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  1. Article ; Online: Misbehaviors, bad outcomes and malpractice claims against general surgeons.

    Fan, Xin / Shi, Xin / Tang, Wen-Hao

    Asian journal of surgery

    2022  Volume 45, Issue 12, Page(s) 2852–2853

    MeSH term(s) Humans ; Malpractice ; Surgeons
    Language English
    Publishing date 2022-06-21
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.06.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region.

    Deng, Chen-Yao / Zhang, Zhe / Tang, Wen-Hao / Jiang, Hui

    Asian journal of andrology

    2022  Volume 25, Issue 1, Page(s) 5–12

    Abstract: Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main structural chromosomal abnormalities that cause ... ...

    Abstract Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main structural chromosomal abnormalities that cause male infertility. Assisted reproductive technology (ART) has been used to overcome natural fertilization barriers, allowing infertile couples to have children. However, these techniques increase the risk of vertical transmission of genetic defects. Despite widespread awareness of AZF microdeletions, the occurrence of de novo deletions and overexpression, as well as the expansion of AZF microdeletion vertical transmission, remains unknown. This review summarizes the mechanism of AZF microdeletion and the function of the candidate genes in the AZF region and their corresponding clinical phenotypes. Moreover, vertical transmission cases of AZF microdeletions, the impact of vertical inheritance on male fertility, and the prospective direction of research in this field are also outlined.
    MeSH term(s) Humans ; Male ; Azoospermia/genetics ; Sex Chromosome Aberrations ; Prospective Studies ; Chromosome Deletion ; Chromosomes, Human, Y/genetics ; Infertility, Male/genetics ; Sertoli Cell-Only Syndrome/genetics ; Oligospermia/genetics
    Language English
    Publishing date 2022-03-08
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja2021130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Novel predictors for livebirth delivery rate in patients with idiopathic non-obstructive azoospermia based on the clinical prediction model.

    Zhang, Li / Wang, Yuan-Yuan / Zheng, Xiao-Ying / Lei, Li / Tang, Wen-Hao / Qiao, Jie / Li, Rong / Liu, Ping

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1233475

    Abstract: Objective: To build a prediction model for live birth delivery per intracytoplasmic sperm injection (ICSI) in iNOA patients by obtaining sperm by microdissection testicular sperm extraction (mTESE).: Methods: A retrospective cohort study of 377 ... ...

    Abstract Objective: To build a prediction model for live birth delivery per intracytoplasmic sperm injection (ICSI) in iNOA patients by obtaining sperm by microdissection testicular sperm extraction (mTESE).
    Methods: A retrospective cohort study of 377 couples with iNOA male partners treated with 519 mTESE-ICSI cycles was conducted from September 2013 to July 2021 at the Reproductive Medical Centre of Peking University Third Hospital. Following exclusions, 377 couples with iNOA male partners treated with 482 mTESE-ICSIs were included. A prediction model for live birth delivery per ICSI cycle was built by multivariable logistic regression and selected by 10-fold cross-validation. Discrimination was evaluated by c-statistics and calibration was evaluated by the calibration slope.
    Results: The live birth delivery rate per mTESE-ICSI cycle was 39.21% (189/482) in these couples. The model identified that the presence of motile sperm during mTESE, bigger testes, higher endometrial thickness on the day of human chorionic gonadotrophin (hCG) administration (ET-hCG), and higher quality embryos are associated with higher live birth delivery success rates. The results of the model were exported based on 10-fold cross-validation. In addition, the area under the mean ROC curve was 0.71 ± 0.05 after 10-fold cross-validation, indicating that the prediction model had certain prediction precision. A calibration plot with an estimated intercept of -1.653 (95% CI: -13.403 to 10.096) and a slope of 1.043 (95% CI: 0.777 to 1.308) indicated that the model was well-calibrated.
    Conclusion: Our prediction model will provide valuable information about the chances of live birth delivery in couples with iNOA male partners who have a plan for mTESE-ICSI treatment. Therefore, it can improve and personalize counseling for the medical treatment of these patients.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Azoospermia/therapy ; Live Birth/epidemiology ; Retrospective Studies ; Models, Statistical ; Prognosis ; Semen
    Language English
    Publishing date 2023-10-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1233475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: AF cell derived exosomes regulate endothelial cell migration and inflammation: Implications for vascularization in intervertebral disc degeneration

    Sun, Zhen / Zhao, Hang / Liu, Bing / Gao, Yang / Tang, Wen-Hao / Liu, Zhi-Heng / Luo, Zhuo-Jing

    Life sciences. 2021 Jan. 15, v. 265

    2021  

    Abstract: The intervertebral disc is the largest avascular organ of the body. Vascularization of the disc has been typically regarded as a pathological feature of intervertebral disc degeneration (IDD). However, the underlying mechanism of vascularization in IDD ... ...

