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Article ; Online: Role of STING in the treatment of non-small cell lung cancer.

Tang, Wenhua / Zhou, Wenjie / Ji, Mei / Yang, Xin

2024 Volume 22, Issue 1, Page(s) 202

Abstract: Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. ... ...

Abstract	Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients who cannot benefit from them. Consequently, it is essential to identify a novel research target that offers an encouraging perspective. The stimulator of interferon genes (STING) has emerged as such a target. At present, it is confirmed that activating STING in NSCLC tumor cells can impede the proliferation and metastasis of dormant tumor cells. This review focuses on the role of STING in NSCLC treatment and the factors influencing its activation. Additionally, it explores the correlation between STING activation and diverse therapy modalities for NSCLC, such as radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. Furthermore, it proposes the prospect of innovative therapy methods involving nanoparticles, with the aim of using the features of STING to develop more strategies for NSCLC therapy.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/therapy ; Lung Neoplasms/therapy ; Immunotherapy ; Molecular Targeted Therapy ; Nanoparticles
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-024-01586-x
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Article ; Online: Concurrent cisplatin or cetuximab with radiotherapy in patients with locally advanced head and neck squamous cell carcinoma: A meta-analysis.

Tang, Wen-Hua / Sun, Wei / Long, Guo-Xian

Medicine

2020 Volume 99, Issue 36, Page(s) e21785

Abstract: Background: Concurrent cisplatin with radiotherapy (CRT) or concurrent cetuximab with radiotherapy (BRT) improves outcomes in locally advanced head and neck squamous cell carcinoma (HNSCC) compared with radiotherapy alone. Nevertheless, a detailed ... ...

Abstract	Background: Concurrent cisplatin with radiotherapy (CRT) or concurrent cetuximab with radiotherapy (BRT) improves outcomes in locally advanced head and neck squamous cell carcinoma (HNSCC) compared with radiotherapy alone. Nevertheless, a detailed comparison between CRT and BRT in locally advanced HNSCC is required due to inconclusive results. Methods: A comprehensive literature search was conducted on PubMed, Web of Science, Cochrane databases, and EMBASE. Studies that evaluated CRT vs BRT in locally advanced HNSCC were included. The primary outcome that was overall survival (OS), whereas the secondary outcomes were progression-free survival (PFS), locoregional control (LRC), and distant metastasis-free survival (DMFS). Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to evaluate prognosis. All the analyses were performed using Stata Statistical Software 12.0. Results: Twenty-three studies, with a total of 8701 patients, were considered eligible and included in this meta-analysis. Our results revealed that patients treated with CRT had longer OS (HR = 0.51, 95%CI, 0.41-0.64, P < .001), PFS (HR = 0.37, 95%CI, 0.23-0.60, P < .001), LRC (HR = 0.46, 95%CI, 0.37-0.57, P < .001), and DMFS (HR = 0.56, 95%CI, 0.40-0.77, P < .001) than those treated with BRT. Furthermore, the results of the subgroup analyses were consistent with the primary analysis. Conclusions: CRT has a better OS, PFS, LRC, and DMFS than BRT in locally advanced HNSCC, and should be the preferred treatment for patients with the disease.
MeSH term(s)	Aged ; Cetuximab/therapeutic use ; Chemoradiotherapy/methods ; Cisplatin/therapeutic use ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/therapy ; Humans ; Male ; Middle Aged ; Progression-Free Survival ; Squamous Cell Carcinoma of Head and Neck/mortality ; Squamous Cell Carcinoma of Head and Neck/therapy
Chemical Substances	Cetuximab (PQX0D8J21J) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000021785
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Article ; Online: Bariatric surgery in adolescents.

Zhang, Yu / Tang, Wenhua

The lancet. Diabetes & endocrinology

2017 Volume 5, Issue 5, Page(s) 326

Language	English
Publishing date	2017-05
Publishing country	England
Document type	Letter
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(17)30112-2
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Article ; Online: Concerns About Methodology of a Trial Investigating Vaginal Health During Aromatase Inhibitor Therapy for Breast Cancer.

