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  1. Article: Total flavonoids extracted from

    Wang, Sujuan / Li, Wenqing / Liu, Wenxiu / Yu, Lei / Peng, Fu / Qin, Junyuan / Pu, Lin / Tang, Yunli / Xie, Xiaofang / Peng, Cheng

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1253013

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1253013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice.

    Wei, Jiangcun / Tang, Yunli / Qin, Suhong / Ma, Xiumei / Zhong, Wen / Yang, Peng / Deng, Qingmei / Ma, Jiabao

    Molecular biotechnology

    2023  

    Abstract: Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from Laggera alata (TPLA) has been reported to exhibit anti-inflammatory effect in ... ...

    Abstract Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from Laggera alata (TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in RA is still unknown. Here, the protective properties of TPLA were studied in collagen-induced arthritis (CIA)-induced RA mice. RA mouse model was established through the CIA induction. Arthritis score, hind paw thickness, and the body weight of the RA mice were evaluated in each group. H&E staining was conducted in hind paw and joint tissues for histopathological staining. The distal femur was analyzed by microCT, and bone loss-related indicators were assessed. The expression of macrophage polarization markers was detected by immunofluorescence staining in RA mice. The serum levels of inflammatory markers were determined by enzyme-linked immunosorbent assay (ELISA). TPLA reduced the CIA-induced arthritis score and hind paw thickness in mice. The body weight of the CIA mouse was significantly increased by TPLA treatment. TPLA improved the CIA-induced histopathological changes in the hind paw and joint tissues from the mice. TPLA inhibited the bone loss and alleviated bone destruction in CIA mouse model. TPLA altered the macrophage phenotype from M1 macrophages into M2 in CIA mice. TPLA suppressed the levels of inflammatory markers both in the serum and joint tissues of the CIA mice. TPLA mitigated RA development by suppressing inflammatory reaction through the inhibition of M1 microphage polarization.
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1193057-3
    ISSN 1559-0305 ; 1073-6085
    ISSN (online) 1559-0305
    ISSN 1073-6085
    DOI 10.1007/s12033-023-00808-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4031: Show issues Location:
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  3. Article ; Online: The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA sequencing.

    Chen, Yan / Xiang, Qiwen / Peng, Fu / Gao, Song / Yu, Lei / Tang, Yunli / Yang, Zhou / Pu, Wei / Xie, Xiaofang / Peng, Cheng

    Journal of ethnopharmacology

    2023  Volume 315, Page(s) 116639

    Abstract: Ethnopharmacological relevance: Safflower is a traditional Chinese medicine used for treating gynaecological diseases. However, its material basis and mechanism of action in the treatment of endometritis induced by incomplete abortion are still unclear.! ...

    Abstract Ethnopharmacological relevance: Safflower is a traditional Chinese medicine used for treating gynaecological diseases. However, its material basis and mechanism of action in the treatment of endometritis induced by incomplete abortion are still unclear.
    Aim of the study: This study aimed to reveal the material basis and mechanism of action of safflower in the treatment of endometritis induced by incomplete abortion through comprehensive methods, including network pharmacology and 16S rDNA sequencing.
    Materials and methods: Network pharmacology and molecular docking methods were used to screen the main active components and potential mechanisms of action of safflower in the treatment of endometritis induced by incomplete abortion in rats. A rat model of endometrial inflammation by incomplete abortion was established. The rats were treated with safflower total flavonoids (STF) based on forecasting results, serum levels of inflammatory cytokines were analysed, and immunohistochemistry, Western blots, and 16S rDNA sequencing were performed to investigate the effects of the active ingredient and the treatment mechanism.
    Results: The network pharmacology prediction results showed 20 active components with 260 targets in safflower, 1007 targets related to endometritis caused by incomplete abortion, and 114 drug-disease intersecting targets, including TNF, IL6, TP53, AKT1, JUN, VEGFA, CASP3 and other core targets, PI3K/AKT, MAPK and other signalling pathways may be closely related to incomplete abortion leading to endometritis. The animal experiment results showed that STF could significantly repair uterine damage and reduce the amount of bleeding. Compared with the model group, STF significantly down-regulated the levels of pro-inflammatory factors (IL-6, IL-1β, NO, TNF-α) and the expression of JNK, ASK1, Bax, caspase3, and caspase11 proteins. At the same time, the levels of anti-inflammatory factors (TGF-β and PGE2) and the protein expression of ERα, PI3K, AKT, and Bcl2 were up-regulated. Significant differences in the intestinal flora were seen between the normal group and the model group, and the intestinal flora of the rats was closer to the normal group after the administration of STF.
    Conclusions: The characteristics of STF used in the treatment of endometritis induced by incomplete abortion were multi-targeted and involved multiple pathways. The mechanism may be related to the activation of the ERα/PI3K/AKT signalling pathway by regulating the composition and ratio of the gut microbiota.
    MeSH term(s) Female ; Pregnancy ; Humans ; Animals ; Rats ; Abortion, Incomplete ; Carthamus tinctorius ; Estrogen Receptor alpha ; Endometritis/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Abortion, Spontaneous ; DNA, Ribosomal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Estrogen Receptor alpha ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; DNA, Ribosomal ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-05-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dynamic assessment of community resilience in China: empirical surveys from three provinces.

