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Book ; Online: Pseudorabies Virus

Tang, Yan-Dong / Li, Xiangdong

2022

Keywords	Research & information: general ; Biology, life sciences ; Microbiology (non-medical) ; pseudorabies virus ; Liver X receptors ; clathrin-coated pits ; viral entry ; innate immune response ; type I interferons ; apoptosis ; autophagy ; premature termination codon ; genetic code expansion ; virus isolation ; pathogenicity ; mortality ; inflammatory response ; Huaier polysaccharide ; antiviral ; infection ; Vero cell ; TMT-based proteomic analysis ; differentially expressed proteins ; antiviral breeding ; genetic modification ; nectin1 ; pig ; PRV ; disease resistance ; seroprevalence ; epidemiology ; phylogenetic analysis ; variants ; ICP0 protein ; P65 ; NF-κB signaling pathway ; complete genome sequencing ; gene recombination ; variant strain ; genomics ; vaccination ; transmission ; zoonosis ; itch ; mouse ; histamine ; dorsal root ganglion ; metabolomic analysis ; UHPLC-QE-MS ; PK-15 cells ; latent infection ; latency-associated transcripts ; non-coding RNA ; latency ; miRNA ; chromatin ; immune regulation ; variation ; human pseudorabies encephalitis ; pseudorabies virus (PRV) ; tegument protein UL13 ; RIG-I ; MDA5 ; NF-κB ; pathogenesis ; prevention and control ; Aujeszky's disease ; epidemiological characteristics
Language	English
Size	1 electronic resource (294 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030379902
ISBN	9783036559858 ; 303655985X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The role of glimpses with different energy in speech-in-noise recognition.

Tang, Yan

JASA express letters

2022 Volume 2, Issue 2, Page(s) 25201

Abstract: Listeners can understand speech in noise by "glimpsing" some of the speech regions less affected by noise. This study investigates the contributions of those spectro-temporal regions, known as glimpses, at different energy levels to speech ... ...

Abstract	Listeners can understand speech in noise by "glimpsing" some of the speech regions less affected by noise. This study investigates the contributions of those spectro-temporal regions, known as glimpses, at different energy levels to speech intelligibility in noise. Two listening experiments were conducted to examine the intelligibility of speech in different glimpse compositions in two types of noise. The results suggest that glimpsed spectro-temporal regions with energy above the mean noise level are the primary cue for speech perception in noise, and that listeners can use less-robust cues until at least 15 dB below the glimpsing threshold.
MeSH term(s)	Auditory Perception ; Cues ; Noise/adverse effects ; Speech Intelligibility ; Speech Perception
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2691-1191
ISSN (online)	2691-1191
DOI	10.1121/10.0009438
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Article ; Online: Style Transfer of Chinese Art Works Based on Dual Channel Deep Learning Model.

Tang, Yan

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 4376006

Abstract: Aiming at the problems of style loss and lack of content in the style transfer of Chinese art works, this paper puts forward the style transfer technology of Chinese art works based on the dual channel deep learning model. On the basis of clarifying the ... ...

Abstract	Aiming at the problems of style loss and lack of content in the style transfer of Chinese art works, this paper puts forward the style transfer technology of Chinese art works based on the dual channel deep learning model. On the basis of clarifying the technical principle of style transfer of art works, the image of art works is controlled and transformed based on the u-net network. The incomplete information in the restored image is filled, and the multiscale classification feature is used to calculate the color feature data items in the image. The sensitivity coefficient of color difference is calculated by using constraints, and the overlapping color discrimination and image segmentation of art images are realized. Poisson image editing is used to constrain the image spatial gradient to realize the style migration of art works. The experimental results show that this method can effectively avoid the problems of content error, distortion, and distortion in the process of art style migration, and has a better style migration effect.
MeSH term(s)	China ; Deep Learning ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/4376006
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Article ; Online: Research progress on the role of reactive oxygen species in the initiation, development and treatment of breast cancer.

Zhong, Jing / Tang, Yan

Progress in biophysics and molecular biology

2024 Volume 188, Page(s) 1–18

Abstract: According to international cancer data, breast cancer (BC) is the leading type of cancer in women. Although significant progress has been made in treating BC, metastasis and drug resistance continue to be the primary causes of mortality for many patients. ...

