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  1. Article ; Online: Analyzing the low carbon and pro-environment behavior of agricultural enterprises based on organizational commitment and role models' guidance.

    Li, Xuelan / Cifuentes-Faura, Javier / Tan, YuQing

    Environmental science and pollution research international

    2023  

    Abstract: Climate change has always been a core issue in the field of agricultural security. From the perspective of "passive adaptation" and "active change," climate response is manifested as climate "adaptation behavior" and "low carbon and pro-environment ... ...

    Abstract Climate change has always been a core issue in the field of agricultural security. From the perspective of "passive adaptation" and "active change," climate response is manifested as climate "adaptation behavior" and "low carbon and pro-environment behavior" respectively. In the long run, low carbon and pro-environment behavior make more sense. As an indispensable part of the modern agricultural management system, agricultural enterprises are the core power to promote the organic reorganization of various agricultural production factors, and the optimal low carbon and pro-environmental behavior is the key to the implementation of national ecological environmental protection policies. The purpose of this paper is to reveal the mechanism of pro-environment behavior of organization members based on the organizational background of agricultural enterprises. Taking advantage of 189 valid survey data of agricultural enterprises, structural equation model was used to explore the effects of organizational commitment and role models' guidance on low carbon and pro-environment behavior. Results show that organizational commitment has a significant positive effect on the low carbon and pro-environment behavior of agricultural enterprises. And what is not expected is that role models' guidance has a significant negative effect on the low carbon and pro-environment behavior of agricultural enterprises, and organizational commitment has a negative impact on the low carbon and pro-environment behavior of agricultural enterprises through role models' guidance. Recommendations such as practicing green culture and enhancing emotional engagement; fostering social responsibility and strengthening normative commitment; providing a fair path and increasing the influence of role models; improving the selection system of role models and also the criteria; improving the level of leadership and achieving high quality interaction or creating a business environment are proposed.
    Language English
    Publishing date 2023-12-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31302-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epac, a positive or negative signaling molecule in cardiovascular diseases.

    Tan, Yu-Qing / Li, Jun / Chen, Heng-Wen

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 148, Page(s) 112726

    Abstract: Cardiovascular disease (CVD) is one of the leading causes of death and disability, and has always been a hotspot in clinical and scientific research. The illness brings a heavy economic burden and causes psychological pressure on society and families. ... ...

    Abstract Cardiovascular disease (CVD) is one of the leading causes of death and disability, and has always been a hotspot in clinical and scientific research. The illness brings a heavy economic burden and causes psychological pressure on society and families. The pathogenesis of CVD is complex and has not yet been fully elucidated. Mitochondria provide energy for cardiovascular function. cAMP signaling is closely related to the mechanism of action of mitochondria. Epac, an important effector of cAMP, is involved in a variety of physiopathological mechanisms of CVD. Epac acts on a variety of pathways, including ion level regulation, cardiac hypertrophy, cardiac fibrosis, cardiomyocyte apoptosis, and angiogenesis. In this article, we systematically discuss the mechanism of action of Epac in CVDs to provide (i) ideas for the treatment of CVDs such as arrhythmia and heart failure and (ii) a basis for studying biological pathways and carrying out targeted drug research. Although some of the studied mechanisms are inconsistent, they also illustrate the complexity and importance of the effects of Epac.
    MeSH term(s) Cardiomegaly/metabolism ; Cardiovascular Diseases/drug therapy ; Cyclic AMP/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Signal Transduction
    Chemical Substances Guanine Nucleotide Exchange Factors ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2022-02-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation.

    Tan, Yu-Qing / Jin, Min / He, Xuan-Hui / Chen, Heng-Wen

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1025540

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1025540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases.

    Tan, Yu-Qing / Chen, Heng-Wen / Li, Jun

    Drug design, development and therapy

    2020  Volume 14, Page(s) 3731–3746

    Abstract: Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective ... ...

    Abstract Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM.
    MeSH term(s) Astragalus propinquus/chemistry ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/pathology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional ; Molecular Conformation ; Saponins/chemistry ; Saponins/therapeutic use ; Triterpenes/chemistry ; Triterpenes/therapeutic use
    Chemical Substances Drugs, Chinese Herbal ; Saponins ; Triterpenes ; astragaloside A (3A592W8XKE)
    Language English
    Publishing date 2020-09-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S272355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adenosine triphosphate can act as a determinant of lysine acetylation of non-native and native substrates.