    Yan, Cunling / Liu, Xiaoyu / Zhang, Ning / Liu, Ying / Wang, Bingjie / Sun, Caihong / Tang, Yunli / Qi, Yue / Yu, Bingyan / Zhang, Luhao / Ning, Ning

    Frontiers in public health

    2024  Volume 12, Page(s) 1378723

    Abstract: Background: Strengthening the construction of community resilience and reducing disaster impacts are on the agenda of the Chinese government. The COVID-19 pandemic could alter the existing community resilience. This study aims to explore the dynamic ... ...

    Abstract Background: Strengthening the construction of community resilience and reducing disaster impacts are on the agenda of the Chinese government. The COVID-19 pandemic could alter the existing community resilience. This study aims to explore the dynamic change trends of community resilience in China and analyze the primary influencing factors of community resilience in the context of COVID-19, as well as construct Community Resilience Governance System Framework in China.
    Methods: A community advancing resilience toolkit (CART) was used to conduct surveys in Guangdong, Sichuan, and Heilongjiang provinces in China in 2015 and 2022, with community resilience data and information on disaster risk awareness and disaster risk reduction behaviors of residents collected. The qualitative (in-depth interview) data from staffs of government agencies and communities (
    Results: The results indicate that community resilience in China has improved significantly, presenting differences with statistical significance (
    Conclusion: During the pandemic, community resilience in China underwent significant changes. However, community capital was, is, and will be a weak link to community resilience. It is suggested that multi-stages assessments of dynamic change trends of community resilience should be further performed to analyze acting points and core influencing factors of community resilience establishment at different stages.
    MeSH term(s) Humans ; China/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Resilience, Psychological ; Male ; Female ; Surveys and Questionnaires ; Adult ; Middle Aged ; SARS-CoV-2 ; Pandemics
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1378723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Network pharmacology identification and in Vivo validation of key pharmacological pathways of Phyllanthus reticulatus (Euphorbiaceae) leaf extract in liver cancer treatment

    Tang, Yunli / Sun, Luyao / Wei, Jiangcun / Sun, Chen / Gan, Caiyu / Xie, Xiaofang / Liang, Chenyan / Peng, Cheng / Wu, Huaien / Zheng, Zuowen / Pan, Zhirui / Huang, Yuhua

    Journal of ethnopharmacology. 2022 June 14,

    2022  

    Abstract: Phyllanthus reticulatus (Euphorbiaceae) is a medicinal plant that has been used in Zhuang medicine since ancient times. Traditionally, it has the effect of removing toxins and detumescence and can be used to treat hepatitis in China and India. Our ... ...

