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Article ; Online: Bioinspired adhesive hydrogel based on serotonin-modified gelatin and oxidized hyaluronic acid for rapid hemostasis and wound healing.

Jiang, Yongchao / Zhang, Wenjie / Guo, Yingying / Zheng, Xuejing / Tang, Keyong

International journal of biological macromolecules

2024 Volume 261, Issue Pt 1, Page(s) 129739

Abstract: A hybrid hydrogel system (GSOHA) consisting of serotonin-grafted gelatin and oxidized hyaluronic acid (OHA) was developed in this study to efficiently control bleeding and prevent bacterial infections during surgery and trauma. The study results showed ... ...

Abstract	A hybrid hydrogel system (GSOHA) consisting of serotonin-grafted gelatin and oxidized hyaluronic acid (OHA) was developed in this study to efficiently control bleeding and prevent bacterial infections during surgery and trauma. The study results showed that the incorporation of serotonin successfully produced hydrogels with rapid hemostatic, antibacterial, and antioxidant properties. The GSOHA hydrogel exhibited considerably stronger tissue adhesion (15.55 ± 0.36 kPa) to porcine skin than the commercial fibrin glue (1.09 ± 0.04 kPa). In addition, the hydrogel could rapidly absorb blood cells and stimulate cell conjugation with serotonin addition. In vitro experiments using endothelial cells and erythrocytes demonstrated the excellent biocompatibility and hemocompatibility of the hydrogel. Most importantly, the GSOHA hydrogel accelerated the wound healing process in a full-thickness skin defect mice model, and the histological staining results demonstrated that GSOHA significantly promoted collagen deposition and vascularization. In conclusion, this study demonstrated the significant potential of the GSOHA hydrogel as an adhesive dressing for rapid hemostasis and wound healing.
MeSH term(s)	Animals ; Mice ; Swine ; Gelatin/pharmacology ; Hyaluronic Acid/pharmacology ; Hydrogels/pharmacology ; Serotonin/pharmacology ; Endothelial Cells ; Wound Healing ; Anti-Bacterial Agents ; Hemostasis
Chemical Substances	Gelatin (9000-70-8) ; Hyaluronic Acid (9004-61-9) ; Hydrogels ; Serotonin (333DO1RDJY) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129739
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Article ; Online: Protocatechualdehyde-ferric iron tricomplex embedded gelatin hydrogel with adhesive, antioxidant and photothermal antibacterial capacities for infected wound healing promotion

Qiao, Jialu / Jiang, Yongchao / Ren, Zhitao / Tang, Keyong

International Journal of Biological Macromolecules. 2023 July, v. 242 p.125029-

2023

Abstract: Because of the indiscriminate use of antibiotics and the increasing threat of drug-resist bacteria, there is an urgent need to develop novel antibacterial strategies to combat infected wounds. In this work, stable tricomplex molecules (PA@Fe) assembled ... ...

Abstract	Because of the indiscriminate use of antibiotics and the increasing threat of drug-resist bacteria, there is an urgent need to develop novel antibacterial strategies to combat infected wounds. In this work, stable tricomplex molecules (PA@Fe) assembled by protocatechualdehyde (PA) and ferric iron (Fe) were successfully synthesized and then embedded in the gelatin matrix to obtain a series of Gel-PA@Fe hydrogels. The embedded PA@Fe served as a crosslinker to improve the mechanical, adhesive and antioxidant properties of hydrogels through coordination bonds (catechol-Fe) and dynamic Schiff base bonds, meanwhile acting as a photothermal agent to convert near-infrared (NIR) light into heat to kill bacteria effectively. Importantly, in vivo evaluation through an infected full-thickness skin wound mice model revealed that Gel-PA@Fe hydrogel developed collagen deposition, and accelerated reconstruction of wound closure, indicating great potential of Gel-PA@Fe hydrogel in promoting the healing process of infected full-thickness wounds.
Keywords	antioxidants ; collagen ; gelatin ; heat ; hydrogels ; iron ; models ; schiff bases ; Hydrogel ; Photothermal antibacterial property ; Wound healing
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125029
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Article ; Online: Protocatechualdehyde-ferric iron tricomplex embedded gelatin hydrogel with adhesive, antioxidant and photothermal antibacterial capacities for infected wound healing promotion.