Tang, Wenhua / Zhang, Yu

JAMA oncology

2017 Volume 3, Issue 8, Page(s) 1140–1141

MeSH term(s)	Aromatase ; Aromatase Inhibitors ; Breast Neoplasms ; Contraceptive Devices, Female ; Estradiol ; Female ; Humans ; Libido ; Testosterone
Chemical Substances	Aromatase Inhibitors ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E) ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2017-06-30
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2017.2071
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Article ; Online: Effects of Dexamethasone in the Treatment of Recurrent Chronic Subdural Hematoma.

Zhang, Yu / Chen, Shiping / Xiao, Yangchun / Tang, Wenhua

World neurosurgery

2017 Volume 105, Page(s) 115–121

Abstract: Objective: Recurrent chronic subdural hematoma (CSDH) is not rare. Some studies have demonstrated the role of dexamethasone in the medical management of chronic subdural hematoma. However, no systematic study in the treatment of recurrent CSDH has been ... ...

Abstract	Objective: Recurrent chronic subdural hematoma (CSDH) is not rare. Some studies have demonstrated the role of dexamethasone in the medical management of chronic subdural hematoma. However, no systematic study in the treatment of recurrent CSDH has been published. The aim of our study is to evaluate the efficacy and safety of dexamethasone in patients with recurrent CSDH. Methods: We retrospectively reviewed medical records of consecutive patients from July 2010 to September 2014. A total of 27 patients with symptomatic recurrent CSDH were included in the analysis. Follow-up for each patient consisted of computed tomography or magnetic resonance imaging every 28 days from admission to the resolution of hematoma. Data were collected on hematoma volume, complications, and outcome. Results: Among the 27 patients, 3 patients with recurrent CSDH were only treated by burr hole surgery. Of the other 24 patients who primarily underwent dexamethasone treatment, 17 (70.8%) patients were treated successfully with medical treatment, whereas 7 patients required reoperation. Complications were noted in 3 (12.5%) patients (1 hyperglycemia, 1 urinary tract infection, and 1 pneumonia). There was 1 mortality (4.2%) for massive brain infarction. Twenty-one of the 24 patients (87.5%) recovered to their previous functional levels. There was no statistical significance in Fisher text between surgery and dexamethasone regarding success, complication, and functional recovery rate. Conclusions: Patients with recurrent CSDH can be treated successfully and safely with the nonsurgical medical treatment of dexamethasone. By use of this method, reoperation may be avoided.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Dexamethasone/adverse effects ; Dexamethasone/therapeutic use ; Female ; Hematoma, Subdural, Chronic/drug therapy ; Hematoma, Subdural, Chronic/surgery ; Humans ; Male ; Middle Aged ; Recurrence ; Reoperation/methods ; Retrospective Studies ; Secondary Prevention ; Tomography, X-Ray Computed/adverse effects ; Treatment Outcome
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2017.05.135
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Article ; Online: Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma.

Zhu, Wenjun / Chen, Ziqi / Fu, Min / Li, Qianxia / Chen, Xin / Li, Xiaoyu / Luo, Na / Tang, Wenhua / Yang, Feng / Zhang, Yiling / Zhang, Yuanyuan / Peng, Xiaohong / Hu, Guangyuan

Apoptosis : an international journal on programmed cell death

2023 Volume 29, Issue 1-2, Page(s) 169–190

Abstract: Cuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insight into the relationship between cuprotosis ... ...

