LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 161

Search options

  1. Article ; Online: Effects of Heat-Killed

    Kato, Kumiko / Arai, Satoshi / Sato, Soichiro / Iwabuchi, Noriyuki / Takara, Tsuyoshi / Tanaka, Miyuki

    Nutrients

    2024  Volume 16, Issue 2

    Abstract: Previous clinical studies have shown that heat- ... ...

    Abstract Previous clinical studies have shown that heat-killed
    MeSH term(s) Adult ; Humans ; Hot Temperature ; Interferon-alpha ; Lacticaseibacillus paracasei ; Leukocytes, Mononuclear ; Powders ; Double-Blind Method
    Chemical Substances Interferon-alpha ; Powders
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16020216
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Effects of

    Sato, Soichiro / Arai, Satoshi / Kato, Kumiko / Yoshida, Keisuke / Iwabuchi, Noriyuki / Sagami, Toru / Tanaka, Miyuki

    Nutrients

    2024  Volume 16, Issue 6

    Abstract: Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects ... ...

    Abstract Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects of
    MeSH term(s) Adult ; Humans ; Bifidobacterium longum ; Bifidobacterium breve ; Overweight/therapy ; Probiotics ; Body Composition ; Bifidobacterium
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16060815
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial.

    Kubo, Shutaro / Oda, Hirotsugu / Tanaka, Miyuki / Koikeda, Takashi / Tomita, Shinichi

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: To evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. ... ...

    Abstract To evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. Healthy adult subjects orally ingested bLF dissolved in water, or placebo water, followed by exposure to low humidity (20 °C, 20% relative humidity (RH)) for 2 h. The primary endpoint was subjective oral and throat discomfort assessed by a visual analog scale (VAS), which positively correlated with the discomfort. Secondary endpoints were unstimulated whole salivary flow rate (UWSFR) and salivary immunoglobulin A (IgA) secretion rate. Overall, 40 subjects were randomly assigned to two sequences (20 each) and 34 were analyzed. The VAS values for oral and throat discomfort in the bLF treatment were significantly lower than in the placebo treatment, whereas UWSFR and IgA secretion rates were comparable between the two treatments. Adverse drug reactions were not observed. Subjective oral and throat discomfort associated with low humidity is suppressed by a single ingestion of bLF. Our findings demonstrate the novel use of bLF in a clinical situation that leverages its unique characteristics.
    MeSH term(s) Adult ; Humans ; Pharynx ; Lactoferrin ; Cross-Over Studies ; Humidity ; Immunoglobulin A, Secretory ; Water
    Chemical Substances Lactoferrin (EC 3.4.21.-) ; Immunoglobulin A, Secretory ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15184033
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Lactulose Ingestion Induces a Rapid Increase in Genus

    Sakai, Yohei / Ochi, Hiroshi / Tanaka, Miyuki

    Microorganisms

    2022  Volume 10, Issue 9

    Abstract: Oral administration of a low dose of lactulose increases the abundance of ... ...

    Abstract Oral administration of a low dose of lactulose increases the abundance of genus
    Language English
    Publishing date 2022-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10091719
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Clinical research review: usefulness of bovine lactoferrin in child health.

    Miyakawa, Momoko / Oda, Hirotsugu / Tanaka, Miyuki

    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

    2022  Volume 36, Issue 3, Page(s) 473–489

    Abstract: Lactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted ... ...

