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Article ; Online: An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer.

Nooreen, Zulfa / Tandon, Sudeep / Wal, Ankita / Rai, Awani Kumar

2024 Volume 25, Issue 3, Page(s) 201–219

Abstract: Breast cancer is a widespread condition that kills more women from cancer-related causes than any other type of cancer globally. Women who have estrogen-dependent, initial metastatic breast cancer frequently receive treatment with surgery, radiation ... ...

Abstract	Breast cancer is a widespread condition that kills more women from cancer-related causes than any other type of cancer globally. Women who have estrogen-dependent, initial metastatic breast cancer frequently receive treatment with surgery, radiation therapy, and chemotherapy. They may also get more specialized treatments like tamoxifen or aromatase inhibitors (anastrozole or letrozole). The World Health Organisation reported in 2012 that by 2030, breast cancer will be more common worldwide. There are several phytochemicals, such as isoflavones, coumestans, lignans, and prenylflavonoides. Isoflavones have been shown in studies to prevent the spread of breast cancer and to trigger apoptosis. Targeting BCs in metastatic breast cancer may be made possible by combining well-formulated phytochemicals in nanoparticles or other novel drug delivery agents with currently accepted endocrine and/or conventional chemotherapies. Cell signaling, regulation of cell cycles, oxidative stress action, and inflammation could be positively impacted by phytoconstituents. They have the ability to alter non-coding RNAs, to prevent the proliferation and regeneration of cancer cells. The availability of novel approaches helps in disease targeting, safety, effectiveness and efficacy. The current literature helps to know the available drugs i.e. phytoconstituents or novel drug delivery like nanoparticle, microsphere, micelles, liposomes and neosomes. The literature has been taken from PubMed, Google Scholar, SciFinder, or other internet sites.
MeSH term(s)	Humans ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytochemicals/chemistry ; Drug Delivery Systems ; Antineoplastic Agents, Phytogenic/therapeutic use ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/administration & dosage ; Nanoparticles/chemistry
Chemical Substances	Phytochemicals ; Antineoplastic Agents, Phytogenic
Language	English
Publishing date	2024-01-16
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/0113894501277556231221072938
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Article ; Online: An Insight of Naturally Occurring Phytoconstituents and Novel Approaches Towards the Treatment of Diabetes.

Nooreen, Zulfa / Rai, Awani Kumar / Summayya, Fariha / Tandon, Sudeep

Current diabetes reviews

2023 Volume 20, Issue 3, Page(s) e290823220456

Abstract: Background: The rising in diabetes incidents has clearly become one main worldwide health problem. Individuals suffering from diabetes are still more susceptible to many long-term and short-term side effects, which most often cause fatalities. Even ... ...

Abstract	Background: The rising in diabetes incidents has clearly become one main worldwide health problem. Individuals suffering from diabetes are still more susceptible to many long-term and short-term side effects, which most often cause fatalities. Even though chemically synthesized anti-diabetic entities are capable of helping manage and treat, there has been significant risks related with their prolong and repetitive use. Hence, there is a requirement for safer and novel approaches that might be formed and utilized. Objective: Aim of the present review is to explain the naturally occurring phytochemicals and novel approach as anti-diabetic agents in the treatment of diabetes and its related issues. Method: A survey of Google scholar, Research Gate, Pubmed, Science Direct, NCBI database was carried out conducted to determine a most hopeful phytochemicals and novel drug delivery systems in the management of diabetes. Result: The study stressed the significance of phytomolecules and some novel approaches researched or reported in the literature for the management and cure of diabetes. It is suggested that changes in lifestyle can help patients and like nutritional support, assessment and lifestyle guidance must be individualized based on physical and functional capacity. Further evaluations and improved preventative medicine were the result of improving patient outcomes. Conclusion: Conventional or synthetic drugs provide relief for short time but nanoformulations of phytomolecules offer an improved therapeutic with fewer negative side effects. Herbal medicines are rich in phytoconstituents and possess variety of health benefits. This review is compilation of phytoconstituents and novel drug delivery system of phytomolecules i.e. nanoparticles, niosomes, microsphere, microparticle and others.
MeSH term(s)	Humans ; Diabetes Mellitus/drug therapy ; Plants, Medicinal/chemistry ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Drug Delivery Systems
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2023-08-30
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ISSN	1875-6417
ISSN (online)	1875-6417
DOI	10.2174/1573399820666230829094724
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Article ; Online: Essential oil of Lippia alba impedes the growth of Propionibacterium acnes by modulating membrane potential and ROS level