Abstract	According to international cancer data, breast cancer (BC) is the leading type of cancer in women. Although significant progress has been made in treating BC, metastasis and drug resistance continue to be the primary causes of mortality for many patients. Reactive oxygen species (ROS) play a dual role in vivo: normal levels can maintain the body's normal physiological function; however, high levels of ROS below the toxicity threshold can lead to mtDNA damage, activation of proto-oncogenes, and inhibition of tumor suppressor genes, which are important causes of BC. Differences in the production and regulation of ROS in different BC subtypes have important implications for the development and treatment of BC. ROS can also serve as an important intracellular signal transduction factor by affecting the antioxidant system, activating MAPK and PI3K/AKT, and other signal pathways to regulate cell cycle and change the relationship between cells and the activity of metalloproteinases, which significantly impacts the metastasis of BC. Hypoxia in the BC microenvironment increases ROS production levels, thereby inducing the expression of hypoxia inducible factor-1α (HIF-1α) and forming "ROS- HIF-1α-ROS" cycle that exacerbates BC development. Many anti-BC therapies generate sufficient toxic ROS to promote cancer cell apoptosis, but because the basal level of ROS in BC cells exceeds that of normal cells, this leads to up-regulation of the antioxidant system, drug efflux, and apoptosis inhibition, rendering BC cells resistant to the drug. ROS crosstalks with tumor vessels and stromal cells in the microenvironment, increasing invasiveness and drug resistance in BC.
MeSH term(s)	Humans ; Female ; Reactive Oxygen Species/metabolism ; Breast Neoplasms/drug therapy ; Antioxidants ; Phosphatidylinositol 3-Kinases ; Hypoxia ; Tumor Microenvironment
Chemical Substances	Reactive Oxygen Species ; Antioxidants ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	209302-9
ISSN	1873-1732 ; 0079-6107
ISSN (online)	1873-1732
ISSN	0079-6107
DOI	10.1016/j.pbiomolbio.2024.02.005
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Article ; Online: Reply to Hayashi and Konishi: Noneffect of SARS-CoV-2 spike glycoprotein Y217N mutation on affinity between virus and ACE2.

Tang, Yan-Dong

The Journal of biological chemistry

2021 Volume 296, Page(s) 100706

MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; COVID-19 ; Humans ; Mutation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100706
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Article ; Online: A Review of the Utilization of Canola Protein as an Emulsifier in the Development of Food Emulsions.

Tang, Yan Ran / Ghosh, Supratim

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 24

Abstract: Canola is the second-largest cultivated oilseed crop in the world and produces meal consisting of about 35-40% proteins. Despite this, less than 1% of the global plant-based protein market is taken up by canola protein. The reason behind such ... ...

Abstract	Canola is the second-largest cultivated oilseed crop in the world and produces meal consisting of about 35-40% proteins. Despite this, less than 1% of the global plant-based protein market is taken up by canola protein. The reason behind such underutilization of canola protein and its rapeseed counterpart could be the harsh conditions of the industrial oil extraction process, the dark colour of the meal, the presence of various antinutrients, the variability in the protein composition based on the source, and the different properties of the two major protein components. Although academic research has shown immense potential for the use of canola protein and its rapeseed counterpart in emulsion development and stabilization, there is still a vast knowledge gap in efficiently utilizing canola proteins as an effective emulsifier in the development of various emulsion-based foods and beverages. In this context, this review paper summarizes the last 15 years of research on canola and rapeseed proteins as food emulsifiers. It discusses the protein extraction methods, modifications made to improve emulsification, emulsion composition, preparation protocols, and emulsion stability results. The need for further improvement in the scope of the research and reducing the knowledge gap is also highlighted, which could be useful for the food industry to rationally select canola proteins and optimize the processing parameters to obtain products with desirable attributes.
MeSH term(s)	Brassica napus ; Emulsions ; Emulsifying Agents ; Food ; Plant Proteins ; Brassica rapa
Chemical Substances	Emulsions ; Emulsifying Agents ; Plant Proteins
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28248086
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Article ; Online: Impact of digital economy on ecological resilience of resource-based cities: spatial spillover and mechanism.

Tang, Yan / Wang, Yusu

Environmental science and pollution research international

2023 Volume 30, Issue 14, Page(s) 41299–41318

Abstract: Resource-based cities, which are widely distributed in China, contribute significantly to China's sustainable development. The digital economy and the construction of ecological civilization are central issues in the sustainable development of resource- ... ...