Qiao, Jialu / Jiang, Yongchao / Ren, Zhitao / Tang, Keyong

International journal of biological macromolecules

2023 Volume 242, Issue Pt 4, Page(s) 125029

Abstract	Because of the indiscriminate use of antibiotics and the increasing threat of drug-resist bacteria, there is an urgent need to develop novel antibacterial strategies to combat infected wounds. In this work, stable tricomplex molecules (PA@Fe) assembled by protocatechualdehyde (PA) and ferric iron (Fe) were successfully synthesized and then embedded in the gelatin matrix to obtain a series of Gel-PA@Fe hydrogels. The embedded PA@Fe served as a crosslinker to improve the mechanical, adhesive and antioxidant properties of hydrogels through coordination bonds (catechol-Fe) and dynamic Schiff base bonds, meanwhile acting as a photothermal agent to convert near-infrared (NIR) light into heat to kill bacteria effectively. Importantly, in vivo evaluation through an infected full-thickness skin wound mice model revealed that Gel-PA@Fe hydrogel developed collagen deposition, and accelerated reconstruction of wound closure, indicating great potential of Gel-PA@Fe hydrogel in promoting the healing process of infected full-thickness wounds.
MeSH term(s)	Animals ; Mice ; Gelatin ; Hydrogels/pharmacology ; Antioxidants/pharmacology ; Wound Healing ; Catechols/pharmacology ; Anti-Bacterial Agents/pharmacology ; Wound Infection/drug therapy ; Iron
Chemical Substances	Gelatin (9000-70-8) ; Hydrogels ; protocatechualdehyde (4PVP2HCH4T) ; Antioxidants ; Catechols ; Anti-Bacterial Agents ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125029
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Article ; Online: Injectable Modified Sodium Alginate Microspheres for Enhanced Operative Efficiency and Safety in Endoscopic Submucosal Dissection.

Huang, Luzhan / Jiang, Yongchao / Zhang, Pengcheng / Li, Muhan / Liu, Bingrong / Tang, Keyong

Biomacromolecules

2024 Volume 25, Issue 5, Page(s) 2953–2964

Abstract: Endoscopic submucosal dissection (ESD) is an effective method for resecting early-stage tumors in the digestive system. To achieve a low injection pressure of the injected fluid and continuous elevation of the mucosa following injection during the ESD ... ...

Abstract	Endoscopic submucosal dissection (ESD) is an effective method for resecting early-stage tumors in the digestive system. To achieve a low injection pressure of the injected fluid and continuous elevation of the mucosa following injection during the ESD technique, we introduced an innovative injectable sodium-alginate-based drug-loaded microsphere (Cipro-ThSA) for ESD surgery, which was generated through an emulsion reaction involving cysteine-modified sodium alginate (ThSA) and ciprofloxacin. Cipro-ThSA microspheres exhibited notable adhesiveness, antioxidant activity, and antimicrobial properties, providing a certain level of postoperative wound protection.
MeSH term(s)	Alginates/chemistry ; Microspheres ; Animals ; Swine ; Endoscopic Mucosal Resection/methods ; Humans ; Ciprofloxacin/administration & dosage ; Ciprofloxacin/chemistry ; Ciprofloxacin/pharmacology ; Cysteine/chemistry
Chemical Substances	Alginates ; Ciprofloxacin (5E8K9I0O4U) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.4c00081
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Article ; Online: Effects of charge state of nano-chitin on the properties of polyvinyl alcohol composite hydrogel.

Jiao, Shuhao / Yang, Xuefei / Zheng, Xuejing / Pei, Ying / Liu, Jie / Tang, Keyong

Carbohydrate polymers

2024 Volume 330, Page(s) 121776

Abstract: The present work investigates the effects of nano-chitin with different charge, obtained by acid hydrolysis and TEMPO oxidation, on the structure and properties of borax crosslinked polyvinyl alcohol (PVA) hydrogels. In detail, nano-chitin prepared by ... ...

