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Article ; Online: Progress in pathogenesis and therapy of Rasmussen's encephalitis.

Tang, Chongyang / Yang, Wei / Luan, Guoming

2022 Volume 146, Issue 6, Page(s) 761–766

Abstract: Rasmussen's encephalitis (RE) is a rare condition of unknown etiology that causes a severe chronically neurological disorder with mostly affecting children. The main clinical feature of RE includes frequent seizures with drug-resistant, unilateral ... ...

Abstract	Rasmussen's encephalitis (RE) is a rare condition of unknown etiology that causes a severe chronically neurological disorder with mostly affecting children. The main clinical feature of RE includes frequent seizures with drug-resistant, unilateral hemispheric atrophy, and progressive neurological deficits. In this review, we summarized five pathogenesis on the basis of the current research including virus infection, antibody-mediated degeneration, cell-mediated immunity, microglia-induced degeneration, and genetic mutations. So far, no exact virus in RE brain tissue or definite antigen in humoral immune system was confirmed as the determined etiology. The importance of cytotoxic CD8
MeSH term(s)	Child ; Humans ; Encephalitis/etiology ; Encephalitis/therapy ; Hemispherectomy ; Brain ; Seizures ; Atrophy/pathology
Language	English
Publishing date	2022-10-03
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	90-5
ISSN	1600-0404 ; 0001-6314
ISSN (online)	1600-0404
ISSN	0001-6314
DOI	10.1111/ane.13712
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Article ; Online: Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection.

Yang, Wei / Tang, Chong-Yang / Fan, Dong-Ying / Wang, Yi-Song / Wang, Pei-Gang / An, Jing / Luan, Guo-Ming

Virologica Sinica

2024 Volume 39, Issue 2, Page(s) 251–263

Abstract: Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues of patients with Rasmussen's encephalitis (RE), a ... ...

Abstract	Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues of patients with Rasmussen's encephalitis (RE), a rare chronic neurological disorder often occurred in children, characterized by unihemispheric brain atrophy. Furthermore, a higher cumulative viral score of human herpes viruses (HHVs) was also found to have a significant positive correlation with the unihemispheric atrophy in RE. Type I IFNs (IFN-I) signaling is essential for innate anti-infection response by binding to IFN-α/β receptor (IFNAR). In this study, we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1 (HSV-1) via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain lesions. While all mice exhibited typical viral encephalitis lesions in their brains, HSV-induced epilepsy was only observed in A6 mice. The gene expression matrix, functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced epilepsy. Additionally, ten key genes with the highest scores were identified. Taken together, these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions, thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.
MeSH term(s)	Animals ; Herpesvirus 1, Human/pathogenicity ; Herpesvirus 1, Human/immunology ; Interferon Type I/metabolism ; Interferon Type I/immunology ; Mice ; Signal Transduction ; Brain/pathology ; Brain/virology ; Epilepsy/virology ; Epilepsy/pathology ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/deficiency ; Disease Models, Animal ; Mice, Knockout ; Mice, Inbred C57BL ; Female ; Protein Interaction Maps ; Herpes Simplex/virology ; Herpes Simplex/pathology ; Herpes Simplex/immunology ; Encephalitis, Herpes Simplex/virology ; Encephalitis, Herpes Simplex/immunology ; Encephalitis, Herpes Simplex/pathology ; Humans
Chemical Substances	Interferon Type I ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1016/j.virs.2024.01.002
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Article: Rasmussen's encephalitis: mechanisms update and potential therapy target.

Tang, Chongyang / Luan, Guoming / Li, Tianfu

Therapeutic advances in chronic disease

2020 Volume 11, Page(s) 2040622320971413

Abstract: Rasmussen's encephalitis (RE) is rare neurological diseases characterized as epilepsia partialis continua, invariably hemiparesis, and cognitive impairment. This disease is encountered frequently in childhood and presents with progressive atrophy of the ... ...

