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  1. Article ; Online: Future Directions and Molecular Basis of Ventilator Associated Pneumonia.

    Aykac, Kubra / Ozsurekci, Yasemin / Tanir Basaranoglu, Sevgen

    Canadian respiratory journal

    2017  Volume 2017, Page(s) 2614602

    Abstract: Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care ...

    Abstract Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. A lot of microbes are detected as a causative agent of VAP. The most common isolated VAP pathogens in pediatric patients are
    MeSH term(s) Animals ; Humans ; Pneumonia, Ventilator-Associated/microbiology
    Language English
    Publishing date 2017
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 1213103-9
    ISSN 1916-7245 ; 1198-2241
    ISSN (online) 1916-7245
    ISSN 1198-2241
    DOI 10.1155/2017/2614602
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  2. Article ; Online: Adhesion molecules as diagnostic and severity biomarkers in pediatric community-acquired pneumonia.

    Tanır Basaranoglu, Sevgen / Ozsurekci, Yasemin / Aykac, Kubra / Iyigun, Irem / Satirer, Ozlem / Akin, Mustafa Senol / Ceyhan, Mehmet

    The clinical respiratory journal

    2021  Volume 15, Issue 5, Page(s) 522–529

    Abstract: Background: Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of hospitalization, additional management, and treatment protocols. We aimed to analyze the role of IL6 (Interleukin), IL8, IL10, VCAM-1 (soluble ... ...

    Abstract Background: Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of hospitalization, additional management, and treatment protocols. We aimed to analyze the role of IL6 (Interleukin), IL8, IL10, VCAM-1 (soluble Vascular Cell Adhesion Molecule), and sSELE (soluble E-selectin) in the diagnosis and prognostic evaluation of community-acquired pneumonia (CAP).
    Methods: Pediatric patients with severe pneumonia (SP) were hospitalized and patients with mild disease (MP) were treated in the community. IL6, IL8, IL10, VCAM-1, and sSELE levels of the patients were investigated and compared with the age- and gender-matched healthy subjects.
    Results: A total of 113 patients fulfilling the criteria for a diagnosis of CAP were enrolled in the study, 62 (54.8%) of which had SP and 51 (45%) had MP. MP and SP groups were significantly different in terms of IL8, IL10, and sSELE levels. Patients with SP and MP had significantly different WBC, ESR, and CRP values, as well.
    Conclusions: Besides classical acute phase parameters, inflammatory response parameters such as IL6 and VCAM-1 levels may be helpful in diagnosis of pneumonia. In terms of determination of disease severity in pediatric CAP, systemic inflammatory markers like IL8 and IL10 and adhesion molecules like sSELE seem useful in clinical settings.
    MeSH term(s) Biomarkers ; C-Reactive Protein ; Child ; Community-Acquired Infections ; Humans ; Pneumonia ; Prognosis
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13334
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  3. Article ; Online: Oxidant and antioxidant balance in children with bacteremia.

    Aykac, Kubra / Ozsurekci, Yasemin / Tanir Basaranoglu, Sevgen / Demir, Osman O / Avcioglu, Gamze / Erel, Ozcan / Ceyhan, Mehmet

    Minerva pediatrics

    2020  Volume 75, Issue 6, Page(s) 876–883

    Abstract: Background: There is a crucial balance between oxidant and antioxidant defense mechanisms. We aimed to evaluate the role of the balance of these systems in children with bloodstream infection.: Methods: We analyzed prospectively oxidant and ... ...