Uma Kumari, KM / Chanotiya, Chandan Singh / Yadav, Narayan Prasad / Tandon, Sudeep / Luqman, Suaib

Journal of Herbal Medicine. 2023 Aug. 08, p.100733-

2023 , Page(s) 100733–

Abstract: Propionibacterium acnes (P. acnes) is a rod-shaped, anaerobic, Gram-positive, opportunistic bacterium, that causes infectious and inflammatory diseases, such as acne vulgaris synovitis-acnes-pustulosis-hyperostosis-osteitis syndrome, sarcoidosis, and ... ...

Abstract	Propionibacterium acnes (P. acnes) is a rod-shaped, anaerobic, Gram-positive, opportunistic bacterium, that causes infectious and inflammatory diseases, such as acne vulgaris synovitis-acnes-pustulosis-hyperostosis-osteitis syndrome, sarcoidosis, and prostate cancer. Earlier evidence suggests that essential oils have been used to treat skin diseases and disorders since ancient times. Thus, the present study investigated the anti-microbial activity of 28 essential oils from nine families, including Lamiaceae, Poaceae, Geraniaceae, Myrtaceae, Zingiberaceae, Verbenaceae, Cupressaceae, Asteraceae, and Cyperaceae against P. acnes. The anti-bacterial susceptibility and efficacy of the essential oils were examined using paper disc diffusion, broth micro-dilution, time-kill kinetics and ROS assays. P. acnes was cultured under anaerobic conditions. The kinetic process evaluated the time and dose-dependent effects of essential oils. The alteration in membrane potential and ROS production were measured in terms of mean fluorescence intensity. Consequently, the chemical composition of essential oil was analyzed by GC and GC/MS analysis. Eighteen essential oils inhibited the growth of P. acnes with a clear zone of 5 to 20.33 mm. Eucalyptus, Mentha, Palmarosa, Lemongrass, Citronella, Geranium, Patchouli, Ocimum, and Clarysage possess better antibacterial activity (ZGI: 10.33 ± 2.31 mm - 20.33 ± 4.72 mm). Lippia oil showed the minimum inhibitory concentration (MIC) of 0.125% v/v, and the MIC of Mentha, Ocimum, and Patchouli oils ranged from 0.25 to 0.50% v/v. Further, the concentration and time-kill kinetic study indicated that Lippia alba and O. sanctum oils suppress the growth at MIC till 12 h and at 2 × MIC until 72 h. Moreover, the oils induced ROS production with one fold change at 2 × MIC. In addition, O. sanctum oil altered the membrane integrity with a fold change of 1.0 and 2.0 at MIC and 2 × MIC, respectively, while L. alba oil modified a fold change of 1.0. The essential oils suppressed bacterial growth by inducing ROS and modulating membrane integrity. Therefore, L. alba and O. sanctum essential oils could be used as an alternative to chemicals/drugs for treating microbe-associated acne problems.
Keywords	Asteraceae ; Citronella ; Cupressaceae ; Cymbopogon ; Cyperaceae ; Eucalyptus ; Geranium ; Lippia alba ; Mentha ; Ocimum ; Pogostemon cablin ; Propionibacterium ; Zingiberaceae ; acne ; antibacterial properties ; bacteria ; bacterial growth ; chemical composition ; dose response ; essential oils ; fluorescence ; herbal medicines ; membrane potential ; minimum inhibitory concentration ; oils ; paper ; prostatic neoplasms ; BHIB ; BHIA ; °C ; CFU/mL ; DCF ; DCFDA ; DMSO ; h ; μM ; µg/mL ; mg/mL ; MBC ; MIC ; MIF ; MP ; nm ; OD ; % ; P. acnes ; ROS ; US$ ; v/v ; ZGI ; Anti-bacterial susceptibility ; O. sanctum
Language	English
Dates of publication	2023-0808
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Pre-press version
ISSN	2210-8033
DOI	10.1016/j.hermed.2023.100733
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Linalool reduces the virulence of Pseudomonas syringae pv. tomato DC 3000 by modulating the PsyI/PsyR quorum-sensing system.