Abstract	Rasmussen's encephalitis (RE) is rare neurological diseases characterized as epilepsia partialis continua, invariably hemiparesis, and cognitive impairment. This disease is encountered frequently in childhood and presents with progressive atrophy of the unilateral hemisphere, and there are also sustained neurological complications. Owing to uncertain pathogenesis, the most effective way to limit the influence of seizures currently is cerebral hemispherectomy. In this review, we focus on four main lines of pathogenesis: virus infection, antibody-mediated, cell-mediated immunity, and microglia activation. Although one or more antigenic epitopes may give rise to infiltrating T cell responses in RE brain tissue, no exact antigen was confirmed as the definite cause of the disease. On the other hand, the appearance of antibodies related with RE seem to be a secondary pathological process. Synthetic studies have suggested an adaptive immune mechanism mediated by CD8
Language	English
Publishing date	2020-11-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2554816-5
ISSN	2040-6231 ; 2040-6223
ISSN (online)	2040-6231
ISSN	2040-6223
DOI	10.1177/2040622320971413
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Article ; Online: PtNi/PtIn-Skin Fishbone-Like Nanowires Boost Alkaline Hydrogen Oxidation Catalysis.

Wang, Liyuan / Meng, Shuang / Tang, Chongyang / Zhan, Changhong / Geng, Shize / Jiang, Kezhu / Huang, Xiaoqing / Bu, Lingzheng

ACS nano

2023 Volume 17, Issue 18, Page(s) 17779–17789

Abstract: The development of high-performance platinum (Pt)-based electrocatalysts for the hydrogen oxidation reaction (HOR) is highly desirable for hydrogen fuel cells, but it is limited by the sluggish kinetics and severe carbon monoxide (CO) poisoning in ... ...

Abstract	The development of high-performance platinum (Pt)-based electrocatalysts for the hydrogen oxidation reaction (HOR) is highly desirable for hydrogen fuel cells, but it is limited by the sluggish kinetics and severe carbon monoxide (CO) poisoning in alkaline medium. Herein, we explore a class of facet-selected Pt-nickel-indium fishbone-like nanowires (PtNiIn FNWs) featuring high-index facets (HIFs) of Pt
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c02832
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Article ; Online: Unveiling the nature of Pt-induced anti-deactivation of Ru for alkaline hydrogen oxidation reaction.

Fang, Yanyan / Wei, Cong / Bian, Zenan / Yin, Xuanwei / Liu, Bo / Liu, Zhaohui / Chi, Peng / Xiao, Junxin / Song, Wanjie / Niu, Shuwen / Tang, Chongyang / Liu, Jun / Ge, Xiaolin / Xu, Tongwen / Wang, Gongming

Nature communications

2024 Volume 15, Issue 1, Page(s) 1614

Abstract: While Ru owns superior catalytic activity toward hydrogen oxidation reaction and cost advantages, the catalyst deactivation under high anodic potential range severely limits its potential to replace the Pt benchmark catalyst. Unveiling the deactivation ... ...

Abstract	While Ru owns superior catalytic activity toward hydrogen oxidation reaction and cost advantages, the catalyst deactivation under high anodic potential range severely limits its potential to replace the Pt benchmark catalyst. Unveiling the deactivation mechanism of Ru and correspondingly developing protection strategies remain a great challenge. Herein, we develop atomic Pt-functioned Ru nanoparticles with excellent anti-deactivation feature and meanwhile employ advanced operando characterization tools to probe the underlying roles of Pt in the anti-deactivation. Our studies reveal the introduced Pt single atoms effectively prevent Ru from oxidative passivation and consequently preserve the interfacial water network for the critical H* oxidative release during catalysis. Clearly understanding the deactivation nature of Ru and Pt-induced anti-deactivation under atomic levels could provide valuable insights for rationally designing stable Ru-based catalysts for hydrogen oxidation reaction and beyond.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45873-0
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Article ; Online: Electrocatalytic hydrogenation of acetonitrile to ethylamine in acid.

