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Article: Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis.

Lv, Feng / Tang, Nan

Alternative therapies in health and medicine

2024

Abstract: Context: Due to the different effects of various drugs and the lack of authoritative and unified guidelines in clinical practice, the choice of therapeutic drugs for pulmonary tuberculosis (TB) remains controversial. Rifampicin, levofloxacin, and ... ...

Abstract	Context: Due to the different effects of various drugs and the lack of authoritative and unified guidelines in clinical practice, the choice of therapeutic drugs for pulmonary tuberculosis (TB) remains controversial. Rifampicin, levofloxacin, and isoniazid are all anti-TB drugs. However, no comparative studies of the treatment effects of rifampicin + levofloxacin and rifampicin + isoniazid have occurred. Objective: The study intended to analyze the therapeutic effects of rifampicin + levofloxacin compared to rifampicin + isoniazid in the treatment of pulmonary TB to provide a clinical reference, which could provide new references for future clinical treatment of the disease. Design: The research team conducted a prospective controlled study. Setting: The study took place at Zibo Zhoucun District People's Hospital in Zibo, China. Participants: Participants were 100 patients with pulmonary TB admitted to the hospital between March 2021 and December 2022. Interventions: The research team assigned participants to one of two groups: (1) the intervention group, with 56 participants who received rifampicin + levofloxacin therapy, and (2) the control group, with 44 participants who received rifampicin + isoniazid. Outcome measures: The research team measured: (1) clinical efficacy, (2) incidence of adverse reactions, (3) changes in inflammatory factors, (4) changes in immunoglobulins (Igs), and (5) changes in T lymphocyte subsets. Results: The intervention group's total effective rate for treatment was significantly higher than that of the control group (P = .049). However, no significant difference existed between the groups in the incidence of adverse reactions (P > .05). Postintervention, the intervention group's inflammatory factors-IL-6, TNF-α, hs-CRP, and β-EP-were significantly lower and its immunoglobulins (Igs) G/A/M (IgG/A/M) were significantly higher than those of the control group (P < .05). In addition, the intervention group's T lymphocyte subpopulations of CD3+ and CD4+ and CD4+/CD8+ were significantly higher and CD8+ was significantly lower than those in the control group (P < .05). In other words, the intervention group had a better immune function. Conclusions: Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Empowering human lung development.

Li, Jiao / Tang, Nan

Cell stem cell

2023 Volume 30, Issue 1, Page(s) 5–6

Abstract: By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development. ...

Abstract	By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development.
MeSH term(s)	Humans ; Lung ; Organoids ; Embryo, Mammalian ; Power, Psychological ; Cell Differentiation
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2022.12.012
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Article: Dermoscopy and Histopathology of Hyperkeratosis of Nipple and Areola: A Case Report.

Huang, Qingan / Niu, Mu / Wen, Weilun / Tang, Nan

Clinical, cosmetic and investigational dermatology

2024 Volume 17, Page(s) 649–652

Abstract: We describe a case involving a 19-year-old female with who presented with bilateral nipple-areola brown patches persisting for five years. The diagnosis of hyperkeratosis of the nipple and areola (HNA) was established through dermoscopy and ... ...

Abstract	We describe a case involving a 19-year-old female with who presented with bilateral nipple-areola brown patches persisting for five years. The diagnosis of hyperkeratosis of the nipple and areola (HNA) was established through dermoscopy and histopathology. The findings highlight the value of dermoscopy in the diagnosis and differentiation of HNA.
Language	English
Publishing date	2024-03-15
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S450400
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Article ; Online: Endobronchial ultrasound-guided cautery-assisted transbronchial mediastinal cryobiopsy in the diagnosis of fibrosing mediastinitis secondary to atypical sarcoidosis: a case report.

Tang, Nan / Tao, Tao / Bao, Xiao-Li

AME case reports

2024 Volume 8, Page(s) 49

Abstract: Background: Fibrosing mediastinitis (FM) secondary to atypical sarcoidosis (atypical presentation of sarcoidosis) is rarely reported at home and abroad. Its clinical manifestations represent a lack of specificity, and the initial diagnosis is frequently ...

