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  1. Article ; Online: Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology.

    Tang, Tiffany Y-C / Kim, Justin S / Das, Aditi

    Advances in pharmacology (San Diego, Calif.)

    2023  Volume 97, Page(s) 375–422

    Abstract: Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role in regulation of inflammation, development, neurodegenerative diseases, cancer, and cardiovascular diseases. They elicit this effect via interactions ... ...

    Abstract Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role in regulation of inflammation, development, neurodegenerative diseases, cancer, and cardiovascular diseases. They elicit this effect via interactions with cannabinoid receptors 1 and 2 which are also targeted by plant derived cannabinoid from cannabis. The evidence of the involvement of the endocannabinoid system in cardiopulmonary function comes from studies that show that cannabis consumption leads to cardiovascular effect such as arrythmia and is beneficial in lung cancer patients. Moreover, omega-3 and omega-6 endocannabinoids play several important roles in cardiopulmonary system such as causing airway relaxation, suppressing atherosclerosis and hypertension. These effects are mediated via the cannabinoids receptors that are abundant in the cardiopulmonary system. Overall, this chapter reviews the known role of phytocannabinoids and endocannabinoids in the cardiopulmonary context.
    MeSH term(s) Humans ; Cannabinoids ; Endocannabinoids/pharmacology ; Hallucinogens ; Receptors, Cannabinoid
    Chemical Substances Cannabinoids ; Endocannabinoids ; Hallucinogens ; Receptors, Cannabinoid
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein.

    Wang, David Tzu-Wei / Tang, Tiffany Y C / Kuo, Chun-Ting / Yu, Yun-Ting / Chen, Eric H L / Lee, Ming-Tao / Tsai, Ruei-Fong / Chen, Hung-Ying / Chiang, Yun-Wei / Chen, Rita P Y

    PNAS nexus

    2023  Volume 2, Issue 5, Page(s) pgad162

    Abstract: Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ ...

    Abstract Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ peptides are catabolic products of a type I membrane protein called amyloid precursor protein (APP). Aβ40 is the major product, whereas the 2-residue-longer version, Aβ42, induces amyloid plaque formation in the AD brain. Since cholesterol content is one risk factor for sporadic AD, we aimed to explore whether cholesterol in the membrane affects the structure of the APP transmembrane region, thereby modulating the γ-secretase cutting behavior. Here, we synthesized several peptides containing the APP transmembrane region (sequence 693-726, corresponding to the Aβ
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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