primary osteoporosis compared with placebo was 1.15 (95 % CI 1.05-1.26, I Conclusions: In women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation (P = 0.06) and arrhythmias (P = 0.001) compared with placebo, independent of the risk of major adverse cardiovascular events, angina, and heart failure. However, the sample size of men with primary osteoporosis is small, and the cardiovascular risk of zoledronic acid in men with osteoporosis is uncertain.
MeSH term(s)	Female ; Humans ; Male ; Atrial Fibrillation ; Osteoporosis/drug therapy ; Zoledronic Acid/adverse effects
Chemical Substances	Zoledronic Acid (6XC1PAD3KF)
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2023.152304
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Article ; Online: Identifying spatio‐temporal trends in seagrass meadows to inform future restoration

Dalby, Oliver / Pucino, Nicolas / Tan, Yi Mei / Jackson, Emma L. / Macreadie, Peter I. / Coleman, Rhys A. / Young, Mary A. / Ierodiaconou, Daniel / Sherman, Craig D. H.

Restoration Ecology. 2023 Mar., v. 31, no. 3 p.e13787-

2023

Abstract: Seagrass restoration requires information on a range of factors including site environmental conditions, appropriate planting techniques, and the identification of sites most likely to support seagrass. To address the question of where to focus ... ...

Abstract	Seagrass restoration requires information on a range of factors including site environmental conditions, appropriate planting techniques, and the identification of sites most likely to support seagrass. To address the question of where to focus restoration efforts, a key first step is to identify trends in the spatio‐temporal distribution of seagrasses to identify areas of persistence, loss, and recent gains. Areas of recent recovery (and adjacent areas), can then be targeted by practitioners for assisted recovery and restoration, whilst areas of persistent loss can be avoided. Here we identified the contemporary distribution, density, and species composition of seagrass ecosystems (using Sentinel 2 imagery and supervised object‐based imagery analysis) and integrated these data with historic extents to identify spatio‐temporal trends in seagrass distribution in Western Port, Victoria, Australia. Contemporary classifications demonstrated acceptable accuracies (Overall Accuracy 0.77–0.85, User Accuracy 0.76–0.97) and predicted a contemporary seagrass extent of 222 km²; with 48 km² of low‐density recovery predicted to have occurred since 1999. Comparisons with historical seagrass extents indicated some seagrass recovery since large‐scale losses in 1983, although some areas of loss were also present. Recovery included a net gain of approximately 95 km² in the past 20 years and an eastward range expansion; suggesting environmental conditions have improved and are now conducive for restoration efforts in some areas. Results demonstrate that accurate, low‐cost, remote sensing of seagrass ecosystems is possible and show how understanding spatio‐temporal trends can guide the spatial allocation of resources by prioritizing areas for restoration where recovery is beginning to occur.
Keywords	ecological restoration ; habitat conservation ; image analysis ; seagrasses ; species diversity ; Australia
Language	English
Dates of publication	2023-03
Publishing place	Wiley Periodicals, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	914746-9
ISSN	1526-100X ; 1061-2971
ISSN (online)	1526-100X
ISSN	1061-2971
DOI	10.1111/rec.13787
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Article ; Online: Metabolism-related biomarkers, molecular classification, and immune infiltration in diabetic ulcers with validation.

Ma, Xiao-Xuan / Zhang, Ying / Jiang, Jing-Si / Ru, Yi / Luo, Ying / Luo, Yue / Fei, Xiao-Ya / Song, Jian-Kun / Ma, Xin / Li, Bin / Tan, Yi-Mei / Kuai, Le

International wound journal

2023 Volume 20, Issue 9, Page(s) 3498–3513

Abstract: Diabetes mellitus (DM) can lead to diabetic ulcers (DUs), which are the most severe complications. Due to the need for more accurate patient classifications and diagnostic models, treatment and management strategies for DU patients still need improvement. ...