    Zhou, Jia-Peng / Tan, Yu-Qing / Chen, Zi-Hao / Zhao, Wei / Liu, Tong

    Microbiological research

    2022  Volume 268, Page(s) 127296

    Abstract: The protein lysine acetylation includes acetyl-CoA (AcCoA) or acetyl phosphate (AcP)-mediated nonenzymatic acetylation, and enzymatic acetylation. It is widespread in the proteomes but the acetylation levels of most sites are very low. A thorough ... ...

    Abstract The protein lysine acetylation includes acetyl-CoA (AcCoA) or acetyl phosphate (AcP)-mediated nonenzymatic acetylation, and enzymatic acetylation. It is widespread in the proteomes but the acetylation levels of most sites are very low. A thorough understanding of the determinants of low acetylation levels is highly important for elucidating the physiological relevance of lysine acetylation. In this study, we constructed a non-native substrate library containing 24 synthesized polypeptides, and we showed that ATP could inhibit the AcCoA-mediated nonenzymatic acetylation of these polypeptides through LC-MS/MS analysis. The acetyltransferase PatZ could acetylated these non-native substrates, and the PatZ-catalyzed acetylation of the polypeptides was also inhibited by ATP. Furthermore, the Western blot showed that ATP also inhibited the nonenzymatic (AcCoA or AcP-mediated) and enzymatic (PatZ-catalyzed) acetylation of acetyl-CoA synthetase Acs, which is a native substrate for acetylation. ATP can also inhibit the autoacetylation of acetyltransferase PatZ. Besides, both ADP and AMP could enhance the AcP-mediated acetylation of Acs, but ADP slightly inhibited the AcCoA-mediated acetylation of Acs. However, both ADP and AMP had no evident inhibition on the PatZ-catalyzed acetylation of Acs. Based on these results, we proposed that ATP can act as an inhibitor of acetylation, and it may regulate the function of PatZ by inhibiting its autoacetylation and compensate for the function of deacetylase CobB.
    MeSH term(s) Escherichia coli Proteins/metabolism ; Escherichia coli/metabolism ; Adenosine Triphosphate/metabolism ; Lysine/metabolism ; Acetylation ; Acetyl Coenzyme A/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Acetyltransferases ; Adenosine Diphosphate/metabolism ; Adenosine Monophosphate/metabolism
    Chemical Substances Escherichia coli Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; Lysine (K3Z4F929H6) ; Acetyl Coenzyme A (72-89-9) ; Acetyltransferases (EC 2.3.1.-) ; Adenosine Diphosphate (61D2G4IYVH) ; Adenosine Monophosphate (415SHH325A)
    Language English
    Publishing date 2022-12-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Efficacy, Chemical Constituents, and Pharmacological Actions of

    Tan, Yu-Qing / Chen, Heng-Wen / Li, Jun / Wu, Qing-Juan

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1054

    Abstract: Radix Paeoniae ... ...

    Abstract Radix Paeoniae Rubra
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases.

    Tan, Yu-Qing / Lin, Fei / Ding, Yu-Kun / Dai, Shuang / Liang, Ying-Xin / Zhang, Yun-Shu / Li, Jun / Chen, Heng-Wen

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 107, Page(s) 154458

    Abstract: Background: Scutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. The medicinal properties of this plant are attributed to the total flavonoids of Scutellaria ...