Abstract	Background: Fibrosing mediastinitis (FM) secondary to atypical sarcoidosis (atypical presentation of sarcoidosis) is rarely reported at home and abroad. Its clinical manifestations represent a lack of specificity, and the initial diagnosis is frequently difficult. In particular, this case has multiple pulmonary nodules with mediastinal lymph node enlargement and bilateral pleural effusion, and pulmonary fibrosis still exists after treatment, which is inconsistent with any clinical stage of pulmonary sarcoidosis, further increasing the diagnostic difficulty. We retrospectively analyzed the clinical data of a case of FM secondary to atypical sarcoidosis diagnosed by endobronchial ultrasound-guided cautery-assisted transbronchial mediastinal cryobiopsy (EBUS-CA-TBMCB) in Chongqing University Fuling Hospital, to improve clinicians' attention to FM and understand that EBUS-CA-TBMCB remains an effective way of etiological diagnosis. Case description: A 70-year-old man was hospitalized with cough and dyspnea for two months. After admission, through chest computed tomography (CT), ultrasound guided bilateral lung biopsy, left parietal pleural biopsy, and EBUS-CA-TBMCB, the final diagnosis was atypical sarcoidosis secondary FM. After taking glucocorticoid orally, the patient's condition improved significantly, and was discharged from the hospital. We continued following up outside the hospital, and the patient's condition was further improved. Conclusions: The diagnosis of FM is mainly based on typical imaging manifestations. When the contrast-enhanced chest CT finds localized or diffuse soft tissue density shadows around the mediastinum and pulmonary hilum with an irregular shape, with or without calcification, particular attention should be paid to exclude FM. EBUS-CA-TBMCB, as an improved minimally invasive method, can obtain enough tissue samples for pathological diagnosis, which may be the effective biopsy method for the etiology of FM to avoid missed diagnosis and misdiagnosis in the future.
Language	English
Publishing date	2024-03-27
Publishing country	China
Document type	Case Reports
ISSN	2523-1995
ISSN (online)	2523-1995
DOI	10.21037/acr-23-160
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Article: Endoscopic submucosal dissection combined with adjuvant chemotherapy for early-stage neuroendocrine carcinoma of the esophagus: A case report.

Tang, Nan / Feng, Zhen

World journal of clinical cases

2022 Volume 10, Issue 10, Page(s) 3164–3169

Abstract: Background: Neuroendocrine carcinoma (NEC) of the esophagus is rare and highly aggressive, and lacks biological features. Currently, there are no established standard treatments for this cancer. In this report, we describe a patient with large-cell NEC ... ...

Abstract	Background: Neuroendocrine carcinoma (NEC) of the esophagus is rare and highly aggressive, and lacks biological features. Currently, there are no established standard treatments for this cancer. In this report, we describe a patient with large-cell NEC of the esophagus who was successfully treated using endoscopic submucosal dissection (ESD) combined with adjuvant chemotherapy. Case summary: A 55-year-old woman presented with intermittent mild dysphagia for 2 mo. Gastroscopy revealed a disc-shaped protruding lesion about 18 mm × 18 mm in size on the upper esophagus. Endoscopic ultrasonography demonstrated that the bulged lesion originated from the muscularis mucosa. We assessed Conclusion: En bloc
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i10.3164
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Article ; Online: Deep learning analysis for rapid detection and classification of household plastics based on Raman spectroscopy.

Qin, Yazhou / Qiu, Jiaxin / Tang, Nan / He, Yingsheng / Fan, Li

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 309, Page(s) 123854

Abstract: The overuse of plastics releases large amounts of microplastics. These tiny and complex pollutants may cause immeasurable damage to human social life. Raman spectroscopy detection technology is widely used in the detection, identification and analysis of ...

