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  1. AU="Tang, Yi-Han"
  2. AU="Parodi, Jose F"
  3. AU="Kabata, Yudai"
  4. AU="Butler, Javed"
  5. AU=Du L
  6. AU="Artin, Hewa"
  7. AU="Bardakov, V M"
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  9. AU="Boo, Irene"
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  11. AU="Pierfrancesco Pagella"
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  13. AU=Yasir Kashif Ammar
  14. AU="Gümüş, Funda"
  15. AU=Bhowmik Deep AU=Bhowmik Deep
  16. AU="Eugene, Alexis"
  17. AU="Janesomboon, Sujintana"
  18. AU="Sonkhya, Nishi"
  19. AU="Vaz, André"
  20. AU="Rugo, Hope S"
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  22. AU="Molday, Robert S"
  23. AU="Yaodong Hu"
  24. AU=Gimenez-Mascarell Paula
  25. AU="Orlandi, D"
  26. AU="Takeishi, Yasuchika"
  27. AU="Kamath, Karthik Shantharam" AU="Kamath, Karthik Shantharam"
  28. AU="Innocente, Alessandra"
  29. AU="Xing, Lei"
  30. AU="Chen, Mingyu"
  31. AU="Riedl, Sophie"
  32. AU="Ding, Haiyan"
  33. AU=Hu Xiumei AU=Hu Xiumei
  34. AU="Simmonds, Peter"
  35. AU="Chaturvedi, Apeksha"
  36. AU="Madden, Wyatt"
  37. AU="Wald, Moshe"
  38. AU="Zalesak, J."
  39. AU="Krach, Florian"
  40. AU="Modak, Manisha A"
  41. AU="Ottolini, Matteo"
  42. AU="Douglas Hanahan"
  43. AU="Bieniaszewska, Maria"
  44. AU="Alovisi, Camilla"
  45. AU="Lijfering, Willem M."
  46. AU="Rademacher, Jessica"
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  48. AU="Denicola, Anthony J"
  49. AU="Zhang, Xuewei"
  50. AU="Li, Yanjiao"
  51. AU="Botelho Meireles de Souza, Guilherme"
  52. AU="Gong, Yu-Qing"
  53. AU="Eisch, J"
  54. AU=De Vito Eduardo L
  55. AU="Lowsky, Robert"
  56. AU="Lindner, M."
  57. AU="Mugnai, Giacomo"
  58. AU="Chollet-Krugler, Marylène"
  59. AU="Firsanov, Denis"
  60. AU="Jo, Dong-Gyu"
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  65. AU="Zgubič, M"
  66. AU="Russo, Rosita"
  67. AU="Ruiz-Ortega, Marta"
  68. AU="T Talbot"
  69. AU="Emoto, Kasey C"
  70. AU="Moos, W H" AU="Moos, W H"
  71. AU=Singh Sweta AU=Singh Sweta
  72. AU="Pimentel, Mauricio"
  73. AU="Kim, Ji Hee"
  74. AU=Ross Jeffrey S
  75. AU=Malhotra Atul
  76. AU="Tiesler, Carla M T"
  77. AU="Merighi, Adalberto" AU="Merighi, Adalberto"

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  1. Artikel ; Online: Seasonality in a tidal reach: Existence, impact and a possible approach for design flood level estimation.

    Tang, Yi-Han / Chen, Xiao-Hong

    The Science of the total environment

    2020  Band 714, Seite(n) 136478

    Abstract: Heterogeneity caused by seasonality could lead to the estimation error of the design flood level (DFL). This research intended to examine the existence of seasonality in the extreme water levels in a tidal reach and to quantify its impact on the DFL ... ...

