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Article ; Online: Protein modifications and diseases.

Tang, Shuang

2024 Volume 239, Issue 3, Page(s) e31194

MeSH term(s)	Protein Processing, Post-Translational ; Proteomics ; Disease ; Humans
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Editorial
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.31194
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Article ; Online: Inferring the energy sensitivity and band gap of electronic transport in a network of carbon nanotubes.

Tang, Shuang

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2060

Abstract: Since the industrialization of single-phase nanomaterial-based devices is still challenging, intensive research focus has been given to complex materials consisting of multiple nanoscale entities, including networks and matrices of nanowires, nanotubes, ... ...

Abstract	Since the industrialization of single-phase nanomaterial-based devices is still challenging, intensive research focus has been given to complex materials consisting of multiple nanoscale entities, including networks and matrices of nanowires, nanotubes, nanoribbons, or other large molecules; among these complex materials, networks of carbon nanotubes are a typical example. Detailed knowledge of the energy sensitivity and band gap of electronic transport in such a material system is difficult to detect, despite its importance in electronic, energetic and sensing applications. Here, we propose a new methodology to obtain these quantities using the measured Seebeck coefficient at a certain temperature but different Fermi levels. We discover that the network consisting of semiconducting (11,10)-carbon nanotubes actually exhibits metallic transport at room temperature. It is also interesting to verify that intrananotube ballistic transport is dominant over diffusive scattering by long-range disorder, as well as the quantum hopping resistance at the contact points. The transport asymmetry ratio between the holes and electrons (1.75) is similar to the value observed in pristine graphene samples (1.50).
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06078-x
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Article ; Online: Extracting the Energy Sensitivity of Charge Carrier Transport and Scattering.

Tang, Shuang

Scientific reports

2018 Volume 8, Issue 1, Page(s) 10597

Abstract: It is a challenge to extract the energy sensitivity of charge carriers' transport and scattering from experimental data, although a theoretical estimation in which the existing scattering mechanism(s) are preliminarily assumed can be easily done. To ... ...

Abstract	It is a challenge to extract the energy sensitivity of charge carriers' transport and scattering from experimental data, although a theoretical estimation in which the existing scattering mechanism(s) are preliminarily assumed can be easily done. To tackle this problem, we have developed a method to experimentally determine the energy sensitivities, which can then serve as an important statistical measurement to further understand the collective behaviors of multi-carrier transport systems. This method is validated using a graphene system at different temperatures. Further, we demonstrate the application of this method to other two-dimensional (2D) materials as a guide for future experimental work on the optimization of materials performance for electronic components, Peltier coolers, thermoelectricity generators, thermocouples, thermopiles, electrical converters and other conductivity and/or Seebeck-effect-related sensors.
Language	English
Publishing date	2018-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-28288-y
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Article ; Online: Circadian clock-mediated nuclear receptors in cancer.

Niu, Ya / Tang, Shuang

Journal of cellular physiology

2022

Abstract: Circadian system coordinates the daily periodicity of physiological and biochemical functions to adapt to environmental changes. Circadian disruption has been identified to increase the risk of cancer and promote cancer progression, but the underlying ... ...

Abstract	Circadian system coordinates the daily periodicity of physiological and biochemical functions to adapt to environmental changes. Circadian disruption has been identified to increase the risk of cancer and promote cancer progression, but the underlying mechanism remains unclear. And further mechanistic understanding of the crosstalk between clock components and cancer is urgent to achieve clinical anticancer benefits from chronochemotherapy. Recent studies discover that several nuclear receptors regulating circadian clock, also play crucial roles in mediating multiple cancer processes. In this review, we aim to summarize the latest developments of clock-related nuclear receptors in cancer biology and dissect mechanistic insights into how nuclear receptors coordinate with circadian clock to regulate tumorigenesis and cancer treatment. A better understanding of circadian clock-related nuclear receptors in cancer could help prevent tumorigenesis and improve anticancer efficacy.
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30905
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Article ; Online: Dual antiplatelet therapy after intravenous thrombolysis for patients with minor ischemic stroke：A meta-analysis.

