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Article ; Online: Determination of aloesone in rat plasma by LC-MS/MS spectrometry and its application in a pharmacokinetic study.

Ren, Xikang / Wang, Zheng / Wang, Xuesong / Li, Youbin / Tan, Yinfeng

Bioanalysis

2024

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio-2023-0231
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Article ; Online: Synergistic stabilization of high internal phase Pickering emulsions by peanut isolate proteins and cellulose nanocrystals for β-carotene encapsulation.

Nie, Chunling / Liu, Bingqian / Tan, Yinfeng / Wu, Pengrui / Niu, Yefan / Fan, Guangsen / Wang, Jianguo

International journal of biological macromolecules

2024 Volume 267, Issue Pt 1, Page(s) 131196

Abstract: In this study, high internal phase Pickering emulsions (HIPPEs) were stabilized by the complexes of peanut protein isolate (PPI) and cellulose nanocrystals (CNCs) for encapsulation β-carotene to retard its degradation during processing and storage. CNCs ... ...

Abstract	In this study, high internal phase Pickering emulsions (HIPPEs) were stabilized by the complexes of peanut protein isolate (PPI) and cellulose nanocrystals (CNCs) for encapsulation β-carotene to retard its degradation during processing and storage. CNCs were prepared by H
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131196
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Article: Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/β-catenin/survivin signaling pathway in glioblastoma.

Wang, Hua / Tan, Yinfeng / Jia, Hao / Liu, Danqi / Liu, Rangru

Frontiers in pharmacology

2022 Volume 13, Page(s) 905082

Abstract: Posaconazole (POS) has been reported to present potential antitumor activity for glioblastoma (GBM). However, its molecular mechanisms remain unclear. In this study, we found that POS has potent cytotoxicity and inhibits cell viability and proliferation ... ...

Abstract	Posaconazole (POS) has been reported to present potential antitumor activity for glioblastoma (GBM). However, its molecular mechanisms remain unclear. In this study, we found that POS has potent cytotoxicity and inhibits cell viability and proliferation in GBM. In addition, we adopted a sphere formation assay to detect the self-renewal capacity, performed western blotting to measure cancer stem-like cells (CSCs) marker proteins (CD133, SOX2, Nanog and Oct4) and applied flow cytometry to monitor the subpopulation of CD144
Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.905082
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Article: Simultaneous determination of two galangin metabolites from

Liu, Rangru / Li, Hailong / Wei, Na / Tan, Yinfeng

PeerJ

2021 Volume 9, Page(s) e11041

Abstract: Galangin has multiple pharmacological efficacies, such as anti-cancer, anti-inflammation and anti-oxidation. Galangin can be rapidly converted into glucuronidated metabolites in vivo. This study aimed to establish an UFLC-MS/MS analytical method to ... ...

Abstract	Galangin has multiple pharmacological efficacies, such as anti-cancer, anti-inflammation and anti-oxidation. Galangin can be rapidly converted into glucuronidated metabolites in vivo. This study aimed to establish an UFLC-MS/MS analytical method to simultaneously determine the concentrations of two glucuronidated metabolites of galangin, galangin-3-O-β-D-glucuronic acid (GG-1) and galangin-7-O-β-D-glucuronic acid (GG-2) in rat plasma. After oral administration of galangal extract (0.3 g/kg), blood samples were collected from the orbital sinus, then treated by methanol precipitation and further gradient-eluted with Phenomenex Kinetex 2.6 µm XB-C18 column. The mass spectrometer was manipulated in the negative electrospray ionization (ESI) and selected multiple reaction monitoring (MRM) mode for the analytes. The precursor-to-product ion pairs applied for GG-1, GG-2 and chrysin (as the internal standard, IS) were m/z 445.2→269.0, 445.2→268.9 and 253.0→142.9, respectively. The results showed that the linear ranges for both GG-1 and GG-2 were 2.0-2000.0 ng/mL (
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11041
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Article ; Online: Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering.

Chen, Kai / Li, Yonghui / Li, Youbin / Tan, Yinfeng / Liu, Yingshuo / Pan, Weisan / Tan, Guoxin

Journal of nanobiotechnology

2023 Volume 21, Issue 1, Page(s) 237

Abstract: The stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an ... ...