    Abstract The intervertebral disc is the largest avascular organ of the body. Vascularization of the disc has been typically regarded as a pathological feature of intervertebral disc degeneration (IDD). However, the underlying mechanism of vascularization in IDD is still unclear. The current study aimed to investigate the role of AF cell derived exosome (AF-exo) in the interaction with human umbilical vein endothelial cells (HUVECs) and its potential role in the regulation of vascularization in IDD.Human AF tissues were obtained from patients with IDD and idiopathic scoliosis. The AF-exo were isolated and identified by transmission electron microscopy (TEM), nanoparticle trafficking analysis (NTA) and Western blotting. Then, the AF-exo were used for HUVECs cultures. The migration of HUVECs was observed in 2D and 3D cultures. The inflammatory phenotype of HUVECs was examined by Real-time PCR and enzyme-linked immunosorbent assay (ELISA). Additionally, apoptosis of HUVECs were analyzed by flow cytometry.Here, we for the first time found that AF cells could secrete AF-exo and that the AF-exo could be phagocytosed by HUVECs. Additionally, we found that degenerated AF-exo exerted pro-vascularization effect on HUVECs by promoting cell migration (in 2D and 3D cultures) and inflammatory factor expression including IL-6, TNF-α, MMP-3, MMP-13 and VEGF, whereas the application of non-degenerated AF-exo demonstrated inverse effects.These results showed that AF-exo is an essential regulator mediating intercellular communication between AF cells and HUVECs, suggesting its important role in vascularization in the intervertebral disc.
    Keywords apoptosis ; cell communication ; cell movement ; enzyme-linked immunosorbent assay ; exosomes ; inflammation ; interleukin-6 ; intervertebral disks ; phenotype ; quantitative polymerase chain reaction ; scoliosis ; transmission electron microscopy
    Language English
    Dates of publication 2021-0115
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-light
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118778
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 73/732: Show issues

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  5. Article: A retrospective cohort study of geographic differences in the semen of 1,012 sperm donors in China.

    Zhao, Qian-Cheng / Zhang, Zhe / Zhao, Lian-Ming / Deng, Zhen-Feng / Gao, Jiang-Man / Zhang, Hong-Liang / Lin, Hao-Cheng / Liu, De-Feng / Mao, Jia-Ming / Zhang, Hai-Tao / Chen, Yu-Long / Tang, Wen-Hao / Jiang, Hui

    Translational andrology and urology

    2023  Volume 12, Issue 2, Page(s) 187–196

    Abstract: Background: Male reproductive health has become a serious public health concern, and semen quality is essential to male reproduction. We aimed to investigate geographical differences in the semen quality of sperm donors from northern and southern China ... ...

    Abstract Background: Male reproductive health has become a serious public health concern, and semen quality is essential to male reproduction. We aimed to investigate geographical differences in the semen quality of sperm donors from northern and southern China by enrolling donors across the country.
    Methods: A total of 1,012 sperm donors were enrolled in this study between 2015 and 2019. Donors were first divided into two parts based on their birthplace according to the "Qinling-Huaihe" line, and secondly, by their residential latitude. Finally, donors were re-classified into two groups (typically north and south) which contained 667 samples.
    Results: Statistically significant differences in sperm concentration were observed among men from different latitudes in China (P=0.04). The sperm concentrations of males from 18° to 27° north latitude were significantly lower than those from 36° to 45° and 45° to 54° [median 131, 134, and 146, respectively, P=0.021 (18° to 27°
    Conclusion: We hypothesize environmental pollution and mental stress due to the increased population size may be the main factors underlying differences in the sperm quality of men in northern and southern China.
    Language English
    Publishing date 2023-02-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-22-578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Outcomes after HSCT for mucolipidosis II (I-cell disease) caused by novel compound heterozygous GNPTAB mutations.

    He, Si-Jia / Li, Dong-Jun / Lv, Wen-Qiong / Tang, Wen-Hao / Sun, Shu-Wen / Zhu, Yi-Ping / Liu, Ying / Wu, Jin / Lu, Xiao-Xi

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1199489

    Abstract: Background: Mucolipidosis type II (MLII), or I-cell disease, is a rare lysosomal storage disease (LSD) caused by variants in the : Methods: Sanger sequencing of the : Results: The patient's limb muscle tension was significantly reduced, and his ... ...

    Abstract Background: Mucolipidosis type II (MLII), or I-cell disease, is a rare lysosomal storage disease (LSD) caused by variants in the
    Methods: Sanger sequencing of the
    Results: The patient's limb muscle tension was significantly reduced, and his gross and fine motor skills were improved four months after transplantation. DST(Developmental Screen Test) results showed that the patient's fine motor skills and mental development were improved compared with before HSCT.
    Conclusion: MLII is a very severe lysosomal storage disease, to date, only 3 cases have been reported on the use of HSCT to treat MLII. Our data show that HSCT is a potential way to prolong the life of patients and improve their quality of life. Due to the lack of comparable data and time, the exact benefit remains unclear in MLII patients. Longer-term follow-up and in-depth prospective studies are indispensable.
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1199489
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  7. Article ; Online: Stabbing plus cupping: A less invasive but more powerful sucking approach for superficial abscesses.

