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Article: Association of non-HDL-C/apoB ratio with long-term mortality in the general population: A cohort study.

Zhang, Kerui / Wei, Chenchen / Shao, Yaqing / Wang, Li / Zhao, Zongquan / Yin, Song / Tang, Xuejun / Li, Yuan / Gou, Zhongshan

Heliyon

2024 Volume 10, Issue 6, Page(s) e28155

Abstract: Background: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable ... ...

Abstract	Background: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable indicator for assessing the risk of cardiovascular disease. However, the ability of non-HDL-C/apoB ratio to predict the risk of long-term mortality among the general population remains uncertain. The aim of this study is to explore the association of non-HDL-C/apoB ratio with long-term all-cause and cardiovascular mortality in adults of the United States. Methods: This retrospective cohort study was a further analysis of existing information from the National Health and Nutrition Examination Survey (NHANES). In the ultimate analysis, 12,697 participants from 2005 to 2014 were included. Kaplan-Meier (K-M) curves and the log-rank test were applied to visualize survival differences between groups. Multivariate Cox regression and restricted cubic spline (RCS) models were applied to evaluate the association of non-HDL-C/apoB ratio with all-cause and cardiovascular mortality. Subgroup analysis was conducted for the variables of age, sex, presence of coronary artery disease, diabetes and hypertriglyceridemia and usage of lipid-lowering drugs. Results: The average age of the cohort was 46.8 ± 18.6 years, with 6215 (48.9%) participants being male. During a median follow-up lasting 68.0 months, 891 (7.0%) deaths were documented and 156 (1.2%) patients died of cardiovascular disease. Individuals who experienced all-cause and cardiovascular deaths had a lower non-HDL-C/apoB ratio compared with those without events (1.45 ± 0.16 Conclusions: The non-HDL-C/apoB ratio may serve as a potential biomarker for predicting long-term mortality among the general population, independent of traditional risk factors.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28155
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research on operation and maintenance cost of power grid equipment based on standard operation-taking 220kV transformer substation as an example

Zhang Xuefei / Li Zhiwei / Wang Chengzhi / Tang Xuejun / Yang Sen

E3S Web of Conferences, Vol 292, p

2021 Volume 01005

Abstract: In view of the inadequate implementation of the grid operation and maintenance standards and specifications current, the lack of planning in cost usage, and the inability to achieve single equipment collection of costs, taking 220kV substation as an ... ...

Abstract	In view of the inadequate implementation of the grid operation and maintenance standards and specifications current, the lack of planning in cost usage, and the inability to achieve single equipment collection of costs, taking 220kV substation as an example, this paper proposes a single asset operation and maintenance cost calculation method based on grid standard operations, and puts forward suggestions on the cost management of grid equipment operation and maintenance. Through verification and analysis with the relevant provisions of the cost supervision and examination method, the power grid company will face greater operating pressure, and the cost management level needs to be further improved. Through the calculation of the operation and maintenance cost of a single asset, it provides a reference basis for the distribution of the operation and maintenance cost of the power grid enterprise, and at the same time provides a reasonable explanation for the power grid enterprise to adapt to the cost supervision and review of the transportation dispatching pricing.
Keywords	Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimization strategy of operation and maintenance based on econometric model

Zhang Xuefei / Li Zhiwei / Wang Chengzhi / Tang Xuejun / Yang Sen

E3S Web of Conferences, Vol 292, p

2021 Volume 03028

Abstract: With the continuous development of power grid, the investment of equipment assets is increasing sharply during the 13th Five Year Plan Period. There is a growing need for equipment maintenance as the equipment ages and varies in different types from ... ...

Abstract	With the continuous development of power grid, the investment of equipment assets is increasing sharply during the 13th Five Year Plan Period. There is a growing need for equipment maintenance as the equipment ages and varies in different types from transmission to distribution equipment. Equipment is the base element of healthy power grid development. Therefore, it is important to raise the efficiency and quality of equipment status via operation and maintenance. To improve the effectiveness of equipment maintenance, reduce the maintenance cost, improve the safe operation level and power supply reliability of power grid, this paper uses econometric model of correlation analysis to build the correlation between daily overhaul, operation and maintenance and fault frequency and voltage qualification rate, so as to provide optimal decision for the development of operation, inspection and maintenance of power grid company.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article: Temporal Variation and Reduction Strategy of Nutrient Loads from an Urban River Catchment into a Eutrophic Lake, China

Qin, Chengxin / Du, Pengfei / Hao, Qianting / Li, Zhiyi / Tang, Xuejun / Wu, Yihui / Xie, Pengcheng

Water. 2019 Jan. 17, v. 11, no. 1

2019

Abstract: Excessive nutrient input from urban areas increases the occurrence of eutrophication. Control of nutrient loads is perceived as the primary restoration method. Quantifying temporal variation of nutrient loads is essential to understand the dynamic ... ...

