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Article ; Online: Pulmonary hyalinising granuloma: a rare and elusive cause of multiple lung nodules.

Tang, Ivan / Moore, Alastair J / Fryer, Eve / Sykes, Annemarie

BMJ case reports

2020 Volume 13, Issue 3

Abstract: A 72-year-old woman was referred with incidentally detected multiple lung nodules, one of which was identified ... ...

Abstract	A 72-year-old woman was referred with incidentally detected multiple lung nodules, one of which was identified as
MeSH term(s)	Aged ; Diagnosis, Differential ; Female ; Fluorodeoxyglucose F18 ; Granuloma/diagnostic imaging ; Granuloma/surgery ; Humans ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/surgery ; Positron Emission Tomography Computed Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-03-25
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-233327
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recurrent metastatic breast cancer presenting with portal hypertension and pseudocirrhosis.

Adler, Maciej / Tang, Ivan / Gach, Michael William / MacFaul, George

BMJ case reports

2019 Volume 12, Issue 11

Abstract: We present a case of a 63-year-old woman with an acute history of abdominal distension and shortness of breath. She had no risk factors for liver disease though her prior medical history was positive for breast carcinoma, in remission for 14 years. ... ...

Abstract	We present a case of a 63-year-old woman with an acute history of abdominal distension and shortness of breath. She had no risk factors for liver disease though her prior medical history was positive for breast carcinoma, in remission for 14 years. Examination and investigations were initially consistent with decompensated cirrhosis, thought to be due to subclinical autoimmune hepatitis. Imaging revealed hepatic contour irregularity, atrophy of the liver parenchyma and numerous lesions highly suggestive for multifocal hepatocellular carcinoma. Surprisingly, tissue histology revealed no evidence of cirrhosis, but recurrence of breast cancer which had mimicked cirrhosis. Pseudocirrhosis may be indistinguishable from true cirrhosis without histopathology. It has previously been linked to chemotherapy-induced hepatic injury and nodular regenerative hyperplasia, although our case illustrates an uncommon pathophysiology. Pseudocirrhosis often represents a poor prognosis even with a good baseline performance status, and early involvement of palliative care specialists may be advisable.
MeSH term(s)	Breast Neoplasms/complications ; Breast Neoplasms/pathology ; Carcinoma/complications ; Carcinoma/diagnosis ; Carcinoma/secondary ; Diagnosis, Differential ; Female ; Humans ; Hypertension, Portal/diagnosis ; Hypertension, Portal/etiology ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Middle Aged ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2019-11-24
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-231044
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel coronavirus (COVID-19) infection: What a doctor on the frontline needs to know.

Down, Billy / Kulkarni, Sagar / Khan, Ameer Hamid Ahmed / Barker, Benjamin / Tang, Ivan

Annals of medicine and surgery (2012)

2020 Volume 55, Page(s) 24–29

Abstract: Coronavirus disease 2019 (COVID-19) is a zoonotic respiratory infection originating from Wuhan, China. Rapidly spreading from Wuhan to all inhabited continents of the world, the World Health Organisation declared COVID-19 a pandemic on March 11, 2019. ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a zoonotic respiratory infection originating from Wuhan, China. Rapidly spreading from Wuhan to all inhabited continents of the world, the World Health Organisation declared COVID-19 a pandemic on March 11, 2019. Infected patients present with fever and cough; radiological features include bilateral infiltrates on chest x-ray and computed tomography scanning. Management is supportive with oxygen supplementation, broad-spectrum antibiotics as well as careful fluid balancing. A number of drugs, both new and old, are currently in clinical trials and being used on an experimental basis in clinical practice. The COVID-19 pandemic is the greatest worldwide public health crisis of a generation, and has led to seismic political, economic and social changes. This review provides an overview of COVID-19 for junior doctors who find themselves on a new frontline of healthcare.
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.05.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial.

