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  1. Article ; Online: Sodium alginate/carboxymethyl cellulose films embedded with liposomes encapsulated green tea extract: characterization, controlled release, application.

    Feng, Xin / Li, Yang / Cui, Zhuoyu / Tang, Rongrong

    RSC advances

    2024  Volume 14, Issue 1, Page(s) 245–254

    Abstract: To maintain the freshness of the fruit during storage, sodium alginate/carboxymethyl cellulose films embedded with pH-senstive liposomes encapsulated green tea extract were developed (SA/CMC/TP-Lip). An orthogonal design was used to optimise the ... ...

    Abstract To maintain the freshness of the fruit during storage, sodium alginate/carboxymethyl cellulose films embedded with pH-senstive liposomes encapsulated green tea extract were developed (SA/CMC/TP-Lip). An orthogonal design was used to optimise the preparation of TP-Lip and SA/CMC/TP-Lip was prepared through response surface. The stability of TP-Lip structure was measured. The morphology of SA/CMC/TP-Lip was characterised by SEM, and the mechanical properties and oxidation resistance of films were measured. Special attention was paid to the pH sensitivity of TP-Lip and the improvement of film properties. The zeta potential and encapsulation rate of TP-Lip were -45.85 ± 2.13 mV and 61.45 ± 0.23%. The average release rate of TP encapsulated into TP-Lip at pH 3 was 41.08%, an increase of 23.07% over pH 6 during 12 h. SEM and FTIR showed that TP-Lip was structurally stable and had good compatibility with SA/CMC. Tensile strength was increased by 30.55% and DPPH radical scavenging capacity was increased by 7.16% with the addition of TP-Lip. SA/CMC/TP-Lip is applied to blueberries to reduce their weight loss and improve the loss of freshness of blueberries during storage. Thus, SA/CMC/TP-Lip could provide a new way to extend active packaging materials and maintain fruit freshness during storage.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05196j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of a Clove Essential Oil Slow-Release Microencapsulated Composite Film and Its Preservation Effects on Blueberry.

    Li, Yang / Bian, Boya / Tang, Rongrong / Zhang, Kexin

    ACS omega

    2024  Volume 9, Issue 11, Page(s) 12643–12656

    Abstract: In order to extend the shelf life of fruits and vegetables, a sodium alginate-sodium carboxymethyl cellulose composite film loaded with poly(vinyl alcohol) microcapsules was prepared in this paper. The optimal film substrate ratios were obtained after ... ...

    Abstract In order to extend the shelf life of fruits and vegetables, a sodium alginate-sodium carboxymethyl cellulose composite film loaded with poly(vinyl alcohol) microcapsules was prepared in this paper. The optimal film substrate ratios were obtained after the response surface optimization. Poly(vinyl alcohol) microcapsules were prepared, clove essential oil was loaded into them to investigate the effects of microcapsules on the composite film properties, and the microcapsule composite film with the best overall performance was selected to be applied to blueberry preservation. The results showed that the composite film of 0.84% sodium alginate, 0.25% sodium carboxymethyl cellulose, and 0.56% glycerol presented excellent mechanical properties after adding 1.75% microcapsules. It had a good inhibitory effect on
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Variable Impedance Control Based on Target Position and Tracking Error for Rehabilitation Robots During a Reaching Task.

    Tang, Rongrong / Yang, Qianqian / Song, Rong

    Frontiers in neurorobotics

    2022  Volume 16, Page(s) 850692

    Abstract: To obtain an anthropomorphic performance in physical human-robot interaction during a reaching task, a variable impedance control (vIC) algorithm with human-like characteristics is proposed in this article. The damping value of the proposed method is ... ...

    Abstract To obtain an anthropomorphic performance in physical human-robot interaction during a reaching task, a variable impedance control (vIC) algorithm with human-like characteristics is proposed in this article. The damping value of the proposed method is varied with the target position as well as through the tracking error. The proposed control algorithm is compared with the impedance control algorithm with constant parameters (IC) and another vIC algorithm, which is only changed with the tracking error (vIC-e). The different control algorithms are validated through the simulation study, and are experimentally implemented on a cable-driven rehabilitation robot. The results show that the proposed vIC can improve the tracking accuracy and trajectory smoothness, and reduce the interaction force at the same time.
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453002-5
    ISSN 1662-5218
    ISSN 1662-5218
    DOI 10.3389/fnbot.2022.850692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.