    Abstract Phyllanthus reticulatus (Euphorbiaceae) is a medicinal plant that has been used in Zhuang medicine since ancient times. Traditionally, it has the effect of removing toxins and detumescence and can be used to treat hepatitis in China and India. Our previous studies have proved that the ethyl acetate extract of its leaves (PRPE) has an anti-hepatoma effect. To predict targets of an ethyl acetate extract of Phyllanthus reticulatus leaves (PRPE) in hepatoma treatment via network pharmacology and verify the predictions in a mouse model of liver cancer. Chemical constituents and therapeutic targets of P. reticulatus (PRP) were searched and predicted via public databases. A protein-protein interaction network comprising common targets was constructed, and the key gene targets were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for biological function and pathway enrichment analyses. The effects of PRP on BEL-7404 and HepG₂ cells were determined by MTT assay, apoptosis was measured by flow cytometry and hoechst44432/PI. And a nude mouse xenograft model was established to verify the anti-tumour effect in vivo. The histopathology of tumours was observed by staining with haematoxylin and eosin (H&E). Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry were used to determine the gene and protein expression levels of phosphoinositide 3-kinase (PI3K), Akt1, p53, caspase-3, Bcl-2 and Bax, respectively. Twenty-seven chemical components and 567 potential therapeutic targets of PRP were identified. GO analysis indicated that these targets are mainly associated with peptidyl-tyrosine phosphorylation and steroid metabolic process. KEGG analysis showed that the targets are mainly located in the PI3K/Akt, apoptosis, mitogen-activated protein kinase (MAPK), Ras and vascular endothelial growth factor (VEGF) signalling pathways. According to the p-adjust value, the PI3K/Akt pathway is the core pathway. In vitro, PRPE could inhibit proliferation and induce apoptosis in hepatoma cells. IC₅₀ values of PRPE were 2.48 and 6.34 mg/mL for BEL-7404 and hepG₂ cells, respectively. PRPE significantly reduced tumour volume and weight. H&E results showed that PRPE repaired necrotic areas in hepatoma cells. PRPE reduced the protein expression of PI3K, Akt1 and Bcl-2 and increased the protein expression of p53 and Bax. Meanwhile, PRPE reduced the mRNA expression of PI3K, AKT1 and BCL₂ and increased the mRNA expression of TP53, CASP3 and BAX. The targets of PRPE are the PI3K/Akt, apoptosis, MAPK, Ras and VEGF signalling pathways. Passing through the PI3K/Akt pathway to induce apoptosis is the main mechanism of PRPE.
    Keywords Euphorbiaceae ; Phyllanthus reticulatus ; apoptosis ; cancer therapy ; caspase-3 ; eosin ; ethyl acetate ; flow cytometry ; gene expression ; gene ontology ; genes ; hepatitis ; hepatoma ; histopathology ; immunohistochemistry ; leaf extracts ; medicinal plants ; mice ; mitogen-activated protein kinase ; pharmacology ; phosphatidylinositol 3-kinase ; phosphorylation ; protein synthesis ; protein-protein interactions ; reverse transcriptase polymerase chain reaction ; traditional medicine ; vascular endothelial growth factors ; xenotransplantation ; China ; India
    Language English
    Dates of publication 2022-0614
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115479
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin

    Chen, Junren / Li, Gangmin / Sun, Chen / Peng, Fu / Yu, Lei / Chen, Yan / Tan, Yuzhu / Cao, Xiaoyu / Tang, Yunli / Xie, Xiaofang / Peng, Cheng

    Phytotherapy research. 2022 Apr., v. 36, no. 4

    2022  

    Abstract: Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti‐ ... ...

