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  1. AU="Tanner, Rachel"
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  1. Article ; Online: Demonstrating the utility of the ex vivo murine mycobacterial growth inhibition assay (MGIA) for high-throughput screening of tuberculosis vaccine candidates against multiple Mycobacterium tuberculosis complex strains.

    Painter, Hannah / Willcocks, Sam / Zelmer, Andrea / Reljic, Rajko / Tanner, Rachel / Fletcher, Helen

    Tuberculosis (Edinburgh, Scotland)

    2024  Volume 146, Page(s) 102494

    Abstract: Human tuberculosis (TB) is caused by various members of the Mycobacterium tuberculosis (Mtb) complex. Differences in host response to infection have been reported, illustrative of a need to evaluate efficacy of novel vaccine candidates against multiple ... ...

    Abstract Human tuberculosis (TB) is caused by various members of the Mycobacterium tuberculosis (Mtb) complex. Differences in host response to infection have been reported, illustrative of a need to evaluate efficacy of novel vaccine candidates against multiple strains in preclinical studies. We previously showed that the murine lung and spleen direct mycobacterial growth inhibition assay (MGIA) can be used to assess control of ex vivo mycobacterial growth by host cells. The number of mice required for the assay is significantly lower than in vivo studies, facilitating testing of multiple strains and/or the incorporation of other cellular analyses. Here, we provide proof-of-concept that the murine MGIA can be applied to evaluate vaccine-induced protection against multiple Mtb clinical isolates. Using an ancient and modern strain of the Mtb complex, we demonstrate that ex vivo bacillus Calmette-Guérin (BCG)-mediated mycobacterial growth inhibition recapitulates protection observed in the lung and spleen following in vivo infection of mice. Further, we provide the first report of cellular and transcriptional correlates of BCG-induced growth inhibition in the lung MGIA. The ex vivo MGIA represents a promising platform to gain early insight into vaccine performance against a collection of Mtb strains and improve preclinical evaluation of TB vaccine candidates.
    MeSH term(s) Mice ; Humans ; Animals ; Tuberculosis Vaccines ; Mycobacterium tuberculosis ; BCG Vaccine ; High-Throughput Screening Assays ; Tuberculosis/microbiology ; Mycobacterium bovis
    Chemical Substances Tuberculosis Vaccines ; BCG Vaccine
    Language English
    Publishing date 2024-02-13
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2024.102494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development and application of the direct mycobacterial growth inhibition assay: a systematic review.

    Painter, Hannah / Harriss, Eli / Fletcher, Helen A / McShane, Helen / Tanner, Rachel

    Frontiers in immunology

    2024  Volume 15, Page(s) 1355983

    Abstract: Introduction: First described by Wallis et al. in 2001 for the assessment of TB drugs, the direct mycobacterial growth inhibition assay (MGIA) offers a tractable : Methods: We have performed a systematic review on the primary published literature ... ...

    Abstract Introduction: First described by Wallis et al. in 2001 for the assessment of TB drugs, the direct mycobacterial growth inhibition assay (MGIA) offers a tractable
    Methods: We have performed a systematic review on the primary published literature describing the development and applications of the direct MGIA from 2001 to June 2023 in accordance with the PRISMA reporting guidelines.
    Results: We describe 63 studies in which the direct MGIA has been applied across species for the evaluation of TB drugs and novel TB vaccine candidates, the study of clinical cohorts including those with comorbidities, and to further understanding of potential immune correlates of protection from TB. We provide a comprehensive update on progress of the assay since its conception and critically evaluate current findings and evidence supporting its utility, highlighting priorities for future directions.
    Discussion: While further standardisation and validation work is required, significant advancements have been made in the past two decades. The direct MGIA provides a potentially valuable tool for the early evaluation of TB drug and vaccine candidates, clinical cohorts, and immune mechanisms of mycobacterial control.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023423491.
    MeSH term(s) Humans ; BCG Vaccine ; Mycobacterium tuberculosis ; Tuberculosis/microbiology ; Tuberculosis Vaccines
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1355983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Determinants of COVID-19 immunisation uptake in a country with high mortality and a low vaccination rate.