    Abstract Background: There is a crucial balance between oxidant and antioxidant defense mechanisms. We aimed to evaluate the role of the balance of these systems in children with bloodstream infection.
    Methods: We analyzed prospectively oxidant and antioxidant stress parameters from serum samples of children with BSI besides demographic and clinical data of children. Serum levels of the total antioxidant status (TAS), total oxidant status (TOS), albumin, plasma thiol, disulphide, catalase (CAT), myeloperoxidase (MPO), ischemia-modified albumin (IMA) levels, ferroxidase and arylesterase (ARES) activity were evaluated in both patients and healthy controls.
    Results: A total of 113 children were evaluated, 50 of them had bacteremia and the remaining 63 were healthy subjects. The median TOS values were 18.5 µmol H<inf>2</inf>O<inf>2</inf>/L and 13.1 µmol H<inf>2</inf>O<inf>2</inf>/L in patient and control groups, respectively with a statistically significant difference between groups. The mean serum IMA levels were 0.8±0.1 absorbance unit (ABSU) in patients and 0.5±0.09 ABSU in control, the difference between groups was statistically significant. The native thiol, total thiol levels and the disulphide levels were significantly lower in the patient group as compared with the control group. The myeloperoxidase level was 136 U/L in patients and 107 in controls with a statistically significant difference between groups.
    Conclusions: TOS, IMA, MPO, and particularly plasma thiols seem good candidates for accurate diagnosis of bacteremia in children.
    MeSH term(s) Humans ; Child ; Antioxidants/metabolism ; Oxidants ; Peroxidase ; Biomarkers ; Oxidative Stress ; Serum Albumin ; Disulfides ; Sulfhydryl Compounds ; Bacteremia/diagnosis
    Chemical Substances Antioxidants ; Oxidants ; Peroxidase (EC 1.11.1.7) ; Biomarkers ; Serum Albumin ; Disulfides ; Sulfhydryl Compounds
    Language English
    Publishing date 2020-09-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.20.05748-5
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  4. Article ; Online: Etiological and Clinical Profile of Acute Nonbacterial Encephalitis in Children: A Single-Center Prospective Study.

    Cengiz, Ali Bülent / Günbey, Ceren / Ceyhan, Mehmet / Korukluoğlu, Gülay / Tanır Başaranoğlu, Sevgen / Eroğlu Ertuğrul, Nesibe Gevher / Coşgun, Yasemin / Konuşkan, Bahadır / Özsürekci, Yasemin / Anlar, Banu

    Neuropediatrics

    2021  Volume 52, Issue 6, Page(s) 448–454

    Abstract: Encephalitis is a serious neurological syndrome caused by inflammation of the brain. The diagnosis can be challenging and etiology remains unidentified in about half of the pediatric cases. We aimed to investigate demographic, clinical, laboratory, ... ...

    Abstract Encephalitis is a serious neurological syndrome caused by inflammation of the brain. The diagnosis can be challenging and etiology remains unidentified in about half of the pediatric cases. We aimed to investigate demographic, clinical, laboratory, electroencephalographic and neuroimaging findings, and outcome of acute encephalitis of nonbacterial etiology. This prospective study included children hospitalized with the diagnosis of acute encephalitis between 2017 and 2019. Microbiological investigations of the cerebrospinal fluid (CSF) were recorded. All CSF specimens were tested for anti-N methyl D-aspartate receptor (NMDAR) antibodies. In total, 31 children aged 10 months to 17 years (median = 6 years) were included. Pathogens were confirmed in CSF in three patients (9.7%): varicella zoster virus, herpes simplex virus type 1 (HSV-1), and both HSV-1 and NMDAR antibodies. Presenting features included encephalopathy (100%), fever (80.6%), seizure (45.2%), focal neurological signs (29%), and ataxia (19.4%). On clinical follow-up of median 9 (6-24) months, six patients showed neurological deficits: together with two patients who died in hospital, total eight (25.8%) patients were considered to have unfavorable outcome. Need for intubation, receiving immunomodulatory treatment, prolonged hospitalization, and high erythrocyte sedimentation rate at admission were associated with unfavorable outcome. The etiology of encephalitis remains unexplained in the majority of children. HSV-1 is the most frequently detected virus, consistent with the literature. The fact that anti-NMDAR encephalitis was detected in one child suggests autoimmune encephalitis not being rare in our center. The outcome is favorable in the majority while about one-fifth of cases suffer from sequelae.
    MeSH term(s) Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy ; Child ; Hashimoto Disease/complications ; Humans ; Infant ; Neuroimaging ; Prospective Studies ; Seizures/complications
    Language English
    Publishing date 2021-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0041-1723954
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    Zs.A 728: Show issues Location:
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  5. Article ; Online: Absceso perianal en niños: perspectiva desde el campo de la infectología pediátrica.

    Tanır Basaranoglu, Sevgen / Ozsurekci, Yasemin / Cengiz, Ali Bulent / Karadag Oncel, Eda / Aykac, Kubrac / Kara, Ates / Ceyhan, Mehmet

    Anales de pediatria

    2018  Volume 90, Issue 6, Page(s) 370–375

    Abstract: Introduction: There are limited data on the aetiology and management of perianal abscesses (PAs). The aim of this retrospective study was to define the characteristics of children with PAs; describe our experience with PA from the perspective of ... ...

