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Book ; Online: Induced Impairment of Neurogenesis and Brain Diseases

Tang, FengRu

2023

Keywords	Medicine ; Neurosciences ; neurogenesis ; TGF-β ; smad ; depression ; stress ; complementary and alternative medicines ; natural products ; peripheral nerve injury ; nerve repair ; nerve regeneration ; functional recovery ; neuroinflammation ; microglia ; TSPO ; mitochondria ; cytokines ; antioxidants ; γ-irradiation ; miR-34a-5p ; tia1 ; N6-methyladenosine ; Mettl3 ; Mettl14 ; Fto ; Ythdf1 ; neurodevelopment ; neurodegeneration ; SMG6 ; NMD ; neurodevelopmental syndromes ; ionizing radiation ; aging ; brain ; oxidative stress ; mitochondrial dysfunction ; DNA damage ; gut microbiota ; gut-brain axis ; adult neurogenesis ; ageing ; neural stem cells ; nutrients ; polyphenols ; TRIM32 ; excitatory-inhibitory imbalance ; cortex development ; ASD ; NPCs ; GHSR1 ; ghrelin ; hypoxia ; transcription factors ; progenitor cells ; adult hippocampal neurogenesis ; Alzheimer's disease ; Aβ peptide ; DNA methylation ; gene expression ; NXN ; CNTNAP1 ; SEPT5-GP1BB ; TBX5 ; miR-146b ; cognition ; anxiety ; astrocytes ; neuronal development ; Gdnf ; microcephaly ; MCPH1 ; central domain ; brain development ; gonad development
Language	English
Size	1 electronic resource (282 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030378393
ISBN	9783036562131 ; 3036562133
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Interview with Dr. Mingliang Fang, 2023 Young Investigator Award Recipient, American Chemical Society Division of Chemical Toxicology.

Tang, Feng

Chemical research in toxicology

2023 Volume 36, Issue 11, Page(s) 1651–1652

Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Letter
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/acs.chemrestox.3c00265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent advances in antibody glycoengineering for the gain of functions.

Liu, Zhi / Zou, Xiangman / Tang, Feng / Huang, Wei

Current opinion in chemical biology

2024 Volume 78, Page(s) 102420

Abstract: Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in ... ...

Abstract	Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemo-enzymatic antibody glycoengineering, and yeast expression system-based antibody engineering, as well as the applications of glycoengineering in antibody-drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.
MeSH term(s)	Animals ; Glycosylation ; Antibodies/genetics ; Polysaccharides/metabolism ; Mammals
Chemical Substances	Antibodies ; Polysaccharides
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1439176-4
ISSN	1879-0402 ; 1367-5931
ISSN (online)	1879-0402
ISSN	1367-5931
DOI	10.1016/j.cbpa.2023.102420
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Article ; Online: Successful intraoperative radiation therapy for a rapidly recurrent smooth muscle tumor of uncertain malignant potential.

Chung, Yu-Hsuan / Liang, Peir-In / Tang, Feng-Hsiang

The Kaohsiung journal of medical sciences

2024

Language	English
Publishing date	2024-04-16
Publishing country	China (Republic : 1949- )
Document type	Letter
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12831
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Article ; Online: Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis.

Duan, Yu / Deng, Yao / Tang, Feng / Li, Jian

Aging

2024 Volume 16, Issue 7, Page(s) 6135–6146

Abstract: Dysfunction of tight junction proteins-associated damage to the blood-brain barrier (BBB) plays an important role in the pathogenesis of ischemic stroke. Lifibrate, an inhibitor of cholinephosphotransferase (CPT), has been used as an agent for serum ... ...

Abstract	Dysfunction of tight junction proteins-associated damage to the blood-brain barrier (BBB) plays an important role in the pathogenesis of ischemic stroke. Lifibrate, an inhibitor of cholinephosphotransferase (CPT), has been used as an agent for serum lipid lowering. However, the protective effects of Lifibrate in ischemic stroke and the underlying mechanism have not been clearly elucidated. Here, we employed an
MeSH term(s)	Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Ischemic Stroke/drug therapy ; Zonula Occludens-1 Protein/metabolism ; Zonula Occludens-1 Protein/genetics ; Mice ; Male ; Humans ; Myosin-Light-Chain Kinase/metabolism ; Myosin Light Chains/metabolism ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Neuroprotective Agents/pharmacology ; Cell Line ; Infarction, Middle Cerebral Artery/metabolism
Chemical Substances	Zonula Occludens-1 Protein ; Myosin-Light-Chain Kinase (EC 2.7.11.18) ; Myosin Light Chains ; Tjp1 protein, mouse ; Neuroprotective Agents
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205692
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Article ; Online: Enhancement in thermal stability and mechanical performance of modified polyketone/aramid short fiber composites with controlled interface

Tang, Feng / Jeong, Young Gyu

Composites Part A. 2023 Aug., v. 171 p.107558-

2023

Abstract: The influence of aramid short fiber (ASF) on the rheological, thermal, and mechanical properties of thermoplastic polyketone (PK)-based composites is investigated. To attain improved interfacial adhesion between the ASF filler and the PK matrix, glycidyl ...