Deepa, Nikky / Chauhan, Shivam / Kumari, Poonam / Rai, Abhishek Kumar / Tandon, Sudeep / Singh, Akanksha

Microbial pathogenesis

2022 Volume 173, Issue Pt A, Page(s) 105884

Abstract: Quorum sensing modulatory effect of linalool was tested for the first time against Pseudomonas syringae pv. tomato DC 3000, a bacterial plant pathogen responsible for causing huge losses worldwide. DC 3000 extensively regulates its virulence traits ... ...

Abstract	Quorum sensing modulatory effect of linalool was tested for the first time against Pseudomonas syringae pv. tomato DC 3000, a bacterial plant pathogen responsible for causing huge losses worldwide. DC 3000 extensively regulates its virulence traits through quorum sensing mechanism involving expression of psyI, an acyl-homoserine lactone (AHL) synthase gene and psyR, a luxR-type regulator. In this study, exposure of DC 3000 to 80 ppm linalool concentration resulted in reduced biofilm formation, hampered motility, decreased AHL production, and reduced secretion of plant cell wall-degrading enzymes followed by negligible effect on the bacterial count and its metabolic activity. Extracellular polymeric substances (EPS), which play a crucial role in the development of biofilm and subsequent infection was significantly reduced which was further confirmed by Fourier Transform Infrared Spectroscopy. The qRT PCR analysis of the gene expression analysis of virulence genes (syringafactin production gene syfA, type III secretion system gene hrpA, flagellar genes fleQ and fliC, and coronatine production gene cfl unveiled significant downregulation of the same under Lin 80 ppm concentration. To further confirm the aforementioned possibilities, docking simulations run between PsyR and linalool suggested a strong interaction with the developed protein model. Overall, the treatment of DC 3000 with Lin 80 ppm affected the phenotypic and genotypic expressions associated with quorum sensing, thereby significantly reducing the infection rate as observed in in-vivo plant assay.
MeSH term(s)	Pseudomonas syringae/genetics ; Quorum Sensing/genetics ; Virulence/genetics ; Lycopersicon esculentum ; Bacterial Proteins/metabolism ; Acyl-Butyrolactones/metabolism
Chemical Substances	linalool (D81QY6I88E) ; Bacterial Proteins ; Acyl-Butyrolactones
Language	English
Publishing date	2022-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105884
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Zs.A 2136: Show issues

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Article ; Online: Taxoids-rich extract from Taxus wallichiana alleviates high-fat diet-induced insulin resistance in C57BL/6 mice through inhibition of low-grade inflammation.

Binwal, Monika / Babu, Vineet / Israr, K M Monazza / Kashyap, Praveen K / Maurya, Anil Kumar / Padalia, Rajendra Chandra / Tandon, Sudeep / Bawankule, Dnyaneshwar U

Inflammopharmacology

2023 Volume 31, Issue 1, Page(s) 451–464

Abstract: The needle powder of Taxus wallichiana is in use for the management of diabetes and inflammation-related complications in the Indian and Chinese Systems of Traditional Medicine but the lack of proper pharmacological intervention has prompted us to ... ...