    Abstract Lactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted considering these properties, which reported the usefulness of bLF. This review was aimed to provide an overview of the clinical evidence in children. We searched clinical reports investigating the effects of bLF in children and identified 36 studies on the role of bLF in infections, iron metabolism, body growth, cerebral development, and fecal microbiome. Considering the accumulated evidence, bLF may contribute to the child health, particularly by suppressing or alleviating gastrointestinal and respiratory symptoms, and improving the iron status of children with anemia or those at high risk of anemia. The dose of bLF varies depending on the expected effect and target age, but may not necessarily have to be as high as human LF in human milk. Some of the beneficial effects of bLF have not been fully validated due to limited clinical evidence or being observed in the secondary analysis of some studies. Further clinical evidence would add significant value to the use of bLF in child health.
    MeSH term(s) Child ; Humans ; Anemia/therapy ; Child Health ; Iron/metabolism ; Lactoferrin/administration & dosage ; Lactoferrin/chemistry ; Lactoferrin/therapeutic use ; Milk, Human
    Chemical Substances Iron (E1UOL152H7) ; Lactoferrin (EC 3.4.21.-)
    Language English
    Publishing date 2022-08-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1112688-7
    ISSN 1572-8773 ; 0966-0844
    ISSN (online) 1572-8773
    ISSN 0966-0844
    DOI 10.1007/s10534-022-00430-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2515: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Lactulose Ingestion Induces a Rapid Increase in Genus Bifidobacterium in Healthy Japanese: A Randomised, Double-Blind, Placebo-Controlled Crossover Trial

    Sakai, Yohei / Ochi, Hiroshi / Tanaka, Miyuki

    Microorganisms. 2022 Aug. 26, v. 10, no. 9

    2022  

    Abstract: Oral administration of a low dose of lactulose increases the abundance of genus Bifidobacterium in the large intestine; however, the details of the daily variation in Bifidobacterium have not been researched. To observe how the intestinal microbiota, ... ...

    Abstract Oral administration of a low dose of lactulose increases the abundance of genus Bifidobacterium in the large intestine; however, the details of the daily variation in Bifidobacterium have not been researched. To observe how the intestinal microbiota, including Bifidobacterium, change, especially immediately after the initiation of ingestion, we conducted a randomised, placebo-controlled, double-blind crossover study of ingestion of 4 g lactulose/day for 2 weeks in 36 healthy Japanese (including males and females). The primary outcome was the percentage of Bifidobacterium in the faecal bacteria. In the lactulose-treatment group, the percentage of Bifidobacterium was already significantly higher 2 days after starting lactulose ingestion than in the placebo group (20.5 ± 1.2% vs. 17.1 ± 1.2%, p = 0.021). Significant differences were maintained, gradually widening, until the end of the 2-week intervention period. There were significant increases in the percentage and the number of Bifidobacterium with ingestion of 4 g lactulose/day for 2 weeks, but no significant changes in the beta diversity of the intestinal microbiota between lactulose and placebo ingestion. The percentage of Bifidobacterium in the faecal bacteria returned to its original level within a week of the end of intervention with lactulose.
    Keywords Bifidobacterium ; cross-over studies ; ingestion ; intestinal microorganisms ; lactulose ; large intestine ; oral administration ; placebos ; species diversity
    Language English
    Dates of publication 2022-0826
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10091719
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Effects of Heat-Killed

    Sato, Soichiro / Arai, Satoshi / Iwabuchi, Noriyuki / Tanaka, Miyuki / Hase, Ryosuke / Sakane, Naoki

    Nutrients

    2023  Volume 15, Issue 15

    Abstract: We previously reported that the intake of heat- ... ...

    Abstract We previously reported that the intake of heat-killed
    MeSH term(s) Humans ; Adult ; Female ; Lacticaseibacillus paracasei ; Lacticaseibacillus ; Hot Temperature ; Powders ; Double-Blind Method
    Chemical Substances Powders
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15153450
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Screening of novel DPP-IV inhibitory peptides derived from bovine milk proteins using a peptide array platform.

    Arai, Sayuri / Kurimoto, Masaki / Nakada, Hajime / Tanaka, Masayoshi / Ochi, Hiroshi / Tanaka, Miyuki / Okochi, Mina

    Journal of bioscience and bioengineering

    2023  Volume 137, Issue 2, Page(s) 94–100

    Abstract: Dipeptidyl peptidase IV (DPP-IV) has become an important target in the prevention and treatment of diabetes. Although many DPP-IV inhibitory peptides have been identified by a general approach involving the repeated fractionation of food protein ... ...