Abstract	Diabetes mellitus (DM) can lead to diabetic ulcers (DUs), which are the most severe complications. Due to the need for more accurate patient classifications and diagnostic models, treatment and management strategies for DU patients still need improvement. The difficulty of diabetic wound healing is caused closely related to biological metabolism and immune chemotaxis reaction dysfunction. Therefore, the purpose of our study is to identify metabolic biomarkers in patients with DU and construct a molecular subtype-specific prognostic model that is highly accurate and robust. RNA-sequencing data for DU samples were obtained from the Gene Expression Omnibus (GEO) database. DU patients and normal individuals were compared regarding the expression of metabolism-related genes (MRGs). Then, a novel diagnostic model based on MRGs was constructed with the random forest algorithm, and classification performance was evaluated utilizing receiver operating characteristic (ROC) analysis. The biological functions of MRGs-based subtypes were investigated using consensus clustering analysis. A principal component analysis (PCA) was conducted to determine whether MRGs could distinguish between subtypes. We also examined the correlation between MRGs and immune infiltration. Lastly, qRT-PCR was utilized to validate the expression of the hub MRGs with clinical validations and animal experimentations. Firstly, 8 metabolism-related hub genes were obtained by random forest algorithm, which could distinguish the DUs from normal samples validated by the ROC curves. Secondly, DU samples could be consensus clustered into three molecular classifications by MRGs, verified by PCA analysis. Thirdly, associations between MRGs and immune infiltration were confirmed, with LYN and Type 1 helper cell significantly positively correlated; RHOH and TGF-β family remarkably negatively correlated. Finally, clinical validations and animal experiments of DU skin tissue samples showed that the expressions of metabolic hub genes in the DU groups were considerably upregulated, including GLDC, GALNT6, RHOH, XDH, MMP12, KLK6, LYN, and CFB. The current study proposed an auxiliary MRGs-based DUs model while proposing MRGs-based molecular clustering and confirmed the association with immune infiltration, facilitating the diagnosis and management of DU patients and designing individualized treatment plans.
MeSH term(s)	Animals ; Humans ; Ulcer ; Biomarkers ; Consensus ; Databases, Factual ; Diabetes Mellitus
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14223
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Article ; Online: Impact of solar ultraviolet radiation on daily outpatient visits of atopic dermatitis in Shanghai, China.

Gu, Hui-Jing / Peng, Li / Jiang, Wen-Cai / Tan, Yi-Mei / Zhou, Guo-Jiang / Kan, Hai-Dong / Chen, Ren-Jie / Zou, Ying

Environmental science and pollution research international

2021 Volume 28, Issue 14, Page(s) 18081–18088

Abstract: The potential roles of solar ultraviolet radiation (UVR) as an environmental risk factor in inducing atopic dermatitis (AD) have not been well quantified. To determine the short-term associations between UVR and AD outpatient visits, we obtained daily ... ...

Abstract	The potential roles of solar ultraviolet radiation (UVR) as an environmental risk factor in inducing atopic dermatitis (AD) have not been well quantified. To determine the short-term associations between UVR and AD outpatient visits, we obtained daily outpatient visits of AD in Shanghai Skin Disease Hospital from 2013 to 2018. Data of hourly ground UVR were collected. We applied overdispersed generalized additive model to explore its associations. We found that daily exposure to UVR-A rather than UVR-B was positively associated with AD outpatient visits. The visits increased on the present day (lag 0 days) and decreased appreciably with longer lags and became insignificant at lag 4 days. For 10 w/m
MeSH term(s)	Air Pollution/analysis ; Child ; Child, Preschool ; China/epidemiology ; Dermatitis, Atopic/epidemiology ; Humans ; Infant ; Infant, Newborn ; Outpatients ; Ultraviolet Rays
Language	English
Publishing date	2021-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-11907-5
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Article: A proposed decision support tool for prioritising conservation planning of Southeast Asian seagrass meadows: combined approaches based on ecosystem services and vulnerability analyses

Tan, Yi Mei / Justine E. Saunders / Siti Maryam Yaakub

Botanica marina. 2018 June 27, v. 61, no. 3

2018

Abstract: Seagrass habitats provide a range of goods and benefits to coastal communities by supporting ecosystem functioning, food provisioning, and cultural values. However, they are at risk worldwide from anthropogenic activities, climate change impacts and ... ...

