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  1. Article ; Online: Nanotechnology-Inspired Extracellular Vesicles Theranostics for Diagnosis and Therapy of Central Nervous System Diseases.

    Tian, Tian / Qiao, Shuya / Tannous, Bakhos A

    ACS applied materials & interfaces

    2022  

    Abstract: Shuttling various bioactive substances across the blood-brain barrier (BBB) bidirectionally, extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy of central nervous system (CNS) diseases. However, clinical ... ...

    Abstract Shuttling various bioactive substances across the blood-brain barrier (BBB) bidirectionally, extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy of central nervous system (CNS) diseases. However, clinical translation of EV-based theranostics remains challenging due to difficulties in effective EV engineering for superior imaging/therapeutic potential, ultrasensitive EV detection for small sample volume, as well as scale-up and standardized EV production. In the past decade, continuous advancement in nanotechnology provided extensive concepts and strategies for EV engineering and analysis, which inspired the application of EVs for CNS diseases. Here we will review the existing types of EV-nanomaterial hybrid systems with improved diagnostic and therapeutic efficacy for CNS diseases. A summary of recent progress in the incorporation of nanomaterials and nanostructures in EV production, separation, and analysis will also be provided. Moreover, the convergence between nanotechnology and microfluidics for integrated EV engineering and liquid biopsy of CNS diseases will be discussed.
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c07981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanotechnology-Inspired Extracellular Vesicles Theranostics for Diagnosis and Therapy of Central Nervous System Diseases

    Tian, Tian / Qiao, Shuya / Tannous, Bakhos A.

    ACS Applied Materials & Interfaces. 2022 Aug. 05, v. 15, no. 1, p. 182-199

    2022  , Page(s) 182–199

    Abstract: Shuttling various bioactive substances across the blood–brain barrier (BBB) bidirectionally, extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy of central nervous system (CNS) diseases. However, clinical ... ...

    Abstract Shuttling various bioactive substances across the blood–brain barrier (BBB) bidirectionally, extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy of central nervous system (CNS) diseases. However, clinical translation of EV-based theranostics remains challenging due to difficulties in effective EV engineering for superior imaging/therapeutic potential, ultrasensitive EV detection for small sample volume, as well as scale-up and standardized EV production. In the past decade, continuous advancement in nanotechnology provided extensive concepts and strategies for EV engineering and analysis, which inspired the application of EVs for CNS diseases. Here we will review the existing types of EV–nanomaterial hybrid systems with improved diagnostic and therapeutic efficacy for CNS diseases. A summary of recent progress in the incorporation of nanomaterials and nanostructures in EV production, separation, and analysis will also be provided. Moreover, the convergence between nanotechnology and microfluidics for integrated EV engineering and liquid biopsy of CNS diseases will be discussed.
    Keywords biopsy ; blood-brain barrier ; central nervous system ; microfluidic technology ; nanomaterials ; precision medicine ; extracellular vesicles ; nanotechnology ; nanomedicine ; central nervous system diseases
    Language English
    Dates of publication 2022-0805
    Size p. 182-199
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c07981
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Small but Fierce: Tracking the Role of Extracellular Vesicles in Glioblastoma Progression and Therapeutic Resistance.

    Schweiger, Markus W / Tannous, Bakhos A

    Advanced biosystems

    2020  Volume 4, Issue 12, Page(s) e2000035

    Abstract: Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains rare, owing to a combination of rapid progression/degeneration, lack of successful treatments, and high recurrence rates. ...

    Abstract Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains rare, owing to a combination of rapid progression/degeneration, lack of successful treatments, and high recurrence rates. Extracellular vesicles are cell-derived membranous structures involved in numerous physiological and pathological processes. In the context of cancer, these biological nanoparticles play an important role in intercellular communication, allowing cancer cells to exchange information with each other, the tumor microenvironment as well as distant cells. Here, light is shed on the role of extracellular vesicles in glioblastoma heterogeneity, tumor microenvironment interactions, and therapeutic resistance, and an overview on means to track their release, uptake, and cargo delivery is provided.
    MeSH term(s) Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Communication ; Drug Resistance, Neoplasm ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/metabolism ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Tumor Microenvironment/physiology
    Language English
    Publishing date 2020-09-03
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2366-7478
    ISSN 2366-7478
    DOI 10.1002/adbi.202000035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Olfactory ensheathing cells travel their natural nasal pathway to deliver therapeutics to brain tumors.

    Carvalho, Litia A / Tannous, Bakhos A

    Oncotarget

    2019  Volume 10, Issue 43, Page(s) 4351–4353

    Language English
    Publishing date 2019-07-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A TNF-NF-κB-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors.

    Tannous, Bakhos A / Badr, Christian E

    Cell death & disease

    2019  Volume 10, Issue 4, Page(s) 268

    MeSH term(s) Apoptosis Regulatory Proteins ; Enhancer of Zeste Homolog 2 Protein ; Glioma ; Humans ; NF-kappa B ; STAT3 Transcription Factor
    Chemical Substances Apoptosis Regulatory Proteins ; NF-kappa B ; STAT3 Transcription Factor ; STAT3 protein, human ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
    Language English
    Publishing date 2019-03-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-019-1505-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.

    Payne, N Connor / Maksoud, Semer / Tannous, Bakhos A / Mazitschek, Ralph

    Cell chemical biology

    2022  Volume 29, Issue 8, Page(s) 1333–1340.e5

    Abstract: We describe a generalizable time-resolved Förster resonance energy transfer (TR-FRET)-based platform to profile the cellular action of heterobifunctional degraders (or proteolysis-targeting chimeras [PROTACs]) that is capable of both accurately ... ...