    Abstract Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti‐microorganisms, immunomodulation, analgesia, wound healing, and vasodilation. Based on these various pharmacological activities, increasing studies have focused on the potency of quercitrin in diverse diseases in recent years, such as bone metabolic diseases, gastrointestinal diseases, cardiovascular and cerebrovascular diseases, and others. In this paper, by collecting and summarizing publications from the recent years, the natural sources, pharmacological activities and roles in various diseases, pharmacokinetics, structure–activity relationship, as well as the toxicity of quercitrin were systematically reviewed. In addition, the underlying molecular mechanisms of quercitrin in treating related diseases, the dose‐effect relationships, and the novel preparations were discussed on the purpose of broadening the application prospect of quercitrin as functional food and providing reference for its clinical application. Notably, clinical studies of quercitrin are insufficient at present, further high‐quality studies are needed to firmly establish the clinical efficacy of quercitrin.
    Keywords analgesia ; functional foods ; gastrointestinal system ; immunomodulation ; ingredients ; pharmacokinetics ; phytotherapy ; quercitrin ; research ; structure-activity relationships ; toxicity ; vasodilation
    Language English
    Dates of publication 2022-04
    Size p. 1545-1575.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article
    Note REVIEW
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7397
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Pharmacological Activities of Safflower Yellow and Its Clinical Applications.

    Chen, Yan / Li, Meifeng / Wen, Jiayu / Pan, Xiaoqi / Deng, Zixin / Chen, Junren / Chen, Guanru / Yu, Lei / Tang, Yunli / Li, Gangmin / Xie, Xiaofang / Peng, Cheng

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 2108557

    Abstract: Background: Safflower is an annual herb used in traditional Chinese herbal medicine. It consists of the dried flowers of the Compositae plant safflower. It is found in the central inland areas of Asia and is widely cultivated throughout the country. Its ...

    Abstract Background: Safflower is an annual herb used in traditional Chinese herbal medicine. It consists of the dried flowers of the Compositae plant safflower. It is found in the central inland areas of Asia and is widely cultivated throughout the country. Its resistance to cold weather and droughts and its tolerance and adaptability to salts and alkalis are strong. Safflower has the effect of activating blood circulation, dispersing blood stasis, and relieving pain. A natural pigment named safflower yellow (SY) can be extracted from safflower petals. Chemically, SY is a water-soluble flavonoid and the main active ingredient of safflower. The main chemical constituents, pharmacological properties, and clinical applications of SY are reviewed in this paper, thereby providing a reference for the use of safflower in preventing and treating human diseases.
    Methods: The literature published in recent years was reviewed, and the main chemical components of SY were identified based on chemical formula and structure. The pharmacological properties of hydroxysafflor yellow A (HSYA), SYA, SYB, and anhydrosafflor yellow B (AHSYB) were reviewed.
    Results: The main chemical constituents of SY included HSYA, SYA, SYB, and AHSYB. These ingredients have a wide range of pharmacological activities. SY has protective effects on the heart, kidneys, liver, nerves, lungs, and brain. Moreover, its effects include, but are not limited to, improving cardiovascular and cerebrovascular diseases, abirritation, regulating lipids, and treating cancer and diabetic complications. HSYA is widely recognised as an effective ingredient to treat cardiovascular and cerebrovascular diseases.
    Conclusion: SY has a wide range of pharmacological activities, among which improving cardiovascular and cerebrovascular diseases are the most significant.
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/2108557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  8. Article ; Online: Network pharmacology identification and in Vivo validation of key pharmacological pathways of Phyllanthus reticulatus (Euphorbiaceae) leaf extract in liver cancer treatment.

    Tang, Yunli / Sun, Luyao / Wei, Jiangcun / Sun, Chen / Gan, Caiyu / Xie, Xiaofang / Liang, Chenyan / Peng, Cheng / Wu, Huaien / Zheng, Zuowen / Pan, Zhirui / Huang, Yuhua

    Journal of ethnopharmacology

    2022  Volume 297, Page(s) 115479

    Abstract: Ethnopharmacological relevance: Phyllanthus reticulatus (Euphorbiaceae) is a medicinal plant that has been used in Zhuang medicine since ancient times. Traditionally, it has the effect of removing toxins and detumescence and can be used to treat ... ...