    Fan, Xin / Raghoonundun, Chetna-Devi / Tang, Wen-Hao

    Asian journal of surgery

    2017  Volume 40, Issue 6, Page(s) 498–499

    MeSH term(s) Abscess/surgery ; Anal Canal ; Breast ; Face ; Female ; Humans ; Male ; Medicine, Chinese Traditional/instrumentation ; Medicine, Chinese Traditional/methods ; Suction/instrumentation ; Suction/methods
    Language English
    Publishing date 2017-10-14
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2017.09.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  8. Article ; Online: Transcoelomic spread and ovarian seeding during ovulation: A possible pathogenesis of Krukenberg tumor.

    Shah, Bikash / Tang, Wen-Hao / Karn, Shammi

    Journal of cancer research and therapeutics

    2017  Volume 13, Issue 1, Page(s) 152–153

    MeSH term(s) Female ; Humans ; Krukenberg Tumor/pathology ; Neoplasm Metastasis/pathology ; Neoplasm Seeding ; Ovarian Neoplasms/pathology ; Ovulation
    Language English
    Publishing date 2017-05-15
    Publishing country India
    Document type Letter
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.206234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Psychological status of infertile men during the Coronavirus Disease 2019 Pandemic in China: a cross-sectional investigation.

    Zhang, Zhe / Yang, Yu-Zhuo / Zhang, Hai-Tao / Xi, Yu / Wang, Cun-Tong / Liu, De-Feng / Mao, Jia-Ming / Lin, Hao-Cheng / Tang, Wen-Hao / Zhao, Lian-Ming / Zhang, Xian-Sheng / Dai, Yu-Tian / Jiang, Hui

    Basic and clinical andrology

    2023  Volume 33, Issue 1, Page(s) 8

    Abstract: Background: The coronavirus disease 2019 (COVID-19) outbreak has had a widespread and profound impact on people's mental health. The factors associated with mental symptoms among men diagnosed with infertility, a disease closely related to psychological ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) outbreak has had a widespread and profound impact on people's mental health. The factors associated with mental symptoms among men diagnosed with infertility, a disease closely related to psychological conditions, remain unclear. The aim of this study is to investigate the risk factors associated with mental symptoms among infertile Chinese men during the pandemic.
    Results: A total of 4,098 eligible participants were recruited in this cross-sectional, nationwide study, including 2,034 (49.6%) with primary infertility and 2,064 (50.4%) with secondary infertility. The prevalence of mental health conditions was 36.3%, 39.6%, and 6.7% for anxiety, depression, and post-pandemic stress, respectively. Sexual dysfunction is associated with a higher risk with adjusted odds ratios (ORs) of 1.40 for anxiety, 1.38 for depression, and 2.32 for stress. Men receiving infertility drug therapy displayed a higher risk for anxiety (adjusted OR, 1.31) and depression (adjusted OR, 1.28) symptoms, while those receiving intrauterine insemination had a lower risk of anxiety (adjusted OR, 0.56) and depression (adjusted OR, 0.55) symptoms.
    Conclusion: The COVID-19 pandemic has had a significant psychological impact on infertile men. Several psychologically vulnerable populations were identified, including individuals with sexual dysfunction, respondents receiving infertility drug therapy, and those experiencing control measures for COVID-19. The findings provide a comprehensive profile of the mental health status of infertile Chinese men during the COVID-19 outbreak and provide potential psychological intervention strategies.
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2732675-5
    ISSN 2051-4190
    ISSN 2051-4190
    DOI 10.1186/s12610-022-00177-5
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  10. Article ; Online: Sperm retrieval outcomes of contralateral testis in men with nonobstructive azoospermia and unsuccessful unilateral microdissection testicular sperm extraction.

    Zhang, Zhe / Xi, Yu / Liu, De-Feng / Mao, Jia-Ming / Zhang, Hai-Tao / Lin, Hao-Cheng / Tang, Wen-Hao / Jiang, Hui / Hong, Kai / Zhao, Lian-Ming

    Fertility and sterility

    2023  Volume 121, Issue 3, Page(s) 540–542

    Abstract: ...

    Abstract ▪▪▪.
    MeSH term(s) Humans ; Male ; Testis/surgery ; Azoospermia/diagnosis ; Azoospermia/surgery ; Sperm Retrieval ; Microdissection ; Retrospective Studies ; Semen ; Spermatozoa
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Letter
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.11.023
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