    Title translation Perianal abscess in children: A pediatric infectious disease perspective.
    Abstract Introduction: There are limited data on the aetiology and management of perianal abscesses (PAs). The aim of this retrospective study was to define the characteristics of children with PAs; describe our experience with PA from the perspective of paediatric infectious medicine and determine the factors that influence clinical outcomes.
    Methods: We performed a retrospective review of cases of PA in children with no underlying disease managed in a tertiary referral hospital between January 2005 and July 2015. We collected data on demographic characteristics, symptoms, abscess size and location, abscess recurrences, laboratory and microbiological findings, treatment modalities, diagnosis of systemic illness at the end of the diagnostic workup and clinical outcomes.
    Results: We included a total of 47 patients in the study, with a predominance of male patients (93.6 vs 6.4%, P<.001). The median age was 7.7 months (IQR 1.8-13.7 months), and 40 children (85.1%) were younger than 2 years of age. Four PAs drained spontaneously and 7 healed without need of drainage (23.4%). Drainage by simple incision was applied to 36 patients (76.5%) and six PAs required fistulotomy (12.7%). Recurrent abscesses were found in 25 patients (53.1%). Three patients with recurrent PA were diagnosed with inflammatory bowel disease at the end of the diagnostic evaluation.
    Conclusions: Based on the findings of our study, measurement of white blood cell counts and serum levels of acute phase reactants may be useful in the initial evaluation of children with PA. In light of the high relapse rates observed in surgically managed patients, it seems reasonable to use a conservative approach in patients aged less than 2 years.
    MeSH term(s) Abscess/diagnosis ; Abscess/therapy ; Anus Diseases/diagnosis ; Anus Diseases/therapy ; Female ; Humans ; Infant ; Male ; Retrospective Studies
    Language Spanish
    Publishing date 2018-06-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2018.03.020
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  6. Article ; Online: Presepsin: A new marker of catheter related blood stream infections in pediatric patients: Reply to Rivera-Moran Javier et al.

    Tanır Basaranoglu, Sevgen / Karadag-Oncel, Eda / Aykac, Kubra / Ozsurekci, Yasemin / Aycan, Ahmet Emre / Cengiz, Ali Bulent / Kara, Ates / Ceyhan, Mehmet

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2018  Volume 24, Issue 8, Page(s) 687

    MeSH term(s) Bacteremia ; Biomarkers ; Calcitonin ; Child ; Humans ; Lipopolysaccharide Receptors ; Peptide Fragments
    Chemical Substances Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; presepsin protein, human ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2018-05-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2018.04.008
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  7. Article ; Online: Respiratory viral infections in infants with possible sepsis.

    Aykac, Kubra / Karadag-Oncel, Eda / Tanır Basaranoglu, Sevgen / Alp, Alpaslan / Cengiz, Ali Bulent / Ceyhan, Mehmet / Kara, Ates

    Journal of medical virology

    2018  Volume 91, Issue 2, Page(s) 171–178

    Abstract: Background: Knowledge of infections leading to sepsis is needed to develop comprehensive infection prevention and sepsis, as well as early recognition and treatment strategies.The aim of this study was to investigate the etiology of sepsis and evaluate ... ...