Abstract	The stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an intelligent drug delivery platform, stimuli-responsive nanofibers can efficiently load drugs and then be stimulated by specific conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) to achieve slow, on-demand or targeted release, showing great potential in areas such as drug delivery, tumor therapy, wound dressing, and tissue engineering. Therefore, this paper reviews the recent trends of stimuli-responsive electrospun nanofibers as intelligent drug delivery platforms in the field of biomedicine.
MeSH term(s)	Humans ; Nanofibers ; Tissue Engineering ; Drug Delivery Systems ; Bandages ; Neoplasms/drug therapy
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-023-01987-z
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Article ; Online: Physicochemical Characterization, Antioxidant and Anticancer Activity Evaluation of an Acidic Polysaccharide from

Wen, Huan / Kuang, Yangjun / Lian, Xiuxia / Li, Hailong / Zhou, Mingyan / Tan, Yinfeng / Zhang, Xuguang / Pan, Yipeng / Zhang, Junqing / Xu, Jian

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: AHP-3a, a triple-helix acidic polysaccharide isolated ... ...

Abstract	AHP-3a, a triple-helix acidic polysaccharide isolated from
MeSH term(s)	Alpinia/chemistry ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Polysaccharides/isolation & purification ; Humans ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Cell Proliferation/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Hep G2 Cells ; Molecular Weight ; Cell Line, Tumor ; Monosaccharides/analysis ; Monosaccharides/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Picrates/chemistry ; Picrates/antagonists & inhibitors ; Spectroscopy, Fourier Transform Infrared ; Biphenyl Compounds
Chemical Substances	Polysaccharides ; Antioxidants ; Antineoplastic Agents ; Monosaccharides ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Plant Extracts ; Antineoplastic Agents, Phytogenic ; Picrates ; Biphenyl Compounds
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081810
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Article: One-Pot Synthesis of α-Ketoamides from α-Keto Acids and Amines Using Ynamides as Coupling Reagents

Ma, Jianting / Cui, Xue / Xu, Junyu / Tan, Yinfeng / Wang, Yan / Wang, Xuesong / Li, Youbin

Journal of organic chemistry. 2022 Jan. 14, v. 87, no. 5

2022

Abstract: A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction ... ...

Abstract	A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction features advantages such as practical coupling procedure, wide functional group tolerance, and extremely mild conditions and has potential applications in synthetic and medicinal chemistry.
Keywords	acids ; amines ; couplings ; journals ; medicinal properties ; organic chemistry ; synthesis
Language	English
Dates of publication	2022-0114
Size	p. 3661-3667.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02453
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Article ; Online: Determination of nootkatone in rat plasma by LC-tandem mass spectrometry and its application in a pharmacokinetic study.

Qin, Zhen-Miao / Li, Yong-Hui / Tan, Yin-Feng / Li, Hai-Long

Biomedical chromatography : BMC

2021 Volume 35, Issue 12, Page(s) e5197

Abstract: This study aimed to develop a rapid, sensitive, and specific LC-tandem mass spectrometry method for the determination of nootkatone in rat plasma. α-Cyperone was chosen as the internal standard (IS). The plasma was processed using a one-step acetonitrile ...

Abstract	This study aimed to develop a rapid, sensitive, and specific LC-tandem mass spectrometry method for the determination of nootkatone in rat plasma. α-Cyperone was chosen as the internal standard (IS). The plasma was processed using a one-step acetonitrile protein precipitation method. Chromatographic separation of nootkatone was achieved on a Phenomenex Kinetex XB-C18 column (2.10 × 50 mm, 2.6 μm) at 35°C with a mobile phase consisting of acetonitrile and water under a gradient elution at a flow rate of 0.35 mL/min. An electrospray ionization source was applied and operated in positive ion and multiple reaction monitoring modes. Nootkatone and IS were quantified using the transitions of m/z 219.200 → 163.110 and m/z 219.200 → 111.000, respectively. The calibration curves were linear over the range of 10-2000 ng/mL (r = 0.9943). The lower limit of quantification was 10 ng/mL. The intra- and inter-day precision (relative standard deviation) ranged from 2.56% to 8.41%, with the accuracy values ranging from 98.9% to 99.17% for four different concentration levels. The matrix effect and extraction recovery were within acceptable limits. The validated method was successfully applied to the pharmacokinetic study of nootkatone in rats after oral and intravenous administration at three dosages. The main pharmacokinetic parameters were calculated, showing low bioavailability of nootkatone.
MeSH term(s)	Animals ; Chromatography, Liquid/methods ; Female ; Limit of Detection ; Linear Models ; Polycyclic Sesquiterpenes/blood ; Polycyclic Sesquiterpenes/chemistry ; Polycyclic Sesquiterpenes/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Chemical Substances	Polycyclic Sesquiterpenes ; nootkatone (IZ2Y119N4J)
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5197
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Article ; Online: One-Pot Synthesis of α-Ketoamides from α-Keto Acids and Amines Using Ynamides as Coupling Reagents.