    Abstract Heterogeneity caused by seasonality could lead to the estimation error of the design flood level (DFL). This research intended to examine the existence of seasonality in the extreme water levels in a tidal reach and to quantify its impact on the DFL estimation. The mixed-distribution, a commonly used method for design value estimation with heterogeneous samples, was tested. A case study was carried out in the Pearl River Delta, South China. Results showed that a significant seasonality existed in the extreme water levels that were generated from the flood-tide interactions in the delta. If the DFL was estimated with a single distribution, the DFL with a return period smaller than 1.1 years would be underestimated and more information of the non-flood season would be lost. The mixed-distribution was superior in its consideration of seasonality, however, when the return period was over 10 years or smaller than 5 years, the DFL estimation results of this approach were only shifted by <1% from that of a single distribution.
    Sprache Englisch
    Erscheinungsdatum 2020-01-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.136478
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  2. Artikel: Seasonality in a tidal reach: Existence, impact and a possible approach for design flood level estimation

    Tang, Yi-han / Chen, Xiao-hong

    Science of the total environment. 2020 Apr. 20, v. 714

    2020  

    Abstract: Heterogeneity caused by seasonality could lead to the estimation error of the design flood level (DFL). This research intended to examine the existence of seasonality in the extreme water levels in a tidal reach and to quantify its impact on the DFL ... ...

    Abstract Heterogeneity caused by seasonality could lead to the estimation error of the design flood level (DFL). This research intended to examine the existence of seasonality in the extreme water levels in a tidal reach and to quantify its impact on the DFL estimation. The mixed-distribution, a commonly used method for design value estimation with heterogeneous samples, was tested. A case study was carried out in the Pearl River Delta, South China. Results showed that a significant seasonality existed in the extreme water levels that were generated from the flood-tide interactions in the delta. If the DFL was estimated with a single distribution, the DFL with a return period smaller than 1.1 years would be underestimated and more information of the non-flood season would be lost. The mixed-distribution was superior in its consideration of seasonality, however, when the return period was over 10 years or smaller than 5 years, the DFL estimation results of this approach were only shifted by <1% from that of a single distribution.
    Schlagwörter case studies ; river deltas ; rivers ; tides ; China
    Sprache Englisch
    Erscheinungsverlauf 2020-0420
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.136478
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  3. Artikel ; Online: Clonal hematopoiesis in patients with HIV and cancer.

    Gillis, Nancy / Dickey, Brittney L / Colin-Leitzinger, Christelle / Tang, Yi-Han / Putney, Ryan M / Mesa, Tania E / Yoder, Sean J / Suneja, Gita / Spivak, Adam M / Patel, Ami B / Extermann, Martine / Giuliano, Anna R / Teng, Mingxiang / Kresovich, Jacob / Berglund, Anders / Coghill, Anna E

    The Journal of infectious diseases

    2024  

    Abstract: Background: Cancer-related deaths for people living with HIV (PWH) are increasing due to longer life expectancies and disparately poor cancer-related outcomes. We hypothesize that advanced biological aging contributes to cancer-related morbidity and ... ...

    Abstract Background: Cancer-related deaths for people living with HIV (PWH) are increasing due to longer life expectancies and disparately poor cancer-related outcomes. We hypothesize that advanced biological aging contributes to cancer-related morbidity and mortality for PWH and cancer. We sought to determine the impact of clonal hematopoiesis (CH) on cancer disparities in PWH.
    Methods: We conducted a retrospective study to compare the prevalence and clinical outcomes of CH in PWH and people without HIV (PWoH) and cancer. Included in the study were PWH and similar PWoH based on tumor site, age, tumor sequence, and cancer treatment status. Biological aging was also measured using epigenetic methylation clocks.
    Results: In 136 patients with cancer, PWH had twice the prevalence of CH compared to similar PWoH (23% vs 11%, p=0.07). After adjusting for patient characteristics, PWH were four-times more likely to have CH than PWoH (OR 4.1, 95% CI 1.3-13.9, p=0.02). The effect of CH on survival was most pronounced in PWH, who had a 5-year survival rate of 38% if they had CH (vs 59% if no CH), compared to PWoH who had a 5-year survival rate of 75% if they had CH (vs 83% if no CH).
    Conclusion: This study provides the first evidence that PWH may have a higher prevalence of CH than PWoH with the same cancers. CH may be an independent biological aging risk factor contributing to inferior survival for PWH and cancer.
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae212
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Clonal Hematopoiesis as a Molecular Risk Factor for Doxorubicin-Induced Cardiotoxicity: A Proof-of-Concept Study.