    Abstract Background: Knowledge of infections leading to sepsis is needed to develop comprehensive infection prevention and sepsis, as well as early recognition and treatment strategies.The aim of this study was to investigate the etiology of sepsis and evaluate the proportion of respiratory viral pathogens in infants under two years of age with possible sepsis.
    Methods: The prospective study was performed in two years. Multiplex reverse transcriptase polymerase chain reaction (RT-PCR) was performed to detect viral pathogens. All patients who were included in this study had sepsis symptoms as defined by the Surviving Sepsis Campaign.
    Results: We compared 90 patients with sepsis into three groups as patients (n = 33) who had only viral positivity in nasopharyngeal swab, patients (17) had proven bacterial infection with or without viral infection, and patients (40) without the pathogen detection. Human rhinovirus (16.7%) and influenza (7.8%) were the most commonly seen viruses. A cough was more common in the viral infection group than other groups ( P = 0.02) and median thrombocyte count was lower in the bacterial infection group than the others ( P = 0.01). Patients having bacterial sepsis had the longest duration of hospitalization than the other groups ( P = 0.04). During winter and spring seaons, patients with sepsis had more viral infection; however, in summer and autumn period, patients were mostly in a state that we could not prove infection agents ( P = 0.02).
    Conclusions: Our results suggest that respiratory tract viruses may play an important role in patients with sepsis and they should be kept in mind, especially during winter and spring seasons. In overall infection, viral respiratory viruses as a single pathogen with a detection rate of 36.6% in sepsis etiology.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Infant ; Male ; Prospective Studies ; Respiratory Tract Infections/complications ; Sepsis/etiology ; Virus Diseases/epidemiology ; Virus Diseases/virology ; Viruses/classification ; Viruses/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2018-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25309
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    Zs.A 1320: Show issues Location:
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  8. Article ; Online: Surveillance of penicillin resistance of

    Karadag Oncel, Eda / Ceyhan, Mehmet / Tanir Basaranoglu, Sevgen / Gurbuz, Venhar / Aycan, Ahmet Emre / Ozsurekci, Yasemin / Kurugol, Zafer / Keser Emiroglu, Melike / Devrim, Ilker / Karbuz, Adem / Altay Akisoglu, Havva Ozlem / Gurler, Nezahat

    Journal of chemotherapy (Florence, Italy)

    2020  Volume 32, Issue 4, Page(s) 213–216

    Abstract: Neisseria ... ...

    Abstract Neisseria meningitidis
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Meningitis, Meningococcal/drug therapy ; Meningitis, Meningococcal/epidemiology ; Microbial Sensitivity Tests ; Neisseria meningitidis/isolation & purification ; Penicillin Resistance/drug effects ; Turkey/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2020.1721176
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  9. Article ; Online: Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era.

    Tanır Basaranoglu, Sevgen / Karadag Oncel, Eda / Aykac, Kubra / Ozsurekci, Yasemin / Cengiz, Ali Bülent / Kara, Ates / Ceyhan, Mehmet

    Human vaccines & immunotherapeutics

    2017  Volume 13, Issue 4, Page(s) 962–964

    Abstract: A breakthrough infection occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in Turkey are previously described. A breakthrough infection is defined as IPD in a child who had received ≥ 1 PCV-7 or PCV-13 and for which the pneumococcal isolate ...

    Abstract A breakthrough infection occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in Turkey are previously described. A breakthrough infection is defined as IPD in a child who had received ≥ 1 PCV-7 or PCV-13 and for which the pneumococcal isolate was a vaccine serotype. During one year period, among 6 patients with invasive pneumococcal infection, 2 patients were considered to have a vaccine failure with serotype 19F. Antibiotic resistance results were remarkable; macrolide resistance were observed in all strains except one, and high and intermediate penicillin resistance were determined in 2 strains.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Bacteremia/prevention & control ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Humans ; Infant ; Male ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/microbiology ; Meningitis, Bacterial/prevention & control ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/immunology ; Serogroup ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/isolation & purification ; Tertiary Care Centers ; Treatment Failure ; Turkey
    Chemical Substances Anti-Bacterial Agents ; Pneumococcal Vaccines
    Language English
    Publishing date 2017-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2016.1256519
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  10. Article: Add-On Therapy with Ertapenem in Infections with Multidrug Resistant Gram-Negative Bacteria: Pediatric Experience.

    Tanır Basaranoglu, Sevgen / Ozsurekci, Yasemin / Aykac, Kubra / Arıkan, Kamile Oktay / Buyukcam, Ayse / Cengiz, Ali Bulent / Ceyhan, Mehmet / Kara, Ates

    Case reports in infectious diseases

    2017  Volume 2017, Page(s) 8096420

    Abstract: Optimal therapy for infections with carbapenem resistant GNB is not well established due to the weakness of data. Patients presenting with bloodstream infections caused by multidrug ... ...

    Abstract Optimal therapy for infections with carbapenem resistant GNB is not well established due to the weakness of data. Patients presenting with bloodstream infections caused by multidrug resistant
    Language English
    Publishing date 2017-07-26
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2017/8096420
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