Abstract	The overuse of plastics releases large amounts of microplastics. These tiny and complex pollutants may cause immeasurable damage to human social life. Raman spectroscopy detection technology is widely used in the detection, identification and analysis of microplastics due to its advantages of fast speed, high sensitivity and non-destructive. In this work, we first recorded the Raman spectra of eight common plastics in daily life. By adjusting parameters such as laser wavelength, laser power, and acquisition time, the Raman data under different acquisition conditions were diversified, and the corresponding Raman spectra were obtained, and a database of eight household plastics was established. Combined with deep learning algorithms, an accurate, fast and simple classification and identification method for 8 types of plastics is established. Firstly, the acquired spectral data were preprocessed for baseline correction and noise reduction, Then, four machine learning algorithms, linear discriminant analysis (LDA), decision tree, support vector machine (SVM) and one-dimensional convolutional neural network (1D-CNN), are used to classify and identify the preprocessed data. The results showed that the classification accuracy of the three machine learning models for the Raman spectra of standard plastic samples were 84%, 93% and 93% respectively. The 1D-CNN model has an accuracy rate of up to 97% for Raman spectroscopy. Our study shows that the combination of Raman spectroscopy detection techniques and deep learning algorithms is a very valuable approach for microplastic classification and identification.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123854
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Article ; Online: A rare BCR-ABL1 transcript in chronic myeloid leukemia: Case report and literature review.

Zhao, Zhen-Yu / Tang, Nan / Lin, Li-Er

Leukemia research

2023 Volume 133, Page(s) 107369

Abstract: Background: The purpose of this report is to enhance our scientific understanding of the clinicopathologic features of chronic myeloid leukemia (CML) with the e12a3 transcript and to provide insights into potential treatment options for this rare ... ...

Abstract	Background: The purpose of this report is to enhance our scientific understanding of the clinicopathologic features of chronic myeloid leukemia (CML) with the e12a3 transcript and to provide insights into potential treatment options for this rare subtype of CML. Case summary: We present the case of a 21-year-old Chinese male patient who was diagnosed with chronic myeloid leukemia (CML) with the e12a3 transcript. Biopsy of his left iliac soft tissue mass indicated that he was in the blast crisis phase of CML. The patient was treated with tyrosine kinase inhibitor (TKI) drugs and achieved remission, but relapsed soon after. Despite receiving prognostic chemotherapy, the disease progressed and eventually led to the patient's death. Conclusion: To avoid missed diagnosis and misdiagnosis, it is recommended to conduct a thorough clinical evaluation and actively identify the underlying etiology.
MeSH term(s)	Male ; Humans ; Young Adult ; Adult ; Fusion Proteins, bcr-abl/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Blast Crisis/genetics ; Blast Crisis/drug therapy ; Prognosis ; Protein Kinase Inhibitors
Chemical Substances	Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Case Reports ; Review ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2023.107369
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Article ; Online: Stem cells in pulmonary alveolar regeneration.

Wu, Huijuan / Tang, Nan

Development (Cambridge, England)

2021 Volume 148, Issue 2

Abstract: The lungs are constantly exposed to the external environment and are therefore vulnerable to insults that can cause infection and injury. Maintaining the integrity and barrier function of the lung epithelium requires complex interactions of multiple cell ...

Abstract	The lungs are constantly exposed to the external environment and are therefore vulnerable to insults that can cause infection and injury. Maintaining the integrity and barrier function of the lung epithelium requires complex interactions of multiple cell lineages. Elucidating the cellular players and their regulation mechanisms provides fundamental information to deepen understanding about the responses and contributions of lung stem cells. This Review focuses on advances in our understanding of mammalian alveolar epithelial stem cell subpopulations and discusses insights about the regeneration-specific cell status of alveolar epithelial stem cells. We also consider how these advances can inform our understanding of post-injury lung repair processes and lung diseases.
MeSH term(s)	Alveolar Epithelial Cells/cytology ; Animals ; Humans ; Models, Biological ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/physiology ; Regeneration/physiology ; Stem Cell Niche ; Stem Cells/cytology
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.193458
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Article ; Online: The diversity of adult lung epithelial stem cells and their niche in homeostasis and regeneration.

Wang, Yanxiao / Tang, Nan

Science China. Life sciences

2021 Volume 64, Issue 12, Page(s) 2045–2059

Abstract: The adult lung, a workhorse for gas exchange, is continually subjected to a barrage of assaults from the inhaled particles and pathogens. Hence, homeostatic maintenance is of paramount importance. Epithelial stem cells interact with their particular ... ...