    Mammadova, Jamila / Colin-Leitzinger, Christelle / Nguyen, Diep / Mhaskar, Rahul / Ganesan, Shridar / Tang, Yi-Han / Teng, Mingxiang / Ismail-Khan, Roohi / Gillis, Nancy

    JCO precision oncology

    2023  Band 7, Seite(n) e2300208

    Abstract: Purpose: The main dose-limiting toxicity of anthracyclines is cardiotoxicity. Clonal hematopoiesis (CH), somatic mutations in hematopoietic stem or progenitor cells in patients without hematologic malignancy, is also associated with risk for adverse ... ...

    Abstract Purpose: The main dose-limiting toxicity of anthracyclines is cardiotoxicity. Clonal hematopoiesis (CH), somatic mutations in hematopoietic stem or progenitor cells in patients without hematologic malignancy, is also associated with risk for adverse cardiovascular events and worse outcomes overall. We hypothesize that CH increases risk for doxorubicin-induced cardiotoxicity (DIC).
    Methods: We conducted a retrospective cohort study in patients treated with doxorubicin for cancer (N = 100). Patients (n = 25) had incident symptomatic heart failure, decline in left ventricular ejection fraction, or arrhythmia. CH was identified using paired peripheral blood and tumor DNA.
    Results: After adjusting for age at doxorubicin initiation, diabetes, dyslipidemia, and chest radiation, high cumulative dose of doxorubicin (>240 mg/m
    Conclusion: This study provides preliminary evidence for CH as a predictive risk factor for DIC, which, with further investigation, could serve as an important precision medicine biomarker for the large number of patients with cancer who have CH.
    Mesh-Begriff(e) Humans ; Cardiotoxicity/etiology ; Clonal Hematopoiesis/genetics ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; Risk Factors ; Doxorubicin/adverse effects
    Chemische Substanzen Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2023-09-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00208
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  5. Artikel ; Online: Copper-Catalyzed Bisannulations of Malonate-Tethered

    Miao, Chun-Bao / Guan, Hong-Rong / Tang, YiHan / Wang, Kun / Ren, Wen-Long / Lyu, Xinyu / Yao, ChangSheng / Yang, Hai-Tao

    Organic letters

    2021  Band 23, Heft 22, Seite(n) 8699–8704

    Abstract: A copper-catalyzed bisannulation reaction of malonate- ... ...

    Abstract A copper-catalyzed bisannulation reaction of malonate-tethered
    Sprache Englisch
    Erscheinungsdatum 2021-11-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c03078
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  6. Artikel: Copper-Catalyzed Bisannulations of Malonate-Tethered O-Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues

    Miao, Chun-Bao / Guan, Hong-Rong / Tang, YiHan / Wang, Kun / Ren, Wen-Long / Lyu, Xinyu / Yao, ChangSheng / Yang, Hai-Tao

    Organic letters. 2021 Nov. 01, v. 23, no. 22

    2021  

    Abstract: A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes with pyridine, pyrazine, pyridazine, and quinoline derivatives has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones and ... ...

    Abstract A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes with pyridine, pyrazine, pyridazine, and quinoline derivatives has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones and their analogues. The present reaction shows excellent regioselectivity and stereoselectivity. Theoretical calculations reveal that the coordination effect of the carbonyl group in the nucleophilic substrate determines the excellent regioselectivity. Further functionalization of the generated dihydroindolizine-fused pyrrolidinone could be easily realized through substitution, Michael addition, selective aminolysis, and hydrolysis reactions.
    Schlagwörter Lewis bases ; aminolysis ; hydrolysis ; oximes ; pyrazines ; pyridines ; pyrrolidones ; quinoline ; regioselectivity ; stereoselectivity
    Sprache Englisch
    Erscheinungsverlauf 2021-1101
    Umfang p. 8699-8704.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.1c03078
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  7. Artikel ; Online: Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry.