Abstract	Cuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insight into the relationship between cuprotosis and LGG patients' prognosis, we conducted this study in which LGG patients were divided into two clusters based on the expression of 18 cuprotosis-related genes. We found that LGG patients in cluster A had better prognosis than those in cluster B. The two clusters also differed in terms of immune cell infiltration and biological functions. Moreover, we identified differentially expressed genes (DEGs) between the two clusters and developed a cuprotosis-related prognostic signature through the least absolute shrinkage and selection operator (LASSO) analysis in the TCGA training cohort. This signature divided LGG patients into high- and low-risk groups, with the high-risk group having significantly shorter overall survival (OS) time than the low-risk group. Its predictive reliability for prognosis in LGG patients was confirmed by the TCGA internal validation cohort, CGGA325 cohort and CGGA693 cohort. Additionally, a nomogram was used to predict the 1-, 3-, and 5-year OS rates of each patient. The analysis of immune checkpoints and tumor mutation burden (TMB) has revealed that individuals belonging to high-risk groups have a greater chance of benefiting from immunotherapy. Functional experiments confirmed that interfering with the signature gene TNFRSF11B inhibited LGG cell proliferation and migration. Overall, this study shed light on the importance of cuprotosis in LGG patient prognosis. The cuprotosis-related prognostic signature is a reliable predictor for patient outcomes and immunotherapeutic response and can help to develop new therapies for LGG.
MeSH term(s)	Humans ; Reproducibility of Results ; Apoptosis ; Cell Death ; Glioma/genetics ; Glioma/therapy ; Immunotherapy
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1452360-7
ISSN	1573-675X ; 1360-8185
ISSN (online)	1573-675X
ISSN	1360-8185
DOI	10.1007/s10495-023-01880-y
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Article ; Online: Two-Year Outcome after Endovascular Treatment for Stroke.

Zhang, Yu / Chen, Shiping / Tang, Wenhua

The New England journal of medicine

2017 Volume 376, Issue 26, Page(s) 2597

MeSH term(s)	Brain Ischemia ; Humans ; Stroke
Language	English
Publishing date	2017--29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1705673
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Article: Supramolecular Copolymerization Strategy for Realizing the Broadband White Light Luminescence Based on N-Deficient Porous Graphitic Carbon Nitride (g-C3N4)

Tang, Wenhua / Tian, Ying / Chen, BoWen / Xu, Yayan / Li, Bingpeng / Jing, Xufeng / Zhang, Junjie / Xu, Shiqing

ACS applied materials & interfaces. 2020 Jan. 09, v. 12, no. 5

2020

Abstract: The N-deficient porous g-C3N4 with broadband white light emission was constructed by supramolecular copolymerization design, which combined organic copolymers cyanuric acid and 2,4,6-triaminopyrimidine with melamine upon the mixture gas environment of ( ... ...

Abstract	The N-deficient porous g-C3N4 with broadband white light emission was constructed by supramolecular copolymerization design, which combined organic copolymers cyanuric acid and 2,4,6-triaminopyrimidine with melamine upon the mixture gas environment of (95%)N2/(5%)H2. Herein, we achieved great breakthrough in narrowing the band gap of g-C3N4 from 2.64 to 1.39 eV. Furthermore, in contrast to pristine g-C3N4, we demonstrated that the emission wavelengths of N-deficient porous g-C3N4 can be tuned from narrow blue to broadband white range, where the optimal white light coordinate position is (0.297, 0.345). The prepared N-deficient porous g-C3N4 overcomes the limitation of the narrow adjusting range of optical properties while using conventional g-C3N4 and makes it more promising for applications in solid-state displays.
Keywords	carbon nitride ; composite polymers ; copolymerization ; graphene ; luminescence ; melamine ; optical properties ; wavelengths ; white light
Language	English
Dates of publication	2020-0109
Size	p. 6396-6406.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.9b19338
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis and Evaluating Their Prognostic Value.

Zhou, Yangmei / Yang, Li / Zhang, Xiaoxi / Chen, Rui / Chen, Xiuqiong / Tang, Wenhua / Zhang, Mengxian

BioMed research international

2019 Volume 2019, Page(s) 6581576

Abstract: Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding the mechanisms of glioblastoma at the molecular level is essential for clinical treatment. In the present study, we used bioinformatics ... ...

