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  1. Article ; Online: Antithrombin Replacement in Cardiac Surgery: Was Too Much of a Good Thing Bad?

    Mazzeffi, Michael / Tanaka, Kenichi

    Anesthesia and analgesia

    2023  Volume 136, Issue 6, Page(s) 1039–1042

    MeSH term(s) Antithrombins/adverse effects ; Anticoagulants/adverse effects ; Cardiac Surgical Procedures/adverse effects
    Chemical Substances Antithrombins ; Anticoagulants
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Andexanet alfa or prothrombin complex concentrate for acute reversal of oral factor Xa inhibitors: monitoring of antidote effects.

    Tanaka, Kenichi A / Levy, Jerrold H

    British journal of anaesthesia

    2023  Volume 132, Issue 2, Page(s) 215–217

    Abstract: This study in vitro comprehensively assessed reversal of the anticoagulant effects of rivaroxaban, an oral factor Xa inhibitor, using andexanet alfa and various prothrombin complex concentrate (PCC) products in a battery of tests. In static coagulation ... ...

    Abstract This study in vitro comprehensively assessed reversal of the anticoagulant effects of rivaroxaban, an oral factor Xa inhibitor, using andexanet alfa and various prothrombin complex concentrate (PCC) products in a battery of tests. In static coagulation assays, andexanet alpha outperformed PCCs except for activated PCC being more effective in standard coagulation times. However, in a flow chamber model mimicking arterial shear, both andexanet alpha and high-concentration PCC restored fibrin formation, but not platelet adhesion. In the Russell's viper venom test and anti-Xa assay, only andexanet alpha could be tested for efficacy. The antidote effects of andexanet alpha and PCCs in restoring coagulation can be qualitatively or selectively demonstrated using in vitro coagulation tests.
    MeSH term(s) Humans ; Factor Xa Inhibitors/pharmacology ; Antidotes/pharmacology ; Antidotes/therapeutic use ; Blood Coagulation Factors/pharmacology ; Blood Coagulation Factors/therapeutic use ; Rivaroxaban/pharmacology ; Factor IX ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Anticoagulants/adverse effects ; Factor Xa
    Chemical Substances prothrombin complex concentrates (37224-63-8) ; PRT064445 ; Factor Xa Inhibitors ; Antidotes ; Blood Coagulation Factors ; Rivaroxaban (9NDF7JZ4M3) ; Factor IX (9001-28-9) ; Recombinant Proteins ; Anticoagulants ; Factor Xa (EC 3.4.21.6)
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Editorial
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.11.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sepsis Management: Heeding the Sirens and Navigating Between Scylla and Charybdis.

    Vandyck, Kofi B / Mazzeffi, Michael A / Tanaka, Kenichi A

    Anesthesia and analgesia

    2024  Volume 138, Issue 6, Page(s) e44–e45

    MeSH term(s) Humans ; Sepsis/therapy
    Language English
    Publishing date 2024-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Forget-Me-Not: The Primary Hemostasis Defect in Extracorporeal Membrane Oxygenation May Require Unique Treatment.

    Mazzeffi, Michael / Tanaka, Kenichi

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2022  Volume 69, Issue 1, Page(s) e52

    MeSH term(s) Extracorporeal Membrane Oxygenation/adverse effects ; Hemostasis ; Anticoagulants ; Retrospective Studies
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is a Nomogram a Viable Predictive Tool for Managing Heparin Resistance in Pediatric Cardiac Surgery?

    Spann, Karli / Stewart, Kenneth / Butt, Amir L / Tanaka, Kenichi A

    Anesthesia and analgesia

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "Women with severe postpartum hemorrhage have a decreased endogenous thrombin potential before delivery": Comment from Mishima et al.

    Mishima, Yuko / Butt, Amir L / Stewart, Kenneth E / Tanaka, Kenichi A

    Journal of thrombosis and haemostasis : JTH

    2024  Volume 22, Issue 3, Page(s) 877–878

    MeSH term(s) Pregnancy ; Female ; Humans ; Postpartum Hemorrhage/diagnosis ; Postpartum Hemorrhage/therapy ; Thrombin ; Postpartum Period ; Delivery, Obstetric
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.11.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 295: Show issues

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  7. Article ; Online: Does Selective β1 Blockade with Landiolol Improve Mortality After Coronary Artery Bypass Graft Surgery?

    Kinoshita, Miyu / Butt, Amir L / Kinoshita, Hiroyuki / Tanaka, Kenichi A

    Anesthesia and analgesia

    2024  Volume 138, Issue 4, Page(s) e17–e18

    MeSH term(s) Coronary Artery Bypass/adverse effects ; Adrenergic beta-Antagonists/therapeutic use ; Morpholines ; Urea/therapeutic use ; Urea/analogs & derivatives ; Treatment Outcome
    Chemical Substances landiolol (62NWQ924LH) ; Adrenergic beta-Antagonists ; Morpholines ; Urea (8W8T17847W)
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neostigmine and Postoperative Cognitive Dysfunction in the Elderly: Teaching an Old Dog a New Trick?

    Okada, Hisako / Butt, Amir L / Roberts, Pamela R / Tanaka, Kenichi A

    Anesthesia and analgesia

    2024  Volume 138, Issue 5, Page(s) e27–e28

    MeSH term(s) Humans ; Aged ; Neostigmine/adverse effects ; Postoperative Cognitive Complications ; Sugammadex ; Neuromuscular Blockade
    Chemical Substances Neostigmine (3982TWQ96G) ; Sugammadex (361LPM2T56)
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Two Cases of Painful Thyroiditis With Subsequent Hypothyroidism Following Cord Blood Transplant.

    Soga, Rika / Okada, Yosuke / Tanaka, Kenichi / Koikawa, Kenji / Tanaka, Yoshiya

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57952

    Abstract: We report two rare cases of painful thyroiditis approximately 100 days after unrelated cord blood transplantation (CBT), which progressed to hypothyroidism. Patient one, a 45-year-old woman, developed goiter, tenderness, and thyrotoxicity on day 100 ... ...

    Abstract We report two rare cases of painful thyroiditis approximately 100 days after unrelated cord blood transplantation (CBT), which progressed to hypothyroidism. Patient one, a 45-year-old woman, developed goiter, tenderness, and thyrotoxicity on day 100 after CBT for relapsed acute lymphocytic leukemia. Scintigraphy suggested destructive thyroiditis; symptoms improved with one-month beta-blocker and prednisolone treatment. Two months later, hypothyroidism developed which required supplementation-based treatment. Patient two, a 49-year-old man, developed goiter, tenderness, and thyrotoxicosis on day 96 after CBT for acute myelogenous leukemia. Hypothyroidism developed after nonsteroidal anti-inflammatory drug treatment. Thyroiditis and hypothyroidism should be considered in patients who develop neck pain after CBT.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In response: Caution in extrapolating hypercoagulable viscoelastic coagulation test results to in vivo hemostasis.

    Butt, Amir L / Ramarapu, Srikiran / Kyo, Hiroki / Tanaka, Kenichi A

    Transfusion

    2024  Volume 64, Issue 3, Page(s) 563–564

    MeSH term(s) Humans ; Hemostasis ; Blood Coagulation Tests/methods ; Thrombophilia ; Thrombelastography ; Blood Coagulation Disorders
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17734
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