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Book ; Conference proceedings: Exercise for preventing common diseases

Tanaka, Hiroaki

1999

Event/congress	International Symposium Optimal Exercise for Preventing Common Diseases (1998, Fukuoka)
Author's details	H. Tanaka ... (eds.). [International Symposium Optimal Exercise for Preventing Common Diseases held at Fukuoka University on July 13, 1998]
Keywords	Primary Prevention / methods / congresses ; Exercise / congresses ; Gesundheitssport ; Präventivmedizin ; Zivilisationskrankheit ; Präventives Training
Subject	Gesundheitstraining ; Wohlstandskrankheit ; Lifestyle Disease ; Prophylaktische Medizin ; Vorsorgemedizin ; Prävention ; Präventive Medizin
Language	English
Size	IX, 212 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Tokyo u.a.
Publishing country	Japan
Document type	Book ; Conference proceedings
HBZ-ID	HT011248397
ISBN	4-431-70271-7 ; 978-4-431-70271-9
Database	Catalogue ZB MED Medicine, Health

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Article: [Pharmacological Profile and Clinical Study Results of endothelin receptor antagonist, Clazosentan Sodium (PIVLAZ

Takahashi, Shuya / Tanaka, Hiroaki

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

2022 Volume 157, Issue 6, Page(s) 464–473

Abstract: Cerebral vasospasm occurs within 4 to 14 days from the onset of aneurysmal subarachnoid hemorrhage (aSAH) in 40 to 70% of patients. Of patients with cerebral vasospasm, 17 to 40% experience delayed ischemic neurological deficits and about half of them ... ...

Abstract	Cerebral vasospasm occurs within 4 to 14 days from the onset of aneurysmal subarachnoid hemorrhage (aSAH) in 40 to 70% of patients. Of patients with cerebral vasospasm, 17 to 40% experience delayed ischemic neurological deficits and about half of them develop cerebral infarction. Although the mechanism of the onset of cerebral vasospasm has not been fully elucidated, one of mechanisms is considered that after the onset of aSAH, the level of endothelin, a potent and sustained vasoconstriction substance, increases by production induced by oxyhemoglobin and release from erythrocytes and thus cerebral vasospasm develops via endothelin (ET)
MeSH term(s)	Humans ; Cerebral Infarction/etiology ; Cerebral Infarction/complications ; Endothelin Receptor Antagonists/pharmacology ; Endothelin Receptor Antagonists/therapeutic use ; Quality of Life ; Receptor, Endothelin A ; Sodium/therapeutic use ; Subarachnoid Hemorrhage/drug therapy ; Treatment Outcome ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/prevention & control
Chemical Substances	clazosentan (3DRR0X4728) ; Endothelin Receptor Antagonists ; Receptor, Endothelin A ; Sodium (9NEZ333N27)
Language	Japanese
Publishing date	2022-11-03
Publishing country	Japan
Document type	Clinical Trial ; English Abstract ; Journal Article
ZDB-ID	1097532-9
ISSN	1347-8397 ; 0015-5691
ISSN (online)	1347-8397
ISSN	0015-5691
DOI	10.1254/fpj.22065
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Article ; Online: Spatiotemporal distribution of veterinary and human drugs and its predictability in Japanese catchments.

Hanamoto, Seiya / Yamamoto-Ikemoto, Ryoko / Tanaka, Hiroaki

The Science of the total environment

2023 Volume 867, Page(s) 161514

Abstract: Little is known about the predictability of mass flows of veterinary drugs in Asian catchments, where effluent from livestock farms is a major source. We therefore conducted this study to understand the applicability and limitations of a population-based ...