    Aksentijevic, Dunja / Tanner, Rachel / Lazović-Pita, Lejla / Peštek, Almir / Abdić, Ademir

    Journal of infection and public health

    2023  Volume 16, Issue 8, Page(s) 1322–1331

    Abstract: Background: Research concerned with attitudes towards COVID-19 vaccination in upper middle-income countries such as Bosnia and Herzegovina (B&H) is scarce. Currently, B&H has the lowest number of fully vaccinated adults in Europe, and the highest ... ...

    Abstract Background: Research concerned with attitudes towards COVID-19 vaccination in upper middle-income countries such as Bosnia and Herzegovina (B&H) is scarce. Currently, B&H has the lowest number of fully vaccinated adults in Europe, and the highest cumulative number of COVID-19 deaths and SARS-CoV-2 infected individuals. The aim of our study was to examine the factors associated with COVID-19 vaccination status in B&H.
    Methods: An online survey among 1304 B&H adults was conducted in October 2021 evaluating vaccine acceptance, together with socio-demographic variables, attitudes and beliefs related to COVID-19 vaccination.
    Results: The results from a binary logistic regression indicate that those who believed that the COVID-19 vaccine was effective were 45 times more likely to be vaccinated compared to those who did not. We also show that those who had received childhood immunisations were 41 times more likely to be vaccinated against COVID-19 compared to those who had never been previously immunised. Other significant factors were related to respondents' trust in government institutions and healthcare policymakers as well as trust in public healthcare workers.
    Conclusion: We suggest that future vaccination campaigns should be aimed at educating the public regarding the importance and safety of vaccines, together with strengthening trust in the public health system.
    MeSH term(s) Adult ; Humans ; Child ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Immunization
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2023.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: MMR Vaccine Attitude and Uptake Research in the United Kingdom: A Critical Review.

    Torracinta, Louis / Tanner, Rachel / Vanderslott, Samantha

    Vaccines

    2021  Volume 9, Issue 4

    Abstract: This review critically assesses the body of research about Measles-Mumps-and-Rubella (MMR) vaccine attitudes and uptake in the United Kingdom (UK) over the past 10 years. We searched PubMed and Scopus, with terms aimed at capturing relevant literature on ...

    Abstract This review critically assesses the body of research about Measles-Mumps-and-Rubella (MMR) vaccine attitudes and uptake in the United Kingdom (UK) over the past 10 years. We searched PubMed and Scopus, with terms aimed at capturing relevant literature on attitudes about, and uptake of, the MMR vaccine. Two researchers screened for abstract eligibility and after de-duplication 934 studies were selected. After screening, 40 references were included for full-text review and thematic synthesis by three researchers. We were interested in the methodologies employed and grouped findings by whether studies concerned: (1) Uptake and Demographics; (2) Beliefs and Attitudes; (3) Healthcare Worker Focus; (4) Experimental and Psychometric Intervention; and (5) Mixed Methods. We identified group and individual level determinants for attitudes, operating directly and indirectly, which influence vaccine uptake. We found that access issues, often ignored within the public "anti-vax" debate, remain highly pertinent. Finally, a consistent theme was the effect of misinformation or lack of knowledge and trust in healthcare, often stemming from the Wakefield controversy. Future immunisation campaigns for children, including for COVID-19, should consider both access and attitudinal aspects of vaccination, and incorporate a range of methodologies to assess progress, taking into account socio-economic variables and the needs of disadvantaged groups.
    Language English
    Publishing date 2021-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9040402
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  5. Article ; Online: Chronovaccination: Harnessing circadian rhythms to optimize immunisation strategies.

    Otasowie, Claire O / Tanner, Rachel / Ray, David W / Austyn, Jonathan M / Coventry, Brendon J

    Frontiers in immunology

    2022  Volume 13, Page(s) 977525

    Abstract: Vaccination, as a public health measure, offers effective protection of populations against infectious diseases. Optimising vaccination efficacy, particularly for higher-risk individuals, like the elderly whose immunocompromised state can prevent the ... ...

    Abstract Vaccination, as a public health measure, offers effective protection of populations against infectious diseases. Optimising vaccination efficacy, particularly for higher-risk individuals, like the elderly whose immunocompromised state can prevent the development of robust vaccine responses, is vital. It is now clear that 24-hour circadian rhythms, which govern virtually all aspects of physiology, can generate oscillations in immunological responses. Consequently, vaccine efficacy may depend critically on the time of day of administration(s), including for Covid-19, current vaccines, and any future diseases or pandemics. Published clinical vaccine trials exploring diurnal immune variations suggest this approach could represent a powerful adjunct strategy for optimising immunisation, but important questions remain to be addressed. This review explores the latest insights into diurnal immune variation and the outcomes of circadian timing of vaccination or 'chronovaccination'.
    MeSH term(s) Humans ; Aged ; Circadian Rhythm ; COVID-19/prevention & control ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.977525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Replacing, reducing and refining the use of animals in tuberculosis vaccine research.