Abstract	Excessive nutrient input from urban areas increases the occurrence of eutrophication. Control of nutrient loads is perceived as the primary restoration method. Quantifying temporal variation of nutrient loads is essential to understand the dynamic relationships of nutrient source-impacts in the urban water system and investigate the operational efficiency of treatment facilities for eutrophication control. Here, a holistic approach was developed to estimate nutrient loads from different sources and evaluate nutrient impacts on the urban water environment. An integrated catchment model of nutrient loads was built and applied to calculate river nutrient loads from untreated rainfall runoff, untreated sewage, and treated recharge into the eutrophic Dianchi Lake from an urban river catchment with limited infrastructure. Nutrient impacts on the lake were evaluated and a load reduction strategy was given a hint to reduce nutrient impacts of urban rivers. During the study period 2014–2016, nutrient loads from the urban river generally decreased except during heavy winter rainfall events and high-intensity pollution events associated with rainfall runoff. The average contribution of annual nutrient loads to the lake capacity indicated the underestimation of nutrient impacts of urban rivers. This approach provides new insights into urban water management and underscores the importance of sewage infrastructure.
Keywords	eutrophication ; infrastructure ; lakes ; models ; pollution load ; rain ; rivers ; runoff ; sewage ; temporal variation ; urban areas ; water management ; watersheds ; winter ; China
Language	English
Dates of publication	2019-0117
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w11010166
Database	NAL-Catalogue (AGRICOLA)

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Article: Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN.

Zhu, Yingwei / Tang, Hong / Zhang, Lili / Gong, Lei / Wu, Gaojue / Ni, Jingbin / Tang, Xuejun

Cancer management and research

2019 Volume 11, Page(s) 955–968

Abstract: Background: TNF-related apoptosis-inducing ligand (TRAIL) functions as a selective apoptosis-inducing ligand in cancer cells with normal cells remaining unaffected; however, resistance limits its anticancer properties. Cancer stem cells (CSCs) are ... ...

Abstract	Background: TNF-related apoptosis-inducing ligand (TRAIL) functions as a selective apoptosis-inducing ligand in cancer cells with normal cells remaining unaffected; however, resistance limits its anticancer properties. Cancer stem cells (CSCs) are involved in the treatment of resistant cancer cases including liver cancer (LC). The aim of this study was to look into the approaches for increasing the sensitivity of liver cancer stem cells (LCSCs) toward TRAIL. Methodology: PLC, HepG2 and Huh7 LC cell lines were used in this study. Quantitative reverse transcription PCR (qRT-PCR) analysis was done for evaluating the expression of miR-21-3b. Fluorescent-activated cell-sorting equipment was used for separation and identification of LCSCs and non-LCSCs. The cells were transfected with RNA along with miR-21-3p mimics, anti- miR-21-3p, miR-NC and the phosphatase and tensin homologue (PTEN) siRNA. MTT assay for cell viability, Luciferase assay for luciferase activity, Western blots for the expression of proteins and flow cytometry for the measurement of ROS and apoptosis, respectively, were carried out. Tumor xenografts nude mice were used for tumor growth in vivo. Results: We found that miR-21-3p was overexpressed in LCSCs compared to non-LCSCs and that the suppression of miR-21-3p along with anti-miR-21-3p enhanced the sensitivity of LCSCs to TRAIL-mediated apoptosis. We further found that miR-21-3p regulated the expression of PTEN in Huh7-LCSCs directly and that the suppression of miR-21-3p enhanced the levels of PTEN. The study confirmed that inhibition of the PI3K/Akt/Bad signaling pathway was involved in enhancing TRAIL-mediated apoptosis of LC cells. Conclusion: The study suggested that overexpression of miR-21-3p suppresses the sensitivity to TRAIL in LCSCs. This study concludes that the suppression of miR-21-3p is a potential approach for enhancing the sensitivity of LC cells toward TRAIL by PI3K/Akt/Bad cascade via the miR-21-3p/PTEN axis.
Language	English
Publishing date	2019-01-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S183328
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Article: Elevated MIR100HG promotes colorectal cancer metastasis and is associated with poor prognosis.

