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  1. Article ; Online: Reply

    Tanpitukpongse, T P / Petrella, J R

    AJNR. American journal of neuroradiology

    2017  Volume 38, Issue 9, Page(s) E62

    MeSH term(s) Hippocampus
    Language English
    Publishing date 2017-05-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A5259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?

    Tanpitukpongse, T P / Mazurowski, M A / Ikhena, J / Petrella, J R

    AJNR. American journal of neuroradiology

    2017  Volume 38, Issue 3, Page(s) 546–552

    Abstract: Background and purpose: Alzheimer disease is a prevalent neurodegenerative disease. Computer assessment of brain atrophy patterns can help predict conversion to Alzheimer disease. Our aim was to assess the prognostic efficacy of individual-versus- ... ...

    Abstract Background and purpose: Alzheimer disease is a prevalent neurodegenerative disease. Computer assessment of brain atrophy patterns can help predict conversion to Alzheimer disease. Our aim was to assess the prognostic efficacy of individual-versus-combined regional volumetrics in 2 commercially available brain volumetric software packages for predicting conversion of patients with mild cognitive impairment to Alzheimer disease.
    Materials and methods: Data were obtained through the Alzheimer's Disease Neuroimaging Initiative. One hundred ninety-two subjects (mean age, 74.8 years; 39% female) diagnosed with mild cognitive impairment at baseline were studied. All had T1-weighted MR imaging sequences at baseline and 3-year clinical follow-up. Analysis was performed with NeuroQuant and Neuroreader. Receiver operating characteristic curves assessing the prognostic efficacy of each software package were generated by using a univariable approach using individual regional brain volumes and 2 multivariable approaches (multiple regression and random forest), combining multiple volumes.
    Results: On univariable analysis of 11 NeuroQuant and 11 Neuroreader regional volumes, hippocampal volume had the highest area under the curve for both software packages (0.69, NeuroQuant; 0.68, Neuroreader) and was not significantly different (
    Conclusions: Of the multiple regional volume measures available in FDA-cleared brain volumetric software packages, hippocampal volume remains the best single predictor of conversion of mild cognitive impairment to Alzheimer disease at 3-year follow-up. Combining volumetrics did not add additional prognostic efficacy. Therefore, future prognostic studies in mild cognitive impairment, combining such tools with demographic and other biomarker measures, are justified in using hippocampal volume as the only volumetric biomarker.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Cognitive Dysfunction/pathology ; Disease Progression ; Female ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Humans ; Logistic Models ; Magnetic Resonance Imaging/methods ; Male ; ROC Curve ; Software
    Language English
    Publishing date 2017-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A5061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure.

    Kranz, P G / Tanpitukpongse, T P / Choudhury, K R / Amrhein, T J / Gray, L

    AJNR. American journal of neuroradiology

    2016  Volume 37, Issue 7, Page(s) 1374–1378

    Abstract: Background and purpose: Patients with spontaneous intracranial hypotension often exhibit low CSF pressure and changes on brain MR imaging and/or evidence of CSF leak on myelography. We investigated whether individual imaging signs of spontaneous ... ...

