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  1. Article ; Online: Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies.

    Tanaka, Ryota / Hattori, Nobutaka

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 12, Page(s) 1908–1917

    Abstract: Circadian blood pressure (BP) rhythm is important for the maintenance of healthy daily life, and its disruption is associated with poor outcomes. Cardiovascular autonomic failure is often observed in older populations but has a greater impact on ... ...

    Abstract Circadian blood pressure (BP) rhythm is important for the maintenance of healthy daily life, and its disruption is associated with poor outcomes. Cardiovascular autonomic failure is often observed in older populations but has a greater impact on neurodegenerative disorders such as α-synucleinopathies. These BP abnormalities include orthostatic hypotension (OH), supine hypertension (SH), and a loss of nocturnal BP fall. OH not only causes falls or syncope but is also related to cognitive impairment in α-synucleinopathies. For example, OH doubles or triples the risk for the development of cognitive impairment in Parkinson's disease (PD). The diffuse central and peripheral neuropathology of α-synuclein may contribute to both OH and cognitive impairment. Moreover, repeated cerebral hypoperfusion in OH is thought to be related to cerebrovascular and neuronal damage, which may cause cognitive impairment. SH, which often coexists with OH, is also associated with cognitive impairment through cerebrovascular damage, such as white matter lesions and cerebral microbleeds. The reverse-dipping (riser) pattern on ambulatory BP monitoring is commonly observed in PD (∼56%), regardless of disease duration and severity. It is also related to cognitive impairment and more pronounced when coexisting with OH. These abnormal circadian BP profiles may be synergistically associated with cognitive impairment and poor outcomes in α-synucleinopathies. Although evidence for aggressive control of BP dysregulation improving cognitive impairment and outcomes is limited, regular BP monitoring appears to be important for total management of α-synucleinopathies.
    MeSH term(s) Humans ; Aged ; Blood Pressure/physiology ; Synucleinopathies ; Hypotension, Orthostatic ; Cognitive Dysfunction/complications ; Blood Pressure Monitoring, Ambulatory ; Parkinson Disease/complications ; Hypertension/complications ; Circadian Rhythm/physiology
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01032-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
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  2. Article ; Online: Immune-related adverse events in various organs caused by immune checkpoint inhibitors.

    Okiyama, Naoko / Tanaka, Ryota

    Allergology international : official journal of the Japanese Society of Allergology

    2022  Volume 71, Issue 2, Page(s) 169–178

    Abstract: Current cancer immunotherapies target immune checkpoint molecules such as the inhibitory receptor programmed cell death-1 (PD-1), one of its ligands, programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen 4 (CTLA-4), a competitive ... ...

    Abstract Current cancer immunotherapies target immune checkpoint molecules such as the inhibitory receptor programmed cell death-1 (PD-1), one of its ligands, programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen 4 (CTLA-4), a competitive ligand for CD28 binding to stimulatory receptors CD80 and CD86. Multiple biological drugs use monoclonal antibodies targeting PD-1, PD-L1 and CTLA-4 as cancer immunotherapies. These are termed immune checkpoint inhibitors (ICIs). However, activation of the immune system by ICIs can induce the development of immune-related adverse events (irAEs), which can affect multiple organ systems. The most frequent irAEs are cutaneous and mimic various types of spontaneous skin disorders. Most irAEs are classified as autoimmune conditions mediated by ICI-activated CD8
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; CTLA-4 Antigen/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunotherapy/adverse effects ; Neoplasms/drug therapy ; Neoplasms/etiology ; Quality of Life
    Chemical Substances Antineoplastic Agents, Immunological ; CTLA-4 Antigen ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2022.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bromide-Induced Acneiform Eruption.

    Endo, Ruriko / Tanaka, Ryota / Nomura, Toshifumi

    Dermatitis : contact, atopic, occupational, drug

    2023  Volume 34, Issue 4, Page(s) 276–277

    MeSH term(s) Humans ; Bromides/adverse effects ; Acneiform Eruptions/chemically induced
    Chemical Substances Bromides
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2022.0047
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    Zs.A 3680: Show issues Location:
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  4. Article: Modified open-thoracotomy-view approach in robotic-assisted thoracoscopic lung resection.

