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Artikel ; Online: In Search of a Predictive Model for Preeclampsia: The Beat Goes On.

Tanner, Rikki M / Bello, Natalie A

Hypertension (Dallas, Tex. : 1979)

2020 Band 76, Heft 6, Seite(n) 1707–1708

Mesh-Begriff(e)	Blood Pressure ; Female ; Humans ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Vascular Stiffness
Sprache	Englisch
Erscheinungsdatum	2020-11-11
Erscheinungsland	United States
Dokumenttyp	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.120.15160
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hypertension severity, apparent treatment resistant hypertension and hyperuricemia in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

Tanner, Rikki M / Chaudary, Ninad / Colantonio, Lisandro D / Merriman, Tony R / Reynolds, Richard J / Bridges, S Louis / Cushman, Mary / Saag, Kenneth / Limdi, Nita / Muntner, Paul / Howard, George / Irvin, M Ryan

Journal of hypertension

2023 Band 41, Heft 6, Seite(n) 1033–1039

Abstract: Background: Prior studies have identified an association between hypertension and hyperuricemia; however, there has been limited research on the association between hypertension severity and hyperuricemia.: Method: We studied 997 Black and white ... ...

Abstract	Background: Prior studies have identified an association between hypertension and hyperuricemia; however, there has been limited research on the association between hypertension severity and hyperuricemia. Method: We studied 997 Black and white adults with serum urate data from the reasons for geographic and racial differences in stroke (REGARDS) study. Hypertension was defined as SBP ≥ 140 mmHg or DBP ≥ 90 mmHg or self-reported use of antihypertensive medication. Apparent treatment-resistant hypertension (aTRH) was defined as a SBP ≥ 140 mmHg or DBP ≥ 90 mmHg with concurrent use of three classes of antihypertensive medications, or taking four or more classes of antihypertensive medication regardless of BP level. Controlled BP was defined as SBP <140 mmHg and DBP <90 mmHg. Results: Overall 5.9% of participants had aTRH and 36.6% had hyperuricemia, defined as serum urate >7.0 mg/dl for men and >6.0 mg/dl for women. After full multivariable adjustment, the odds ratio (OR) for hyperuricemia associated with hypertension was 1.60 [95% confidence interval (95% CI): 1.06-2.40]. Compared to participants not taking antihypertensive medication, the ORs for hyperuricemia for participants taking one, two and three classes of antihypertensive medication without aTRH were 1.98 (95% CI: 1.23-3.20), 2.08 (95% CI: 1.25-3.43), 4.31 (95% CI: 2.07-8.97), respectively, and 3.96 (95% CI: 1.75-8.96) for aTRH. Compared to participants without hypertension, the odds ratios for hyperuricemia were 1.67 (95% CI: 1.08-2.58) and 1.46 (95% CI: 0.88-2.44) among those with hypertension with and without controlled BP, respectively. Diuretic use was associated with a higher odds of hyperuricemia. Conclusion: This study suggests that individuals taking more classes of antihypertensive medication may benefit from monitoring for hyperuricemia.
Mesh-Begriff(e)	Male ; Adult ; Humans ; Female ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Uric Acid ; Race Factors ; Hypertension/complications ; Hypertension/drug therapy ; Stroke/complications ; Blood Pressure
Chemische Substanzen	Antihypertensive Agents ; Uric Acid (268B43MJ25)
Sprache	Englisch
Erscheinungsdatum	2023-04-04
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003425
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Black-White Differences in Cardiovascular Disease Mortality: A Prospective US Study, 2003-2017.

Tajeu, Gabriel S / Safford, Monika M / Howard, George / Howard, Virginia J / Chen, Ligong / Long, D Leann / Tanner, Rikki M / Muntner, Paul

American journal of public health

2020 Band 110, Heft 5, Seite(n) 696–703

Abstract: Objectives. ...

Abstract	Objectives.
Mesh-Begriff(e)	Black or African American/statistics & numerical data ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/mortality ; Comorbidity ; Female ; Health Behavior ; Humans ; Lipids/blood ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Sex Distribution ; Socioeconomic Factors ; United States/epidemiology ; White People/statistics & numerical data
Chemische Substanzen	Lipids
Sprache	Englisch
Erscheinungsdatum	2020-03-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2019.305543
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prevalence and characteristics of systolic blood pressure thresholds in individuals 60 years or older.