    Tang, Rongrong / Cui, Haiyan / Dou, Rongrong / Tao, Lin / Tan, Linlin / Guo, Ting / Luo, Dan

    Cellular and molecular biology (Noisy-le-Grand, France)

    2023  Volume 69, Issue 12, Page(s) 1–5

    Abstract: Psoriasis seriously harms people's physical and mental health. More and more people pay attention to improving the psoriasis process by immune cells. Our study alters the course of psoriasis by discovering the effect of ErbB4 on the ratio of Th1/Th17 ... ...

    Abstract Psoriasis seriously harms people's physical and mental health. More and more people pay attention to improving the psoriasis process by immune cells. Our study alters the course of psoriasis by discovering the effect of ErbB4 on the ratio of Th1/Th17 cells. We detected the expression of ErbB4 in CD4-positive T cells in peripheral blood of clinical patients and clinical samples by qPCR and detected the expression of ErbB4 in mouse samples of the model group. ErbB4 siRNA was designed and transfected into cells. The effect of ErbB4 siRNA on Th1/Th17 cell ratio was observed by flow cytometry. ErbB4 siRNA was transfected into mice by lentivirus infection to observe its effect on psoriasis. Finally, the mechanism of ErbB4 affecting psoriasis was observed by Western Blot. According to the results, ErbB4 is highly expressed in clinical samples of psoriasis and CD4-positive T cells of patients with psoriasis. Inhibition of ErbB4 expression can reduce the proportion of Th1/Th17 cells, improve the pathogenesis of psoriasis and have therapeutic effect on psoriasis. Western Blot results showed that ErbB4 affected psoriasis through the IL23/IL17A signal axis. Our study demonstrates that ErbB4 could be a potential immune target for the treatment of psoriasis.
    MeSH term(s) Animals ; Humans ; Mice ; Cell Differentiation ; Psoriasis/genetics ; Psoriasis/drug therapy ; RNA, Small Interfering/metabolism ; Th1 Cells/metabolism ; Th17 Cells/metabolism
    Chemical Substances RNA, Small Interfering ; ERBB4 protein, human (EC 2.7.10.1) ; Erbb4 protein, mouse (EC 2.7.10.1)
    Language English
    Publishing date 2023-11-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2023.69.12.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A pathway model of chronic pain and frailty in older Chinese cancer patients: The mediating effect of sleep.

    Zhang, Qin / Yu, Ming / Tang, Rongrong / Wang, Hui / Xiao, Mingbing / Geng, Guiling / Xie, Juan / Yan, Haiou

    Geriatric nursing (New York, N.Y.)

    2023  Volume 50, Page(s) 215–221

    Abstract: This study aimed to explore the association between chronic pain, sleep quality, and frailty, and whether sleep quality will mediate the relationship between chronic pain and frailty. A cross-sectional study was conducted between June 2020 and July 2021 ... ...

    Abstract This study aimed to explore the association between chronic pain, sleep quality, and frailty, and whether sleep quality will mediate the relationship between chronic pain and frailty. A cross-sectional study was conducted between June 2020 and July 2021 among 308 patients in Nantong city. The relationship between chronic pain and frailty was tested using linear regression. The bootstrap method was used to examine mediating effect of sleep quality. Chronic pain was significantly correlated with frailty (r=0.271, P<.001). Sleep quality played a partially mediating role between chronic pain and frailty (β=0.160, R
    MeSH term(s) Humans ; Aged ; Frailty ; Chronic Pain ; Frail Elderly ; Cross-Sectional Studies ; East Asian People ; Sleep ; Neoplasms/complications
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632559-2
    ISSN 1528-3984 ; 0197-4572
    ISSN (online) 1528-3984
    ISSN 0197-4572
    DOI 10.1016/j.gerinurse.2023.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Can serum ferritin serve as a biomarker for the prognosis of gynecological malignant tumors? A retrospective cohort study.