Abstract	The present work investigates the effects of nano-chitin with different charge, obtained by acid hydrolysis and TEMPO oxidation, on the structure and properties of borax crosslinked polyvinyl alcohol (PVA) hydrogels. In detail, nano-chitin prepared by acid hydrolysis (ACh) is positively charged (+28.8 mV). The electrostatic attraction between ACh and borax ions leads to a maximum tensile stress of composite hydrogel (ACh/PB), 54.25 KPa, 17 times of the borax crosslinked PVA (PB). In contrast, nano-chitin prepared by TEMPO-oxidation (TCh) shows negative charge (-59.0 mV). Due to the electrostatic repulsion with borax ions, the maximum tensile stress of composite hydrogel (TCh/PB) is only 9.25 KPa, a very limit reinforcing effect. However, TCh/PB showed better self-healing efficiency (96.0 %) as well as ionic conductivity (1.25 × 10
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2024.121776
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Article ; Online: Hydrophobically modified hydrogel with enhanced tissue adhesion and antibacterial capacity for wound healing.

Jiang, Yongchao / Li, Gaiying / Qiao, Jialu / Yan, Pengfei / Tang, Keyong

Colloids and surfaces. B, Biointerfaces

2023 Volume 228, Page(s) 113424

Abstract: The increasing emergence of drug-resistant bacteria and bacteria-infected wounds highlights the urgent need for new kinds of antibacterial wound dressing. Herein, we reported a novel bio-adhesive and antibacterial hydrogel consisting of hydrophobically ... ...

Abstract	The increasing emergence of drug-resistant bacteria and bacteria-infected wounds highlights the urgent need for new kinds of antibacterial wound dressing. Herein, we reported a novel bio-adhesive and antibacterial hydrogel consisting of hydrophobically modified gelatin, oxidized konjac glucomannan, and dopamine. This kind of functional hydrogel was endowed with developed stability in a liquid environment and strong tissue adhesion, even much higher than the commercial fibrin glue to wounds. The excellent bacteria-killing efficiency of hydrophobically modified hydrogel against S. aureus and E. coli was verified, as well as the low hemolysis ratio against erythrocytes in vitro. The hydrogel also exhibited good cytocompatibility in terms of supporting cell proliferation. Most importantly, these abovementioned properties could be customized by altering the substitution degree of hydrophobic groups during manufacturing, demonstrating its great potential in biomedical fields such as tissue adhesive and wound dressing.
MeSH term(s)	Humans ; Tissue Adhesions ; Hydrogels/pharmacology ; Escherichia coli ; Staphylococcus aureus ; Wound Healing ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Hydrogels ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113424
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Article ; Online: Collagen processing with mesoscale aggregates as templates and building blocks.

Pei, Ying / Yang, Wen / Tang, Keyong / Kaplan, David L

Biotechnology advances

2023 Volume 63, Page(s) 108099

Abstract: Collagen presents a well-organized hierarchical multilevel structure. Microfibers, fibers, and fiber bundles are the aggregates of natural collagen; which achieve an ideal balance of mechanical strength and toughness at the mesoscopic scale for ... ...

Abstract	Collagen presents a well-organized hierarchical multilevel structure. Microfibers, fibers, and fiber bundles are the aggregates of natural collagen; which achieve an ideal balance of mechanical strength and toughness at the mesoscopic scale for biological tissue. These mesostructured aggregates of collagen isolated from biological tissues retain these inherent organizational features to enable their use as building blocks for constructing new collagen materials with ideal mechanical performance, thermal and dimensional stability. This strategy is distinct from the more common bottom-up or molecular-level design and assembly approach to generating collagen materials. The present review introduces the hierarchical structure of biological collagen with a focus on mesostructural features. Isolation strategies for these collagen aggregates (CAs) are summarized. Recent progress in the use of these mesostructural components for the construction of new collagen materials with emerging applications is reviewed, including in catalysis, environmental applications, biomedicine, food packaging, electrical energy storage, and flexible sensors. Finally, challenges and prospects are assessed for controllable production of CAs as well as material designs.
MeSH term(s)	Collagen/chemistry
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-01-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	47165-3
ISSN	1873-1899 ; 0734-9750
ISSN (online)	1873-1899
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2023.108099
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Article ; Online: Citric acid crosslinked soluble soybean polysaccharide films for active food packaging applications.

Liu, Jie / Dong, Yitong / Zheng, Xuejing / Pei, Ying / Tang, Keyong

Food chemistry

2023 Volume 438, Page(s) 138009

Abstract: In this work, a nontoxic crosslinking agent, citric acid (CA), was used to crosslink glycerol-plasticized SSPS films via a heat activated reaction. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy results confirmed the ... ...