    Abstract Background: Scutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. The medicinal properties of this plant are attributed to the total flavonoids of Scutellaria baicalensis (TFSB), particularly the main component, baicalin. This study provides a systematic and comprehensive list of the identified TFSB components and their chemical structures. The quality control process, pharmacokinetics, clinical application, and safety of Scutellaria baicalensis are discussed, and its pharmacological effect on cardiovascular diseases (CVDs) is detailed. Finally, the future research trends and prospects of this medicinal plant are provided.
    Methods: The Chinese and English papers related to TFSB were collected from the PubMed and CNKI databases using the relevant keywords. To highlight the pharmacological mechanism, clinical application, and safety of TFSB, the collected articles were screened and classified based on their research content.
    Results: TFSB contains at least 100 different kinds of flavonoids, of which baicalin, baicalein, wogonin, wogonoside, scutellarin, and scutellarein are the main active ingredients. The preparation process of TFSB is relatively well established, and the extraction rate can be significantly increased by enzymatic pretreatment and ultrasonication. The low oral availability of TFSB may be effectively enhanced using nanoformulations. The available pharmacokinetic data show that flavonoid glycosides and aglycones with the same parent nucleus may be converted to structures that are conducive to absorption in vivo. Moreover, TFSB can protect against CVDs by inhibiting apoptosis, regulating oxidative stress response, participating in inflammatory response, protecting against myocardial fibrosis, inhibiting myocardial hypertrophy, and regulating blood vessels. In terms of clinical application and animal safety, the available studies show that TFSB can be applied in a wide range of clinical treatments and is safe to use is animals.
    Conclusion: This article systematically reviews the therapeutic effect and underlying pharmacological mechanism of TFSB against CVDs. The available studies clearly suggest that TFSB has great potential for the treatment of CVDs and is worthy of in-depth research and development.
    MeSH term(s) Animals ; Cardiovascular Diseases/drug therapy ; Flavanones/analysis ; Flavonoids/analysis ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Glycosides/analysis ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Scutellaria baicalensis/chemistry
    Chemical Substances Flavanones ; Flavonoids ; Glycosides
    Language English
    Publishing date 2022-09-15
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases

    Tan, Yu-Qing / Lin, Fei / Ding, Yu-Kun / Dai, Shuang / Liang, Ying-Xin / Zhang, Yun-Shu / Li, Jun / Chen, Heng-Wen

    Phytomedicine. 2022 Dec., v. 107

    2022  

    Abstract: Scutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. The medicinal properties of this plant are attributed to the total flavonoids of Scutellaria baicalensis ( ...

    Abstract Scutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. The medicinal properties of this plant are attributed to the total flavonoids of Scutellaria baicalensis (TFSB), particularly the main component, baicalin. This study provides a systematic and comprehensive list of the identified TFSB components and their chemical structures. The quality control process, pharmacokinetics, clinical application, and safety of Scutellaria baicalensis are discussed, and its pharmacological effect on cardiovascular diseases (CVDs) is detailed. Finally, the future research trends and prospects of this medicinal plant are provided. The Chinese and English papers related to TFSB were collected from the PubMed and CNKI databases using the relevant keywords. To highlight the pharmacological mechanism, clinical application, and safety of TFSB, the collected articles were screened and classified based on their research content. TFSB contains at least 100 different kinds of flavonoids, of which baicalin, baicalein, wogonin, wogonoside, scutellarin, and scutellarein are the main active ingredients. The preparation process of TFSB is relatively well established, and the extraction rate can be significantly increased by enzymatic pretreatment and ultrasonication. The low oral availability of TFSB may be effectively enhanced using nanoformulations. The available pharmacokinetic data show that flavonoid glycosides and aglycones with the same parent nucleus may be converted to structures that are conducive to absorption in vivo. Moreover, TFSB can protect against CVDs by inhibiting apoptosis, regulating oxidative stress response, participating in inflammatory response, protecting against myocardial fibrosis, inhibiting myocardial hypertrophy, and regulating blood vessels. In terms of clinical application and animal safety, the available studies show that TFSB can be applied in a wide range of clinical treatments and is safe to use is animals. This article systematically reviews the therapeutic effect and underlying pharmacological mechanism of TFSB against CVDs. The available studies clearly suggest that TFSB has great potential for the treatment of CVDs and is worthy of in-depth research and development.
    Keywords Scutellaria baicalensis ; absorption ; animals ; apoptosis ; baicalin ; blood ; fibrosis ; glycosides ; hypertrophy ; inflammation ; medicinal plants ; oxidative stress ; pharmacokinetics ; quality control ; research and development ; stress response ; therapeutics ; ultrasonic treatment
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154458
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Efficacy and safety of Chinese herbal medicine Wen Xin granules for the treatment of unstable angina pectoris with Yang deficiency and blood stasis syndrome: study protocol for a randomized controlled trial.