Tang, Chongyang / Wei, Cong / Fang, Yanyan / Liu, Bo / Song, Xianyin / Bian, Zenan / Yin, Xuanwei / Wang, Hongbo / Liu, Zhaohui / Wang, Gongming / Xiao, Xiangheng / Duan, Xiangfeng

Nature communications

2024 Volume 15, Issue 1, Page(s) 3233

Abstract: Electrochemical hydrogenation of acetonitrile based on well-developed proton exchange membrane electrolyzers holds great promise for practical production of ethylamine. However, the local acidic condition of proton exchange membrane results in severe ... ...

Abstract	Electrochemical hydrogenation of acetonitrile based on well-developed proton exchange membrane electrolyzers holds great promise for practical production of ethylamine. However, the local acidic condition of proton exchange membrane results in severe competitive proton reduction reaction and poor selection toward acetonitrile hydrogenation. Herein, we conduct a systematic study to screen various metallic catalysts and discover Pd/C exhibits a 43.8% ethylamine Faradaic efficiency at the current density of 200 mA cm
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47622-9
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Article ; Online: Regulating Surface Reaction Kinetics through Ligand Field Effects for Fast and Reversible Aqueous Zinc Batteries.

Liu, Bo / Wei, Cong / Zhu, Zixuan / Fang, Yanyan / Bian, Zenan / Lei, Xin / Zhou, Ya / Tang, Chongyang / Qian, Yitai / Wang, Gongming

Angewandte Chemie (International ed. in English)

2022 Volume 61, Issue 44, Page(s) e202212780

Abstract: Designing water-deficient solvation sheath of ... ...

Abstract	Designing water-deficient solvation sheath of Zn
Language	English
Publishing date	2022-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202212780
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Article: Vagus nerve stimulation for pharmacoresistant epilepsy secondary to encephalomalacia: A single-center retrospective study.

Guo, Mengyi / Wang, Jing / Xiong, Zhonghua / Deng, Jiahui / Zhang, Jing / Tang, Chongyang / Kong, Xiangru / Wang, Xiongfei / Guan, Yuguang / Zhou, Jian / Zhai, Feng / Luan, Guoming / Li, Tianfu

Frontiers in neurology

2023 Volume 13, Page(s) 1074997

Abstract: Objective: Vagus nerve stimulation (VNS) is an adjunctive treatment for pharmacoresistant epilepsy. Encephalomalacia is one of the most common MRI findings in the preoperative evaluation of patients with pharmacoresistant epilepsy. This is the first ... ...

Abstract	Objective: Vagus nerve stimulation (VNS) is an adjunctive treatment for pharmacoresistant epilepsy. Encephalomalacia is one of the most common MRI findings in the preoperative evaluation of patients with pharmacoresistant epilepsy. This is the first study that aimed to determine the effectiveness of VNS for pharmacoresistant epilepsy secondary to encephalomalacia and evaluate the potential predictors of VNS effectiveness. Methods: We retrospectively analyzed the seizure outcomes of VNS with at least 1 year of follow-up in all patients with pharmacoresistant epilepsy secondary to encephalomalacia. Based on the effectiveness of VNS (≥50% or <50% reduction in seizure frequency), patients were divided into two subgroups: responders and non-responders. Preoperative data were analyzed to screen for potential predictors of VNS effectiveness. Results: A total of 93 patients with epilepsy secondary to encephalomalacia who underwent VNS therapy were recruited. Responders were found in 64.5% of patients, and 16.1% of patients achieved seizure freedom at the last follow-up. In addition, the responder rate increased over time, with 36.6, 50.5, 64.5, and 65.4% at the 3-, 6-, 12-, and 24-month follow-ups, respectively. After multivariate analysis, seizure onset in adults (>18 years old) (OR: 0.236, 95%CI: 0.059-0.949) was found to be a positive predictor, and the bilateral interictal epileptic discharges (IEDs) (OR: 3.397, 95%CI: 1.148-10.054) and the bilateral encephalomalacia on MRI (OR: 3.193, 95%CI: 1.217-8.381) were found to be negative predictors of VNS effectiveness. Conclusion: The results demonstrated the effectiveness and safety of VNS therapy in patients with pharmacoresistant epilepsy secondary to encephalomalacia. Patients with seizure onset in adults (>18 years old), unilateral IEDs, or unilateral encephalomalacia on MRI were found to have better seizure outcomes after VNS therapy.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.1074997
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Article ; Online: Lattice oxygen-mediated electron tuning promotes electrochemical hydrogenation of acetonitrile on copper catalysts.