Abstract	The influence of aramid short fiber (ASF) on the rheological, thermal, and mechanical properties of thermoplastic polyketone (PK)-based composites is investigated. To attain improved interfacial adhesion between the ASF filler and the PK matrix, glycidyl methacrylate-grafted PK (PKGMA) is prepared by in situ melt-blending. The modified PK-based composites with various ASF contents of 0.5–10.0 wt% are manufactured via melt-compounding and injection-molding. The electron microscopic images show that ASFs at 0.5–7.0 wt% loadings are dispersed uniformly in the PKGMA-based composites and they have good interfacial bonding with the PKGMA matrix. The infrared spectroscopic analysis confirms the effectual modification of PKGMA and the presence of hydrogen bonding interactions as well as chemical reactions between the amide group of ASFs and the GMA group of the PKGMA matrix in the PKGMA/ASF composites, unlike a PK/ASF composite. The melt-rheological data support the existence of chemical grafting reactions of PKGMA on the ASF filler. As a result, the crystallization of the PKGMA matrix in the composites is hindered by the presence of the ASF filler. However, the thermal stability of PKGMA/ASF composites is improved noticeably. In addition, the tensile and dynamic mechanical moduli of PKGMA are improved most significantly with the addition of 7.0 wt% ASFs.
Keywords	adhesion ; crystallization ; electron microscopy ; hydrogen ; injection molding ; spectral analysis ; thermal stability ; thermoplastics ; Aramid short fiber ; Modified polyketone ; Composites ; Mechanical property
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2012223-8
ISSN	1359-835X
ISSN	1359-835X
DOI	10.1016/j.compositesa.2023.107558
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Radiation-induced neuropathological changes in the oligodendrocyte lineage with relevant clinical manifestations and therapeutic strategies.

Lee, Rui Xue / Tang, Feng Ru

International journal of radiation biology

2022 Volume 98, Issue 10, Page(s) 1519–1531

Abstract: Purpose: With technological advancements in radiation therapy for tumors of the central nervous system (CNS), high doses of ionizing radiation can be delivered to the tumors with improved accuracy. Despite the reduction of ionizing radiation-induced ... ...

Abstract	Purpose: With technological advancements in radiation therapy for tumors of the central nervous system (CNS), high doses of ionizing radiation can be delivered to the tumors with improved accuracy. Despite the reduction of ionizing radiation-induced toxicity to surrounding tissues of the CNS, a wide array of side effects still occurs, particularly late-delayed changes. These alterations, such as white matter damages and neurocognitive impairments, are often debilitative and untreatable, significantly affecting the quality of life of these patients, especially children. Oligodendrocytes, a major class of glial cells, have been identified to be one of the targets of radiation toxicity and are recognized be involved in late-delayed radiation-induced neuropathological changes. These cells are responsible for forming the myelin sheaths that surround and insulate axons within the CNS. Here, the effects of ionizing radiation on the oligodendrocyte lineage as well as the common clinical manifestations resulting from radiation-induced damage to oligodendrocytes will be discussed. Potential prophylactic and therapeutic strategies against radiation-induced oligodendrocyte damage will also be considered. Conclusion: Oligodendrocytes and oligodendrocyte progenitor cells (OPCs) are radiosensitive cells of the CNS. Here, general responses of these cells to radiation exposure have been outlined. However, several findings have not been consistent across various studies. For instance, cognitive decline in irradiated animals was observed to be accompanied by obvious demyelination or white matter changes in several studies but not in others. Hence, further studies have to be conducted to elucidate the level of contribution of the oligodendrocyte lineage to the development of late-delayed effects of radiation exposure, as well as to classify the dose and brain region-specific responses of the oligodendrocyte lineage to radiation. Several potential therapeutic approaches against late-delayed changes have been discussed, such as the transplantation of OPCs into irradiated regions and implementation of exercise. Many of these approaches show promising results. Further elucidation of the mechanisms involved in radiation-induced death of oligodendrocytes and OPCs would certainly aid in the development of novel protective and therapeutic strategies against the late-delayed effects of radiation.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Lineage ; Central Nervous System ; Myelin Sheath ; Oligodendroglia/pathology ; Oligodendroglia/physiology ; Quality of Life
Language	English
Publishing date	2022-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2022.2055804
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Article ; Online: Research on Energy Harvesting Mechanism and Low Power Technology in Wireless Sensor Networks.

Chen, Weimin / Tang, Feng / Cui, Fang / Chen, Chen

Sensors (Basel, Switzerland)

2023 Volume 24, Issue 1

Abstract: Wireless sensor networks (WSNs) are widely used in various fields such as military, industrial, and transportation for real-time monitoring, sensing, and data collection of different environments or objects. However, the development of WSNs is hindered ... ...