    Abstract Ethnopharmacological relevance: Phyllanthus reticulatus (Euphorbiaceae) is a medicinal plant that has been used in Zhuang medicine since ancient times. Traditionally, it has the effect of removing toxins and detumescence and can be used to treat hepatitis in China and India. Our previous studies have proved that the ethyl acetate extract of its leaves (PRPE) has an anti-hepatoma effect.
    Aim of the study: To predict targets of an ethyl acetate extract of Phyllanthus reticulatus leaves (PRPE) in hepatoma treatment via network pharmacology and verify the predictions in a mouse model of liver cancer.
    Materials and methods: Chemical constituents and therapeutic targets of P. reticulatus (PRP) were searched and predicted via public databases. A protein-protein interaction network comprising common targets was constructed, and the key gene targets were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for biological function and pathway enrichment analyses. The effects of PRP on BEL-7404 and HepG
    Results: Twenty-seven chemical components and 567 potential therapeutic targets of PRP were identified. GO analysis indicated that these targets are mainly associated with peptidyl-tyrosine phosphorylation and steroid metabolic process. KEGG analysis showed that the targets are mainly located in the PI3K/Akt, apoptosis, mitogen-activated protein kinase (MAPK), Ras and vascular endothelial growth factor (VEGF) signalling pathways. According to the p-adjust value, the PI3K/Akt pathway is the core pathway. In vitro, PRPE could inhibit proliferation and induce apoptosis in hepatoma cells. IC
    Conclusion: The targets of PRPE are the PI3K/Akt, apoptosis, MAPK, Ras and VEGF signalling pathways. Passing through the PI3K/Akt pathway to induce apoptosis is the main mechanism of PRPE.
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacology ; Euphorbiaceae ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Network Pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phyllanthus/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger ; Tumor Suppressor Protein p53 ; Vascular Endothelial Growth Factor A/metabolism ; bcl-2-Associated X Protein/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Plant Extracts ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; Tumor Suppressor Protein p53 ; Vascular Endothelial Growth Factor A ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-06-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin.

    Chen, Junren / Li, Gangmin / Sun, Chen / Peng, Fu / Yu, Lei / Chen, Yan / Tan, Yuzhu / Cao, Xiaoyu / Tang, Yunli / Xie, Xiaofang / Peng, Cheng

    Phytotherapy research : PTR

    2022  Volume 36, Issue 4, Page(s) 1545–1575

    Abstract: Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti- ... ...

    Abstract Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti-microorganisms, immunomodulation, analgesia, wound healing, and vasodilation. Based on these various pharmacological activities, increasing studies have focused on the potency of quercitrin in diverse diseases in recent years, such as bone metabolic diseases, gastrointestinal diseases, cardiovascular and cerebrovascular diseases, and others. In this paper, by collecting and summarizing publications from the recent years, the natural sources, pharmacological activities and roles in various diseases, pharmacokinetics, structure-activity relationship, as well as the toxicity of quercitrin were systematically reviewed. In addition, the underlying molecular mechanisms of quercitrin in treating related diseases, the dose-effect relationships, and the novel preparations were discussed on the purpose of broadening the application prospect of quercitrin as functional food and providing reference for its clinical application. Notably, clinical studies of quercitrin are insufficient at present, further high-quality studies are needed to firmly establish the clinical efficacy of quercitrin.
    MeSH term(s) Antioxidants/metabolism ; Antioxidants/pharmacology ; Flavonoids/pharmacology ; Oxidative Stress ; Quercetin/analogs & derivatives ; Quercetin/chemistry ; Quercetin/pharmacology
    Chemical Substances Antioxidants ; Flavonoids ; quercitrin (2Y8906LC5P) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein.

    Li, Gang-Min / Chen, Jun-Ren / Zhang, Hui-Qiong / Cao, Xiao-Yu / Sun, Chen / Peng, Fu / Yin, Yan-Peng / Lin, Ziwei / Yu, Lei / Chen, Yan / Tang, Yun-Li / Xie, Xiao-Fang / Peng, Cheng

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 4582412

    Abstract: Rhein, belonging to anthraquinone compounds, is one of the main active components of rhubarb ... ...

    Abstract Rhein, belonging to anthraquinone compounds, is one of the main active components of rhubarb and
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/4582412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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