Zeng, Jing / Xin, Wenli / Tang, Shuang / Xiang, Chengwei / Zeng, Chun

Clinical neurology and neurosurgery

2024 Volume 238, Page(s) 108176

Abstract: Objective: Intravenous thrombolysis (IVT) has been shown to effectively decrease both the disability rate and mortality associated with acute ischemic stroke, however, there is also a risk of vascular re-occlusion. Antiplatelet therapy can mitigate this ...

Abstract	Objective: Intravenous thrombolysis (IVT) has been shown to effectively decrease both the disability rate and mortality associated with acute ischemic stroke, however, there is also a risk of vascular re-occlusion. Antiplatelet therapy can mitigate this risk. Nevertheless, there are no relevant guidelines recommending whether the administration of dual antiplatelet therapy (DAPT) with aspirin and clopidogrel can be performed following thrombolysis. The aim of this study was to conduct a meta-analysis utilizing multiple studies in order to assess the effectiveness and safety of DAPT after IVT in cases of acute mild ischemic stroke (AMIS). Methods: A comprehensive search on English literature published was performed on databases including PubMed, Embase, Web of Science, and Cochrane up until September 1, 2023. All cases were ischemic stroke patients who underwent IVT within a 4.5-hour timeframe and had a National Institutes of Health Stroke Scale (NIHSS) score of ≤5 (or 3) upon admission. The primary efficacy endpoint is the 90-day Modified Rankin Scale (mRS) Score (MRS score 0-1), while the primary safety endpoint encompassed the occurrence of symptomatic intracranial hemorrhage (SICH) and 90-day mortality. The study's secondary objective is the recurrence of any type of stroke (hemorrhagic and ischemic) within a 90-day period. The included studies underwent an evaluation of bias risk using the Newcastle Ottawa scale. Risk ratios (RRs) and CIs were calculated using a random effects model, and the findings and heterogeneity among the included studies were visually presented on a forest plot. (There was a protocol registration (PROSPERO):). Results: Out of the 1081 studies that were obtained, only 3 met the criteria and were included in the meta-analysis (657 patients in total). The findings indicate that, there was a significant difference in the mRS of 0-1 between single antiplatelet therapy (SAPT) with only aspirin or clopidogrel and DAPT with aspirin and clopidogrel ((RR,1.11[95%CI,0.99-1.24];P=0.07;I Conclusions: For patients with acute mild ischemic stroke (AMIS), in conjunction with DAPT after IVT can improve the 90-day prognosis, without increasing the risk of intracranial hemorrhage and 90-day mortality. However, it cannot reduce the risk of stroke recurrence.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/adverse effects ; Ischemic Stroke/drug therapy ; Ischemic Stroke/complications ; Clopidogrel/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/complications ; Treatment Outcome ; Stroke/complications ; Aspirin/therapeutic use ; Intracranial Hemorrhages/complications ; Thrombolytic Therapy/methods
Chemical Substances	Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2024.108176
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Article ; Online: Biological properties of hydroxyapatite coatings on titanium dioxide nanotube surfaces using negative pressure method.

Wang, Yan / Tang, Shuang / Ding, Ning / Zhang, Zutai

Journal of biomedical materials research. Part B, Applied biomaterials

2023 Volume 111, Issue 7, Page(s) 1365–1373

Abstract: Titanium (Ti) exhibits superior biocompatibility and mechanical properties but is bioinert, while hydroxyapatite (HA) possesses excellent osteogenesis and is widely used for the modification of Ti surface coatings. However, the synthesis of homogeneous ... ...