    Zhang, Weidan / Chen, Qiaoqiao / Cheng, Yali / Wang, Miao / Tong, Jinfei / Tang, Rongrong / Pan, Yihong / Yang, Jianhua

    Cancer biomarkers : section A of Disease markers

    2023  Volume 39, Issue 2, Page(s) 127–136

    Abstract: Purpose: It is widely accepted that there is a strong relationship between iron levels and cancer. This study aimed to investigate the relationship between serum ferritin levels and the severity and prognosis of gynecological malignant tumors.: ... ...

    Abstract Purpose: It is widely accepted that there is a strong relationship between iron levels and cancer. This study aimed to investigate the relationship between serum ferritin levels and the severity and prognosis of gynecological malignant tumors.
    Methods: This retrospective study included patients with gynecological malignant tumors at Sir Run Run Shaw Hospital in the Department of Obstetrics and Gynecology from January 2013 to June 2019. Patients were grouped according to their serum ferritin level: low (< 13 μg/L), normal (13-150 μg/L), and high (> 150 μg/L). Correlation analyses were performed between serum ferritin level and other factors. Cox univariable and multivariable analysis and Kaplan-Meier survival curves were used to assess the impact of ferritin on survival in patients with gynecologic tumors.
    Results: The 402 total patients were divided into a low (n= 37), normal (n= 182), and high (n= 183) ferritin level group. Correlation analyses were performed that WBC, MCV, CRP, CA125, and CA153 were significantly positively correlated with serum ferritin level. The Kaplan-Meier survival curves revealed that of the three groups analyzed, the high serum ferritin level group had a significantly shorter survival time versus the normal and low serum ferritin level groups (log-rank P= 0.003). Univariable Cox regression analysis identified that patients with high serum ferritin levels had a significant correlation with risk of death compared to the patients with lower and normal serum ferritin levels. Serum ferritin was not found to be significant (HR = 0.792, 95% CI: 0.351-1.787, P= 0.574) in the multivariable Cox analysis.
    Conclusion: Although this study did not find serum ferritin to be a significant independent prognosis indicator in gynecological malignant tumors, this study did identify that gynecological malignant tumor patients with high serum ferritin levels have significantly less survival time than patients with low or normal serum ferritin levels.
    MeSH term(s) Pregnancy ; Humans ; Female ; Retrospective Studies ; Gynecology ; Prognosis ; Biomarkers ; Neoplasms ; Ferritins
    Chemical Substances Biomarkers ; Ferritins (9007-73-2)
    Language English
    Publishing date 2023-12-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-230040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dual-scale categorization based deep learning to evaluate programmed cell death ligand 1 expression in non-small cell lung cancer.

    Wang, Xiangyun / Chen, Peilin / Ding, Guangtai / Xing, Yishi / Tang, Rongrong / Peng, Chaolong / Ye, Yizhou / Fu, Qiang

    Medicine

    2020  Volume 100, Issue 20, Page(s) e25994

    Abstract: Abstract: In precision oncology, immune check point blockade therapy has quickly emerged as novel strategy by its efficacy, where programmed death ligand 1 (PD-L1) expression is used as a clinically validated predictive biomarker of response for the ... ...

    Abstract Abstract: In precision oncology, immune check point blockade therapy has quickly emerged as novel strategy by its efficacy, where programmed death ligand 1 (PD-L1) expression is used as a clinically validated predictive biomarker of response for the therapy. Automating pathological image analysis and accelerating pathology evaluation is becoming an unmet need. Artificial Intelligence and deep learning tools in digital pathology have been studied in order to evaluate PD-L1 expression in PD-L1 immunohistochemistry image. We proposed a Dual-scale Categorization (DSC)-based deep learning method that employed 2 VGG16 neural networks, 1 network for 1 scale, to critically evaluate PD-L1 expression. The DSC-based deep learning method was tested in a cohort of 110 patients diagnosed as non-small cell lung cancer. This method showed a concordance of 88% with pathologist, which was higher than concordance of 83% of 1-scale categorization-based method. Our results show that the DSCbased method can empower the deep learning application in digital pathology and facilitate computer-aided diagnosis.
    MeSH term(s) B7-H1 Antigen/analysis ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Deep Learning ; Diagnosis, Computer-Assisted/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunohistochemistry ; Lung/immunology ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Patient Selection ; Precision Medicine/methods
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000025994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Efficacy and safety of the Jinling procedure in the treatment of adult Hirschsprung disease].