    Abstract Background and purpose: Patients with spontaneous intracranial hypotension often exhibit low CSF pressure and changes on brain MR imaging and/or evidence of CSF leak on myelography. We investigated whether individual imaging signs of spontaneous intracranial hypotension correlate with measured CSF pressure and how frequently these 2 markers of spontaneous intracranial hypotension were concordant.
    Materials and methods: We performed a retrospective, cross-sectional study of 99 subjects with spontaneous intracranial hypotension. Prevalence of brain and myelographic imaging signs of spontaneous intracranial hypotension was recorded. CSF pressure among subjects with or without individual imaging signs was compared by using a 2-tailed t test and ANOVA. Concordance between low CSF pressure (≤6 cm H2O) and imaging was defined as the presence of the sign in a subject with low CSF pressure or absence of the sign when pressure was not low.
    Results: Dural enhancement, brain sagging, and venous distension sign were present in 83%, 61%, and 75% of subjects, respectively, and myelographic evidence of CSF leak was seen in 55%. Marginal correlations between CSF pressure and brain sagging (P = .046) and the venous distension sign (P = .047) were found. Dural enhancement and myelographic evidence of leak were not significantly correlated with CSF pressure. Rates of concordance between imaging signs and low CSF pressure were generally low, ranging from 39% to 55%.
    Conclusions: Brain and myelographic signs of spontaneous intracranial hypotension correlate poorly with CSF pressure. These findings reinforce the need to base the diagnosis of spontaneous intracranial hypotension on multiple diagnostic criteria and suggest the presence of patient-specific variables that influence CSF pressure in these individuals.
    MeSH term(s) Adult ; Cerebrospinal Fluid Pressure ; Cross-Sectional Studies ; Female ; Humans ; Intracranial Hypotension/cerebrospinal fluid ; Intracranial Hypotension/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myelography/methods ; Neuroimaging/methods ; Prevalence ; Retrospective Studies
    Language English
    Publishing date 2016-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A4689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Radiology reports for incidental thyroid nodules on CT and MRI: high variability across subspecialties.

    Grady, A T / Sosa, J A / Tanpitukpongse, T P / Choudhury, K R / Gupta, R T / Hoang, J K

    AJNR. American journal of neuroradiology

    2014  Volume 36, Issue 2, Page(s) 397–402

    Abstract: Background and purpose: Variability in radiologists' reporting styles and recommendations for incidental thyroid nodules can lead to confusion among clinicians and may contribute to inconsistent patient care. Our aim was to describe reporting practices ... ...

    Abstract Background and purpose: Variability in radiologists' reporting styles and recommendations for incidental thyroid nodules can lead to confusion among clinicians and may contribute to inconsistent patient care. Our aim was to describe reporting practices of radiologists for incidental thyroid nodules seen on CT and MR imaging and to determine factors that influence reporting styles.
    Materials and methods: This is a retrospective study of patients with incidental thyroid nodules reported on CT and MR imaging between January and December 2011, identified by text search for "thyroid nodule" in all CT and MR imaging reports. The studies included CT and MR imaging scans of the neck, spine, and chest. Radiology reports were divided into those that mentioned the incidental thyroid nodules only in the "Findings" section versus those that reported the incidental thyroid nodules in the "Impression" section as well, because this latter reporting style gives more emphasis to the finding. Univariate and multivariate analyses were performed to identify radiologist, patient, and nodule characteristics that influenced reporting styles.
    Results: Three hundred seventy-five patients met the criterion of having incidental thyroid nodules. One hundred thirty-eight (37%) patients had incidental thyroid nodules reported in the "Impression" section. On multivariate analysis, only radiologists' divisions and nodule size were associated with reporting in "Impression." Chest radiologists and neuroradiologists were more likely to report incidental thyroid nodules in the "Impression" section than their abdominal imaging colleagues, and larger incidental thyroid nodules were more likely to be reported in "Impression" (P ≤ .03). Seventy-three percent of patients with incidental thyroid nodules of ≥20 mm were reported in the "Impression" section, but higher variability in reporting was seen for incidental thyroid nodules measuring 10-14 mm and 15-19 mm, which were reported in "Impression" for 61% and 50% of patients, respectively.
    Conclusions: Reporting practices for incidental thyroid nodules detected on CT and MR imaging are predominantly influenced by nodule size and the radiologist's subspecialty. Reporting was highly variable for nodules measuring 10-19 mm; this finding can be partially attributed to different reporting styles among radiology subspecialty divisions. The variability demonstrated in this study further underscores the need to develop CT and MR imaging practice guidelines with the goal of standardizing reporting of incidental thyroid nodules and thereby potentially improving the consistency and quality of patient care.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neck/diagnostic imaging ; Radiography, Thoracic ; Radiology/standards ; Retrospective Studies ; Spine/diagnostic imaging ; Thorax ; Thyroid Nodule/diagnosis ; Thyroid Nodule/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A4089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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