    Tachibana, Keisei / Miura, Jun / Hirata, Yoshifumi / Suda, Kazuharu / Hashimoto, Kohei / Tanaka, Ryota / Kondo, Haruhiko

    Journal of thoracic disease

    2024  Volume 16, Issue 2, Page(s) 1488–1495

    Abstract: Robotic-assisted thoracoscopic surgery (RATS) is widely performed in thoracic surgery. The open-thoracotomy-view approach (OTVA) is one approach in RATS lung resection. OTVA is a good surgical approach that provides the same field of view as that with ... ...

    Abstract Robotic-assisted thoracoscopic surgery (RATS) is widely performed in thoracic surgery. The open-thoracotomy-view approach (OTVA) is one approach in RATS lung resection. OTVA is a good surgical approach that provides the same field of view as that with open thoracotomy and allows active participation of the assistant. However, the OTVA has certain limitations compared with other approaches, such as difficulty placing a robotic arm in the lower intercostal space, the assistant port is positioned further from the hilum, and CO
    Language English
    Publishing date 2024-02-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-1653
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  5. Article: Usefulness of Belimumab in Adult Patients With Systemic Lupus Erythematosus Evaluated Using Single Indexes: A Meta-Analysis and Systematic Review.

    Yoshijima, Chisato / Suzuki, Yosuke / Oda, Ayako / Tanaka, Ryota / Ono, Hiroyuki / Itoh, Hiroki / Ohno, Keiko

    Current therapeutic research, clinical and experimental

    2024  Volume 100, Page(s) 100738

    Abstract: Background: Belimumab is the first antibody drug approved for systemic lupus erythematosus (SLE), and is a fully human monoclonal antibody that inhibits soluble B lymphocyte stimulator protein. In clinical trials, a composite index was used to assess ... ...

    Abstract Background: Belimumab is the first antibody drug approved for systemic lupus erythematosus (SLE), and is a fully human monoclonal antibody that inhibits soluble B lymphocyte stimulator protein. In clinical trials, a composite index was used to assess efficacy of belimumab. However, clinical guidelines on SLE treatment currently use single efficacy indexes.
    Objective: The main objective of this study was to perform a meta-analysis to evaluate the efficacy of belimumab utilizing single indexes used in routine clinical practice, rather than the composite efficacy index used in clinical trials during the development phase. As a secondary endpoint, safety was also evaluated.
    Methods: Several databases were searched to identify reports published up to December 1, 2021 on randomized controlled trials examining the efficacy of belimumab in adult patients with SLE. From the clinical trial data, efficacy was evaluated using single indexes including the SLE Disease Activity Index (SLEDAI), British Isles Lupus Assessment Group Index, and Physician Global Assessment. Safety was also assessed. Data were synthesized and analyzed using Review Manager 5.4. This study protocol was registered in the UMIN Clinical Trials Registry (Registration number: UMIN000052846).
    Results: The search identified 12 reports that met the inclusion criteria. Five reports were included in efficacy evaluation and 9 in safety evaluation. The primary endpoint was SLEDAI. Significantly more belimumab-treated patients achieved a ≥4-point reduction in SLEDAI (relative risk 1.28; 95% confidence interval, 1.16-1.40;
    Conclusions: The present meta-analysis evaluating clinical trial data using various single indexes recommended by clinical guidelines for SLE verifies that addition of belimumab to standard of care is efficacious for moderate-to-severe SLE.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2024.100738
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    Zs.A 306: Show issues Location:
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  6. Article ; Online: Pencil-core granuloma.

    Matsuoka, Ko / Tanaka, Ryota / Nomura, Toshifumi

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 1, Page(s) E14

    MeSH term(s) Aged ; Diagnosis, Differential ; Finger Injuries/complications ; Finger Injuries/etiology ; Granuloma, Foreign-Body/etiology ; Graphite ; Humans ; Male ; Time Factors ; Wounds, Stab/complications
    Chemical Substances Graphite (7782-42-5)
    Language English
    Publishing date 2022-01-10
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.211094
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  7. Article ; Online: [No title information]

    Matsuoka, Ko / Tanaka, Ryota / Nomura, Toshifumi

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 13, Page(s) E511–E512

    Title translation Granulome induit par la mine d’un crayon.
    MeSH term(s) Granuloma ; Humans
    Language French
    Publishing date 2022-03-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.211094-f
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  8. Article: The Role of HGF/MET Signaling in Metastatic Uveal Melanoma.