Shimbo, Daichi / Tanner, Rikki M / Muntner, Paul

JAMA internal medicine

2014 Band 174, Heft 8, Seite(n) 1397–1400

Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Male ; Middle Aged ; Practice Guidelines as Topic ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Systole ; United States/epidemiology
Chemische Substanzen	Antihypertensive Agents
Sprache	Englisch
Erscheinungsdatum	2014-06-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2014.2492
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Genomics of Postprandial Lipidomics in the Genetics of Lipid-Lowering Drugs and Diet Network Study

Irvin, Marguerite R. / Montasser, May E. / Kind, Tobias / Fan, Sili / Barupal, Dinesh K. / Patki, Amit / Tanner, Rikki M. / Armstrong, Nicole D. / Ryan, Kathleen A. / Claas, Steven A. / O’Connell, Jeffrey R. / Tiwari, Hemant K. / Arnett, Donna K.

Nutrients. 2021 Nov. 10, v. 13, no. 11

2021

Abstract: Postprandial lipemia (PPL) is an important risk factor for cardiovascular disease. Inter-individual variation in the dietary response to a meal is known to be influenced by genetic factors, yet genes that dictate variation in postprandial lipids are not ... ...

Abstract	Postprandial lipemia (PPL) is an important risk factor for cardiovascular disease. Inter-individual variation in the dietary response to a meal is known to be influenced by genetic factors, yet genes that dictate variation in postprandial lipids are not completely characterized. Genetic studies of the plasma lipidome can help to better understand postprandial metabolism by isolating lipid molecular species which are more closely related to the genome. We measured the plasma lipidome at fasting and 6 h after a standardized high-fat meal in 668 participants from the Genetics of Lipid-Lowering Drugs and Diet Network study (GOLDN) using ultra-performance liquid chromatography coupled to (quadrupole) time-of-flight mass spectrometry. A total of 413 unique lipids were identified. Heritable and responsive lipid species were examined for association with single-nucleotide polymorphisms (SNPs) genotyped on the Affymetrix 6.0 array. The most statistically significant SNP findings were replicated in the Amish Heredity and Phenotype Intervention (HAPI) Heart Study. We further followed up findings from GOLDN with a regional analysis of cytosine-phosphate-guanine (CpGs) sites measured on the Illumina HumanMethylation450 array. A total of 132 lipids were both responsive to the meal challenge and heritable in the GOLDN study. After correction for multiple testing of 132 lipids (α = 5 × 10⁻⁸/132 = 4 × 10⁻¹⁰), no SNP was statistically significantly associated with any lipid response. Four SNPs in the region of a known lipid locus (fatty acid desaturase 1 and 2/FADS1 and FADS2) on chromosome 11 had p < 8.0 × 10⁻⁷ for arachidonic acid FA(20:4). Those SNPs replicated in HAPI Heart with p < 3.3 × 10⁻³. CpGs around the FADS1/2 region were associated with arachidonic acid and the relationship of one SNP was partially mediated by a CpG (p = 0.005). Both SNPs and CpGs from the fatty acid desaturase region on chromosome 11 contribute jointly and independently to the diet response to a high-fat meal.
Schlagwörter	arachidonic acid ; cardiovascular diseases ; diet ; fatty acid desaturase ; genomics ; genotyping ; heart ; high fat foods ; hyperlipidemia ; inheritance (genetics) ; lipidomics ; loci ; mass spectrometry ; metabolism ; phenotype ; risk factors ; ultra-performance liquid chromatography
Sprache	Englisch
Erscheinungsverlauf	2021-1110
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114000
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.

The Journal of clinical investigation

2023 Band 133, Heft 18

Abstract: Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and ... ...