Li, Wenhua / Yuan, Fukang / Zhang, Xin / Chen, Wanyuan / Tang, Xuejun / Lu, Lungen

Oncology letters

2019 Volume 18, Issue 6, Page(s) 6483–6490

Abstract: mir-100-let-7a-2-mir-125b-1 cluster host gene (MIR100HG), which is located on chromosome 11q24.1, is a polycistronic microRNA host gene. MIR100HG overexpression in colorectal cancer (CRC) has been demonstrated to be associated with cetuximab resistance; ... ...

Abstract	mir-100-let-7a-2-mir-125b-1 cluster host gene (MIR100HG), which is located on chromosome 11q24.1, is a polycistronic microRNA host gene. MIR100HG overexpression in colorectal cancer (CRC) has been demonstrated to be associated with cetuximab resistance; however, the role of MIR100HG in CRC metastasis remains unclear. The present study aimed to investigate the impact of aberrant MIR100HG expression on metastasis and prognosis in patients with CRC. The results from reverse transcription-quantitative PCR demonstrated that MIR100HG expression was higher in CRC tissues compared with in corresponding normal mucosa tissues. In particular, MIR100HG expression was higher in advanced CRC compared with in early stage CRC. Furthermore, the results from Kaplan-Meier analysis followed by a log-rank test revealed that patients with CRC and high MIR100HG expression exhibited poorer disease-free survival and overall survival compared with patients with CRC and lower MIR100HG expression. Furthermore, results from
Language	English
Publishing date	2019-11-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2019.11060
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Article: Anchoring ultrafine Pt nanoparticles on the 3D hierarchical self-assembly of graphene/functionalized carbon black as a highly efficient oxygen reduction catalyst for PEMFCs

Tang, Xuejun / Yachao Zeng / Longsheng Cao / Limeng Yang / Zhiqiang Wang / Dahui Fang / Yanyan Gao / Zhigang Shao / Baolian Yi

Journal of materials chemistry. 2018 Aug. 7, v. 6, no. 31

2018

Abstract: 3D graphene-based nanostructures have been recently considered to be promising supports in the fuel cell field. However, the problems of complexity and high cost in their preparation process limit their practical applications. Herein, we developed a ... ...

Abstract	3D graphene-based nanostructures have been recently considered to be promising supports in the fuel cell field. However, the problems of complexity and high cost in their preparation process limit their practical applications. Herein, we developed a facile and cost-effective approach to fabricate a novel 3D hierarchical architecture constructed from reduced graphene oxide (rGO) and poly(diallyldimethylammoniumchloride) functionalized carbon black (FCB) to anchor Pt NPs as an efficient electrocatalyst for proton exchange membrane fuel cells (PEMFCs). By optimizing the weight ratio of rGO/FCB, we find that the Pt/rGO₁−FCB₂ possesses a well-defined 3D interconnecting framework with large surface area, desirable porosity, high graphitic crystallinity and homogeneous dispersion of ultra-fine Pt nanoparticles. Benefiting from the unique structural features, the Pt/rGO₁–FCB₂ catalyst exhibits notably improved activity and remarkable stability for the oxygen reduction reaction (ORR) compared to commercial Pt/C. Moreover, an electrode prepared with this architecture demonstrates superior performance in single cell testing, with a peak power density of 1.344 W cm⁻² and a maximum mass specific power density of 7.5 W mgPₜ⁻¹, which are 1.25-fold greater than those of the conventional Pt/C electrode. Additionally, the variation of the electrochemically active surface area, power density and the kinetic resistance during the accelerated degradation process implies that the Pt/rGO₁–FCB₂ electrode possesses much enhanced electrochemical durability compared to Pt/C. The research results indicate that the 3D Pt/rGO–FCB will be a promising candidate for next generation of cathode electrocatalysts in PEMFCs.
Keywords	catalysts ; cathodes ; cost effectiveness ; crystal structure ; durability ; electrochemistry ; fuel cells ; graphene ; graphene oxide ; nanoparticles ; oxygen ; porosity ; surface area
Language	English
Dates of publication	2018-0807
Size	p. 15074-15082.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/c8ta02453g
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Article ; Online: Facile synthesis of Pt-decorated Ir black as a bifunctional oxygen catalyst for oxygen reduction and evolution reactions.