    Abstract Dipeptidyl peptidase IV (DPP-IV) has become an important target in the prevention and treatment of diabetes. Although many DPP-IV inhibitory peptides have been identified by a general approach involving the repeated fractionation of food protein hydrolysates, the obtained results have been dependent on the content of each peptide and fractionation conditions. In the present study, a peptide array that provides comprehensive assays of peptide sequences was used to identify novel DPP-IV inhibitory peptides derived from bovine milk proteins; these peptides were then compared with those identified using the general approach. While the general approach identified only known peptides that were abundant in the hydrolysate, the peptide array-based approach identified 10 novel DPP-IV inhibitory peptides, all of which had proline at the second residue from the N-terminus. The proper or combined use of these two approaches, which have different advantages, will enable the efficient development of novel bioactive foods and drugs.
    MeSH term(s) Milk Proteins ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Peptides/chemistry ; Amino Acid Sequence
    Chemical Substances Milk Proteins ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Dipeptidyl-Peptidase IV Inhibitors ; Peptides
    Language English
    Publishing date 2023-12-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1465387-4
    ISSN 1347-4421 ; 1389-1723
    ISSN (online) 1347-4421
    ISSN 1389-1723
    DOI 10.1016/j.jbiosc.2023.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4728: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Validation of an LC-MS/MS method for the quantitation of phytosterols derived from Aloe vera gel

    Nabeshima, Kazumi / Mizutani, Atsushi / Misawa, Eriko / Tanaka, Miyuki / Yamauchi, Koji / Abe, Fumiaki

    MethodsX. 2022, v. 9

    2022  

    Abstract: A method to quantitate five minor phytosterols named Aloe sterols identified from Aloe vera gel was validated using AVGP (Aloe vera gel powder) as the sample. To measure the Aloe sterols content, AVGP was extracted with chloroform/methanol (2:1, v/v) and ...

    Abstract A method to quantitate five minor phytosterols named Aloe sterols identified from Aloe vera gel was validated using AVGP (Aloe vera gel powder) as the sample. To measure the Aloe sterols content, AVGP was extracted with chloroform/methanol (2:1, v/v) and analyzed by liquid chromatography-tandem mass spectrometry. The calibration curve revealed a high coefficient of determination (>0.999). The limit of quantification was 2.3–4.1 ng/mL. Average recoveries ranged from 95 to 105%. The intra-day and inter-day precision were 2.6–6.4% and 3.8–7.3%, respectively, confirming good method precision. Aloe sterols were also quantified in AVGE (Aloe vera gel extract) using this method. We showed that the composition ratio of each Aloe sterol in AVGP did not change in AVGE. Additionally, we measured the concentration of Aloe sterols in the capsule containing AVGE, and confirmed that it was stable even after 1 year of storage. In conclusion, a quantification method was established to simultaneously measure multiple plant sterols with similar structures. • A quantification method to simultaneously measure several plant sterols with similar structures was established. • Results from the intra-day precision and the inter-day precision confirmed good precision. • This method can be applied to processed raw materials and/or foods in long-term storage.
    Keywords Aloe vera ; chloroform ; gels ; liquid chromatography ; methanol ; phytosterols ; storage time ; tandem mass spectrometry
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2022.101642
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Lipemia Retinalis: Hyperreflective Vascular Changes Detected by Optical Coherence Tomography.

    Tanaka, Miyuki / Azuma, Takeshi / Shinohara, Kosei

    Retina (Philadelphia, Pa.)

    2020  Volume 41, Issue 2, Page(s) e10–e11

    MeSH term(s) Disease Progression ; Fluorescein Angiography/methods ; Fundus Oculi ; Humans ; Hyperlipidemias/complications ; Hyperlipidemias/diagnosis ; Male ; Middle Aged ; Retinal Diseases/diagnosis ; Retinal Diseases/etiology ; Retinal Vessels/pathology ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top