Tang, Ivan / Turnbull, Chris D / Sen, Dushendree / Craig, Sonya / Kohler, Malcolm / Stradling, John R

BMJ open respiratory research

2020 Volume 7, Issue 1

Abstract: The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular ( ... ...

Abstract	The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46-1.51).
MeSH term(s)	Aged ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Continuous Positive Airway Pressure/methods ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Proportional Hazards Models ; Randomized Controlled Trials as Topic ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy ; Treatment Outcome
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2020-000742
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Post pancreatitis/cholecystectomy gluten intolerance.

Tang, Ivan / MacFaul, George / Madhotra, Ravi / Rostami, Kamran

Gastroenterology and hepatology from bed to bench

2018 Volume 11, Issue 3, Page(s) 273–275

Abstract: This case report describes the journey of a patient who suffered from life-limiting gastrointestinal symptoms after an acute bout of pancreatitis following ERCP for cholelithiasis bile following a ductal stone, and subsequent cholecystectomy. She was ... ...

Abstract	This case report describes the journey of a patient who suffered from life-limiting gastrointestinal symptoms after an acute bout of pancreatitis following ERCP for cholelithiasis bile following a ductal stone, and subsequent cholecystectomy. She was diagnosed and treated for IBS with medication without significant improvement. On implementation of a simple gluten and lactose exclusion diet she recovered to her premorbid state, and trials of gluten challenge triggered flares of symptoms. This case report will go on to discuss current evidence for use of gluten and lactose exclusion diets in some gluten sensitive patients misdiagnosed with IBS.
Language	English
Publishing date	2018-07-12
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel coronavirus (COVID-19) infection: What a doctor on the frontline needs to know

Down, Billy / Kulkarni, Sagar / Ahmed Khan, Ameer Hamid / Barker, Benjamin / Tang, Ivan

Abstract	Coronavirus disease 2019 (COVID-19) is a zoonotic respiratory infection originating from Wuhan, China. Rapidly spreading from Wuhan to all inhabited continents of the world, the World Health Organisation declared COVID-19 a pandemic on March 11, 2019. Infected patients present with fever and cough; radiological features include bilateral infiltrates on chest x-ray and computed tomography scanning. Management is supportive with oxygen supplementation, broad-spectrum antibiotics as well as careful fluid balancing. A number of drugs, both new and old, are currently in clinical trials and being used on an experimental basis in clinical practice. The COVID-19 pandemic is the greatest worldwide public health crisis of a generation, and has led to seismic political, economic and social changes. This review provides an overview of COVID-19 for junior doctors who find themselves on a new frontline of healthcare.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #245314
Database	COVID19

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Article ; Online: Novel coronavirus (COVID-19) infection

Down, Billy / Kulkarni, Sagar / Khan, Ameer Hamid Ahmed / Barker, Benjamin / Tang, Ivan

Annals of Medicine and Surgery

What a doctor on the frontline needs to know

2020 Volume 55, Page(s) 24–29

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.05.014
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Revisit of Optimal Donor Number Estimation in the Hong Kong Bone Marrow Donor Registry.

Ho, Jenny Chung Yee / Cheung, Stephen Kwok Fan / Lui, Zhongyi / Tang, Ivan Wing Hong / Yang, Wanling / Ip, Patrick / Lee, Cheuk Kwong / Middleton, Derek / Kwok, Janette Siu Yin

Frontiers in immunology

2021 Volume 12, Page(s) 638253

Abstract: High resolution typing of the HLA-DPB1 locus for patient who requested for hematopoietic stem cell transplantation (HSCT) workup has recently become mandatory by the National Marrow Donor Program (NMDP) in order to facilitate matching between donors and ... ...