    Tian, Pan-Pan / Wu, Qing-Juan / Li, Jun / Chen, Heng-Wen / Wu, Ji / Deng, Ya-Wen / Xie, Zi-Cong / Zhao, Wei / Tan, Yu-Qing

    Trials

    2021  Volume 22, Issue 1, Page(s) 798

    Abstract: Introduction: Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after ... ...

    Abstract Introduction: Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after revascularization or conventional medication due to the microvascular lesions, endothelial dysfunction, chronic inflammation, in-stent restenosis, and other factors. As an important part of China's medical and health care system, traditional Chinese medicine (TCM) has rich clinical experience in the treatment of UAP. According to the theory of TCM, Yang deficiency and blood stasis syndrome is a common type of UAP. Wen Xin decoction, as a type of Chinese herbal medicine, has been used in the clinic for years and shown great efficacy in the treatment of UAP with Yang deficiency and blood stasis syndrome. This study aims to evaluate the efficacy and safety of Wen Xin granular in patients with UAP.
    Methods and analysis: This is a double-blinded, randomized, placebo-controlled clinical trial. A total of 502 participants will be randomly allocated to the intervention group and the placebo group. Based on conventional medication, the intervention group will be treated with Wen Xin granular and the placebo group will be treated with Wen Xin granular placebo. The primary outcomes are major adverse cardiovascular events (MACE). Assessments will be performed 1 year after the treatment. The secondary outcomes include TCM symptom scale score, Seattle angina questionnaire, and thromboelastography. Assessments will be performed at baseline (before randomization) and 4 and 8 weeks after randomization.
    Discussion: This trial will provide high-quality data on the benefits and risks of Wen Xin granular in patients with UAP.
    Trial registration: ClinicalTrials.gov NCT04661709 . Registered on 30 November 2020.
    MeSH term(s) Angina, Unstable/diagnosis ; Angina, Unstable/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Humans ; Medicine, Chinese Traditional ; Myocardial Infarction ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Yang Deficiency
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-11-13
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-021-05771-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Preliminary study on antibacterial activity of artemisinin and its derivatives].

    Huang, Mei / Shen, Jian-Ying / DU, Cheng-Cheng / Yin, Ting / Ge, Fang-Ji / Tan, Yu-Qing / Luo, Jun

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2019  Volume 44, Issue 9, Page(s) 1946–1952

    Abstract: In this study,in order to detect the antimicrobial activity of artemisinin and its derivatives artesunate and dihydroartemisinin,two methods including broth dilution and plate punching method were used to detect the antibacterial activity against gram- ... ...

    Abstract In this study,in order to detect the antimicrobial activity of artemisinin and its derivatives artesunate and dihydroartemisinin,two methods including broth dilution and plate punching method were used to detect the antibacterial activity against gram-negative bacteria(Escherichia coli)and gram-positive bacteria(Staphylococcus aureus)of artemisinin,dihydroartemisinin and artesunate at various concentrations within 5 mmol·L~(-1)and at four time points(8,16,24,32 h).Two antibacterial positive drugs,streptomycin against E.coli and penicillin against S.aureus,were used as positive controls.Plate punching method showed that,unlike the results of 5 mmol·L~(-1)dihydroartemisinin or artesunate,no inhibition zone was detected at the same concentration of artemisinin after 24 h-treatment against E.coli.Broth dilution method showed that,the antibacterial activity of dihydroartemisinin against E.coli.was stronger than those of both artesunate and artemisinin;IC_(50)at24 h-treatment was 155.9μmol·L~(-1)for dihydroartemisinin,370.0μmol·L~(-1)for artesunate and none for artemisinin.Interestingly,dihydroartemisinin and artesunate showed the strongest antibacterial activity between 16-24 h,while artemisinin showed relatively stronger antibacterial activity between 8-16 h.Dihydroartermisinin showed no antibacterial activity against S.aureus.Above all,the antibacterial activity of artemisinins against E.coli is dihydroartemisinin>artesunate>artemisinin.Artemisinin and its derivatives have showed different antibacterial kinetics,and no antibacterial activity against S.aureus.has been detected with dihydroartemisinin.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Artemisinins/pharmacology ; Artesunate/pharmacology ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents ; Artemisinins ; Artesunate (60W3249T9M) ; artemisinin (9RMU91N5K2)
    Language Chinese
    Publishing date 2019-09-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20190131.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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