    Tanaka, Ryota / Terai, Mizue / Londin, Eric / Sato, Takami

    Cancers

    2021  Volume 13, Issue 21

    Abstract: Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell ... ...

    Abstract Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell survival, proliferation, cell motility, and migration. Furthermore, HGF/MET signaling has emerged as a critical player not only in the tumor itself but also in the tumor microenvironment. Expression of MET is frequently observed in metastatic uveal melanoma and is associated with poor prognosis. It has been reported that HGF/MET signaling pathway activation is the major mechanism of treatment resistance in metastatic UM (MUM). To achieve maximal therapeutic benefit in MUM patients, it is important to understand how MET signaling drives cellular functions in uveal melanoma cells. Here, we review the HGF/MET signaling biology and the role of HGF/MET blockades in uveal melanoma.
    Language English
    Publishing date 2021-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13215457
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  9. Article: Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling.

    van Hoogdalem, Matthijs W / Tanaka, Ryota / Abduljalil, Khaled / Johnson, Trevor N / Wexelblatt, Scott L / Akinbi, Henry T / Vinks, Alexander A / Mizuno, Tomoyuki

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To allow ... ...

    Abstract Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To allow the conceptualization of fetal buprenorphine exposure, a maternal-fetal physiologically based pharmacokinetic (PBPK) model for sublingual buprenorphine was developed using Simcyp (v21.0). Buprenorphine transplacental passage was predicted from its physicochemical properties. The maternal-fetal PBPK model integrated reduced transmucosal absorption driven by lower salivary pH and induced metabolism observed during pregnancy. Maternal pharmacokinetics was adequately predicted in the second trimester, third trimester, and postpartum period, with the simulated area under the curve from 0 to 12 h, apparent clearance, and peak concentration falling within the 1.25-fold prediction error range. Following post hoc adjustment of the likely degree of individual maternal sublingual absorption, umbilical cord blood concentrations at delivery (n = 21) were adequately predicted, with a geometric mean ratio between predicted and observed fetal concentrations of 1.15 and with 95.2% falling within the 2-fold prediction error range. The maternal-fetal PBPK model developed in this study can be used to forecast fetal buprenorphine exposure and would be valuable to investigate its correlation to NOWS severity.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030375
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  10. Article ; Online: Comparison of the diagnostic and prognostic abilities of flexible laryngoscopy and dynamic digital radiography for vocal cord paralysis: A prospective observational study.

    Shibuya, Yukimi / Hirano, Koichi / Miyamoto, Makoto / Mitsuma, Tomoya / Nakazato, Yoko / Matsutani, Noritsugu / Tanaka, Ryota / Machida, Haruhiko / Kondo, Haruhiko

    Head & neck

    2024  

    Abstract: Background: Although flexible laryngoscopy (FL) is the reference modality for diagnosing vocal cord paralysis (VCP), FL involves patient discomfort and insertion intolerance. Dynamic digital radiography (DDR) with high spatial and temporal resolution is ...

    Abstract Background: Although flexible laryngoscopy (FL) is the reference modality for diagnosing vocal cord paralysis (VCP), FL involves patient discomfort and insertion intolerance. Dynamic digital radiography (DDR) with high spatial and temporal resolution is easier to use and less invasive when evaluating VCP.
    Methods: Seventy-eight patients underwent FL and DDR before and after neck surgery. Qualitative and quantitative vocal cord movement (VCM) evaluations were conducted. Patients with postoperative VCP were followed-up regularly.
    Results: DDR exhibited diagnostic performance with 67% sensitivity and 100% specificity. The cutoff for VCM was 2.4 mm, with DDR exhibiting 100% sensitivity and 78% specificity. All cords with transient VCP had positive VCM at both 3 weeks and 2 months. Additionally, 50% and 75% of cords with permanent VCP had negative VCM at 3 weeks and 2 months, respectively.
    Conclusions: DDR is promising for the diagnosis of postoperative VCP and early prediction of permanent postoperative VCP.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27756
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