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  1. Article: Scoring microvascular invasion in hepatocellular carcinoma: are we meeting the grade?

    Erstad, Derek J / Tanabe, Kenneth K

    Hepatobiliary surgery and nutrition

    2024  Volume 13, Issue 1, Page(s) 184–187

    Language English
    Publishing date 2024-01-18
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adjuvant Systemic Therapy for High-Risk Melanoma.

    Cohen, Sonia / Tanabe, Kenneth K

    Annals of surgical oncology

    2023  Volume 30, Issue 5, Page(s) 2568–2569

    MeSH term(s) Humans ; Melanoma/drug therapy ; Combined Modality Therapy ; Adjuvants, Immunologic/therapeutic use ; Skin Neoplasms/drug therapy ; Chemotherapy, Adjuvant
    Chemical Substances Adjuvants, Immunologic
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13105-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Cancer gene therapy

    Tanabe, Kenneth K.

    (Surgical oncology clinics of North America ; 7,3)

    1998  

    Author's details Kenneth K. Tanabe, guest ed
    Series title Surgical oncology clinics of North America ; 7,3
    Collection
    Keywords Krebs ; Gentherapie
    Subject Somatische Gentherapie ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size XI S., S. 421 - 631 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008881488
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1339 -7,3- verfügbar in Königswinter Königswinter

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  4. Article ; Online: ASO Author Reflections: Variations and Inconsistencies in the Guidelines for the Clinical Management of Cholangiocarcinoma.

    Fong, Zhi Ven / Tanabe, Kenneth K

    Annals of surgical oncology

    2021  Volume 28, Issue Suppl 3, Page(s) 860–861

    MeSH term(s) Bile Duct Neoplasms/therapy ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/therapy ; Humans
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09703-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver.

    Leaker, Ben D / Sojoodi, Mozhdeh / Tanabe, Kenneth K / Popov, Yury V / Tam, Joshua / Anderson, R Rox

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 8, Page(s) e23585

    Abstract: Fractional laser ablation is a technique developed in dermatology to induce remodeling of skin scars by creating a dense pattern of microinjuries. Despite remarkable clinical results, this technique has yet to be tested for scars in other tissues. As a ... ...

    Abstract Fractional laser ablation is a technique developed in dermatology to induce remodeling of skin scars by creating a dense pattern of microinjuries. Despite remarkable clinical results, this technique has yet to be tested for scars in other tissues. As a first step toward determining the suitability of this technique, we aimed to (1) characterize the response to microinjuries in the healthy and cirrhotic liver, and (2) determine the underlying cause for any differences in response. Healthy and cirrhotic rats were treated with a fractional laser then euthanized from 0 h up to 14 days after treatment. Differential expression was assessed using RNAseq with a difference-in-differences model. Spatial maps of tissue oxygenation were acquired with hyperspectral imaging and disruptions in blood supply were assessed with tomato lectin perfusion. Healthy rats showed little damage beyond the initial microinjury and healed completely by 7 days without scarring. In cirrhotic rats, hepatocytes surrounding microinjury sites died 4-6 h after ablation, resulting in enlarged and heterogeneous zones of cell death. Hepatocytes near blood vessels were spared, particularly near the highly vascularized septa. Gene sets related to ischemia and angiogenesis were enriched at 4 h. Laser-treated regions had reduced oxygen saturation and broadly disrupted perfusion of nodule microvasculature, which matched the zones of cell death. Our results demonstrate that the cirrhotic liver has an exacerbated response to microinjuries and increased susceptibility to ischemia from microvascular damage, likely related to the vascular derangements that occur during cirrhosis development. Modifications to the fractional laser tool, such as using a femtosecond laser or reducing the spot size, may be able to prevent large disruptions of perfusion and enable further development of a laser-induced microinjury treatment for cirrhosis.
    MeSH term(s) Animals ; Rats ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Ischemia/metabolism ; Ischemia/pathology ; Liver/metabolism ; Liver/pathology ; Laser Therapy/methods ; Rats, Sprague-Dawley ; Hepatocytes/metabolism
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202301438RR
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  6. Article ; Online: A Shifting Paradigm in Diagnosis and Management of Hepatic Adenoma.

    Krause, Kate / Tanabe, Kenneth K

    Annals of surgical oncology

    2020  Volume 27, Issue 9, Page(s) 3330–3338

    Abstract: Background: New insights into molecular pathogenesis of hepatocellular adenomas (HCA) have allowed sub-classification based on distinct genetic alterations and a fresh look at characterizations of natural history. Clinically, this is important in ... ...