    Abstract We describe a generalizable time-resolved Förster resonance energy transfer (TR-FRET)-based platform to profile the cellular action of heterobifunctional degraders (or proteolysis-targeting chimeras [PROTACs]) that is capable of both accurately quantifying protein levels in whole-cell lysates in less than 1 h and measuring small-molecule target engagement to endogenous proteins, here specifically for human bromodomain-containing protein 4 (BRD4). The detection mix consists of a single primary antibody targeting the protein of interest, a luminescent donor-labeled anti-species nanobody, and a fluorescent acceptor ligand. Importantly, our strategy can readily be applied to other targets of interest and will greatly facilitate the cell-based profiling of small-molecule inhibitors and PROTACs in a high-throughput format with unmodified cell lines. We furthermore validate our platform in the characterization of celastrol, a p-quinone methide-containing pentacyclic triterpenoid, as a broad cysteine-targeting E3 ubiquitin ligase warhead for potent and efficient targeted protein degradation.
    MeSH term(s) Cell Cycle Proteins/metabolism ; Humans ; Nuclear Proteins/metabolism ; Pentacyclic Triterpenes ; Proteolysis ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances BRD4 protein, human ; Cell Cycle Proteins ; Nuclear Proteins ; Pentacyclic Triterpenes ; Transcription Factors ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; celastrol (L8GG98663L)
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An allosteric inhibitor of SHP2 effectively targets PDGFRα-driven glioblastoma.

    Tannous, Bakhos A / Badr, Christian E

    Neuro-oncology

    2019  Volume 21, Issue 11, Page(s) 1348–1349

    MeSH term(s) Glioblastoma ; Humans ; Receptor Protein-Tyrosine Kinases ; Receptor, Platelet-Derived Growth Factor alpha ; Signal Transduction
    Chemical Substances Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2019-10-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noz176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Mesenchymal Transformation: The Rosetta Stone of Glioblastoma Pathogenesis and Therapy Resistance.

    Azam, Zulfikar / To, Shing-Shun Tony / Tannous, Bakhos A

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 22, Page(s) 2002015

    Abstract: Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms of cancers. The high level of inter- and intratumoral heterogeneity along with its biological location, the brain, are major barriers against effective treatment. ... ...

    Abstract Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms of cancers. The high level of inter- and intratumoral heterogeneity along with its biological location, the brain, are major barriers against effective treatment. Molecular and single cell analysis identifies different molecular subtypes with varying prognosis, while multiple subtypes can reside in the same tumor. Cellular plasticity among different subtypes in response to therapies or during recurrence adds another hurdle in the treatment of GBM. This phenotypic shift is induced and sustained by activation of several pathways within the tumor itself, or microenvironmental factors. In this review, the dynamic nature of cellular shifts in GBM and how the tumor (immune) microenvironment shapes this process leading to therapeutic resistance, while highlighting emerging tools and approaches to study this dynamic double-edged sword are discussed.
    Language English
    Publishing date 2020-09-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202002015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes.

    Chiu, Norman H L / Simpson, Jennifer H / Wang, Hongzhou / Tannous, Bakhos A

    BBA advances

    2021  Volume 1, Page(s) 100025

    Abstract: Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers. Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA ... ...

    Abstract Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers. Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA duplexes focused on selected individual epitranscriptomic variation. There are also limited development on the computational modeling of RNA duplexes containing a specific epitranscriptomic variation. This study aims to theoretically estimate the physical properties of different modified ribonucleosides and compare their variations with respect to altering the molecular structure of an RNA duplex.
    Language English
    Publishing date 2021-09-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-1603
    ISSN (online) 2667-1603
    DOI 10.1016/j.bbadva.2021.100025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Design and Implementation of a Leadership Development Program for Early-Stage Investigators: Initial Results.

    Bredella, Miriam A / Patel, Karan A / Leyne, Maire / Levy, Anne S / Tannous, Bakhos A / Bouxsein, Mary L

    The Journal of continuing education in the health professions

    2023  

    Abstract: Introduction: Leadership skills are essential for a successful career in medical research but are often not formally taught. To address these gaps, we designed a leadership development program for early-stage investigators.: Methods: A 9-month ... ...

    Abstract Introduction: Leadership skills are essential for a successful career in medical research but are often not formally taught. To address these gaps, we designed a leadership development program for early-stage investigators.
    Methods: A 9-month virtual program with monthly 2-hour interactive sessions was designed, covering topics such as Leadership in Research, Mentoring, Building Diverse and Inclusive Teams, Managing Conflict, Influencing without Authority, Grant Administration, and Management. An anonymized survey was sent to participants before and after completion of the program, and the results were compared using the chi-squared test.
    Results: Over a 2-year period, we selected two cohorts of 41 and 46 participants, respectively. After completion of the program, 92% of survey respondents indicated that the program met their expectations and 74% had made use of skills they learned. Participants enjoyed meeting new people and discussing common challenges. There was an increase in participants' perceived understanding of personal leadership qualities, mentoring, communication, conflict resolution, grant management, and collaboration with industry (P < .05).
    Discussion: A leadership development program for early-stage investigators led to a significant increase in participants' perceived understanding of personal leadership qualities and competencies. It also offered participants the opportunity to meet other researchers in the institution and discuss common challenges.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639445-0
    ISSN 1554-558X ; 0894-1912
    ISSN (online) 1554-558X
    ISSN 0894-1912
    DOI 10.1097/CEH.0000000000000518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2557: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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