Ma, Jianting / Cui, Xue / Xu, Junyu / Tan, Yinfeng / Wang, Yan / Wang, Xuesong / Li, Youbin

The Journal of organic chemistry

2022 Volume 87, Issue 5, Page(s) 3661–3667

Abstract	A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction features advantages such as practical coupling procedure, wide functional group tolerance, and extremely mild conditions and has potential applications in synthetic and medicinal chemistry.
MeSH term(s)	Amines/chemistry ; Indicators and Reagents ; Keto Acids ; Oxidation-Reduction
Chemical Substances	Amines ; Indicators and Reagents ; Keto Acids
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02453
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Article ; Online: A new labdane diterpenoid from Scoparia dulcis improving pancreatic function against islets cell apoptotic by Bax/Bcl-2/Caspase-3 pathway.

Dong, Lin / Chen, Mimi / Huang, Zibao / Tan, Yinfeng / Zhang, Caiyun / Zhang, Shouwen / Zhang, Yong / Zhang, Xiaopo

Journal of ethnopharmacology

2023 Volume 322, Page(s) 117571

Abstract: Ethnopharmacological relevance: Scoparia dulcis has been identified as a significant ethnopharmacological substance in the Li, Zhuang, and Dai ethnic groups of China. Traditional medicine use S. dulcis to treat numerous illnesses, most notably diabetes. ...

Abstract	Ethnopharmacological relevance: Scoparia dulcis has been identified as a significant ethnopharmacological substance in the Li, Zhuang, and Dai ethnic groups of China. Traditional medicine use S. dulcis to treat numerous illnesses, most notably diabetes. The considerable antidiabetic properties of this herbal remedy have been established by several clinical investigations and animal experiments. The islet is the intended target of S. dulcis, although the cause of its activity and mechanism for diabetes treatment is unclear. The diterpenoids from S. dulcis have been shown in the literature to have significant hypoglycemic efficacy and to protect islet cells in vitro. Diterpenoids may be the components of this herbal remedy that preserve islets, but further research is needed. Aim of the study: This study was projected to investigate the new diterpenoid scoparicol E from S. dulcis and examined its islet-protective effect and the potential mechanism both in vitro and in vivo. Methods: The structure of the novel diterpenoid scoparicol E was clarified by employing a wide range of spectroscopic methods. Using CCK-8 tests, cytotoxicity and antiapoptotic activity of scoparicol E were detected. Serum biochemical analysis and pathologic examination were performed to study the protective effect of scoparicol E against islet damage. The specific mechanism of action of scoparicol E was investigated through the mitochondrial membrane potential, Annexin V-FITC flow cytometry, and western blotting. Results: Scoparicol E reduced MLD-STZ-induced hyperglycemia in mice and increased insulin and islet apoptosis. Scoparicol E effectively suppressed the Bax/Bcl-2/Caspase-3 pathway, according to the in vivo western blot investigation. Scoparicol E showed significant antiapoptotic action in vitro. We also showed that scoparicol E might prevent islet cells from dying by inhibiting the Bax/Bcl-2/Caspase-3 pathway. The Annexin V-FITC flow cytometry results revealed that MIN6 cell apoptosis was considerably decreased following scoparicol E intervention, showing anti-islet cell apoptosis action. Furthermore, the Caspase-3-mediated apoptosis pathway depends on cytochrome c and the potential of the mitochondrial membrane. Scoparicol E prevented the release of cytochrome c, restored the mitochondrial membrane potential, and prevented MIN6 cell apoptosis. Conclusion: We demonstrated the new diterpenoid scoparicol E could protect islet cells apoptosis by modulating the Bax/Bcl-2/Caspase-3 pathway.
MeSH term(s)	Mice ; Animals ; Caspase 3/metabolism ; bcl-2-Associated X Protein/metabolism ; Scoparia/metabolism ; Cytochromes c/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Islets of Langerhans ; Apoptosis ; Diabetes Mellitus/metabolism ; Diterpenes/pharmacology ; Diterpenes/metabolism
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein ; Cytochromes c (9007-43-6) ; Proto-Oncogene Proteins c-bcl-2 ; Diterpenes
Language	English
Publishing date	2023-12-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117571
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