LIVIVO - Search results -

Search results

Result 1 - 10 of total 131

Search options

Article ; Online: Protocol for geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.

Shin, Justin D / Tang, Wenbo / Jadhav, Shantanu P

STAR protocols

2023 Volume 4, Issue 3, Page(s) 102513

Abstract: Memory generalization is the ability to abstract knowledge from prior experiences and is critical for flexible behavior in novel situations. Here, we describe a protocol for simultaneous recording of hippocampal (area CA1)-prefrontal cortical neural ... ...

Abstract	Memory generalization is the ability to abstract knowledge from prior experiences and is critical for flexible behavior in novel situations. Here, we describe a protocol for simultaneous recording of hippocampal (area CA1)-prefrontal cortical neural ensembles in Long-Evans rats during task generalization across two distinct environments. We describe steps for building and assembling experimental apparatuses, animal preparation and surgery, and performing experiments. We then detail procedures for histology, data processing, and assessing population geometry using Uniform Manifold Approximation and Projection. For complete details on the use and execution of this protocol, please refer to Tang et al. (2023).
MeSH term(s)	Rats ; Animals ; Rats, Long-Evans ; Hippocampus ; Generalization, Psychological ; Cognition
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102513
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.

Tang, Wenbo / Shin, Justin D / Jadhav, Shantanu P

Cell reports

2023 Volume 42, Issue 3, Page(s) 112246

Abstract: The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry. The hippocampus encodes navigational information in a ... ...

Abstract	The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry. The hippocampus encodes navigational information in a cognitive map, but it remains unclear how cognitive maps are transformed across hippocampal-prefrontal circuits to support abstraction and generalization. Here, we simultaneously record hippocampal-prefrontal ensembles as rats generalize navigational rules across distinct environments. We find that, whereas hippocampal representational maps maintain specificity of separate environments, prefrontal maps generalize across environments. Furthermore, while both maps are structured within a neural manifold of population activity, they have distinct representational geometries. Prefrontal geometry enables abstraction of rule-informative variables, a representational format that generalizes to novel conditions of existing variable classes. Hippocampal geometry lacks such abstraction. Together, these findings elucidate how cognitive maps are structured into distinct geometric representations to support abstraction and generalization while maintaining memory specificity.
MeSH term(s)	Rats ; Animals ; Prefrontal Cortex ; Hippocampus ; Cognition
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112246
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multiple-Timescale Representations of Space: Linking Memory to Navigation.

Tang, Wenbo / Jadhav, Shantanu P

Annual review of neuroscience

2021 Volume 45, Page(s) 1–21

Abstract: When navigating through space, we must maintain a representation of our position in real time; when recalling a past episode, a memory can come back in a flash. Interestingly, the brain's spatial representation system, including the hippocampus, supports ...

Abstract	When navigating through space, we must maintain a representation of our position in real time; when recalling a past episode, a memory can come back in a flash. Interestingly, the brain's spatial representation system, including the hippocampus, supports these two distinct timescale functions. How are neural representations of space used in the service of both real-world navigation and internal mnemonic processes? Recent progress has identified sequences of hippocampal place cells, evolving at multiple timescales in accordance with either navigational behaviors or internal oscillations, that underlie these functions. We review experimental findings on experience-dependent modulation of these sequential representations and consider how they link real-world navigation to time-compressed memories. We further discuss recent work suggesting the prevalence of these sequences beyond hippocampus and propose that these multiple-timescale mechanisms may represent a general algorithm for organizing cell assemblies, potentially unifying the dual roles of the spatial representation system in memory and navigation.
MeSH term(s)	Hippocampus ; Memory ; Space Perception
Language	English
Publishing date	2021-12-22
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	282459-0
ISSN	1545-4126 ; 0147-006X
ISSN (online)	1545-4126
ISSN	0147-006X
DOI	10.1146/annurev-neuro-111020-084824
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1433: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Near-infrared spectroscopy combined with fuzzy fast pseudoinverse linear discriminant analysis to discriminate mee tea grades.

Wu, Bin / Tang, Wenbo / Zhou, Jin / Jia, Hongwen / Shen, Hualei / Qi, Zuxuan

Heliyon

2024 Volume 10, Issue 5, Page(s) e27732

Abstract: Mee tea, one of the major types of green tea in China, is often used for export because of its elegant appearance, high fragrance and strong taste. However, the quality of tea differs greatly due to the difference in raw material selection and production ...

