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Article ; Online: Laser ablation of anal fistulae: a 6-year experience in a tertiary teaching hospital in Malaysia.

Tang, Chu-Yik / Roslani, April Camilla

2022 Volume 37, Issue 8, Page(s) 3291–3296

Abstract: Background: Several studies have investigated the role of laser ablation of anal fistulae in the European setting. However, long-term follow-up results following laser fistula ablations are not widely investigated and no study was performed in the Asia- ... ...

Abstract	Background: Several studies have investigated the role of laser ablation of anal fistulae in the European setting. However, long-term follow-up results following laser fistula ablations are not widely investigated and no study was performed in the Asia-Pacific, a region with a distinctive prevalence of tuberculosis. The primary objective of this study is to report a single-centre experience with laser ablation of anal fistulae in Malaysia over a period of 6 years. Method: This was a retrospective observational study assessing the outcomes following 70 laser ablations of anal fistulae from February 2014 till December 2019. All cases were assessed using endoanal ultrasound. The laser ablation procedures were performed using laser systems and fibres from Endoteq Medizinische Laser GmBH, Germany, and Biolitec AG, Jena, Germany. Laser fibres were introduced into the fistula tract and laser energy was emitted radially in continuous mode when activated during the procedure. Pre-defined post-procedural outcomes (primary healing, healing failure or recurrence) were recorded as either present or absent during subsequent follow-up appointments and the data was analysed. Results: Over a median follow-up period of 10 months, primary healing was reported following 42 procedures (60.0%). Healing failure was reported following 28 procedures (40.0%) whilst recurrence was seen after 16 procedures (22.86%). No new cases of incontinence were reported following the procedure. Conclusion: The reported primary healing rate following laser ablation of anal fistulae in this study appears consistent with existing literature published by other international centres. The most apparent clinical advantage of this procedure is sphincter-function preservation. However, the primary healing rate after isolated laser fistula ablation is still suboptimal. Judicious patient selection and application in anal fistulae with suitable characteristics could potentially improve the post-procedural outcomes.
MeSH term(s)	Anal Canal/surgery ; Hospitals, Teaching ; Humans ; Laser Therapy/methods ; Malaysia/epidemiology ; Rectal Fistula/surgery ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2022-08-31
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-022-03628-7
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Article: Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder.

Tang, Cai-Yun / Wen, Fang

World journal of clinical cases

2022 Volume 10, Issue 22, Page(s) 7749–7759

Abstract: Background: Iron plays an important role in neurodevelopmental functions in the brain. Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children.: Aim: To explore the ... ...

Abstract	Background: Iron plays an important role in neurodevelopmental functions in the brain. Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children. Aim: To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age effects. Methods: A total of 1565 children with attention deficit hyperactivity disorder (ADHD), 1694 children with tic disorder (TD), 93 children with ASD and 1997 healthy control children were included between January 1, 2020, and December 31, 2021 at Beijing Children's Hospital. We describe the differences in age levels and ferritin levels between different disease groups and their sex differences. The differences between the sexes in each disease were analyzed using the t test. The incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups. A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control group. Analysis of variance was used for comparisons between subgroups, and regression analysis was used for confounding factor control. Results: A total of 1565 ADHD patients aged 5-12 years were included in this study, and the average serum ferritin levels of male and female children were 36.82 ± 20.64 μg/L and 35.64 ± 18.56 μg/L, respectively. A total of 1694 TD patients aged 5-12 years were included in this study, and the average serum ferritin levels of male and female children were 35.72 ± 20.15 μg/L and 34.54 ± 22.12 μg/L, respectively. As age increased, the incidence of low serum ferritin in ADHD and TD first decreased and then increased, and 10 years old was the turning point of rising levels. The incidence of ADHD with low serum ferritin was 8.37%, the incidence of TD with low serum ferritin was 11.04%, and the incidence of the healthy control group with low serum ferritin was 8.61%, among which male children with TD accounted for 9.25% and female children with TD accounted for 11.62%. There was a significant difference among the three groups ( Conclusion: In conclusion, low serum ferritin is not a risk factor for ADHD or TD. The incidence of low serum ferritin levels in children with ADHD and TD between 5 and 12 years old decreases first and then increases with age.
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i22.7749
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Article ; Online: Empowering ultrathin polyamide membranes at the water-energy nexus: strategies, limitations, and future perspectives.

Sarkar, Pulak / Wu, Chenyue / Yang, Zhe / Tang, Chuyang Y

Chemical Society reviews

2024

Abstract: Membrane-based separation is one of the most energy-efficient methods to meet the growing need for a significant amount of fresh water. It is also well-known for its applications in water treatment, desalination, solvent recycling, and environmental ... ...