Abstract	Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding the mechanisms of glioblastoma at the molecular level is essential for clinical treatment. In the present study, we used bioinformatics analysis to identify potential biomarkers associated with prognosis in glioblastoma and elucidate the underlying mechanisms. The result revealed that 552 common genes were differentially expressed between glioblastoma and normal tissues based on TCGA, GSE4290, and GSE 50161 datasets. Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and protein-protein interaction (PPI) network were carried out to gain insight into the actions of differentially expressed genes (DEGs). As a result, 20 genes (CALB1, CDC20, CDCA8, CDK1, CEP55, DLGAP5, KIF20A, KIF4A, NDC80, PBK, RRM2, SYN1, SYP, SYT1, TPX2, TTK, VEGFA, BDNF, GNG3, and TOP2A) were found as hub genes via CytoHubba in Cytoscape and functioned mainly by participating in cell cycle and p53 signaling pathway; among them, RRM2 and CEP55 were considered to have relationship with the prognosis of glioblastoma, especially RRM2. High expression of RRM2 was consistent with shorter overall survival time. In conclusion, our study displayed the bioinformatic analysis methods in screening potential oncogenes in glioblastoma and underlying mechanisms. What is more is that we successfully identified RRM2 as a novel biomarker linked with prognosis, which might be expected to be a promising target for the therapy of glioblastoma.
MeSH term(s)	Biomarkers, Tumor/genetics ; Cell Cycle Proteins/genetics ; Computational Biology ; Databases, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Prognosis ; Ribonucleoside Diphosphate Reductase/genetics
Chemical Substances	Biomarkers, Tumor ; Cell Cycle Proteins ; Cep55 protein, human ; Neoplasm Proteins ; Nuclear Proteins ; ribonucleotide reductase M2 (EC 1.17.4.-) ; Ribonucleoside Diphosphate Reductase (EC 1.17.4.1)
Language	English
Publishing date	2019-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/6581576
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Article ; Online: Investigation of actual exposure to facial sheet mask preceding its risk assessment.

Zhou, Lihong / Chen, Jian / Chen, Tian / Chang, Huailong / Cui, Wenguang / She, Yuanyuan / Li, Zhu / Tang, Wenhua / Yuan, Dengfeng / Chen, Zhitao / Su, Jin

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1215

Abstract: The present study aimed to reveal the amount per application of facial sheet masks and its influencing factors in Chinese population to form the base for an accurate exposure assessment. A total of 175 healthy subjects aged 18 years or older were ... ...

Abstract	The present study aimed to reveal the amount per application of facial sheet masks and its influencing factors in Chinese population to form the base for an accurate exposure assessment. A total of 175 healthy subjects aged 18 years or older were recruited and divided into two subgroups: one group of 35 subjects were asked to apply same mask for 5, 10, 15, 20, 25, and 30 min respectively, and the other 140 subjects were instructed to apply one of four types of facial sheet masks presented in the market for 15 min. Furthermore, phenoxyethanol and methylparaben were measured to reflect actual exposure to chemicals. The sharp increase in the relative exposure to phenoxyethanol (CAS NO.122-99-6) and methylparaben at 25 min and longer suggests applying facial sheet masks for longer than 20 min may drive the exposure to hazardous chemicals to increase significantly. The 90th percentile of amount per application for plant-cellulose, bamboo charcoal fiber, bio-cellulose, and binchotan charcoal fiber-based masks was 5.753, 5.371, 5.017, and 4.821 g respectively. In addition, men and subjects with sebaceous skin demonstrated lower amount per application compared to women and subjects with dry skin, respectively. Finally, our data showed that the larger the contacting area between face and mask, the more amount per application. We concluded that the appropriate time of application should be less than 20 min. And mask fabrics, gender, sebum content, and contacting area could significantly impact the risk assessment of facial sheet masks. Our data for the first time provides insights into a realistic risk assessment of facial sheet masks in Chinese population.
MeSH term(s)	Administration, Cutaneous ; Adult ; Cosmetics/administration & dosage ; Face ; Female ; Humans ; Male ; Middle Aged ; Risk Assessment ; Skin/drug effects
Chemical Substances	Cosmetics
Language	English
Publishing date	2022-01-24
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05351-3
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