Abstract	Little is known about the predictability of mass flows of veterinary drugs in Asian catchments, where effluent from livestock farms is a major source. We therefore conducted this study to understand the applicability and limitations of a population-based emission model, which assumed usage of veterinary and human drugs to be evenly distributed over the national livestock or human population throughout the year, and sources to be effluent discharges at livestock farms, households, and sewage treatment plants in Japanese catchments. We monitored five veterinary drugs (lincomycin, sulfamonomethoxine, tiamulin, tylosin, and tilmicosin), two human and livestock drugs (sulfamethoxazole and trimethoprim), two human drugs (carbamazepine and clarithromycin), and a metabolite (sulfapyridine) of a human drug once a month over 2 years in eight Japanese rivers which have active livestock farming in their catchments. Mass flows of carbamazepine and sulfapyridine were stable, while those of veterinary drugs fluctuated widely, especially sulfamonomethoxine and tilmicosin, whose 25 %-100 % ranges averaged 1.5 and 1.2 log units, respectively, attributable mainly to their usage patterns. The model accurately predicted mean mass flows of carbamazepine in the rivers with errors of <±0.3 log unit. Although it slightly to moderately overestimated those of the other four human-related compounds, the incorporation of an empirical correction factor, determined to minimize mean absolute error (MAE) among the rivers, substantially lowered their MAEs to <0.23 log units. However, the MAEs of the five veterinary drugs were as high as 0.42 (sulfamonomethoxine) to 0.60 (tiamulin) log units even with the coefficient, likely due mainly to the spatial distribution of their usage per capita. So as not to overlook spatiotemporal elevation of risks of veterinary drugs, a stochastic method should be applied in their management. This is the first study to assess the use of spatiotemporal homogeneity in usage per capita of veterinary drugs in Asian catchments.
MeSH term(s)	Anti-Bacterial Agents/analysis ; Environmental Monitoring/methods ; Sulfamonomethoxine ; Sulfapyridine ; Veterinary Drugs ; Water Pollutants, Chemical/analysis ; Japan
Chemical Substances	Anti-Bacterial Agents ; Sulfamonomethoxine (U700P169W2) ; Sulfapyridine (Y5V2N1KE8U) ; tiamulin (E38WZ4U54R) ; tilmicosin (XL4103X2E3) ; Veterinary Drugs ; Water Pollutants, Chemical
Language	English
Publishing date	2023-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161514
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Article ; Online: High-speed running quadruped robot with a multi-joint spine adopting a 1DoF closed-loop linkage.

Matsumoto, Ojiro / Tanaka, Hiroaki / Kawasetsu, Takumi / Hosoda, Koh

Frontiers in robotics and AI

2023 Volume 10, Page(s) 1148816

Abstract: Improving the mobility of robots is an important goal for many real-world applications and implementing an animal-like spine structure in a quadruped robot is a promising approach to achieving high-speed running. This paper proposes a feline-like multi- ... ...

Abstract	Improving the mobility of robots is an important goal for many real-world applications and implementing an animal-like spine structure in a quadruped robot is a promising approach to achieving high-speed running. This paper proposes a feline-like multi-joint spine adopting a one-degree-of-freedom closed-loop linkage for a quadruped robot to realize high-speed running. We theoretically prove that the proposed spine structure can realize 1.5 times the horizontal range of foot motion compared to a spine structure with a single joint. Experimental results demonstrate that a robot with the proposed spine structure achieves 1.4 times the horizontal range of motion and 1.9 times the speed of a robot with a single-joint spine structure.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2023.1148816
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Article ; Online: Evaluation of virus removal in membrane bioreactor (MBR) and conventional activated sludge (CAS) processes based on long-term monitoring at two wastewater treatment plants.

Tang, Yu / Sasaki, Kenta / Ihara, Masaru / Sugita, Daichi / Yamashita, Naoyuki / Takeuchi, Haruka / Tanaka, Hiroaki

Water research

2024 Volume 253, Page(s) 121197

Abstract: The membrane bioreactor (MBR) process always offers better wastewater treatment than conventional activated sludge (CAS) treatment. However, the difference in their efficacy of virus reduction remains unknown. To investigate this, we monitored virus ... ...

Abstract	The membrane bioreactor (MBR) process always offers better wastewater treatment than conventional activated sludge (CAS) treatment. However, the difference in their efficacy of virus reduction remains unknown. To investigate this, we monitored virus concentrations before and after MBR and CAS processes over 2 years. Concentrations of norovirus genotypes I and II (NoV GI and GII), aichivirus (AiV), F-specific RNA phage genotypes I, II, and III (GI-, GII-, and GIII-FRNAPHs), and pepper mild mottle virus (PMMoV) were measured by a quantitative polymerase chain reaction (qPCR) method at two municipal wastewater treatment plants (WWTPs A and B) in Japan. Virus concentration datasets containing left-censored data were estimated by using both maximum likelihood estimation (MLE) and robust regression on order statistics (rROS) approaches. PMMoV was the most prevalent at both WWTPs, with median concentrations of 7.5 to 8.8 log
MeSH term(s)	Sewage ; Viruses ; Wastewater ; Bioreactors ; Water Purification/methods ; Waste Disposal, Fluid/methods
Chemical Substances	Sewage ; Wastewater
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121197
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Article: A Machine Learning Approach for Prediction of CDAI Remission with TNF Inhibitors: A Concept of Precision Medicine from the FIRST Registry.

