Article ; Online: Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology.
2024 Volume 25, Issue 1, Page(s) 2
Abstract: Background: Despite the functions of TLRs in the parasitic infections have been extensively reported, few studies have addressed the role of TLR3 in the immune response to Schistosoma japonicum infections. The aim of this study was to investigate the ... ...
| Abstract | Background: Despite the functions of TLRs in the parasitic infections have been extensively reported, few studies have addressed the role of TLR3 in the immune response to Schistosoma japonicum infections. The aim of this study was to investigate the properties of TLR3 in the liver of C57BL/6 mice infected by S. japonicum. Methods: The production of TLR3 Results: Flow cytometry results showed that the expression of TLR3 increased significantly after S. japonicum infection (P < 0.05). Hepatic myeloid and lymphoid cells could express TLR3, and the percentages of TLR3-expressing MDSC, macrophages and neutrophils were increased after infection. Knocking out TLR3 ameliorated the damage and decreased infiltration of inflammatory cells in infected C57BL/6 mouse livers.,The number of WBC was significantly reduced in TLR3 KO-infected mice compared to WT-infected mice (P < 0.01), but the levels of RBC, platelet and HGB were significantly increased in KO infected mice. Moreover, the relative titers of anti-SEA IgG and anti-SEA IgM in the serum of infected KO mice were statistically decreased compared with the infected WT mice. We also compared the activation-associated molecules expression between S.japonicum-infected WT and TLR3 KO mice. Conclusions: Taken together, our data indicated that TLR3 played potential roles in the context of S. japonicum infection and it may accelerate the progression of S. japonicum-associated liver pathology. |
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| MeSH term(s) | Animals ; Mice ; Schistosoma japonicum/metabolism ; Toll-Like Receptor 3/metabolism ; Mice, Inbred C57BL ; Immunoglobulin G ; Immunoglobulin M |
| Chemical Substances | Toll-Like Receptor 3 ; Immunoglobulin G ; Immunoglobulin M ; TLR3 protein, mouse |
| Language | English |
| Publishing date | 2024-01-03 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2041500-X |
| ISSN | 1471-2172 ; 1471-2172 |
| ISSN (online) | 1471-2172 |
| ISSN | 1471-2172 |
| DOI | 10.1186/s12865-023-00586-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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