Abstract	Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of ischemic stroke than White individuals. However, it is not known whether the A allele is responsible for worse stroke outcomes. To directly test the in vivo effect of this variant on stroke, we generated mice in which F2rl3 was replaced by F2RL3, thereby expressing human PAR4 (hPAR4) with either Thr120 or Ala120. Compared with hPAR4 Ala120 mice, hPAR4 Thr120 mice had worse stroke outcomes, mediated in part by enhanced platelet activation and platelet-neutrophil interactions. Analyses of 7,620 Black subjects with 487 incident ischemic strokes demonstrated the AA genotype was a risk for incident ischemic stroke and worse functional outcomes. In humanized mice, ticagrelor with or without aspirin improved stroke outcomes in hPAR4 Ala120 mice, but not in hPAR4 Thr120 mice. P selectin blockade improved stroke outcomes and reduced platelet-neutrophil interactions in hPAR4 Thr120 mice. Our results may explain some of the racial disparity in stroke and support the need for studies of nonstandard antiplatelet therapies for patients expressing PAR4 Thr120.
Mesh-Begriff(e)	Humans ; Animals ; Mice ; Receptors, Thrombin/genetics ; Platelet Aggregation/genetics ; Blood Platelets/physiology ; Platelet Aggregation Inhibitors/pharmacology ; Stroke/genetics ; Ischemic Stroke ; Receptor, PAR-1
Chemische Substanzen	protease-activated receptor 4 (JWE1M73YZN) ; Receptors, Thrombin ; Platelet Aggregation Inhibitors ; Receptor, PAR-1
Sprache	Englisch
Erscheinungsdatum	2023-09-15
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI169608
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies.

Armstrong, Nicole D / Srinivasasainagendra, Vinodh / Patki, Amit / Tanner, Rikki M / Hidalgo, Bertha A / Tiwari, Hemant K / Limdi, Nita A / Lange, Ethan M / Lange, Leslie A / Arnett, Donna K / Irvin, Marguerite R

Frontiers in genetics

2021 Band 12, Seite(n) 781451

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2021-12-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.781451
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genomics of Postprandial Lipidomics in the Genetics of Lipid-Lowering Drugs and Diet Network Study.

Irvin, Marguerite R / Montasser, May E / Kind, Tobias / Fan, Sili / Barupal, Dinesh K / Patki, Amit / Tanner, Rikki M / Armstrong, Nicole D / Ryan, Kathleen A / Claas, Steven A / O'Connell, Jeffrey R / Tiwari, Hemant K / Arnett, Donna K

Nutrients

2021 Band 13, Heft 11

Abstract	Postprandial lipemia (PPL) is an important risk factor for cardiovascular disease. Inter-individual variation in the dietary response to a meal is known to be influenced by genetic factors, yet genes that dictate variation in postprandial lipids are not completely characterized. Genetic studies of the plasma lipidome can help to better understand postprandial metabolism by isolating lipid molecular species which are more closely related to the genome. We measured the plasma lipidome at fasting and 6 h after a standardized high-fat meal in 668 participants from the Genetics of Lipid-Lowering Drugs and Diet Network study (GOLDN) using ultra-performance liquid chromatography coupled to (quadrupole) time-of-flight mass spectrometry. A total of 413 unique lipids were identified. Heritable and responsive lipid species were examined for association with single-nucleotide polymorphisms (SNPs) genotyped on the Affymetrix 6.0 array. The most statistically significant SNP findings were replicated in the Amish Heredity and Phenotype Intervention (HAPI) Heart Study. We further followed up findings from GOLDN with a regional analysis of cytosine-phosphate-guanine (CpGs) sites measured on the Illumina HumanMethylation450 array. A total of 132 lipids were both responsive to the meal challenge and heritable in the GOLDN study. After correction for multiple testing of 132 lipids (α = 5 × 10
Mesh-Begriff(e)	Adult ; Aged ; Delta-5 Fatty Acid Desaturase/genetics ; Fatty Acid Desaturases/genetics ; Female ; Genome-Wide Association Study ; Genomics ; Genotype ; Humans ; Hypolipidemic Agents/pharmacology ; Lipidomics ; Lipids ; Male ; Meals ; Middle Aged ; Phenotype ; Plasma ; Polymorphism, Single Nucleotide ; Postprandial Period/drug effects ; Postprandial Period/genetics
Chemische Substanzen	Delta-5 Fatty Acid Desaturase ; Hypolipidemic Agents ; Lipids ; Fatty Acid Desaturases (EC 1.14.19.-) ; FADS1 protein, human (EC 1.14.19.3) ; FADS2 protein, human (EC 1.14.19.3)
Sprache	Englisch
Erscheinungsdatum	2021-11-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114000
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Stress and Depression Are Associated With Life's Simple 7 Among African Americans With Hypertension: Findings From the Jackson Heart Study.