Abstract	In this work, a nontoxic crosslinking agent, citric acid (CA), was used to crosslink glycerol-plasticized SSPS films via a heat activated reaction. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy results confirmed the occurrence of esterification reaction between CA and SSPS. Microstructure of the CA-crosslinked SSPS films were characterized by scanning electron microscopy, atomic force microscopy and X-ray diffraction. The water resistance, mechanical, UV-barrier, water vapor barrier, antioxidant and thermal properties of SSPS films were enhanced by CA crosslinking. The SSPS film crosslinked with 5 % CA exhibited a maximum tensile strength of 6.5 MPa and a minimum water solubility of 34.3 %. The CA-crosslinked SSPS film also presented superior antibacterial properties against Gram-positive and Gram-negative bacteria. Application test results showed that the CA-crosslinked SSPS film can effectively delay the oxidative deterioration of lard during storage, suggesting that the developed CA-crosslinked SSPS film could be a promising candidate for active food packaging.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Glycine max ; Food Packaging/methods ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Polysaccharides/chemistry ; Permeability
Chemical Substances	Anti-Bacterial Agents ; Polysaccharides
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.138009
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Article ; Online: Hydrophobically modified hydrogel with enhanced tissue adhesion and antibacterial capacity for wound healing

Jiang, Yongchao / Li, Gaiying / Qiao, Jialu / Yan, Pengfei / Tang, Keyong

Colloids and Surfaces B: Biointerfaces. 2023 Aug., v. 228 p.113424-

2023

Abstract	The increasing emergence of drug-resistant bacteria and bacteria-infected wounds highlights the urgent need for new kinds of antibacterial wound dressing. Herein, we reported a novel bio-adhesive and antibacterial hydrogel consisting of hydrophobically modified gelatin, oxidized konjac glucomannan, and dopamine. This kind of functional hydrogel was endowed with developed stability in a liquid environment and strong tissue adhesion, even much higher than the commercial fibrin glue to wounds. The excellent bacteria-killing efficiency of hydrophobically modified hydrogel against S. aureus and E. coli was verified, as well as the low hemolysis ratio against erythrocytes in vitro. The hydrogel also exhibited good cytocompatibility in terms of supporting cell proliferation. Most importantly, these abovementioned properties could be customized by altering the substitution degree of hydrophobic groups during manufacturing, demonstrating its great potential in biomedical fields such as tissue adhesive and wound dressing.
Keywords	Escherichia coli ; adhesion ; bioadhesives ; cell proliferation ; dopamine ; drug resistance ; erythrocytes ; fibrin ; gelatin ; hemolysis ; hydrogels ; hydrophobicity ; konjac mannan ; liquids ; Hydrogel ; Anti-bacteria ; Wound dressing
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113424
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Article ; Online: Collagen processing with mesoscale aggregates as templates and building blocks

Bei, Ying / Yang, Wen / Tang, Keyong / Kaplan, David L.

Biotechnology Advances. 2023 Mar., Apr., v. 63 p.108099-

2023

Abstract	Collagen presents a well-organized hierarchical multilevel structure. Microfibers, fibers, and fiber bundles are the aggregates of natural collagen; which achieve an ideal balance of mechanical strength and toughness at the mesoscopic scale for biological tissue. These mesostructured aggregates of collagen isolated from biological tissues retain these inherent organizational features to enable their use as building blocks for constructing new collagen materials with ideal mechanical performance, thermal and dimensional stability. This strategy is distinct from the more common bottom-up or molecular-level design and assembly approach to generating collagen materials. The present review introduces the hierarchical structure of biological collagen with a focus on mesostructural features. Isolation strategies for these collagen aggregates (CAs) are summarized. Recent progress in the use of these mesostructural components for the construction of new collagen materials with emerging applications is reviewed, including in catalysis, environmental applications, biomedicine, food packaging, electrical energy storage, and flexible sensors. Finally, challenges and prospects are assessed for controllable production of CAs as well as material designs.
Keywords	biotechnology ; catalytic activity ; collagen ; dimensional stability ; electric power ; medicine ; strength (mechanics) ; Collagen aggregates ; Biopolymer isolation ; Biopolymer reconstitution ; Collagen mesostructure
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	47165-3
ISSN	0734-9750
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2023.108099
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