Abstract	The needle powder of Taxus wallichiana is in use for the management of diabetes and inflammation-related complications in the Indian and Chinese Systems of Traditional Medicine but the lack of proper pharmacological intervention has prompted us to investigate the pharmacological mechanism against inflammation-induced insulin resistance in high-fat diet-fed C57BL/6 mice. Hexane (Tw-H), chloroform (Tw-C), and ethyl acetate (Tw-EA) extracts were prepared from a needle of T. wallichiana and its effect on glucose uptake against TNF-α-induced insulin resistance in skeletal muscle cells was studied. Among all, Tw-EA extract has shown promising glucose uptake potential. Tw-EA treatment is also able to decrease the lipid accumulation in adipocytes. Chemical signature of Tw-EA using HPLC showed the presence of taxoids. Efficacy of taxoids-rich extract from T. wallichiana (Tw-EA) was further validated in in vivo system against high-fat diet (HFD)-induced insulin resistance in C57BL/6 mice. Oral treatment of Tw-EA showed significant reduction in blood glucose, pro-inflammatory cytokine production and body weight gain when compared with vehicle-treated HFD-induced insulin resistance in C57BL/6 mice. Histopathology and immunohistochemistry study in skeletal muscle and adipose tissue revealed that oral treatment of Tw-EA is able to reduce the infiltration of inflammatory cells in skeletal muscles, ameliorate the hypertrophy in adipose tissue and upregulate the GLUT4 protein expression. Treatment with Tw-EA significantly up-regulated mRNA expression of insulin signaling pathway (IRS-1, PI3K, AKT, GLUT 4). This study suggested the beneficial effect of taxoids-rich extract from Taxus wallichiana against the inflammation-associated insulin resistance condition.
MeSH term(s)	Mice ; Animals ; Insulin Resistance/physiology ; Diet, High-Fat ; Taxus/metabolism ; Taxoids/therapeutic use ; Mice, Inbred C57BL ; Inflammation/drug therapy ; Insulin/metabolism ; Blood Glucose/metabolism
Chemical Substances	Taxoids ; Insulin ; Blood Glucose
Language	English
Publishing date	2023-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-022-01119-3
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Zs.A 3274: Show issues

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Article: New chemical constituent from the stem of Cuscuta reflexa Roxb. and its biological activities

Nooreen, Zulfa / Tandon, Sudeep / Yadav, Narayan Prasad / Ahmad, Ateeque

Natural product research. 2021 July 18, v. 35, no. 14

2021

Abstract: Chemical investigations on the stem of Cuscuta reflexa Roxb. (Convolvulaceae) led to the isolation of one new compound characterised as 3′,4′-dimethoxy-1-phenyl-1α, 2-ethanediol (1), along with eight known compounds as tridecanyl palmitate, palmitic acid, ...

Abstract	Chemical investigations on the stem of Cuscuta reflexa Roxb. (Convolvulaceae) led to the isolation of one new compound characterised as 3′,4′-dimethoxy-1-phenyl-1α, 2-ethanediol (1), along with eight known compounds as tridecanyl palmitate, palmitic acid, n-pentatriacontane, n-triacont-21, 27-dien-1-ol, kaempherol, chlorogenic acid, 5,7-dimethoxyapigenin and quercitin. The chemical structures were established with the help of physical, chemical and spectroscopic methods. The antimicrobial potential of the new compound (1) was evaluated against three bacterial and three fungal pathogenic strain and showed significant activities.
Keywords	Cuscuta reflexa ; chlorogenic acid ; fungi ; palmitates ; palmitic acid ; research ; spectroscopy ; virulent strains
Language	English
Dates of publication	2021-0718
Size	p. 2429-2432.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2019.1669033
Database	NAL-Catalogue (AGRICOLA)

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Article: Calliterpenone, a natural plant growth promoter from a medicinal plant

Pandey, Praveen / Pandey, Shiv Shanker / Awasthi, Ashutosh / Tripathi, Arpita / Singh, Hemendra Pratap / Singh, Anil Kumar / Tandon, Sudeep / Kalra, Alok

Frontiers in plant science

2022 Volume 13, Page(s) 960717

Abstract: The global population is rising at an alarming rate, which is threatening food and nutritional security. Although chemical fertilizers and pesticides are important for achieving food security, their excessive usage critically affects soil health and adds ...