Abstract	Resource-based cities, which are widely distributed in China, contribute significantly to China's sustainable development. The digital economy and the construction of ecological civilization are central issues in the sustainable development of resource-based cities, and it is necessary to analyze the impact of the digital economy on the ecological resilience of resource-based cities. Thus, this paper measures ecological resilience of 117 resource-based cities from 2011 to 2020 using the entropy weight TOPSIS (technique for order preference by similarity to ideal solution; see Table 1 for a list of acronyms) method and empirically investigates the impact and mechanism of digital economy on ecological resilience using the spatial Durbin model (SDM) and intermediary effect model. The results show that the ecological resilience of resource-based cities has a certain upward trend, with a stepwise distribution pattern from east to west. There is a significant positive correlation between ecological resilience of resource-based cities, showing the phenomenon of club convergence which is primarily dominated by high-high (H-H) and low-low (L-L). The digital economy has a significant spatial spillover effect, which promotes ecological resilience of resource-based cities in the local and adjacent regions. A mechanism analysis reveals that technological innovation and industrial structure are mediators between digital economy and ecological resilience of resource-based cities, with significant heterogeneity in region and growth cycle. Among them, the intermediary role of technological innovation is stronger. Following the above findings, this paper proposes policy suggestions related to digital economy evolution and ecological resilience enhancement. This paper further enriches the literature on the ecological resilience and provides a theoretical basis for government policy-making.
MeSH term(s)	Cities ; China ; Entropy ; Industry ; Interior Design and Furnishings ; Economic Development
Language	English
Publishing date	2023-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-25155-w
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Article ; Online: A time series driven model for early sepsis prediction based on transformer module.

Tang, Yan / Zhang, Yu / Li, Jiaxi

BMC medical research methodology

2024 Volume 24, Issue 1, Page(s) 23

Abstract: Sepsis remains a critical concern in intensive care units due to its high mortality rate. Early identification and intervention are paramount to improving patient outcomes. In this study, we have proposed predictive models for early sepsis prediction ... ...

Abstract	Sepsis remains a critical concern in intensive care units due to its high mortality rate. Early identification and intervention are paramount to improving patient outcomes. In this study, we have proposed predictive models for early sepsis prediction based on time-series data, utilizing both CNN-Transformer and LSTM-Transformer architectures. By collecting time-series data from patients at 4, 8, and 12 h prior to sepsis diagnosis and subjecting it to various network models for analysis and comparison. In contrast to traditional recurrent neural networks, our model exhibited a substantial improvement of approximately 20%. On average, our model demonstrated an accuracy of 0.964 (± 0.018), a precision of 0.956 (± 0.012), a recall of 0.967 (± 0.012), and an F1 score of 0.959 (± 0.014). Furthermore, by adjusting the time window, it was observed that the Transformer-based model demonstrated exceptional predictive capabilities, particularly within the earlier time window (i.e., 12 h before onset), thus holding significant promise for early clinical diagnosis and intervention. Besides, we employed the SHAP algorithm to visualize the weight distribution of different features, enhancing the interpretability of our model and facilitating early clinical diagnosis and intervention.
MeSH term(s)	Humans ; Time Factors ; Sepsis/diagnosis ; Sepsis/therapy ; Algorithms ; Intensive Care Units ; Mental Recall
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-023-02138-6
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Article: Nomogram Based on Clinical Characteristics to Predict 28-Day Mortality Among Patients with CRAB-BSI.

Xiong, Jiong / Zhou, Xiaoqian / Tang, Yan

Clinical laboratory

2024 Volume 70, Issue 3

Abstract: Background: The drug resistance of carbapenem-resistant Acinetobacter baumannii bloodstream infections (CRAB-BSI), especially hospital-acquired infections, has promoted their rapid and vast spread. It is necessary to use reliable methods to establish ... ...