Abstract	The adult lung, a workhorse for gas exchange, is continually subjected to a barrage of assaults from the inhaled particles and pathogens. Hence, homeostatic maintenance is of paramount importance. Epithelial stem cells interact with their particular niche in the adult lung to orchestrate both natural tissue rejuvenation and robust post-injury regeneration. Advances in single-cell sequencing, lineage tracing, and living tissue imaging have deepened our understanding about stem cell heterogeneities, transition states, and specific cell lineage markers. In this review, we provided an overview of the known stem/progenitor cells and their subpopulations in different regions of the adult lung, and explored the regulatory networks in stem cells and their respective niche which collectively coordinated stem cell quiescence and regeneration states. We finally discussed relationships between dysregulated stem cell function and lung disease.
MeSH term(s)	Adult ; Adult Stem Cells/physiology ; Animals ; Homeostasis/physiology ; Humans ; Idiopathic Pulmonary Fibrosis/physiopathology ; Lung/cytology ; Lung/physiology ; Pulmonary Alveoli/cytology ; Regeneration/physiology ; Respiratory Mucosa/cytology ; Rodentia
Language	English
Publishing date	2021-04-30
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-020-1902-3
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Article ; Online: Comparative efficacy and safety of medical treatments for proximal humerus fractures: a systematic review and network meta-analysis.

Zheng, Yun / Tang, Nan / Zhang, Wen-Jie / Shi, Wei / Zhao, Wen-Wen / Yang, Kun

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 17

Abstract: Background: Various surgical techniques and conservative therapies are useful tools for treating proximal humerus fractures (PHFs), but it is important to understand how to properly utilize them. Therefore, we performed a systematic review and network ... ...

Abstract	Background: Various surgical techniques and conservative therapies are useful tools for treating proximal humerus fractures (PHFs), but it is important to understand how to properly utilize them. Therefore, we performed a systematic review and network meta-analysis to compare and rank the efficacy and safety of medical treatments for PHF. Methods: PubMed, Embase, the Cochrane Library, and the ClinicalTrials.gov databases were systematically searched for eligible randomized controlled trials (RCTs) from inception until June 2022. Conservative therapy-controlled or head-to-head RCTs of open reduction internal fixation (ORIF), intramedullary nailing (IMN), hemiarthroplasty (HA), and reverse total shoulder arthroplasty (RTSA) used for the treatment of adult patients with PHF were included. The surface under the cumulative ranking (SUCRA) probabilities were applied to compare and rank the effects of medical treatments for PHF. Results: Eighteen RCTs involving 1,182 patients with PHF were selected for the final analysis. Mostly baseline characteristics among groups were well balanced, and the imbalanced factors only included age, injury type, medial comminution, blood loss, and cognitive function in single trial. The SUCRA probabilities found that RTSA provided the best effect on the Constant-Murley score (SUCRA: 100.0%), and the disabilities of the arm, shoulder and hand (DASH) score (SUCRA: 99.0%). Moreover, HA (SUCRA: 85.5%) and RTSA (SUCRA: 68.0%) had a relatively better effect on health-related quality of life than the other treatment modalities. Furthermore, conservative therapy (SUCRA: 84.3%) and RTSA (SUCRA: 80.7%) were associated with a lower risk of secondary surgery. Finally, the best effects on the risk of complications are varied, including infection was observed with conservative therapy (SUCRA: 94.2%); avascular necrosis was observed in HA (SUCRA: 78.1%), nonunion was observed in RTSA (SUCRA: 69.6%), and osteoarthritis was observed in HA (SUCRA: 93.9%). Conclusions: This study found that RTSA was associated with better functional outcomes, while the comparative outcomes of secondary surgery and complications varied. Optimal treatment for PHF should consider patient-specific factors.
MeSH term(s)	Adult ; Humans ; Arthroplasty, Replacement, Shoulder ; Hemiarthroplasty/adverse effects ; Humeral Fractures/surgery ; Humerus/surgery ; Network Meta-Analysis ; Shoulder Fractures/surgery ; Shoulder Fractures/etiology ; Treatment Outcome
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-07053-x
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