Fang, Dahui / Tang, Xuejun / Yang, Limeng / Xu, Dongyan / Zhang, Hongjie / Sun, Shucheng / Shao, Zhigang / Yi, Baolian

Nanoscale

2019 Volume 11, Issue 18, Page(s) 9091–9102

Abstract: Pt-Decorated Ir black (Pt@Ir) nanoparticles with two varying Pt mass fractions (Pt4@Ir96 and Pt16@Ir84) were generated by a facile method in water with the aid of Ir black. The Pt@Ir nanoparticles were investigated as a bifunctional oxygen catalysts for ... ...

Abstract	Pt-Decorated Ir black (Pt@Ir) nanoparticles with two varying Pt mass fractions (Pt4@Ir96 and Pt16@Ir84) were generated by a facile method in water with the aid of Ir black. The Pt@Ir nanoparticles were investigated as a bifunctional oxygen catalysts for both the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in acidic medium. Benefiting from the good dispersion of ultrafine Pt nanodots on the Ir black surface and the synergistic effect between the Pt and underlying Ir atoms, Pt@Ir nanoparticles have exhibited outstanding ORR activity and comparable OER performance in comparison with commercial Ir black. In particular, Pt16@Ir84 shows an ORR mass activity of 2.6 times that of commercial Pt black and exhibits much better bifunctional performances than a mixture of Pt black and Ir black with a Ir/Pt mass ratio of 50/50 (Pt50Ir50). Our work highlights the effectiveness of decorating Ir black with Pt nanodots to fabricate bifunctional oxygen catalysts.
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c9nr00279k
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Article ; Online: Cadmium pollution from phosphate fertilizers in arable soils and crops

Andrea Giovanna NIÑO-SAVALA, Zhong ZHUANG, Xin MA, Andreas FANGMEIER, Huafen LI, Aohan TANG, Xuejun LIU

Frontiers of Agricultural Science and Engineering, Vol 6, Iss 4, Pp 419-

an overview

2019 Volume 430

Abstract: The application of mineral and organic phosphorus fertilizers to arable land has greatly increased crop yield to meet the world food demand. On the other hand, impurities in these fertilizers, such as heavy metals, are being added to agricultural soils, ... ...

Abstract	The application of mineral and organic phosphorus fertilizers to arable land has greatly increased crop yield to meet the world food demand. On the other hand, impurities in these fertilizers, such as heavy metals, are being added to agricultural soils, resulting both from the raw materials themselves and the processes used to obtain the final product. Cadmium, a non-essential and toxic heavy metal, has been found in relatively high amounts in common P fertilizers obtained from sediments. This metal poses a high risk for soil fertility, crop cultivation, and plants in general. Furthermore, human health might be compromised by the cadmium concentrations in agricultural and livestock products, due to the bioaccumulation effect in the food web. The accumulation in the different matrixes is the result of the high mobility and flexible availability of this harmful metal. This review summarizes risks to human health, the factors influencing cadmium movement in soils and crop uptake, as well as common plant responses to its toxicity. In addition, it summarizes cadmium balances in soils, trends, long-term experiments, and further studies. Cadmium inputs and outputs in arable soil, together with their calculated concentrations, are compared between two different regions: the European countries (in particular Germany) and China. The comparison appears useful because of the different proportions in the inputs and outputs of cadmium, and the diverse geographical, environmental and social factors. Moreover, these variables and their influences on cadmium contamination improve the understanding of the pollution from phosphate fertilizers and will help to establish future mitigation policies.
Keywords	soil pollution\|arable land\|crop production\|cadmium balance\|p fertilizer\|cadmium toxicity ; Agriculture (General) ; S1-972
Subject code	910
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Higher Education Press
Document type	Article ; Online
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Article: [Risk analysis of the canceration of colorectal large polyps].