Abstract	Background: The drug resistance of carbapenem-resistant Acinetobacter baumannii bloodstream infections (CRAB-BSI), especially hospital-acquired infections, has promoted their rapid and vast spread. It is necessary to use reliable methods to establish better prediction models. According to Cox proportional hazards regression, a nomogram was established. Methods: A retrospective cohort study among patients who were diagnosed with CRAB-BSI was performed from January 2020 to December 2022. Univariate and multivariate Cox proportional hazards regression analyses were used to determine independent prognostic factors regarding CRAB-BSI. Then, nomograms were used to calculate the area under the curve (AUC), C-index, and calibration curve to determine the predictive accuracy and dis-criminability. Decision curve analysis (DCA) was employed to further confirm the clinical effectiveness of the nomogram. Results: A total of 98 cases were included in the comparison between the 28-day mortality group consisting of 32 patients and the 28-day survival group with 66 patients. The use of cefoperazone-sulbactam was significantly higher among patients who survived than among those who died. Univariable analysis revealed that factors such as primary diagnosis, time to inadequate antimicrobial therapy, and high serum creatinine and procalcitonin (PCT) levels were more prevalent in the mortality group. However, only primary diagnosis, time to inadequate antimicrobial therapy, and high PCT levels emerged as statistically significant risk factors for death in multivariate analysis and were used to construct the nomogram. The nomogram validation exhibited excellent performance. Conclusions: The nomogram was sufficiently accurate to predict the risk and prognostic factors of CRAB-BSI, allowing for individualized clinical decisions for future clinical work. The cefoperazone-sulbactam did have an effect, but more studies are needed to interpret it.
MeSH term(s)	Humans ; Nomograms ; Sulbactam/pharmacology ; Cefoperazone/pharmacology ; Cefoperazone/therapeutic use ; Retrospective Studies ; Acinetobacter baumannii ; Anti-Infective Agents/pharmacology ; Sepsis/drug therapy ; Prognosis
Chemical Substances	Sulbactam (S4TF6I2330) ; Cefoperazone (7U75I1278D) ; Anti-Infective Agents
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230732
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Article ; Online: TMEM97 knockdown inhibits 5-fluorouracil resistance by regulating epithelial-mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathway in 5-fluorouracil-resistant colorectal cancer cells.

Xu, Yi / Tang, Yan / Xu, Qiu / He, Wenguang

Chemical biology & drug design

2024 Volume 103, Issue 2, Page(s) e14490

Abstract: Resistance to 5-fluorouracil (5-FU) is still a primary setback to the success of colorectal cancer (CRC) chemotherapy. Transmembrane protein 97 (TMEM97) functions as an oncogene in CRC. However, the role and mechanism of TMEM97 in regulating 5-FU ... ...

Abstract	Resistance to 5-fluorouracil (5-FU) is still a primary setback to the success of colorectal cancer (CRC) chemotherapy. Transmembrane protein 97 (TMEM97) functions as an oncogene in CRC. However, the role and mechanism of TMEM97 in regulating 5-FU resistance in CRC cells remains unclear. TMEM97 expression in CRC samples was analyzed by GEPIA and human protein atlas (HPA) databases. TMEM97, E-cadherin, Vimentin, N-cadherin, P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1)/ABCC1, ABCC2, and the changes of protein kinase B/mammalian target of rapamycin (mTOR) pathway were explored by western blot analysis. IC50 value for 5-FU and cell viability was examined by MTT assay. Apoptosis was evaluated by flow cytometry. TMEM97 was highly expressed in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) based on GEPIA and HPA databases. TMEM97 knockdown attenuated 5-FU resistance in HCT116/R and SW480/R cells, as evidenced by the reduced IC50 value for 5-FU and the increased apoptosis. TMEM97 knockdown suppressed epithelial-mesenchymal transition (EMT), expression of ATP-binding cassette (ABC) transporters, and the Akt/mTOR pathway. Mechanistically, activation of Akt/mTOR pathway abolished the inhibitory effects of TMEM97 knockdown on 5-FU resistance, EMT, and ABC transporter expression. In conclusion, TMEM97 knockdown inhibited 5-FU resistance in CRC by regulating EMT and ABC transporter expression via inactivating the Akt/mTOR pathway.
MeSH term(s)	Humans ; Fluorouracil/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Colonic Neoplasms/drug therapy ; ATP-Binding Cassette Transporters/metabolism ; Adenocarcinoma/drug therapy ; Colorectal Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; TOR Serine-Threonine Kinases/metabolism ; Epithelial-Mesenchymal Transition ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Membrane Proteins/genetics ; Membrane Proteins/metabolism
Chemical Substances	Fluorouracil (U3P01618RT) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; ATP-Binding Cassette Transporters ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; TMEM97 protein, human ; Membrane Proteins
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14490
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