    Tanner, Rachel / McShane, Helen

    ALTEX

    2017  Volume 34, Issue 1, Page(s) 157–166

    Abstract: Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely ... ...

    Abstract Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (Mtb) in challenge experiments to evaluate protective efficacy, raising ethical issues regarding the procedure of infection itself, symptoms of disease and humane end-points. We summarize the importance and limitations of animal models in TB vaccine research and review current alternatives and modifications in the context of the NC3Rs framework for replacing, reducing and refining the use of animals for scientific purposes.
    MeSH term(s) Animal Testing Alternatives ; Animals ; BCG Vaccine ; Cattle ; Disease Models, Animal ; Guinea Pigs ; Humans ; Mice ; Mycobacterium tuberculosis/immunology ; Primates ; Research ; Tuberculosis/prevention & control ; Tuberculosis Vaccines
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 165707-0
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    DOI 10.14573/altex.1607281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2971: Show issues Location:
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  7. Article: Healthcare information technology.

    Tanner, Rachel

    Issue brief (Health Policy Tracking Service)

    2007  , Page(s) 1–29

    MeSH term(s) Confidentiality ; Federal Government ; Health Policy ; Humans ; Legislation, Medical ; Medicaid/economics ; Medicaid/legislation & jurisprudence ; Medical Informatics/economics ; Medical Informatics/legislation & jurisprudence ; Medical Informatics/standards ; Medical Order Entry Systems/economics ; Medical Order Entry Systems/legislation & jurisprudence ; Medical Order Entry Systems/standards ; Medical Records Systems, Computerized/economics ; Medical Records Systems, Computerized/legislation & jurisprudence ; Medical Records Systems, Computerized/standards ; Privacy ; Private Sector/economics ; Private Sector/legislation & jurisprudence ; Quality of Health Care ; State Government ; United States ; United States Agency for Healthcare Research and Quality
    Language English
    Publishing date 2007-01-08
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Healthcare quality of care.

    Tanner, Rachel

    Issue brief (Health Policy Tracking Service)

    2007  , Page(s) 1–21

    MeSH term(s) Evidence-Based Medicine/legislation & jurisprudence ; Humans ; Patient Satisfaction/legislation & jurisprudence ; Physician Incentive Plans/legislation & jurisprudence ; Quality of Health Care/legislation & jurisprudence ; State Government ; United States
    Language English
    Publishing date 2007-01-08
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Medical errors and patient safety.

    Tanner, Rachel

    Issue brief (Health Policy Tracking Service)

    2007  , Page(s) 1–15

    MeSH term(s) Federal Government ; Health Policy ; Humans ; Legislation, Hospital ; Legislation, Medical ; Mandatory Reporting ; Medical Errors/economics ; Medical Errors/legislation & jurisprudence ; Medical Errors/prevention & control ; Safety/economics ; Safety/legislation & jurisprudence ; State Government ; United States
    Language English
    Publishing date 2007-01-08
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Chorioallantoic Membrane Assay in Nanotoxicological Research-An Alternative for

    Buhr, Christoph R / Wiesmann, Nadine / Tanner, Rachel C / Brieger, Jürgen / Eckrich, Jonas

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 12

    Abstract: Nanomaterials unveil many applicational possibilities for technical and medical purposes, which range from imaging techniques to the use as drug carriers. Prior to any human application, analysis of undesired effects and characterization of their ... ...

    Abstract Nanomaterials unveil many applicational possibilities for technical and medical purposes, which range from imaging techniques to the use as drug carriers. Prior to any human application, analysis of undesired effects and characterization of their toxicological profile is mandatory. To address this topic, animal models, and rodent models in particular, are most frequently used. However, as the reproducibility and transferability to the human organism of animal experimental data is increasingly questioned and the awareness of animal welfare in society increases at the same time, methodological alternatives are urgently required. The chorioallantoic membrane (CAM) assay is an increasingly popular
    Language English
    Publishing date 2020-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10122328
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