Abstract	Titanium (Ti) exhibits superior biocompatibility and mechanical properties but is bioinert, while hydroxyapatite (HA) possesses excellent osteogenesis and is widely used for the modification of Ti surface coatings. However, the synthesis of homogeneous and stable HA on metallic materials is still a major challenge. In this study, porous titanium dioxide nanotube arrays were prepared on Ti surface by anodic oxidation, loaded with calcium and phosphorus precursors by negative pressure immersion, and HA coating was formed by in situ crystallization of calcium and phosphorus on the surface by hydrothermal heating. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and bonding strength were conducted to confirm the surface characteristics of each group. The cell proliferation, mineralization degree, and alkaline phosphatase (ALP) activity of MC3T3-E1 cells on samples were calculated and compared in vitro experiments. Cylindrical samples were implanted into rat femurs to evaluate biocompatibility and osteogenesis in vivo. The results showed that HA crystals successfully synthesized in TiO
MeSH term(s)	Animals ; Rats ; Calcium ; Osteogenesis ; Titanium/pharmacology ; Durapatite/pharmacology ; Nanotubes ; Phosphorus ; Surface Properties ; Coated Materials, Biocompatible/pharmacology ; Osteoblasts
Chemical Substances	Calcium (SY7Q814VUP) ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Durapatite (91D9GV0Z28) ; Phosphorus (27YLU75U4W) ; Coated Materials, Biocompatible
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35240
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Article ; Online: Temporal expectations mediated the repetition effect in a sequence in two ways.

Yan, Haiqiong / Tang, Shuang / Huang, Furong

Cognitive processing

2023 Volume 24, Issue 4, Page(s) 463–469

Abstract: The repetition priming effect generally refers to facilitated responding in instances where the same stimulus or a very similar stimulus repeats after an initial occurrence. Prior studies showed that the repetition priming effect was greater when ... ...

Abstract	The repetition priming effect generally refers to facilitated responding in instances where the same stimulus or a very similar stimulus repeats after an initial occurrence. Prior studies showed that the repetition priming effect was greater when repetitive stimuli appeared at expected times than when they appeared at less expected times. However, in addition to the expectation for repetition, the expectation for nonrepetitive stimuli may also arise in a sequence, especially after repetitive stimuli continuously appeared several times. This study was designed to further reveal how these two kinds of expectations influence the repetition effect in a sequence. Participants were asked to solve 3, 4 or 5 repetitive tasks followed by a novel task in the experimental group, a situation where the expectations for repetitive events arise in the first three serial positions but that for nonrepetitive events arise in the fourth, fifth and sixth serial positions, or were asked to continuously solve 3-5 repetitive tasks in the control group, a situation where only the expectation for repetitive events appears. The results showed that the repetition effect appeared steadily in the whole sequence for the control group, whereas the repetition effect appeared in the early serial positions but was reduced in the later serial position for the experimental group. The findings revealed the dual influences of temporal expectations on repetition effects in a sequence.
MeSH term(s)	Humans ; Motivation ; Repetition Priming
Language	English
Publishing date	2023-05-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-023-01141-5
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Article: Predictive value of hyponatremia for short-term mortality in supratentorial spontaneous intracerebral hemorrhage: a single center study.

Qian, Ao / Zheng, Longyi / He, Zeyuan / Zhou, Jing / Tang, Shuang / Xing, Wenli

Frontiers in neurology

2024 Volume 15, Page(s) 1301197

Abstract: Background: Hyponatremia is a common electrolyte disturbance in patients with neurological disease; however, its predictive role for outcome in patients with supratentorial spontaneous intracerebral hemorrhage (sICH) is controversial. This study aims to ...