Wei, Cong / Fang, Yanyan / Liu, Bo / Tang, Chongyang / Dong, Bin / Yin, Xuanwei / Bian, Zenan / Wang, Zhandong / Liu, Jun / Qian, Yitai / Wang, Gongming

Nature communications

2023 Volume 14, Issue 1, Page(s) 3847

Abstract: Copper is well-known to be selective to primary amines via electrocatalytic nitriles hydrogenation. However, the correlation between the local fine structure and catalytic selectivity is still illusive. Herein, we find that residual lattice oxygen in ... ...

Abstract	Copper is well-known to be selective to primary amines via electrocatalytic nitriles hydrogenation. However, the correlation between the local fine structure and catalytic selectivity is still illusive. Herein, we find that residual lattice oxygen in oxide-derived Cu nanowires (OD-Cu NWs) plays vital roles in boosting the acetonitrile electroreduction efficiency. Especially at high current densities of more than 1.0 A cm
MeSH term(s)	Copper ; Electrons ; Hydrogenation ; Acetonitriles ; Nitriles ; Catalysis ; Oxides ; Oxygen
Chemical Substances	Copper (789U1901C5) ; acetonitrile (Z072SB282N) ; Acetonitriles ; Nitriles ; Oxides ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39558-3
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Article ; Online: Aberrant adenosine signaling in patients with focal cortical dysplasia.

Guo, Mengyi / Zhang, Jing / Wang, Jing / Wang, Xiongfei / Gao, Qing / Tang, Chongyang / Deng, Jiahui / Xiong, Zhonghua / Kong, Xiangru / Guan, Yuguang / Zhou, Jian / Boison, Detlev / Luan, Guoming / Li, Tianfu

Molecular neurobiology

2023 Volume 60, Issue 8, Page(s) 4396–4417

Abstract: Focal cortical dysplasia (FCD), a common malformation of cortical development, is frequently associated with pharmacoresistant epilepsy in both children and adults. Adenosine is an inhibitory modulator of brain activity and a prospective anti-seizure ... ...

Abstract	Focal cortical dysplasia (FCD), a common malformation of cortical development, is frequently associated with pharmacoresistant epilepsy in both children and adults. Adenosine is an inhibitory modulator of brain activity and a prospective anti-seizure agent with potential for clinical translation. Our previous results demonstrated that the major adenosine-metabolizing enzyme adenosine kinase (ADK) was upregulated in balloon cells (BCs) within FCD type IIB lesions, suggesting that dysfunction of the adenosine system is implicated in the pathophysiology of FCD. In our current study, we therefore performed a comprehensive analysis of adenosine signaling in surgically resected cortical specimens from patients with FCD type I and type II via immunohistochemistry and immunoblot analysis. Adenosine enzyme signaling was assessed by quantifying the levels of the key enzymes of adenosine metabolism, i.e., ADK, adenosine deaminase (ADA), and ecto-5'-nucleotidase (CD73). Adenosine receptor signaling was assessed by quantifying the levels of adenosine A
MeSH term(s)	Child ; Adult ; Humans ; Focal Cortical Dysplasia ; Epilepsy/pathology ; Malformations of Cortical Development, Group I/metabolism ; Malformations of Cortical Development, Group I/pathology ; Signal Transduction ; Malformations of Cortical Development ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03351-6
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