Abstract	Wireless sensor networks (WSNs) are widely used in various fields such as military, industrial, and transportation for real-time monitoring, sensing, and data collection of different environments or objects. However, the development of WSNs is hindered by several limitations, including energy, storage space, computing power, and data transmission rate. Among these, the availability of power energy plays a crucial role as it directly determines the lifespan of WSN. To extend the life cycle of WSN, two key approaches are power supply improvement and energy conservation. Therefore, we propose an energy harvesting system and a low-energy-consumption mechanism for WSNs. Firstly, we delved into the energy harvesting technology of WSNs, explored the utilization of solar energy and mechanical vibration energy to ensure a continuous and dependable power supply to the sensor nodes, and analyzed the voltage output characteristics of bistable piezoelectric cantilever. Secondly, we proposed a neighbor discovery mechanism that utilizes a separation beacon, is based on reply to ACK, and can facilitate the identification of neighboring nodes. This mechanism operates at a certain duty cycle ratio, significantly reduces idle listening time and results in substantial energy savings. In comparison to the Disco and U-connect protocols, our proposed mechanism achieved a remarkable reduction of 66.67% and 75% in the worst discovery delay, respectively. Furthermore, we introduced a data fusion mechanism based on integer wavelet transform. This mechanism effectively eliminates data redundancy caused by spatiotemporal correlation, resulting in a data compression rate of 5.42. Additionally, it significantly reduces energy consumption associated with data transmission by the nodes.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24010047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PLA-Based Composite Panels Prepared via Multi-Material Fused Filament Fabrication and Associated Investigation of Process Parameters on Flexural Properties of the Fabricated Composite.

Wang, Zhaogui / Wang, Lihan / Tang, Feng / Shen, Chengyang

Polymers

2023 Volume 16, Issue 1

Abstract: This study prepares composite panels with three Polylactic acid (PLA)-based materials via the multi-material fused filament fabrication method. The influences of four processing parameters on the mechanical properties of 3D-printed samples are ... ...

Abstract	This study prepares composite panels with three Polylactic acid (PLA)-based materials via the multi-material fused filament fabrication method. The influences of four processing parameters on the mechanical properties of 3D-printed samples are investigated employing the Taguchi method. These parameters include the relative volume ratio, material printing order, filling pattern, and filling density. A "larger is better" signal-to-noise analysis is performed to identify the optimal combination of printing parameters that yield maximum bending strength and bending modulus of elasticity. The results reveal that the optimal combination of printing parameters that maximizes the bending strength involves a volume ratio of 1:1:2, a material sequence of PLA/foam-agent-modified eco-friendly PLA (ePLA-LW)/glass fiber-reinforced eco-friendly PLA (ePLA-GF), a Gyroid filling pattern, and a filling density of 80%, and the optimal combination of printing parameters for maximum bending modulus involves a volume ratio of 1:2:1 with a material sequence of PLA/ePLA-LW/ePLA-GF, a Grid filling pattern, and 80% filling density. The Taguchi prediction method is utilized to determine an optimal combination of processing parameters for achieving optimal flexural performances, and predicted outcomes are validated through related experiments. The experimental values of strength and modulus are 43.91 MPa and 1.23 GPa, respectively, both very close to the predicted values of 46.87 MPa and 1.2 GPa for strength and modulus. The Taguchi experiments indicate that the material sequence is the most crucial factor influencing the flexural strength of the composite panels. The experiment result demonstrates that the flexural strength and modulus of the first material sequence are 67.72 MPa and 1.53 GPa, while the flexural strength and modulus of the third material sequence are reduced to 27.09 MPa and 0.72 GPa, respectively, only 42% and 47% of the first material sequence. The above findings provide an important reference for improving the performance of multi-material 3D-printed products.
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16010109
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Article: Guillain-Barré Syndrome with Incomplete Oculomotor Nerve Palsy after Traumatic Brain Injury: Case Report and Literature Review.

Liu, Jinsheng / Tang, Feng / Chen, Xinjun / Li, Zhiqiang

Brain sciences

2023 Volume 13, Issue 4

Abstract: Guillain-Barré syndrome (GBS) is a severe peripheral neuroinflammatory demyelinating disease characterized by symmetrical progressive limb weakness, which can be accompanied by cranial nerve and sensory disturbances. There is usually a history of ... ...

Abstract	Guillain-Barré syndrome (GBS) is a severe peripheral neuroinflammatory demyelinating disease characterized by symmetrical progressive limb weakness, which can be accompanied by cranial nerve and sensory disturbances. There is usually a history of bacterial or viral infection prior to onset. GBS is rarely seen after traumatic brain injury (TBI). We report a case of a 66-year-old male patient who presented with dilated pupils, followed by respiratory failure and symmetrical quadriplegia during a conservative treatment for TBI. He was eventually diagnosed with GBS and was treated with intravenous immunoglobulin, followed by rehabilitation therapy with a good recovery. We summarize previous similar cases and analyze possible causes. It is suggested that the possibility of GBS should be considered when unexplained symptoms occurred in patients with TBI, such as respiratory failure, dilated pupils, and limb weakness.
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13040527
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