Abstract	Background: Hyponatremia is a common electrolyte disturbance in patients with neurological disease; however, its predictive role for outcome in patients with supratentorial spontaneous intracerebral hemorrhage (sICH) is controversial. This study aims to explore the association between hyponatremia within 7 days after bleeding and 90-day mortality in patients with supratentorial sICH. Methods: A retrospective analysis was conducted at our institution. Patients with sICH meeting the inclusion criteria were enrolled in this study. Multivariate regression analyses were performed to determine the predictive value of hyponatremia (serum sodium <135 mmol/L) for 90-day mortality and functional outcome. Subgroup analysis was performed based on the degree and duration of hyponatremia and therapeutic strategies. The Spearman correlation test was performed to explore the relationship between hyponatremia severity and duration with variables in a multivariate regression model. Kaplan-Meier curve was depicted to reveal the relationship between hyponatremia and mortality. The receiver operating characteristic (ROC) curve was plotted to show the diagnostic effect of the minimum concentration of serum sodium (sodium Results: A total of 960 patients were enrolled, 19.6% (188) of whom were patients with hyponatremia and 26.0% (250) had 90-day mortality. The incidence of hyponatremia was roughly 2.5 times in non-survivors compared with survivors (34.8% vs. 14.2%). Multivariate regression analysis revealed that hyponatremia was the independent predictor of 90-day mortality (OR 2.763, 95%CI 1.836-4.157) and adverse outcome (OR 3.579, 95%CI 2.332-6.780). Subgroup analysis indicated an increased trend in mortality risk with both duration (more or less than 48 h) and severity of hyponatremia (mild, moderate, and severe) and confirmed the predictive value of hyponatremia for mortality in patients undergoing surgical intervention (external ventricular drainage, craniotomy, and decompressive craniectomy; all Conclusion: Hyponatremia occurring in the first 7 days after bleeding is an independent predictor of 90-day morality and adverse outcome. Rigorous electrolyte scrutiny in patients treated surgically is required.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1301197
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Article ; Online: Current understanding of macrophages in intracranial aneurysm: relevant etiological manifestations, signaling modulation and therapeutic strategies.

Duan, Jian / Zhao, Qijie / He, Zeyuan / Tang, Shuang / Duan, Jia / Xing, Wenli

Frontiers in immunology

2024 Volume 14, Page(s) 1320098

Abstract: Macrophages activation and inflammatory response play crucial roles in intracranial aneurysm (IA) formation and progression. The outcome of ruptured IA is considerably poor, and the mechanisms that trigger IA progression and rupture remain to be ... ...

Abstract	Macrophages activation and inflammatory response play crucial roles in intracranial aneurysm (IA) formation and progression. The outcome of ruptured IA is considerably poor, and the mechanisms that trigger IA progression and rupture remain to be clarified, thereby developing effective therapy to prevent subarachnoid hemorrhage (SAH) become difficult. Recently, climbing evidences have been expanding our understanding of the macrophages relevant IA pathogenesis, such as immune cells population, inflammatory activation, intra-/inter-cellular signaling transductions and drug administration responses. Crosstalk between macrophages disorder, inflammation and cellular signaling transduction aggravates the devastating consequences of IA. Illustrating the pros and cons mechanisms of macrophages in IA progression are expected to achieve more efficient treatment interventions. In this review, we summarized the current advanced knowledge of macrophages activation, infiltration, polarization and inflammatory responses in IA occurrence and development, as well as the most relevant NF-κB, signal transducer and activator of transcription 1 (STAT1) and Toll-Like Receptor 4 (TLR4) regulatory signaling modulation. The understanding of macrophages regulatory mechanisms is important for IA patients' clinical outcomes. Gaining insight into the macrophages regulation potentially contributes to more precise IA interventions and will also greatly facilitate the development of novel medical therapy.
MeSH term(s)	Humans ; Intracranial Aneurysm/etiology ; Intracranial Aneurysm/therapy ; Signal Transduction ; Causality ; Subarachnoid Hemorrhage/therapy ; Macrophages
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1320098
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Article ; Online: The impact and mechanism of

Liu, Ranyang / Feng, Linlin / Tang, Shuang / Liu, Yin / Yang, Qin

Epigenomics

2023 Volume 15, Issue 10, Page(s) 577–591

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Apoptosis ; Up-Regulation ; Dioxygenases/metabolism
Chemical Substances	TET3 protein, human (EC 1.-) ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2537199-X
ISSN	1750-192X ; 1750-1911
ISSN (online)	1750-192X
ISSN	1750-1911
DOI	10.2217/epi-2023-0146
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