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  1. Article ; Online: Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy.

    Amali, Aseervatham Anusha / Ravikumar, Sharada / Chew, Wei Leong / Tan, Zhaohong / Sam, Qi Hui / Chen, Kaiwen W / Boucher, Dave / MacLaren, Graeme / Chai, Louis Yi Ann

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 78, Issue 1, Page(s) 94–97

    Abstract: We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming ... ...

    Abstract We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.
    MeSH term(s) Humans ; Melioidosis/drug therapy ; Burkholderia pseudomallei/genetics ; Interferon-gamma/genetics ; Extracorporeal Membrane Oxygenation ; Mutation
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  2. Article ; Online: The Divergent Immunomodulatory Effects of Short Chain Fatty Acids and Medium Chain Fatty Acids.

    Sam, Qi Hui / Ling, Hua / Yew, Wen Shan / Tan, Zhaohong / Ravikumar, Sharada / Chang, Matthew Wook / Chai, Louis Yi Ann

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: Fatty acids are derived from diet and fermentative processes by the intestinal flora. Two to five carbon chain fatty acids, termed short chain fatty acids (SCFA) are increasingly recognized to play a role in intestinal homeostasis. However, the ... ...

    Abstract Fatty acids are derived from diet and fermentative processes by the intestinal flora. Two to five carbon chain fatty acids, termed short chain fatty acids (SCFA) are increasingly recognized to play a role in intestinal homeostasis. However, the characteristics of slightly longer 6 to 10 carbon, medium chain fatty acids (MCFA), derived primarily from diet, are less understood. Here, we demonstrated that SCFA and MCFA have divergent immunomodulatory propensities. SCFA down-attenuated host pro-inflammatory IL-1β, IL-6, and TNFα response predominantly through the TLR4 pathway, whereas MCFA augmented inflammation through TLR2. Butyric (C4) and decanoic (C10) acid displayed most potent modulatory effects within the SCFA and MCFA, respectively. Reduction in TRAF3, IRF3 and TRAF6 expression were observed with butyric acid. Decanoic acid induced up-regulation of GPR84 and PPARγ and altered HIF-1α/HIF-2α ratio. These variant immune characteristics of the fatty acids which differ by just several carbon atoms may be attributable to their origins, with SCFA being primarily endogenous and playing a physiological role, and MCFA exogenously from the diet.
    MeSH term(s) Biomarkers ; Butyric Acid/metabolism ; Candida/physiology ; Cytokines/metabolism ; Diet ; Fatty Acids/metabolism ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunomodulation/genetics ; Inflammation Mediators/metabolism ; Toll-Like Receptor 4/metabolism
    Chemical Substances Biomarkers ; Cytokines ; Fatty Acids ; Fatty Acids, Volatile ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Inflammation Mediators ; TLR4 protein, human ; Toll-Like Receptor 4 ; Butyric Acid (107-92-6)
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dominant Negative TRAF3 Variant With Recurrent

    Liew, Mei Fong / Lim, Hui Fang / Liang, Mui Cheng / Lim, Ives / Tan, Zhaohong / Tan, Rachel Ying Min / Sam, Qi Hui / Soe, Win Mar / Tay, Sen Hee / Xu, Shengli / Chang, Matthew Wook / Foo, Roger / Soong, Tuck Wah / Ravikumar, Sharada / Chai, Louis Yi Ann

    Open forum infectious diseases

    2022  Volume 9, Issue 8, Page(s) ofac379

    Abstract: Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor ...

    Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tocilizumab Induces IL-10-Mediated Immune Tolerance in Invasive Candidiasis.

    Tan, Zhaohong / Mok, Michelle Meng Huang / Mar Soe, Win / Thamboo, Thomas Paulraj / Goh, Jessamine Geraldine / Sam, Qi Hui / Osato, Motomi / Ravikumar, Sharada / Chai, Louis Yi Ann

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 8

    Abstract: The existence of a hyperinflammatory state has been observed in patients with invasive fungal infections (IFI). It is being postulated whether morbidity from IFI may, in part, be a consequence of an unnecessarily prolonged or exaggerated proinflammatory ... ...

    Abstract The existence of a hyperinflammatory state has been observed in patients with invasive fungal infections (IFI). It is being postulated whether morbidity from IFI may, in part, be a consequence of an unnecessarily prolonged or exaggerated proinflammatory immune response including interleukin 6 (IL-6) post-infection, in a host with dysregulated or compromised immunity. This, in turn, induces collateral host injury at the tissue and organ level, leading to adverse outcomes. Tocilizumab has become widely used as an immunomodulator in the treatment of inflammatory conditions. Here, we evaluated the use of tocilizumab to curb post-infective inflammatory flare in the setting of an in-vivo mouse model for invasive candidiasis. Following
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7080656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Using Expanded Natural Killer Cells as Therapy for Invasive Aspergillosis.

    Soe, Win Mar / Lim, Joan Hui Juan / Williams, David L / Goh, Jessamine Geraldine / Tan, Zhaohong / Sam, Qi Hui / Chotirmall, Sanjay H / Ali, Nur A'tikah Binte Mohamed / Lee, Soo Chin / Seet, Ju Ee / Ravikumar, Sharada / Chai, Louis Yi Ann

    Journal of fungi (Basel, Switzerland)

    2020  Volume 6, Issue 4

    Abstract: Invasive aspergillosis (IA) is a major opportunistic fungal infection in patients with haematological malignancies. Morbidity and mortality rates are high despite anti-fungal treatment, as the compromised status of immune system prevents the host from ... ...

    Abstract Invasive aspergillosis (IA) is a major opportunistic fungal infection in patients with haematological malignancies. Morbidity and mortality rates are high despite anti-fungal treatment, as the compromised status of immune system prevents the host from responding optimally to conventional therapy. This raises the consideration for immunotherapy as an adjunctive treatment. In this study, we evaluated the utility of expanded human NK cells as treatment against
    Language English
    Publishing date 2020-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof6040231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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