Abstract	Seagrass habitats provide a range of goods and benefits to coastal communities by supporting ecosystem functioning, food provisioning, and cultural values. However, they are at risk worldwide from anthropogenic activities, climate change impacts and limited resources, which hamper efforts to protect them. Effective conservation planning requires prioritisation of sites based on multiple factors, including their relative value and vulnerability (VU). The current study examines the efficacy of combining two well-established approaches – ecosystem service assessments and habitat VU analyses – to test a method for determining conservation priority for selected seagrass meadows in Southeast Asia. Seven seagrass meadows around Southeast Asia were selected and scored by the authors based on (1) the cumulative contribution of 12 ecosystem services (ES) and the condition of the meadows, (2) VU from 16 anthropogenic threats, which were each ranked against five factors (spatial scale, frequency, functional impact, resistance and recovery time) and (3) the combination of the two approaches to create a single numerical index. Prioritisation of sites differed when meadows were scored solely for the ES they provide, compared to how vulnerable they are to anthropogenic threats. The new combined analysis brought the two metrics together to give conservation priority to sites where management intervention will yield maximum conservation benefits from conservation effort, and resulted in the prioritisation of three sites: Barrang Lompo (Indonesia), Cape Bolinao (Philippines) and Beting Tanjung Kupang (Malaysia). This method is easy to use and does not require great technical expertise. It is also auditable, allowing for clear and transparent understanding of decision-making process.
Keywords	anthropogenic activities ; climate change ; cultural values ; decision making ; decision support systems ; ecosystem services ; habitats ; meadows ; planning ; prioritization ; risk ; seagrasses ; Indonesia ; Malaysia ; Philippines
Language	English
Dates of publication	2018-0627
Size	p. 305-320.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	1475447-2
ISSN	1437-4323 ; 0006-8055
ISSN (online)	1437-4323
ISSN	0006-8055
DOI	10.1515/bot-2017-0117
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Article ; Online: Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1.

Yang, Dan / Tan, Yi-Mei / Zhang, Ying / Song, Jian-Kun / Luo, Yue / Luo, Ying / Fei, Xiao-Ya / Ru, Yi / Li, Bin / Jiang, Jing-Si / Kuai, Le

Journal of ethnopharmacology

2022 Volume 303, Page(s) 115954

Abstract: Ethnopharmacological relevance: Diabetic ulcers (DUs) are one of the most severe complications of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is a classical Chinese traditional prescription that can ...

Abstract	Ethnopharmacological relevance: Diabetic ulcers (DUs) are one of the most severe complications of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is a classical Chinese traditional prescription that can significantly attenuate DU defects, but the specific mechanism remains to be fully elucidated. Aim of the study: In order to verify the underlying mechanism of SJHY ointment in accelerating the closure of DUs. Materials and methods: Modular pharmacology and molecular docking were utilized to predict the therapeutic targets of SJHY ointment against DUs. Male db/db diabetic mice and HaCaT cell models induced by methylglyoxal were used to validate the findings. Results: CCN1 was proven to be the core target of SJHY ointment involved in DUs treatment. CCN1 up-regulated by SJHY treatment (0.5 g/cm Conclusions: SJHY ointment ameliorates cutaneous wound healing by up-regulating CCN1.
Language	English
Publishing date	2022-11-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115954
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Article ; Online: N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients.

Yuan, Chao / Wang, Xue-Min / Guichard, Alexandre / Tan, Yi-Mei / Qian, Chun-Yan / Yang, Li-Jie / Humbert, Philippe

Clinical interventions in aging

2014 Volume 9, Page(s) 1163–1169

Abstract: Background: Asteatotic eczema (AE) is characterized by itchy, dry, rough, and scaling skin. The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate salt. N-palmitoylethanolamine (PEA) and N-acetylethanolamine (AEA) ...