Jin, Yan / Yao, Liqing / Zhou, Pinghong / Jin, Shimao / Wang, Xiaoyun / Tang, Xuejun / Peng, Xiaobin / Hua, Ping / Ren, Yuanmei / Gong, Lei

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2018 Volume 21, Issue 10, Page(s) 1161–1166

Abstract: Objective: To analyze the risk factors of carcinogenesis of large colorectal polyps (diameter ≥ 10 mm) found by colonoscopy.: Methods: Clinicopathological and follow-up data of 418 consecutive patients who were diagnosed as colorectal polyps with ... ...

Abstract	Objective: To analyze the risk factors of carcinogenesis of large colorectal polyps (diameter ≥ 10 mm) found by colonoscopy. Methods: Clinicopathological and follow-up data of 418 consecutive patients who were diagnosed as colorectal polyps with diameter≥10 mm by colonoscopy at two endoscopy centers of the Affiliated Wuxi Second People's Hospital, Nanjing Medical University (n=207) and Zhongshan Hospital, Fudan University (n=211) from January 2015 to December 2016 were retrospectively collected. High-grade intraepithelial neoplasia and cancer were defined as malignancy in this study. Chi square test was used for univariate analysis, and logistic regression was used for multivariate analysis (in patients with multiple polyps, if the pathological findings were all low grade intraepithelial neoplasia, one polyp with the largest diameter was selected to enter the model; in patients with high grade intraepithelial neoplasia, one polyp of high grade intraepithelial neoplasia with the largest diameter was selected to enter the model). Associated risk factors of malignancy were analyzed. Results: Among the 418 patients, 278(66.5%) were male and 140(33.5%) were female, with mean age of (58.7±10.2) (range 15-87) years old. Of 398 patients undergoing endoscopic treatment with resected 456 polyps, 142 cases with 150 polyps were malignant, including 134 polyps of high-grade intraepithelial neoplasia and 16 polyps of intra-mucosal cancer. The other 20 patients showed negative elevation signs after endoscopic submucosal injection and were transferred to surgery, of whom 20 polyps were resected. Histological examination of these 20 polyps indicated invasive cancer. Univariate analysis showed that age ≥ 50 years [40.5% (150/370) vs. 25.0% (12/48), χ² =4.323, P=0.041], multiple polyps [77.5%(31/40) vs. 34.7%(131/378), χ² =12.900, P=0.001], polyp locating at rectum [59.0%(36/61) vs. 32.3%(134/415), χ² =22.736, P=0.000], polyp diameter ≥31 mm [74.1%(20/27) vs. 33.4%(150/449), χ² =36.493, P=0.000] and tubular villous adenoma [67.4%(120/178) vs. 16.8%(50/298), χ² =71.810, P=0.000] were associated with malignancy. Multivariate analysis showed that age ≥ 50 years(OR=2.473, 95%CI:1.209-5.058, P=0.013), multiple polyps (OR=2.472, 95%CI: 1.300-4.702, P=0.006), polyp locating at rectum (OR=1.253, 95%CI: 1.091-1.439, P=0.001) and the polyp diameter ≥31 mm (OR=1.500, 95%CI:1.196-1.881, P=0.000) were independent risk factors for malignancy of large colorectal polyps. The mean follow-up time was (9.6±4.2) months. During the follow-up period, 86 patients (20.5%) who received endoscopic resection developed recurrent adenoma which all were successfully removed by colonoscopic polypectomy. Two patients(0.5%) developed colon cancer 6 months after endoscopic resection and both underwent radical surgery and chemotherapy. Their previous pathology from endoscopic resection was tubular villous adenoma and high grade intraepithelial neoplasia. All the patients were alive during the follow-up period. Conclusions: Age ≥50 years old, multiple polyps, polyps locating at rectum and polyps with diameter ≥ 31 mm are the risk factors of malignancy. Emphasized examination should be recommended for those with the above mentioned risk factors to avoid missed diagnosis and misdiagnosis. The choice of endoscopic treatment must be reasonable for curative resection.
MeSH term(s)	Adenoma/pathology ; Adenoma/surgery ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Young Adult
Language	Chinese
Publishing date	2018-10-23
Publishing country	China
Document type	Journal Article
ISSN	1671-0274
ISSN	1671-0274
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