Abstract	The global population is rising at an alarming rate, which is threatening food and nutritional security. Although chemical fertilizers and pesticides are important for achieving food security, their excessive usage critically affects soil health and adds up residues in the food chain. There is an increasing interest in identifying eco-friendly farm inputs that can improve crop productivity through sustainable agricultural practices. One of the most common approaches to reducing chemical inputs in agriculture is the use of plant growth regulators (PGRs). Here, we demonstrate the benefits of a natural and novel plant growth enhancer "calliterpenone," isolated from
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.960717
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Article: Corrigendum: Calliterpenone, a natural plant growth promoter from a medicinal plant

Pandey, Praveen / Pandey, Shiv Shanker / Awasthi, Ashutosh / Tripathi, Arpita / Singh, Hemendra Pratap / Singh, Anil Kumar / Tandon, Sudeep / Kalra, Alok

Frontiers in plant science

2022 Volume 13, Page(s) 1055825

Abstract: This corrects the article DOI: 10.3389/fpls.2022.960717.]. ...

Abstract	[This corrects the article DOI: 10.3389/fpls.2022.960717.].
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.1055825
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Article ; Online: Pharmacological and Toxicological Study of Coumarinolignoids from Cleome viscosa in Small Animals for the Management of Rheumatoid Arthritis.

Babu, Vineet / Singh, Rupali / Kashyap, Praveen K / Washimkar, Kaveri R / Mugale, Madhav N / Tandon, Sudeep / Bawankule, Dnyaneshwar Umrao

Planta medica

2022

Abstract: This study aims to explore the possible pharmacological potential ... ...

Abstract	This study aims to explore the possible pharmacological potential of
Language	English
Publishing date	2022-09-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1906-1837
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Uf I Zs.157: Show issues

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Article ; Online: An efficient process for the extraction of lutein and chemical characterization of other organic volatiles from marigold (Tagetes erecta L.) flower.

Kumar Kashyap, Praveen / Singh, Swati / Kumar Singh, Munmun / Gupta, Atul / Tandon, Sudeep / Shanker, Karuna / Kumar Verma, Rajesh / Swaroop Verma, Ram

Food chemistry

2022 Volume 396, Page(s) 133647

Abstract: Marigold (Tagetes erecta L.) petals are the primary industrial source of lutein, which is used as a colouring agent and nutrient supplement to foods. This research extracted marigold petals using different solvents, covering conventional and non-toxic ... ...

Abstract	Marigold (Tagetes erecta L.) petals are the primary industrial source of lutein, which is used as a colouring agent and nutrient supplement to foods. This research extracted marigold petals using different solvents, covering conventional and non-toxic green solvents. The oleoresin, free lutein, and recrystallized lutein yields varied from 8.47-16.67%, 2.56-9.62%, and 1.11-1.61%, respectively. The purity of lutein was achieved up to 92.57% and 97.64% in conventional and newly established green methods, respectively. The present study described an efficient green process to isolate lutein with significantly improved yield (2.56%) and purity (97.33%) over the conventional methods. Based on the results, 2-methyltetrahydrofurancould be a practical green alternative to the traditional toxic solvents for the processing of lutein. Further, the chemical analysis of the essential oil of the residual receptacles obtained after removing petals revealed the presence of important organic volatiles, including piperitone (54.7%) and piperitenone oxide (6.5%), indicating its usefulness for value-addition.
MeSH term(s)	Calendula ; Flowers/chemistry ; Lutein/chemistry ; Solvents ; Tagetes/chemistry
Chemical Substances	Solvents ; Lutein (X72A60C9MT)
Language	English
Publishing date	2022-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.133647
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