Sonomoto, Koshiro / Fujino, Yoshihisa / Tanaka, Hiroaki / Nagayasu, Atsushi / Nakayamada, Shingo / Tanaka, Yoshiya

Rheumatology and therapy

2024

Abstract: Introduction: This study aimed to develop low-cost models using machine learning approaches predicting the achievement of Clinical Disease Activity Index (CDAI) remission 6 months after initiation of tumor necrosis factor inhibitors (TNFi) as primary ... ...

Abstract	Introduction: This study aimed to develop low-cost models using machine learning approaches predicting the achievement of Clinical Disease Activity Index (CDAI) remission 6 months after initiation of tumor necrosis factor inhibitors (TNFi) as primary biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) for rheumatoid arthritis (RA). Methods: Data of patients with RA initiating TNFi as first b/tsDMARD after unsuccessful methotrexate treatment were collected from the FIRST registry (August 2003 to October 2022). Baseline characteristics and 6-month CDAI were collected. The analysis used various machine learning approaches including logistic regression with stepwise variable selection, decision tree, support vector machine, and lasso logistic regression (Lasso), with 48 factors accessible in routine clinical practice for the prediction model. Robustness was ensured by k-fold cross validation. Results: Among the approaches tested, Lasso showed the advantages in predicting CDAI remission: with a mean area under the curve 0.704, sensitivity 61.7%, and specificity 69.9%. Predicted TNFi responders achieved CDAI remission at an average rate of 53.2%, while only 26.4% of predicted TNFi non-responders achieved remission. Encouragingly, the models generated relied solely on patient-reported outcomes and quantitative parameters, excluding subjective physician input. Conclusions: While external cohort validation is warranted for broader applicability, this study highlights the potential for a low-cost predictive model to predict CDAI remission following TNFi treatment. The approach of the study using only baseline data and 6-month CDAI measures, suggests the feasibility of establishing regional cohorts to generate low-cost models tailored to specific regions or institutions. This may facilitate the application of regional/in-house precision medicine strategies in RA management.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2783278-8
ISSN	2198-6584 ; 2198-6576
ISSN (online)	2198-6584
ISSN	2198-6576
DOI	10.1007/s40744-024-00668-z
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Article: Vestibulo-Ocular Reflex Is Modulated by Noisy Galvanic Vestibular Stimulation.

Matsugi, Akiyoshi / Shiozaki, Tomoyuki / Tanaka, Hiroaki

Frontiers in neurology

2022 Volume 13, Page(s) 826739

Abstract: We investigated whether noisy galvanic vestibular stimulation (nGVS) modulates the vestibulo-ocular reflex (VOR) and whether this effect is correlated with the effect of nGVS on body sway. Thirty healthy young adults participated. The video head impulse ... ...

Abstract	We investigated whether noisy galvanic vestibular stimulation (nGVS) modulates the vestibulo-ocular reflex (VOR) and whether this effect is correlated with the effect of nGVS on body sway. Thirty healthy young adults participated. The video head impulse test (vHIT) was used to estimate the ratio of eye motion velocity/head motion velocity to VOR-gain. The gain 60 ms after the start of head motion (VOR-gain-60 ms) and regression slope (RS) (i.e., gain in eye and head motion; VOR-gain-RS) were calculated. The total path length of the foot center of pressure (COP-TL) during upright standing was calculated to estimate body sway. Noisy Galvanic Vestibular Stimulation at 0.2, 0.6, 1.2 mA, or sham stimulation (direct current: 0 mA) was delivered to the bilateral mastoid process in random order during vHIT and COP measurements. Application of nGVS at 0.2 mA significantly reduced VOR-gain-RS, while application of nGVS at 0.6 mA significantly increased COP-TL. Vestibulo-ocular reflex-gain-60 ms differed significantly between 0.2 and 1.2 mA. There was no significant correlation between COP-TL and VOR-related parameters. These findings suggest that nGVS at 0.2 mA inhibits the VOR, while nGVS at 0.6 mA increases body sway during upright standing, although there may be no relationship between the respective effects in healthy individuals.
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.826739
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Article ; Online: Drying rate of latex coating affected by the deformability of resin particles in convection drying.