Abstract	Membrane-based separation is one of the most energy-efficient methods to meet the growing need for a significant amount of fresh water. It is also well-known for its applications in water treatment, desalination, solvent recycling, and environmental remediation. Most typical membranes used for separation-based applications are thin-film composite membranes created using polymers, featuring a top selective layer generated by employing the interfacial polymerization technique at an aqueous-organic interface. In the last decade, various manufacturing techniques have been developed in order to create high-specification membranes. Among them, the creation of ultrathin polyamide membranes has shown enormous potential for achieving a significant increase in the water permeation rate, translating into major energy savings in various applications. However, this great potential of ultrathin membranes is greatly hindered by undesired transport phenomena such as the geometry-induced "funnel effect" arising from the substrate membrane, severely limiting the actual permeation rate. As a result, the separation capability of ultrathin membranes is still not fully unleashed or understood, and a critical assessment of their limitations and potential solutions for future studies is still lacking. Here, we provide a summary of the latest developments in the design of ultrathin polyamide membranes, which have been achieved by controlling the interfacial polymerization process and utilizing a number of novel manufacturing processes for ionic and molecular separations. Next, an overview of the in-depth assessment of their limitations resulting from the substrate membrane, along with potential solutions and future perspectives will be covered in this review.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d3cs00803g
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Article ; Online: Making waves: Why do we need ultra-permeable nanofiltration membranes for water treatment?

Yang, Zhe / Wu, Chenyue / Tang, Chuyang Y

Water research X

2023 Volume 19, Page(s) 100172

Abstract: Over the last few decades, developing ultra-permeable nanofiltration (UPNF) membranes has been a focus research area to support NF-based water treatment. Nevertheless, there have been ongoing debates and doubts on the need for UPNF membranes. In this ... ...

Abstract	Over the last few decades, developing ultra-permeable nanofiltration (UPNF) membranes has been a focus research area to support NF-based water treatment. Nevertheless, there have been ongoing debates and doubts on the need for UPNF membranes. In this work, we share our perspectives on why UPNF membranes are desired for water treatment. We analyze the specific energy consumption (SEC) of NF processes under various application scenarios, which reveals the potential of UPNF membranes for reducing SEC by 1/3 to 2/3 depending on the prevailing transmembrane osmotic pressure difference. Furthermore, UPNF membranes could potentially enable new process opportunities. Vacuum-driven submerged NF-modules could be retrofitted to existing water/wastewater treatment plants, offering lower SEC and lower cost compared to conventional NF systems. Their use in submerged membrane bioreactors (NF-MBR) can recycle wastewater into high-quality permeate water, which enables energy-efficient water reuse in a single treatment step. The ability for retaining soluble organics may further extend the application of NF-MBR for anaerobic treatment of dilute municipal wastewater. Critical analysis of membrane development reveals huge rooms for UPNF membranes to attain improved selectivity and antifouling performance. Our perspective paper offers important insights for the future development of NF-based water treatment technology, which could potentially lead to a paradigm shift in this burgeoning field.
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Journal Article
ISSN	2589-9147
ISSN (online)	2589-9147
DOI	10.1016/j.wroa.2023.100172
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Article: Tracheal adenoid cystic carcinoma with microscopic positive margin-how we approached with a systematic analysis review of its management.

Krishnasamy, Sivakumar / Tang, Chu-Yik / Tan, Pheng Hian

Indian journal of thoracic and cardiovascular surgery

2023 Volume 40, Issue 3, Page(s) 332–340

Abstract: Purpose: Adenoid cystic carcinoma (ACC) of the trachea is a rare malignancy. We report a patient with ACC who underwent multimodal management including tracheal resection. A systematic review was also conducted on tracheal resection for ACC.: Methods!# ...

Abstract	Purpose: Adenoid cystic carcinoma (ACC) of the trachea is a rare malignancy. We report a patient with ACC who underwent multimodal management including tracheal resection. A systematic review was also conducted on tracheal resection for ACC. Methods: A literature search was conducted on MEDLINE, Embase, and PubMed using the search terms "trachea AND adenoid cystic carcinoma AND (surgery OR resection)" and articles from 2000 to August 2021 were identified. A total of 29 journal articles were included in the review. Results: A total of 403 patients underwent surgery for tracheal ACCs. The mean age was 48.1 years and 54.7% were female. The commonest anatomical location was the lower trachea (46.9%). The mean time from symptom onset to diagnosis was 16.6 months with the commonest symptom being dyspnoea (52%). Fifty-eight percent of the patients had intraluminal growth. Tracheal resection (46.2%) and access via thoracotomy (41.4%) were the commonest procedures described. The mean length of trachea resected was 39.2 mm and the mean tumour size was 31.5 mm. 16.8% of lymph nodes were involved and 73.8% of cases had positive resection margins. The overall complication rate was 1.4-5.4% and the in-hospital mortality rate was 9.8%. The overall survival reported was 61.7% at 5 years and 54.6% at 10 years. Conclusion: Surgical resection followed by adjuvant radiotherapy is the mainstay in the treatment of tracheal ACC, notwithstanding the high rates of involved margins. Achieving tension-free anastomosis should be the first priority given the favourable response of adjuvant therapies in reducing recurrence rate and improving overall survival.
Language	English
Publishing date	2023-09-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2164386-6
ISSN	0973-7723 ; 0970-9134
ISSN (online)	0973-7723
ISSN	0970-9134
DOI	10.1007/s12055-023-01600-w
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Article ; Online: Photogenerated outer electric field induced electrophoresis of organic nanocrystals for effective solid-solid photocatalysis.