Abstract	High resolution typing of the HLA-DPB1 locus for patient who requested for hematopoietic stem cell transplantation (HSCT) workup has recently become mandatory by the National Marrow Donor Program (NMDP) in order to facilitate matching between donors and recipients for better outcomes. The likelihood of identifying HLA matched donors in Hong Kong, on top of the existing HLA-A, -B, -C, and -DRB1 loci, is revisited in this study. HLA-A, -B, -C, -DRB1 and -DPB1 genotypes of 5,266 volunteer unrelated Chinese donors from the Hong Kong Bone Marrow Donor Registry (HKBMDR), were included in this study. Matching models were employed to determine the matching probabilities for 10/10(DPB1) and 9/10(DPB1) HLA match. The matching probabilities are 20% at 10/10(DPB1) HLA match and 55% at 9/10(DPB1) match, based on the existing 130,000 donors in the HKBMDR. The likelihoods of match become 27% and 65% respectively, by increasing the registry to 250,000. However, if DPB T-cell-epitope (TCE) model is considered in the matching, the probability will increase to 46% at 10/10 DPB1 permissive mismatching. Our findings provide vital information about the future planning on the targeted recruitment size, HLA typing and search strategies of the donor registry and arose the transplant physicians' acceptability to 9/10(DBP1) or 10/10(DBP1) HLA match. Nevertheless, the marrow donor registry has planned for increasing the registry size and bringing down the age of recruited donors which will ultimately enhance patient outcome.
MeSH term(s)	Bone Marrow Transplantation ; Directed Tissue Donation ; Epitopes, T-Lymphocyte/genetics ; Gene Frequency ; Genotype ; HLA-DP beta-Chains/genetics ; Histocompatibility ; Histocompatibility Testing ; Hong Kong ; Humans ; Polymorphism, Genetic ; Registries ; Tissue Donors
Chemical Substances	Epitopes, T-Lymphocyte ; HLA-DP beta-Chains ; HLA-DPB1 antigen
Language	English
Publishing date	2021-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.638253
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Massive haemoptysis and ventilatory failure in pregnancy.

Flight, William G / Tang, Ivan / Gates, Alison / Snowball, Joanna / Wrightson, John M / Mackillop, Lucy / Chapman, Stephen J

Thorax

2019 Volume 74, Issue 8, Page(s) 818–820

MeSH term(s)	Adult ; Bronchiectasis/etiology ; Bronchiectasis/therapy ; Cesarean Section ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/therapy ; Female ; Hemoptysis/etiology ; Humans ; Noninvasive Ventilation ; Nutrition Assessment ; Pregnancy ; Pregnancy Complications/etiology ; Pregnancy Complications/therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
Language	English
Publishing date	2019-05-31
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thoraxjnl-2019-213292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong.

Kwok, Janette S Y / Cheung, Stephen K F / Ho, Jenny C Y / Tang, Ivan W H / Chu, Patrick W K / Leung, Eric Y S / Lee, Pamela P W / Cheuk, Daniel K L / Lee, Vincent / Ip, Patrick / Lau, Y L

Frontiers in immunology

2020 Volume 11, Page(s) 1411

Abstract: The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow ... ...

Abstract	The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screening (NBS) programs for Severe Combined Immunodeficiency. The potential applications of combined TREC and KREC assay in PIDD diagnosis and immune reconstitution monitoring in non-neonatal patients have been suggested. Given that ethnicity, gender, and age can contribute to variations in immunity, defining the reference intervals of TREC and KREC levels in the local population is crucial for setting up cut-offs for PIDD diagnosis. In this retrospective study, 479 healthy Chinese sibling donors (240 males and 239 females; age range: 1 month-74 years) from Hong Kong were tested for TREC and KREC levels using a simultaneous quantitative real-time PCR assay. Age-specific 5
MeSH term(s)	Adolescent ; B-Lymphocytes ; Biomarkers/blood ; Child ; Child, Preschool ; DNA, Circular/blood ; Female ; Healthy Volunteers ; Hong Kong ; Humans ; Infant ; Infant, Newborn ; Male ; Neonatal Screening/methods ; Reference Values ; Severe Combined Immunodeficiency/diagnosis ; T-Lymphocytes
Chemical Substances	Biomarkers ; DNA, Circular
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.01411
Database	MEDical Literature Analysis and Retrieval System OnLINE

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