Abstract	Mee tea, one of the major types of green tea in China, is often used for export because of its elegant appearance, high fragrance and strong taste. However, the quality of tea differs greatly due to the difference in raw material selection and production technology level. In order to accurately and quickly differentiate different grades of Mee tea, fuzzy fast pseudoinverse linear discriminant analysis (FFPLDA) was proposed based on fast pseudoinverse linear discriminant analysis (FPLDA) for extracting discriminant information from near-infrared (NIR) spectra. Firstly, NIR spectra of Mee tea samples were acquired, and then they were preprocessed by multiplicative scatter correlation (MSC). Secondly, the compression of data was achieved by principal component analysis (PCA). Thirdly, linear discriminant analysis (LDA), FPLDA, FFPLDA and fuzzy Foley-Sammon transformation (FFST) were respectively performed to retrieve discriminant information from NIR data. Finally, the K-nearest neighbor (KNN) was utilized to classify Mee tea grades. In this study, experimental results showed that the accuracy of FFPLDA was higher than that of LDA, FFST and FPLDA. Therefore, NIR spectroscopy coupled with FFPLDA and KNN has a good effect in discrimination of Mee tea grades and also a great application potential.
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27732
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9

Shan, Erbo / Yu, Yuanyuan / Tang, Wenbo / Wang, Wei / Wang, Xiangkui / Zhou, Shaobo / Gao, Yong

Funct Integr Genomics. 2023 June, v. 23, no. 2 p.77-77

2023

Abstract: Atherosclerosis (AS) is the main cause of cardiovascular diseases. However, the role of AQP9 in AS is not well understood. In the present study, we predicted that miR-330-3p might regulate AQP9 in AS through bioinformatics analysis, and we established AS ...

Abstract	Atherosclerosis (AS) is the main cause of cardiovascular diseases. However, the role of AQP9 in AS is not well understood. In the present study, we predicted that miR-330-3p might regulate AQP9 in AS through bioinformatics analysis, and we established AS model using ApoE⁻/⁻ mouse (C57BL/6) with high-fat diet (HFD). Hematoxylin and eosin (H&E) and Oil red O staining were used to determine atherosclerotic lesions. CCK8 and Ethyny1-2-deoxyuridine (EdU) assays were used to investigate human umbilical vein endothelial cells (HUVECs) proliferation after treatment with 100 μg/mL ox-LDL. Wound scratch healing and transwell assays were used to measure the cell invasion and migration ability. Flow cytometry assay was used to determine apoptosis and cell cycle. A dual-luciferase reporter assay was performed to investigate the binding of miR-330-3p and AQP9. We identified that the expression of miR-330-3p in AS mice model decreased while the expression level of AQP9 increased. miR-330-3p overexpression or down-regulation of AQP9 could reduce cell apoptosis, promote cell proliferation, and migration after ox-LDL treatment. Dual-luciferase reporter assay result presented that AQP9 was directly inhibited by miR-330-3p. These results suggest that miR-330-3p inhibits AS by regulating AQP9. miR-330-3p/AQP9 axis may be a new therapeutic target for AS.
Keywords	apoptosis ; atherosclerosis ; bioinformatics ; bioluminescence assay ; cell cycle ; cell proliferation ; eosin ; flow cytometry ; genomics ; high fat diet ; mice ; models ; therapeutics
Language	English
Dates of publication	2023-06
Size	p. 77.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01001-7
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5230: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Three-channel ion chromatograph for improved metabolic evaluation of urolithiasis.

Li, Qiang / Liu, Guanlin / Cheng, Yue / Tang, Wenbo

BMC urology

2021 Volume 21, Issue 1, Page(s) 151

Abstract: Background: Urolithiasis is a multi-etiological disease resulting from a combination of environmental and genetic factors. One of the most challenging aspects of this disease is its high recurrence rate. For most patients, an in-depth metabolic ... ...