    Gillis, Nancy / Padron, Eric / Wang, Tao / Chen, Karen / DeVos, Jakob D / Spellman, Stephen R / Lee, Stephanie J / Kitko, Carrie L / MacMillan, Margaret L / West, Jeffrey / Tang, Yi-Han / Teng, Mingxiang / McNulty, Samantha / Druley, Todd E / Pidala, Joseph A / Lazaryan, Aleksandr

    Transplantation and cellular therapy

    2023  Band 29, Heft 10, Seite(n) 640.e1–640.e8

    Abstract: Improved treatment options, such as reduced-intensity conditioning (RIC), enable older patients to receive potentially curative allogeneic hematopoietic cell transplantation (HCT). This progress has led to increased use of older HLA-matched sibling ... ...

    Abstract Improved treatment options, such as reduced-intensity conditioning (RIC), enable older patients to receive potentially curative allogeneic hematopoietic cell transplantation (HCT). This progress has led to increased use of older HLA-matched sibling donors. An unintended potential risk associated with older donors is transplantation of donor cells with clonal hematopoiesis (CH) into patients. We aimed to determine the prevalence of CH in older HLA-matched sibling donors pretransplantation and to assess the clinical impact of donor-engrafted CH on HCT outcomes. This was an observational study using donor peripheral blood samples from the Center for International Blood and Marrow Transplant Research repository, linked with corresponding recipient outcomes. To explore engraftment efficiency and evolution of CH mutations following HCT, recipient follow-up samples available through the Bone Marrow Transplant Clinical Trials Network (Protocol 1202) were included. Older donors and patients (both ≥55 years) receiving first RIC HCT for myeloid malignancies were eligible. DNA from archived donor blood samples was used for targeted deep sequencing to identify CH. The associations between donor CH status and recipient outcomes, including acute graft-versus-host disease (aGVHD), chronic GVHD (cGVHD), overall survival, relapse, nonrelapse mortality, disease-free survival, composite GVHD-free and relapse-free survival, and cGVHD-free and relapse-free survival, were analyzed. A total of 299 donors were successfully sequenced to detect CH. At a variant allele frequency (VAF) ≥2%, there were 44 CH mutations in 13.7% (41 of 299) of HLA-matched sibling donors. CH mostly involved DNMT3A (n = 27; 61.4%) and TET2 (n= 9; 20.5%). Post-HCT samples from 13 recipients were also sequenced, of whom 7 had CH
    Sprache Englisch
    Erscheinungsdatum 2023-07-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.07.021
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  8. Artikel: Quantifying Flood Frequency Modification Caused by Multi-Reservoir Regulation

    Tang, Yi-han / Chen, Xiao-hong / Li, Pei-yi / Lin, Kai-rong / Wu, Jie-feng / Zhang, Li-juan

    Water resources management. 2019 Oct., v. 33, no. 13

    2019  

    Abstract: The construction and the operation of multi-reservoir has severely altered the downstream design flood. This paper quantified the flood frequency modifications caused by multi-reservoir regulation with recorded data and a numerical model composed of ... ...

    Abstract The construction and the operation of multi-reservoir has severely altered the downstream design flood. This paper quantified the flood frequency modifications caused by multi-reservoir regulation with recorded data and a numerical model composed of peaks-over-threshold (POT) samples and time-trend models. The whole research was carried out in Dongjiang River Basin, Southern China. Results showed that (1) Sampling with the POT method could eliminate fake changes in change detection and prevent the underestimation of the design floods with an exceeding probability over 90% and the overestimation of the design floods with an exceeding probability less than 80%; (2) Multi-reservoir regulation severely reduced design flood when the exceeding probability was greater than 1% and smaller than 95%. The 10-year floods were mitigated the most. However, when the exceeding probability was over 95%, the impact was insignificant; (3) Flood mitigation was positively correlated to the number of reservoirs, but negatively correlated to the distance between the affecting reservoir and the affected station. However, when multiple reservoirs took effect on the design flood in one station, the closest reservoir did not necessarily take the most effect. The results of this research will amplify the theoretical basis for flood protection and the planning of regulation.
    Schlagwörter flood control ; floods ; mathematical models ; planning ; probability ; watersheds ; China
    Sprache Englisch
    Erscheinungsverlauf 2019-10
    Umfang p. 4451-4470.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    ZDB-ID 59924-4
    ISSN 1573-1650 ; 0920-4741
    ISSN (online) 1573-1650
    ISSN 0920-4741
    DOI 10.1007/s11269-019-02374-w
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