Guo, Yan / Zhu, Bowen / Tang, Chuyang Y / Zhou, Qixin / Zhu, Yongfa

Nature communications

2024 Volume 15, Issue 1, Page(s) 428

Abstract: Rapid mass transfer in solid-solid reactions is crucial for catalysis. Although phoretic nanoparticles offer potential for increased collision efficiency between solids, their implementation is hindered by limited interaction ranges. Here, we present a ... ...

Abstract	Rapid mass transfer in solid-solid reactions is crucial for catalysis. Although phoretic nanoparticles offer potential for increased collision efficiency between solids, their implementation is hindered by limited interaction ranges. Here, we present a self-driven long-range electrophoresis of organic nanocrystals facilitated by a rationally designed photogenerated outer electric field (OEF) on their surface. Employing perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) molecular nanocrystals as a model, we demonstrate that a directional OEF with an intensity of 13.6-0.4 kV m
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44700-w
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Article: Prostate-specific antigen reduction after capecitabine plus oxaliplatin chemotherapy: A case report.

Zou, Qian / Shen, Rui-Lin / Guo, Xiao / Tang, Chen-Ye

World journal of clinical cases

2023 Volume 11, Issue 11, Page(s) 2528–2534

Abstract: Background: Prostate cancer (PC) is currently the most common malignant tumor of the genitourinary system in men. Radical prostatectomy (RP) is recommended for the treatment of patients with localized PC. Adjuvant hormonal therapy (AHT) can be ... ...

Abstract	Background: Prostate cancer (PC) is currently the most common malignant tumor of the genitourinary system in men. Radical prostatectomy (RP) is recommended for the treatment of patients with localized PC. Adjuvant hormonal therapy (AHT) can be administered postoperatively in patients with high-risk or locally advanced PC. Chemotherapy is a vital remedy for castration-resistant prostate cancer (CRPC), and may also benefit patients with PC who have not progressed to CRPC. Case summary: A 68-year-old male was admitted to our hospital because of urinary irritation and dysuria with increased prostate-specific antigen (PSA) levels. After detailed examination, he was diagnosed with PC and treated with laparoscopic RP on August 3, 2020. AHT using androgen deprivation therapy (ADT) was performed postoperatively because of the positive surgical margin, extracapsular extension, and neural invasion but lasted only 6 mo. Unfortunately, he was diagnosed with rectal cancer about half a year after self-cessation of AHT, and was then treated with laparoscopic radical rectal resection and adjuvant chemotherapy using the capecitabine plus oxaliplatin (CapeOx) regimen. During the entire treatment process, the patient's PSA level first declined significantly after treatment of PC with laparoscopic RP and ADT, then rebounded because of self-cessation of ADT, and finally decreased again after CapeOx chemotherapy. Conclusion: CapeOx chemotherapy can reduce PSA levels in patients with high-risk locally advanced PC, indicating that CapeOx may be an alternative chemotherapy regimen for PC.
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i11.2528
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Article ; Online: LSTM-MSA: A Novel Deep Learning Model With Dual-Stage Attention Mechanisms Forearm EMG-Based Hand Gesture Recognition.

Zhang, Haotian / Qu, Hang / Teng, Long / Tang, Chak-Yin

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume 31, Page(s) 4749–4759

Abstract: This paper introduces the Long Short-Term Memory with Dual-Stage Attention (LSTM-MSA) model, an approach for analyzing electromyography (EMG) signals. EMG signals are crucial in applications like prosthetic control, rehabilitation, and human-computer ... ...

Abstract	This paper introduces the Long Short-Term Memory with Dual-Stage Attention (LSTM-MSA) model, an approach for analyzing electromyography (EMG) signals. EMG signals are crucial in applications like prosthetic control, rehabilitation, and human-computer interaction, but they come with inherent challenges such as non-stationarity and noise. The LSTM-MSA model addresses these challenges by combining LSTM layers with attention mechanisms to effectively capture relevant signal features and accurately predict intended actions. Notable features of this model include dual-stage attention, end-to-end feature extraction and classification integration, and personalized training. Extensive evaluations across diverse datasets consistently demonstrate the LSTM-MSA's superiority in terms of F1 score, accuracy, recall, and precision. This research provides a model for real-world EMG signal applications, offering improved accuracy, robustness, and adaptability.
MeSH term(s)	Humans ; Forearm ; Deep Learning ; Electromyography ; Gestures ; Upper Extremity
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2023.3336865
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Article ; Online: [Determination of amanita peptide and tryptamine toxins in wild mushrooms by high performance liquid chromatography-tandem mass spectrometry].