Langford, Aisha T / Butler, Mark / Booth, John N / Jin, Peng / Bress, Adam P / Tanner, Rikki M / Kalinowski, Jolaade / Blanc, Judite / Seixas, Azizi / Shimbo, Daichi / Sims, Mario / Ogedegbe, Gbenga / Spruill, Tanya M

American journal of hypertension

2021 Band 34, Heft 12, Seite(n) 1311–1321

Abstract: Background: The American Heart Association created the Life's Simple 7 (LS7) metrics to promote cardiovascular health (CVH) by achieving optimal levels of blood pressure, cholesterol, blood sugar, physical activity, diet, weight, and smoking status. The ...

Abstract	Background: The American Heart Association created the Life's Simple 7 (LS7) metrics to promote cardiovascular health (CVH) by achieving optimal levels of blood pressure, cholesterol, blood sugar, physical activity, diet, weight, and smoking status. The degree to which psychosocial factors such as stress and depression impact one's ability to achieve optimal CVH is unclear, particularly among hypertensive African Americans. Methods: Cross-sectional analyses included 1,819 African Americans with hypertension participating in the Jackson Heart Study (2000-2004). Outcomes were LS7 composite and individual component scores (defined as poor, intermediate, ideal). High perceived chronic stress was defined as the top quartile of Weekly Stress Inventory scores. High depressive symptoms were defined as Center for Epidemiologic Studies Depression scale scores of ≥16. We compared 4 groups: high stress alone; high depressive symptoms alone; high stress and high depressive symptoms; low stress and low depressive symptoms (reference) using linear regression for total LS7 scores and logistic regression for LS7 components. Results: Participants with both high stress and depressive symptoms had lower composite LS7 scores (B [95% confidence interval] = -0.34 [-0.65 to -0.02]) than those with low stress and depressive symptoms in unadjusted and age/sex-adjusted models. They also had poorer health status for smoking (odds ratio [95% confidence interval] = 0.52 [0.35-0.78]) and physical activity (odds ratio [95% confidence interval] = 0.71 [0.52-0.95]) after full covariate adjustment. Conclusions: The combination of high stress and high depressive symptoms was associated with poorer LS7 metrics in hypertensive African Americans. Psychosocial interventions may increase the likelihood of engaging in behaviors that promote optimal CVH.
Mesh-Begriff(e)	African Americans ; Blood Pressure ; Cardiovascular Diseases ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Longitudinal Studies ; Risk Factors ; United States/epidemiology
Sprache	Englisch
Erscheinungsdatum	2021-07-16
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpab116
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Epidemiology of obesity, the metabolic syndrome, and chronic kidney disease.

Tanner, Rikki M / Brown, Todd M / Muntner, Paul

Current hypertension reports

2012 Band 14, Heft 2, Seite(n) 152–159

Abstract: The prevalence of obesity and metabolic syndrome (MetS) has increased over the past several decades and is expected to continue to increase. Although the individual components of MetS have previously been associated with chronic kidney disease (CKD) and ... ...

Abstract	The prevalence of obesity and metabolic syndrome (MetS) has increased over the past several decades and is expected to continue to increase. Although the individual components of MetS have previously been associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), until recently there were few data on the relationship between MetS itself and incident CKD and ESRD. A recent meta-analysis demonstrated an association between MetS and CKD. When pooling 10 prospective cohort studies, MetS was associated with an increased odds ratio for an estimated glomerular filtration rate (eGFR) less than 60 mL/ min per 1.73 m2 (OR, 1.55; 95% CI, 1.34-1.80). Additionally, published data suggest an association between MetS and albuminuria. Evidence suggests that lifestyle modifications such as weight reduction, reduced dietary fat intake and cholesterol, and pharmacologic treatments may reduce the burden of MetS and thus the risk for CKD, albuminuria, and ESRD.
Mesh-Begriff(e)	Albuminuria/epidemiology ; Blood Pressure ; Humans ; Incidence ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/prevention & control ; Life Style ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/prevention & control ; Obesity/epidemiology ; Prevalence ; Risk Assessment ; United States/epidemiology ; Weight Loss
Sprache	Englisch
Erscheinungsdatum	2012-02-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2057367-4
ISSN	1534-3111 ; 1522-6417
ISSN (online)	1534-3111
ISSN	1522-6417
DOI	10.1007/s11906-012-0254-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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