Abstract	Background: Urolithiasis is a multi-etiological disease resulting from a combination of environmental and genetic factors. One of the most challenging aspects of this disease is its high recurrence rate. For most patients, an in-depth metabolic evaluation may reveal the presence of urinary stones. The fact that different urinary stone-related compounds (USRCs) are measured by different methods renders the metabolic evaluation of urolithiasis quite tedious and complex. Methods: A three-channel ion chromatograph (IC) that automatically measures the concentration of common metabolic indicators of urolithiasis in urine (i.e., oxalate, citrate, uric acid, calcium, and magnesium) was developed to improve the efficiency. To validate its precision and specificity, standard curves were prepared using working solution of these indicators. 100 standard solutions of these indicators were measured with our new IC and three other ICs as the control instruments; analyte concentrations in 100 24-h urine samples from volunteers and 135 calculi patients were also measured. Results: All analytes had good linear relationships in concentration ranges of 0-10 mg/L. The precision experiments in the standard and urine samples showed that the measurement errors of the newly developed IC were all less than 5%. In urine, the recovery rate ranged from 99.6 to 100.4%, the coefficient of variation ranged from 1.39 to 2.99%, and the results matched between our newly developed IC and the control ICs. The results of the efficiency test showed that we can finish the analysis at the average number of 14 people per day with the new IC. While the average number in the control group is 3.85/day (p = 0.000). Conclusions: Overall, this multi-channel system significantly improves the efficiency of metabolic evaluation while retaining accuracy and precision.
MeSH term(s)	Calcium Oxalate/urine ; Chromatography, Ion Exchange/methods ; Citric Acid/urine ; Humans ; Magnesium/urine ; Reproducibility of Results ; Uric Acid/urine ; Urolithiasis/diagnosis ; Urolithiasis/urine
Chemical Substances	Calcium Oxalate (2612HC57YE) ; Uric Acid (268B43MJ25) ; Citric Acid (2968PHW8QP) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-11-06
Publishing country	England
Document type	Journal Article ; Validation Study
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-021-00914-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multiple time-scales of decision-making in the hippocampus and prefrontal cortex.

Tang, Wenbo / Shin, Justin D / Jadhav, Shantanu P

eLife

2021 Volume 10

Abstract: The prefrontal cortex and hippocampus are crucial for memory-guided decision-making. Neural activity in the hippocampus exhibits place-cell sequences at multiple timescales, including slow behavioral sequences (~seconds) and fast theta sequences (~100- ... ...

Abstract	The prefrontal cortex and hippocampus are crucial for memory-guided decision-making. Neural activity in the hippocampus exhibits place-cell sequences at multiple timescales, including slow behavioral sequences (~seconds) and fast theta sequences (~100-200 ms) within theta oscillation cycles. How prefrontal ensembles interact with hippocampal sequences to support decision-making is unclear. Here, we examined simultaneous hippocampal and prefrontal ensemble activity in rats during learning of a spatial working-memory decision task. We found clear theta sequences in prefrontal cortex, nested within its behavioral sequences. In both regions, behavioral sequences maintained representations of current choices during navigation. In contrast, hippocampal theta sequences encoded alternatives for deliberation and were coordinated with prefrontal theta sequences that predicted upcoming choices. During error trials, these representations were preserved to guide ongoing behavior, whereas replay sequences during inter-trial periods were impaired prior to navigation. These results establish cooperative interaction between hippocampal and prefrontal sequences at multiple timescales for memory-guided decision-making.
MeSH term(s)	Animals ; CA1 Region, Hippocampal/cytology ; CA1 Region, Hippocampal/physiology ; Decision Making/physiology ; Learning/physiology ; Male ; Prefrontal Cortex/cytology ; Prefrontal Cortex/physiology ; Rats ; Rats, Long-Evans ; Spatial Memory/physiology ; Theta Rhythm ; Time Factors
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.66227
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: TQB2450 in patients with advanced malignant tumors: results from a phase I dose-escalation and expansion study.

Xue, Junli / Xue, Liqiong / Tang, Wenbo / Ge, Xiaoxiao / Zhao, Wei / Li, Qun / Peng, Wei / Dai, Congqi / Guo, Ye / Li, Jin

Therapeutic advances in medical oncology

2024 Volume 16, Page(s) 17588359231220516

Abstract: Background: Immune checkpoint inhibitor therapy has demonstrated impressive clinical benefits in multiple tumor types. TQB2450, a novel monoclonal antibody targeting programmed cell death ligand 1, has shown safety and efficacy in preclinical studies.!## ...