Tanaka, Hiroaki / Komoda, Yoshiyuki / Horie, Takafumi / Imakoma, Hironobu / Ohmura, Naoto

The European physical journal. E, Soft matter

2022 Volume 45, Issue 1, Page(s) 2

Abstract: Latex paints are widely used, and many researchers pointed out that the film formation process depends on the deformability of dispersed polymer particles. However, the relationship between the film formation process and drying rate has not been totally ... ...

Abstract	Latex paints are widely used, and many researchers pointed out that the film formation process depends on the deformability of dispersed polymer particles. However, the relationship between the film formation process and drying rate has not been totally understood due to the lack of accurate data on drying rate throughout the drying process. In the present study, we measured the drying rate of latex coating by the temperature change method proposed by Imakoma in convective drying. We revealed that the drying process significantly depends on particle deformability, especially in the former stage of the falling drying rate period. At a low drying temperature, the close-packed structure of polymer particles is formed throughout the film at the end of the constant drying rate period. On the other hand, partially deformed soft particles due to wet sintering inhibit the drying rate even under high moisture content at high drying temperatures. In either case, after forming the closest-packed structure, the shrinkage of the gap space between particles due to capillary deformation decreases the drying rate, proportional to the moisture content.
MeSH term(s)	Convection ; Desiccation ; Hot Temperature ; Latex ; Polymers
Chemical Substances	Latex ; Polymers
Language	English
Publishing date	2022-01-10
Publishing country	France
Document type	Journal Article
ZDB-ID	2004003-9
ISSN	1292-895X ; 1292-8941
ISSN (online)	1292-895X
ISSN	1292-8941
DOI	10.1140/epje/s10189-021-00155-1
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Article ; Online: Dynamic Turning of a Soft Quadruped Robot by Changing Phase Difference.

Tanaka, Hiroaki / Chen, Tsung-Yuan / Hosoda, Koh

Frontiers in robotics and AI

2021 Volume 8, Page(s) 629523

Abstract: Dynamic locomotion of a quadruped robot emerges from interaction between the robot body and the terrain. When the robot has a soft body, dynamic locomotion can be realized using a simple controller. This study investigates dynamic turning of a soft ... ...

Abstract	Dynamic locomotion of a quadruped robot emerges from interaction between the robot body and the terrain. When the robot has a soft body, dynamic locomotion can be realized using a simple controller. This study investigates dynamic turning of a soft quadruped robot by changing the phase difference among the legs of the robot. We develop a soft quadruped robot driven by McKibben pneumatic artificial muscles. The phase difference between the hind and fore legs is fixed whereas that between the left and right legs is changed to enable the robot to turn dynamically. Since the robot legs are soft, the contact pattern between the legs and the terrain can be varied adaptively by simply changing the phase difference. Experimental results demonstrate that changes in the phase difference lead to changes in the contact time of the hind legs, and as a result, the soft robot can turn dynamically.
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2021.629523
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Article ; Online: Relationship between Measured Aerobic Capacity and Total Energy Expenditure Obtained by the Doubly Labeled Water Method in Community-Dwelling, Healthy Adults Aged 81-94 Years.

Yasukata, Jun / Yamada, Yosuke / Sagayama, Hiroyuki / Higaki, Yasuki / Tanaka, Hiroaki

Geriatrics (Basel, Switzerland)

2022 Volume 7, Issue 2

Abstract: The doubly labeled water method is a gold-standard method for the measurement of total energy expenditure in daily life. We aimed to identify the relationship between measured aerobic capacity and total energy expenditure, activity energy expenditure, or ...

Abstract	The doubly labeled water method is a gold-standard method for the measurement of total energy expenditure in daily life. We aimed to identify the relationship between measured aerobic capacity and total energy expenditure, activity energy expenditure, or physical activity level using the doubly labeled water method in adults of advanced old age. A total of 12 physically independent older adults (10 men and 2 women), aged 81-94 years, participated in this study. The aerobic capacity was evaluated according to the lactate threshold. Total energy expenditure under free-living conditions was assessed using the doubly labeled water method, and self-reported physical activity was obtained using the Japanese version of the International Physical Activity Questionnaire. The lactate threshold was significantly positively correlated with total energy expenditure, activity energy expenditure, and physical activity level after adjusting for age and sex. We found that the aerobic capacity of the lactate threshold was positively and independently correlated with total energy expenditure, activity energy expenditure, or physical activity level. The present results suggest that maintaining aerobic capacity is an important factor in preventing frailty, although further research is required.
Language	English
Publishing date	2022-04-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2308-3417
ISSN (online)	2308-3417
DOI	10.3390/geriatrics7020048
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