Liu, Lei-Qi / Chen, Jing-Ze / Fu, Wu-Sheng / Tang, Cui-Ying

Se pu = Chinese journal of chromatography

2023 Volume 41, Issue 11, Page(s) 976–985

Abstract: The discovery and identification of mushroom toxins has long been an important area in the fields of toxicology and food safety. Mushrooms are widely favored for their culinary and medicinal value; however, the presence of potentially lethal toxins in ... ...

Abstract	The discovery and identification of mushroom toxins has long been an important area in the fields of toxicology and food safety. Mushrooms are widely favored for their culinary and medicinal value; however, the presence of potentially lethal toxins in some species poses a substantial challenge in ensuring their safe consumption. Therefore, the development of a robust and sensitive analytical method is necessary for accurately identifying the risks associated with mushroom consumption. The study of mushroom toxins, which are characterized by their diversity and substantial variations in chemical structures, present a considerable challenge for achieving precise and high-throughput analysis. To address this issue, the present study employed a robust approach combining a solid-phase extraction (SPE) purification technique with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to establish an analytical method for the detection and quantification of five amatoxins and two tryptamines (psilocybin and bufotenine) present in some mushrooms. Several optimization procedures were undertaken, including optimizing the chromatographic conditions, mass spectrometric parameters, and sample extraction and purification. The procedure involved the extraction of dry mushroom powder with methanol containing 0.3% formic acid, followed by purification using a strong cation exchange cartridge (SCX). The analytes were separated on a T3 chromatographic column (100 mm×2.1 mm, 1.8 μm) using mobile phases of acetonitrile and 5 mmol/L ammonium acetate solution containing 0.1% formic acid. The multiple reaction monitoring (MRM) mode was employed for data acquisition. Amatoxins were quantified using matrix-matched standard calibration curves, whereas isotopic internal standards were used to quantify tryptamine. The results showed that all seven toxins exhibited good linearities (
MeSH term(s)	Chromatography, High Pressure Liquid ; Amanita/chemistry ; Tandem Mass Spectrometry ; Psilocybin ; Bufotenin ; Powders ; Mycotoxins ; Tryptamines ; DNA, Ribosomal
Chemical Substances	formic acid (0YIW783RG1) ; tryptamine (422ZU9N5TV) ; Psilocybin (2RV7212BP0) ; Bufotenin (0A31347TZK) ; Powders ; Mycotoxins ; Tryptamines ; DNA, Ribosomal
Language	Chinese
Publishing date	2023-11-15
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1872-2059
ISSN (online)	1872-2059
DOI	10.3724/SP.J.1123.2023.07013
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Article: Good adaptability of freshmen in medical universities under the Coronavirus 2019 pandemic: a questionnaire-based single center study in China.

Zhu, Lin-Ying / Huang, Huai / Kuang, Yan / Tang, Chun-Yuan

American journal of translational research

2023 Volume 15, Issue 5, Page(s) 3739–3750

Abstract: Objective: To investigate the adaptability of freshmen in medical universities to the Coronavirus Disease 2019 (COVID-19) pandemic and to understand the relevant factors affecting their adaptation in medical university.: Methods: Freshmen in a ... ...

Abstract	Objective: To investigate the adaptability of freshmen in medical universities to the Coronavirus Disease 2019 (COVID-19) pandemic and to understand the relevant factors affecting their adaptation in medical university. Methods: Freshmen in a medical university in Guangdong Province were selected and surveyed using a self-administered general questionnaire and a college student adjustment scale prepared by Fang Xiaoyi et al. The results were analyzed statistically. Results: A total of 741 questionnaires were collected and 736 valid questionnaires were recovered. The adaptation level of freshmen in the medical university was moderately high. There were no differences in gender, age, family geographical location, or higher education level, but there were significant differences in major, type of household, only children (yes/no), and voluntary enrollment in medicine (yes/no). The survey showed that 30.3% of the students had discomfort at the beginning of the semester, 92.5% chose medical university voluntarily, and 83.4% expressed their enhanced motivation to study medicine after the COVID-19 outbreak, but 65.1% exhibited influence in study and life caused by COVID-19, which were statistically significant factors affecting the adaptation score. Conclusions: Freshmen in the medical university are generally well-adjusted with many influencing factors. Medical schools should strengthen adaptability management in order to timely identify the adaptation challenges of the students.
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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