    Quan, Bin / Chen, Qiyi / Jiang, Jun / Ni, Ling / Tang, Rongrong / Huang, Yu / Shi, Yifang / Li, Ning

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2016  Volume 19, Issue 7, Page(s) 763–768

    Abstract: Objective: To investigate the safety, efficacy and long-term outcomes of Jinling procedure in the treatment of adult Hirschsprung disease.: Methods: Clinical and follow-up data of 125 patients with adult Hirschsprung disease undergoing Jinling ... ...

    Abstract Objective: To investigate the safety, efficacy and long-term outcomes of Jinling procedure in the treatment of adult Hirschsprung disease.
    Methods: Clinical and follow-up data of 125 patients with adult Hirschsprung disease undergoing Jinling procedure at the Department of General Surgery between January 2000 and January 2013 were summarized. All the patients were diagnosed by CT, barium enema, anorectal pressure detection and pathology examination. Abdominal symptoms, gastrointestinal quality of life index(GIQLI, the lower score, the worse quality of life), Wexner constipation score (higher score indicated worse symptom), defecography (evaluation included rectocele, mucosal prolapse, intramucosal intussusception, perineal prolapse) and other operative complications were compared before and after operation.
    Results: Among 125 patients, 69 were male and 56 were female with median age of (41.2±15.5) (18 to 75) years. The follow-up rates were 94.4%(118/125), 92.0%(115/125), 89.6%(112/125) and 88.0%(110/125) at postoperative months 1, 3, 6, and 12. Incidences of abdominal distension and abdominal pain were 100% and 82.4%(103/125) before operation, and were 7.3%(8/110) and 20.9%(23/110) at 12 months after surgery. Wexner score was significantly lower at postoperative months 1(8.7±2.9), 3 (7.2±2.8), 6(6.7±2.2) and 12(6.3±1.7) than that before operation (21.4±7.2) (P<0.01). GIQLI score was 51.6±11.9 before operation, though it decreased at 1 month (47.3±5.5)(P<0.05) after surgery, but increased significantly at postoperative months 3, 6, 12(68.9±8.0, 96.5±8.2, 103.2±8.6)(P<0.01). Abnormal rate of defecography was 70.4%(81/115), 48.2%(54/112) and 27.3%(30/110) at postoperative months 3, 6, 12, which was significantly lower than 91.2%(114/125) before operation (P<0.01). Morbidity of postoperative complication was 29.6%(37/125), including 5 cases of surgical site infection (4.0%), 2 of anastomotic bleeding (1.6%), 8 of anastomotic leakage (6.4%, one died of severe abdominal infection), 4 of urinary retention (3.2%), 3 of recurrent constipation (2.4%, without megacolon relapse), 11 of bowel obstruction (8.8%), 2 of anastomotic stricture(1.6%) and 2 of refractory staphylococcus aureus enteritis (1.6%, diagnosed by stool smear and culture, and both died finally).
    Conclusion: Jinling procedure is a safe and effective surgical procedure for adult Hirschsprung's disease.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anastomosis, Surgical ; Colectomy ; Constipation ; Defecography ; Digestive System Surgical Procedures ; Female ; Hirschsprung Disease/surgery ; Humans ; Intestinal Obstruction ; Intussusception ; Male ; Middle Aged ; Perineum ; Postoperative Complications ; Postoperative Period ; Quality of Life ; Rectocele ; Staphylococcus aureus ; Treatment Outcome ; Young Adult
    Language Chinese
    Publishing date 2016-07
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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