Abstract	Background: Asteatotic eczema (AE) is characterized by itchy, dry, rough, and scaling skin. The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate salt. N-palmitoylethanolamine (PEA) and N-acetylethanolamine (AEA) are both endogenous lipids used as novel therapeutic tools in the treatment of many skin diseases. The purpose of this study was to compare a PEA/AEA emollient with a traditional emollient in the treatment of AE. Methods: A monocentric, randomized, double-blind, comparative trial was conducted in 60 AE patients to evaluate and compare the efficacy of the two emollients. The level of skin dryness among the subjects ranged from mild to moderate. The subjects' skin barrier function and the current perception threshold were tested for 28 days by clinical scoring and bioengineering technology. Results: The results showed that, although some aspects were improved in both groups, the group using the emollient containing PEA/AEA presented a better skin surface change in capacitance. However, the most impressive finding was the ability of the PEA/AEA emollient to increase the 5 Hz current perception threshold to a normal level after 7 days, with a significant difference between values at baseline and after 14 days. A current perception threshold of 5 Hz was positively and significantly correlated with skin surface hydration and negatively correlated with transepidermal water loss in the PEA/AEA emollient group. Conclusion: Compared with traditional emollients, regular application of a topical PEA/AEA emollient could improve both passive and active skin functions simultaneously.
MeSH term(s)	Administration, Topical ; Adult ; Amides ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Double-Blind Method ; Eczema/drug therapy ; Emollients/administration & dosage ; Epidermis/drug effects ; Ethanolamine/administration & dosage ; Ethanolamines/administration & dosage ; Female ; Humans ; Middle Aged ; Palmitic Acids/administration & dosage ; Prospective Studies ; Touch Perception ; Treatment Outcome
Chemical Substances	Amides ; Anti-Inflammatory Agents, Non-Steroidal ; Emollients ; Ethanolamines ; Palmitic Acids ; Ethanolamine (5KV86114PT) ; palmidrol (6R8T1UDM3V)
Language	English
Publishing date	2014-07-17
Publishing country	New Zealand
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2364924-0
ISSN	1178-1998 ; 1176-9092
ISSN (online)	1178-1998
ISSN	1176-9092
DOI	10.2147/CIA.S65448
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Article ; Online: Meteorology and ethnicity as critical factors in HRIPT: Comparing responses between Chinese and Indian ethnicities.

Yuan, Chao / Wang, Xue-Min / Galzote, Carlos / Tan, Yi-Mei / Bhagat, Kamlesh V / Yuan, Zhi-Kang / Du, Jian-Fei / Tan, Yuan

Regulatory toxicology and pharmacology : RTP

2013 Volume 66, Issue 1, Page(s) 59–65

Abstract: Background: Human repeated insult patch test (HRIPT) is regarded as one of the confirmatory test in determining the safety of skin sensitizers. A number of important factors should be considered when conducting and interpreting the results of the HRIPT.! ...

Abstract	Background: Human repeated insult patch test (HRIPT) is regarded as one of the confirmatory test in determining the safety of skin sensitizers. A number of important factors should be considered when conducting and interpreting the results of the HRIPT. Objective: To investigate for probable critical factors that influence the results of HRIPT with the same protocol in Shanghai and Mumbai. Methods: Two HRIPTs were carried out in Shanghai and Mumbai in 2011. Six identical products and 1% sodium lauryl sulfate were tested. Two Chinese dermatologists performed the grading in the two cities. Climate conditions of Shanghai and Mumbai were also recorded. Results: For four lower reaction ratio products, cumulative irritation scores in the induction phase were higher in individuals whose ethnicity was Indian rather than Chinese. Reaction ratio of the same four products was highly correlated to the climatic parameters. The other two higher reaction ratio products and the positive control had no difference between the two ethnicities. Conclusion: Greater attention ought to be paid to the impact of climate on the results of HRIPT, especially for the mild irritation cosmetics when giving the interpretation. Greater emphasis also needs to be placed on the ethnicity of the subjects.
MeSH term(s)	Adolescent ; Adult ; China ; Climate ; Cosmetics/administration & dosage ; Cosmetics/adverse effects ; Ethnic Groups ; Female ; Humans ; India ; Irritants/administration & dosage ; Irritants/toxicity ; Male ; Middle Aged ; Patch Tests/methods ; Skin/drug effects ; Skin/pathology ; Skin Irritancy Tests/methods ; Sodium Dodecyl Sulfate/administration & dosage ; Sodium Dodecyl Sulfate/adverse effects ; Young Adult
Chemical Substances	Cosmetics ; Irritants ; Sodium Dodecyl Sulfate (368GB5141J)
Language	English
Publishing date	2013-06
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2013.02.009
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