Abstract	Background: Immune checkpoint inhibitor therapy has demonstrated impressive clinical benefits in multiple tumor types. TQB2450, a novel monoclonal antibody targeting programmed cell death ligand 1, has shown safety and efficacy in preclinical studies. Objectives: This first-in-human study aimed to evaluate the safety/tolerability, pharmacokinetics (PK), immunogenicity, and preliminary antitumor activity of TQB2450 in patients with advanced malignant tumors. Design and methods: In this phase I study, eligible patients with advanced malignant tumors received intravenous TQB2450 once every 3 weeks. This study consisted of a 3 + 3 dose-escalation phase (1-30 mg/kg) and a specific dose-expansion phase (1200 mg). The primary endpoints were maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and safety. The secondary endpoints were PK, immunogenicity, and investigator-assessed response rate. Results: Between April 2018 and February 2020, 40 patients were enrolled (22 in the dose-escalation phase and 18 in the dose-expansion phase). No DLT was reported and the MTD was not reached. Grade ⩾3 or worse treatment-related treatment-emergent adverse events (AEs) occurred in 11 (27.50%) patients, with the most frequent being aspartate aminotransferase increased (5.00%), leukopenia (5.00%), and anemia (5.00%). Treatment-related serious AEs were reported in six patients, the most common of which was decompensated liver function (5.00%). No treatment-related death was reported. The maximum serum concentration of TQB2450 increased in a dose-proportional manner. Treatment-induced anti-drug antibodies were detected in 31.58% (12/38) of patients. The investigator assessed the objective response rate as 5.00% and the disease control rate was 52.50%, including 2 partial responses and 19 stable diseases. The median progression-free survival was 2.69 (95% confidence interval, 2.07-6.14) months. Conclusion: TQB2450 has a manageable safety profile with favorable PK and immunogenicity and has shown early evidence of clinical activity in advanced malignant tumors. Clinicaltrialsgov identifier: NCT03460457.
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359231220516
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Associative and predictive hippocampal codes support memory-guided behaviors.

Liu, Can / Todorova, Ralitsa / Tang, Wenbo / Oliva, Azahara / Fernandez-Ruiz, Antonio

Science (New York, N.Y.)

2023 Volume 382, Issue 6668, Page(s) eadi8237

Abstract: Episodic memory involves learning and recalling associations between items and their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions to be made. The mechanisms that support these ...

Abstract	Episodic memory involves learning and recalling associations between items and their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions to be made. The mechanisms that support these associative and predictive aspects of memory are not yet understood. In this study, we used an optogenetic manipulation to perturb the sequential structure, but not global network dynamics, of place cells as rats traversed specific spatial trajectories. This perturbation abolished replay of those trajectories and the development of predictive representations, leading to impaired learning of new optimal trajectories during memory-guided navigation. However, place cell assembly reactivation and reward-context associative learning were unaffected. Our results show a mechanistic dissociation between two complementary hippocampal codes: an associative code (through coactivity) and a predictive code (through sequences).
MeSH term(s)	Animals ; Rats ; Conditioning, Classical ; Hippocampus/cytology ; Hippocampus/physiology ; Memory, Episodic ; Mental Recall ; Optogenetics ; Theta Rhythm ; Male ; Rats, Long-Evans ; Association Learning
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adi8237
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.

Shan, Erbo / Yu, Yuanyuan / Tang, Wenbo / Wang, Wei / Wang, Xiangkui / Zhou, Shaobo / Gao, Yong

Functional & integrative genomics

2023 Volume 23, Issue 2, Page(s) 77

Abstract	Atherosclerosis (AS) is the main cause of cardiovascular diseases. However, the role of AQP9 in AS is not well understood. In the present study, we predicted that miR-330-3p might regulate AQP9 in AS through bioinformatics analysis, and we established AS model using ApoE
MeSH term(s)	Humans ; Animals ; Mice ; Mice, Inbred C57BL ; Endothelial Cells ; Apoptosis/genetics ; Atherosclerosis/genetics ; MicroRNAs/genetics ; Aquaporins
Chemical Substances	MicroRNAs ; AQP9 protein, human ; Aquaporins ; MIRN330 microRNA, human ; Aqp9 protein, mouse
Language	English
Publishing date	2023-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01001-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5230: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito