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Article ; Online: Adalimumab for treatment of very early onset inflammatory bowel disease.

Xie, Yao / Liu, Li-Li / Jiang, Yi / Tang, Ze-Zhong / Sun, Guo-Yu / Hou, Xin-Lin

2019 Volume 132, Issue 23, Page(s) 2889–2890

MeSH term(s)	Adalimumab/therapeutic use ; Age of Onset ; Blood Sedimentation/drug effects ; C-Reactive Protein/metabolism ; Humans ; Infant, Newborn ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/physiopathology ; Male ; Treatment Outcome
Chemical Substances	C-Reactive Protein (9007-41-4) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2019-11-09
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000528
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Article: [STXBP1 gene mutation in newborns with refractory seizures].

Liu, Li-Li / Hou, Xin-Lin / Zhou, Cong-Le / Tang, Ze-Zhong / Bao, Xin-Hua / Jiang, Yi

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2014 Volume 16, Issue 7, Page(s) 701–704

Abstract: Objective: To study the relationship between STXBP1 gene mutations and refractory seizures with unknown causes in newborns.: Methods: The coding region of STXBP1 gene was detected using direct Sanger sequencing in 11 newborns with refractory seizures ...

Abstract	Objective: To study the relationship between STXBP1 gene mutations and refractory seizures with unknown causes in newborns. Methods: The coding region of STXBP1 gene was detected using direct Sanger sequencing in 11 newborns with refractory seizures of unknown causes. Results: STXBP1 gene mutation was found in 1 out of 11 patients. It was a missense mutation: c.1439C>T (p.P480L). Conclusions: STXBP1 gene mutation can be found in neonatal refractory seizures of unknown causes, suggesting a new approach of further research of this disease.
MeSH term(s)	Humans ; Infant, Newborn ; Munc18 Proteins/genetics ; Mutation ; Seizures/genetics
Chemical Substances	Munc18 Proteins ; STXBP1 protein, human
Language	Chinese
Publishing date	2014-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
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Article: Clinical Manifestations and Amplitude-integrated Encephalogram in Neonates with Early-onset Epileptic Encephalopathy.

Liu, Li-Li / Hou, Xin-Lin / Zhang, Dan-Dan / Sun, Guo-Yu / Zhou, Cong-Le / Jiang, Yi / Tang, Ze-Zhong / Zhang, Rui / Cui, Yun

Chinese medical journal

2017 Volume 130, Issue 23, Page(s) 2808–2815

Abstract: Background: The patients with early-onset epileptic encephalopathy (EOEE) suffer from neurodevelopmental delay. The aim of this study was to analyze the clinical manifestations and amplitude-integrated encephalogram (aEEG) characteristics of infants ... ...

Abstract	Background: The patients with early-onset epileptic encephalopathy (EOEE) suffer from neurodevelopmental delay. The aim of this study was to analyze the clinical manifestations and amplitude-integrated encephalogram (aEEG) characteristics of infants with EOEE with onset within the neonatal period, to make early diagnosis to improve the prognosis. Methods: One-hundred and twenty-eight patients with neonatal seizure were enrolled and followed up till 1 year old. Sixty-six neonates evolved into EOEE were as the EOEE group, the other 62 were as the non-EOEE (nEOEE) group. Then we compared the clinical and aEEG characteristics between the two groups to analyze the manifestations in neonates with EOEE. Results: Compared to the nEOEE group, the incidence of daily seizure attacks, more than two types of convulsions, more than two antiepileptic drugs (AEDs) application, severely abnormal aEEG background, absence of cyclicity, and more than two seizures detection were significantly higher in the EOEE group (P < 0.05) (97% vs. 54.8%; 30.3% vs. 14.5%; 97.0% vs. 25.4%; 39.4% vs. 3.2%; 57.6% vs. 9.7%; and 56% vs. 3.2%, respectively). Severely abnormal background pattern (odds ratio [OR] = 0.081, 95% confidence interval [CI]: 0.009-0.729, P = 0.025) and more than two seizures detection by aEEG (OR = 0.158, 95% CI: 0.043-0.576, P = 0.005) were the independent risk factors for the evolvement into EOEE. The upper and lower margins of active sleep (AS) and quiet sleep (QS) were significantly higher in EOEE group than those of the control group (P < 0.05) (34.3 ± 13.6 vs. 21.3 ± 6.4; 9.9 ± 3.7 vs. 6.7 ± 2.2; 41.2 ± 15.1 vs. 30.4 ± 11.4; and 11.9 ± 4.4 vs. 9.4 ± 4.0; unit: μV, respectively). AS upper margin was demonstrated a higher diagnostic specificity and sensitivity for EOEE than another three parameters according to the receiver operating characteristic curves; the area under the curve was 0.827. Conclusions: The clinical characteristics of the neonatal seizure which will evolve into EOEE were more than two AEDs application, high seizure frequency (daily attack), and more than two types of the seizure. Significant high voltage, severely abnormal background, absence of cyclicity, and more than two seizures detected on aEEG were the meaningful indicators to the prediction of EOEE.
MeSH term(s)	Anticonvulsants/therapeutic use ; Early Diagnosis ; Electroencephalography/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Risk Factors ; Seizures/diagnosis ; Seizures/drug therapy
Chemical Substances	Anticonvulsants
Language	English
Publishing date	2017-12-05
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.219152
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Article: [Studies on hereditary epidemiology of cardia cancer in Shanxi province.].

Wang, Yuan / Han, Xiao-you / Din, Ti / Tang, Ze-zhong / Xu, Yi / Wang, Quan-hong

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2010 Volume 31, Issue 3, Page(s) 294–296

Abstract: Objective: Studies on cardia-cancer caused by hereditary factors.: Methods: Case-control method was adopted, with information including name, sex, date of birth, date of death of all the I, II, III relatives of the patients, diagnosis and the ... ...

Abstract	Objective: Studies on cardia-cancer caused by hereditary factors. Methods: Case-control method was adopted, with information including name, sex, date of birth, date of death of all the I, II, III relatives of the patients, diagnosis and the treatment collected. The hereditary probability of cardia cancer and the separation degree were calculated by Falconer and Li-Mentel-Gart. Results: (1) Prevalence rates of cardia-cancer on relative I, relative II, relative III of cardia-cancer patients appeared to be 0.54%, 0.04%, and 0.05% respectively. Prevalence rates of upper-digestive-tract-cancer of relative I, relative II, relative III of cardia-cancer patients showed as: 2.50%, 0.36% and 0.13% respectively. Data showed that relative I > relative II > relative III and family cluster existed in both males and females. (2) Cardia-cancer hereditary probability of the relative I cardia-cancer probands was 11.71%, with males as 14.01% and females as 14.72%. The upper-digestive-tract-cancer hereditary probability of the relative I cardia-cancer probands was 13.87%, with males as 11.49% and females as 23.08%, both below 25%, indicating this was a low hereditary cancer. (3) The upper-digestive-tract-cancer separation of the blood compatriots of cardia-cancer patients was 0.0452, with males as 0.0441 and females as 0.0507, both below 0.25, indicating the nature of a multi-gene but not single-gene hereditary way. Conclusion: Hereditary factor is recognized as one of the high risk cardia cancer, but not the most risky factor causing the high morbidity of cardia cancer in Shanxi province.
MeSH term(s)	Aged ; Cardia ; China/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/genetics
Language	Chinese
Publishing date	2010-03
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
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Article: [Report of a case with Wilson-Mikity syndrome].

Sun, Yan-ling / Tang, Ze-zhong / Yu, Ren-jie

Zhonghua er ke za zhi = Chinese journal of pediatrics

2003 Volume 41, Issue 1, Page(s) 64

MeSH term(s)	Fatal Outcome ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/physiopathology ; Male ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/physiopathology ; Syndrome
Language	Chinese
Publishing date	2003-01
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
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Article: [Diagnosis and prognosis of neonatal cerebral infarction].

Tang, Ze-zhong / Zhou, Cong-le / Jiang, Yi / Hou, Xin-lin

Zhonghua er ke za zhi = Chinese journal of pediatrics

2004 Volume 42, Issue 6, Page(s) 429–432

Abstract: Objective: To analyze the relationship between clinical characteristics and prognosis of neonatal cerebral infarction and to draw attention to the disease to improve the long-term outcome through early diagnosis and intervention.: Methods: The ... ...

Abstract	Objective: To analyze the relationship between clinical characteristics and prognosis of neonatal cerebral infarction and to draw attention to the disease to improve the long-term outcome through early diagnosis and intervention. Methods: The clinical characteristics of 6 confirmed cases were summarized. Perinatal conditions and other factors were analyzed for possible causes of the disease. The survived patients were followed-up for 6-8 months. Results: The authors diagnosed 6 cases of neonatal cerebral infarction in one year, which accounted for 0.6% (6/969) of all the in-patients in the same time period. Among them 3 cases were confirmed as cerebrovascular malformations by magnetic resonance angiography (MRA), In 1 case the infarction was due to severe bilateral intraventricular hemorrhage, and in another case the disease was related to comprehensive factors such as prematurity, maternal pregnancy induced hypertension and respiratory failure secondary to bronchopulmonary dysplasia (BPD), and in 1 case the cause was undetermined. Four out of the 6 patients presented with varied forms of convulsions, which became the second leading cause for all the neonatal convulsive events (20%). None of the patients had localized neurological signs in the early course except for abnormal muscular tone of some extent. Cerebral ultrasound scanning in 5 out of 6 cases showed positive results. The diffusion-weighted magnetic resonance imaging (DW-MRI) was highly valuable for early confirmative diagnosis. Only one case was found normal within one year of follow-up and all the other 5 cases had unfavorable prognoses of varied severity. Conclusion: Neonatal cerebral infarction is not a rare condition and should be considered as one of the important causes for neonatal convulsion. Imaging study is the main technique for diagnosis. The prognoses were poor for those cases for whom early diagnosis and treatment can not be made or those with widespread cerebral lesions.
MeSH term(s)	Brain/blood supply ; Brain/pathology ; Cerebral Hemorrhage/complications ; Cerebral Infarction/diagnosis ; Cerebral Infarction/etiology ; Follow-Up Studies ; Humans ; Infant, Newborn ; Magnetic Resonance Angiography ; Male ; Prognosis ; Seizures/etiology
Language	Chinese
Publishing date	2004-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
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Article: [Evaluation of early cognitive ability of infants born preterm by near-infrared spectroscopy].

Hou, Xin-Lin / Zhou, Cong-Le / Huang, Lan / Ding, Hai-Shu / Tang, Ze-Zhong / Jiang, Yi

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2006 Volume 8, Issue 5, Page(s) 361–364

Abstract: Objective: To compare the differences in cerebral oxygenation responses between the infants born preterm and full-term infants and to evaluate the early cognitive ability of infants born preterm.: Methods: Cerebral oxygenation after light stimulation ...

Abstract	Objective: To compare the differences in cerebral oxygenation responses between the infants born preterm and full-term infants and to evaluate the early cognitive ability of infants born preterm. Methods: Cerebral oxygenation after light stimulation was detected by near infrared spectroscopy (NIRS) in preterm infants at 3 or 6 months corrected gestational age (GA). The results were compared with those of age-matched infants born at term. Results: The start and peak response time of cerebral oxygenation occurring after light stimulation in preterm infants at 3 months corrected GA was 17.2 +/- 5.2 and 38.4 +/- 9.6 seconds respectively, which were significantly longer than in age-matched term infants (13.1 +/- 2.7 and 28.9 +/- 5.0 seconds respectively) (P < 0.05). The maximum response value of hemoglobin, oxyhemoglobin and regional oxygen saturation of the preterm infants at 3 months corrected GA was (1.2 +/- 0.5)%, (1.5 +/- 0.6)%, and (1.3 +/- 0.4)% respectively , which were significantly lower than that of the term infants [(2.3 +/- 0.3)%, (2.8 +/- 0.3)% and (2.4 +/- 0.5)% respectively] (P < 0.05). Cerebral oxygenation responses to light stimulation in preterm infants examined at 6 months corrected GA were not significantly different from age-matched term infants. Conclusions: Cerebral oxygenation responses to light stimulation in infants born preterm at 3 months corrected GA are not as good as age-matched term infants, but were close to the level of age-matched term infants at 6 months corrected GA. This suggests that the early cognitive ability of preterm infants before 3 months corrected GA might fall behind age-matched term infants.
MeSH term(s)	Brain/metabolism ; Cognition ; Humans ; Infant, Newborn ; Infant, Premature ; Oxygen/metabolism ; Photic Stimulation ; Spectroscopy, Near-Infrared
Chemical Substances	Oxygen (S88TT14065)
Language	Chinese
Publishing date	2006-10
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
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Article ; Online: Integrative genomics analysis of genes with biallelic loss and its relation to the expression of mRNA and micro-RNA in esophageal squamous cell carcinoma.

Hu, Nan / Wang, Chaoyu / Clifford, Robert J / Yang, Howard H / Su, Hua / Wang, Lemin / Wang, Yuan / Xu, Yi / Tang, Ze-Zhong / Ding, Ti / Zhang, Tongwu / Goldstein, Alisa M / Giffen, Carol / Lee, Maxwell P / Taylor, Philip R

BMC genomics

2015 Volume 16, Issue 1, Page(s) 732

Abstract: Background: Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy number (CN) changes in tumors. In ... ...

Abstract	Background: Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy number (CN) changes in tumors. In the current study we focus on biallelic loss and its relation to expression of mRNA and miRNA in ESCC using results from 500 K SNP, mRNA, and miRNA arrays in 30 cases from a high-risk region of China. Results: (i) Biallelic loss was uncommon but when it occurred it exhibited a consistent pattern: only 77 genes (<0.5%) showed biallelic loss in at least 10% of ESCC samples, but nearly all of these genes were concentrated on just four chromosomal arms (i.e., 42 genes on 3p, 14 genes on 9p, 10 genes on 5q, and seven genes on 4p). (ii) Biallelic loss was associated with lower mRNA expression: 52 of the 77 genes also had RNA expression data, and 41 (79%) showed lower expression levels in cases with biallelic loss compared to those without. (iii) The relation of biallelic loss to miRNA expression was less clear but appeared to favor higher miRNA levels: of 60 miRNA-target gene pairs, 34 pairs (57%) had higher miRNA expression with biallelic loss than without, while 26 pairs (43%) had lower miRNA expression. (iv) Finally, the effect of biallelic loss on the relation between miRNA and mRNA expression was complex. Biallelic loss was most commonly associated with a pattern of elevated miRNA and reduced mRNA (43%), but a pattern of both reduced miRNA and mRNA was also common (35%). Conclusion: Our results indicate that biallelic loss in ESCC is uncommon, but when it occurs it is localized to a few specific chromosome regions and is associated with reduced mRNA expression of affected genes. The effect of biallelic loss on miRNA expression and on the relation between miRNA and mRNA expressions was complex.
MeSH term(s)	Adult ; Aged ; Alleles ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; China ; Chromosomes, Human ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Squamous Cell Carcinoma ; Female ; Genetic Association Studies ; Genomic Instability ; Humans ; Male ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Grading ; RNA, Messenger/metabolism ; Transcriptome
Chemical Substances	MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2015-09-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-015-1919-0
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Article ; Online: Common genetic variants related to vitamin D status are not associated with esophageal squamous cell carcinoma risk in China.

Wang, Jian-Bing / Dawsey, Sanford M / Fan, Jin-Hu / Freedman, Neal D / Tang, Ze-Zhong / Ding, Ti / Hu, Nan / Wang, Le-Min / Wang, Chao-Yu / Su, Hua / Qiao, You-Lin / Goldstein, Alisa M / Taylor, Philip R / Abnet, Christian C

Cancer epidemiology

2015 Volume 39, Issue 2, Page(s) 157–159

Abstract: Background: Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC).: Methods: We evaluated the association between 12 single nucleotide ... ...

Abstract	Background: Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC). Methods: We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk using data from a genome-wide association study. Participants were recruited from the Shanxi Upper Gastrointestinal Cancer Genetics Project and the Linxian Nutrition Intervention Trials, and included 1942 ESCC cases and 2111 controls. We used logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the SNP associations, after controlling for age and gender. Results: None of the 12 evaluated SNPs in the four vitamin D-related genes were significantly associated with risk of ESCC. The strongest associations were for rs3794060 (P=0.07) and rs12800438 (P=0.08) in the DHCR7/NADSYN1 gene. No association between vitamin D-related SNPs and risk of ESCC was observed in a genotype score analysis that included all 12 SNPs. ORs for quartiles 2, 3 and 4 of the genotype scores were 0.83 (95% CI: 0.68, 1.01), 1.02 (0.85, 1.21), and 1.08 (0.89, 1.30), respectively, with no evidence for a significant monotonic trend (P=0.120). Conclusions: Our results suggested that common genetic variants related to vitamin D levels are not associated with risk of ESCC in this Chinese population.
MeSH term(s)	Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; China ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Squamous Cell Carcinoma ; Female ; Genetic Variation ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors ; Vitamin D/metabolism
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2015-01-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2014.12.013
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Article ; Online: Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method

Hu Nan / Tang Ze-Zhong / Perkins Roger / Hong Huixiao / Ratnasinghe Luke D / Xie Qian / Taylor Philip R / Tong Weida

BMC Bioinformatics, Vol 6, Iss Suppl 2, p S

2005 Volume 4

Abstract: Abstract Background Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provide breakthroughs in the understanding of complex diseases. ... ...

Abstract	Abstract Background Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provide breakthroughs in the understanding of complex diseases. Understanding how the millions of SNPs in the human genome are involved in conferring susceptibility or resistance to disease, or in rendering a drug efficacious or toxic in the individual is a major goal of the relatively new fields of pharmacogenomics. Esophageal squamous cell carcinoma is a high-mortality cancer with complex etiology and progression involving both genetic and environmental factors. We examined the association between esophageal cancer risk and patterns of 61 SNPs in a case-control study for a population from Shanxi Province in North Central China that has among the highest rates of esophageal squamous cell carcinoma in the world. Methods High-throughput Masscode mass spectrometry genotyping was done on genomic DNA from 574 individuals (394 cases and 180 age-frequency matched controls). SNPs were chosen from among genes involving DNA repair enzymes, and Phase I and Phase II enzymes. We developed a novel adaptation of the Decision Forest pattern recognition method named Decision Forest for SNPs (DF-SNPs). The method was designated to analyze the SNP data. Results The classifier in separating the cases from the controls developed with DF-SNPs gave concordance, sensitivity and specificity, of 94.7%, 99.0% and 85.1%, respectively; suggesting its usefulness for hypothesizing what SNPs or combinations of SNPs could be involved in susceptibility to esophageal cancer. Importantly, the DF-SNPs algorithm incorporated a randomization test for assessing the relevance (or importance) of individual SNPs, SNP types (Homozygous common, heterozygous and homozygous variant) and patterns of SNP types (SNP patterns) that differentiate cases from controls. For example, we found that the different genotypes of SNP GADD45B E1122 are all associated with cancer risk. Conclusion The DF-SNPs method can be used to differentiate esophageal squamous cell carcinoma cases from controls based on individual SNPs, SNP types and SNP patterns. The method could be useful to identify potential biomarkers from the SNP data and complement existing methods for genotype analyses.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	501
Language	English
Publishing date	2005-07-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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