    Abstract Background: New insights into molecular pathogenesis of hepatocellular adenomas (HCA) have allowed sub-classification based on distinct genetic alterations and a fresh look at characterizations of natural history. Clinically, this is important in understanding risk factors for two feared complications: malignant transformation and hemorrhage.
    Methods: PubMed literature search for hepatocellular adenoma over all years, excluding case reports and articles focusing on multiple adenomas or adenomatosis.
    Results: The β-catenin exon 3 mutated HCA accounts for about 10% of all HCAs and is associated with the highest risk of malignant transformation. The HF1α subtype accounts for 30-40% of all HCAs and has the lowest risk of malignant transformation. Gender has also emerged as an increasingly important risk factor and males with HCA are at considerably higher risk of malignant transformation, regardless of tumor size. The increasing use of gadoxetic-enhanced MRI has allowed for improved differentiation of HCAs from focal nodular hyperplasia, as well as the identification of specific radiologic features of some subtypes, particularly the inflammatory and HF1α HCAs.
    Conclusions: Classification of HCA by subtype has important implications for patient counseling and treatment given variable risks of malignant transformation and hemorrhage. Males and those with β-catenin exon 3 mutated HCAs are two groups who should always be counselled to undergo surgical resection. On the other hand, in the lower risk HF1α subtype observation is appropriate in lesions < 5 cm and may even be considered in larger lesions as longer follow-up data is aggregated and tumorigenesis is better understood.
    MeSH term(s) Adenoma, Liver Cell/diagnosis ; Adenoma, Liver Cell/diagnostic imaging ; Adenoma, Liver Cell/therapy ; Focal Nodular Hyperplasia/diagnosis ; Focal Nodular Hyperplasia/diagnostic imaging ; Focal Nodular Hyperplasia/genetics ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/genetics ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Sex Factors
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08580-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: ASO Author Reflections: Developing Personalized Care for Hepatocellular Adenoma Based on Subtype Classification.

    Krause, Kate / Tanabe, Kenneth K

    Annals of surgical oncology

    2020  Volume 27, Issue 9, Page(s) 3339–3340

    MeSH term(s) Adenoma, Liver Cell ; Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms/therapy
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08681-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Are we thinking? A commentary on "is partial-ALPPS safer than ALPPS? A single-center experience".

    Tanabe, Kenneth K

    Annals of surgery

    2015  Volume 261, Issue 4, Page(s) e93

    MeSH term(s) Female ; Hepatectomy/methods ; Humans ; Liver Neoplasms/surgery ; Male ; Portal Vein/surgery
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000001088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Commentary on "Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases?".

    Tanabe, Kenneth K

    Surgery

    2015  Volume 157, Issue 2, Page(s) 204–206

    MeSH term(s) Colorectal Neoplasms ; Female ; Hepatectomy/methods ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2014.08.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.129: Show issues Location:
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  10. Article ; Online: An angiotensin system inhibitor (losartan) potentiates antitumor efficacy of cisplatin in a murine model of non-small cell lung cancer.

    Tang, Hexiao / Abston, Eric / Sojoodi, Mozhdeh / Wang, Yongtao / Erstad, Derek J / Lin, Zenan / Fuchs, Bryan C / Tanabe, Kenneth K / Lanuti, Michael

    JTCVS open

    2024  Volume 18, Page(s) 306–321

    Abstract: Objective: Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer. This study examines whether or not synergistic antitumor effects occur with ... ...

    Abstract Objective: Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer. This study examines whether or not synergistic antitumor effects occur with combination ASI and cisplatin treatment in lung cancer, and whether or not ASI-induced changes in epithelial-mesenchymal transition play a role in the mechanism of this antitumor phenomenon.
    Methods: A set of lung cancer cell lines representing a spectrum of epithelial to mesenchymal phenotypes were identified and characterized. Response of epithelial-mesenchymal transition markers to losartan was characterized. Cell culture models of lung cancer were next treated with losartan, cisplatin, or combination of both. Markers of epithelial-mesenchymal transition or surrogates of other signaling pathways (AKT, Stat3, and programmed death-ligand), and cell viability were quantified. Findings were confirmed in both allogenic and syngeneic in vivo murine flank tumor models.
    Results: Losartan treatment significantly increased E-cadherin and reduced vimentin in human lung cancer cell lines. Combination treatment with losartan and cisplatin enhanced epithelial markers, reduced mesenchymal markers, inhibited promesenchymal signaling mediators, and reduced cell viability. Findings were confirmed in vivo in a murine flank tumor model with transition from mesenchymal to epithelial phenotype and reduced tumor size following combination losartan and cisplatin treatment.
    Conclusions: Combination losartan and cisplatin treatment attenuates the epithelial-mesenchymal transition pathway and enhances the cytotoxic effect of chemotherapy with in vitro and in vivo models of non-small cell lung cancer. This study suggests an important role for ASI therapy in the treatment of lung cancer.
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2024.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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