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Book ; Thesis: Wiederholbarkeit der Messung kornealer Wellenfrontaberrationen mit dem Orbscan II Topographiesystem

Tanyildizi, Yasemin

2014

Author's details	vorgelegt von Yasemin Tanyildizi
Language	German
Size	99 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 2014
HBZ-ID	HT018567087
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Musculoskeletal imaging of senescence.

Daldrup-Link, Heike E / Suryadevara, Vidyani / Tanyildizi, Yasemin / Nernekli, Kerem / Tang, Jian-Hong / Meade, Thomas J

Skeletal radiology

2024

Abstract: Senescent cells play a vital role in the pathogenesis of musculoskeletal (MSK) diseases, such as chronic inflammatory joint disorders, rheumatoid arthritis (RA), and osteoarthritis (OA). Cellular senescence in articular joints represents a response of ... ...

Abstract	Senescent cells play a vital role in the pathogenesis of musculoskeletal (MSK) diseases, such as chronic inflammatory joint disorders, rheumatoid arthritis (RA), and osteoarthritis (OA). Cellular senescence in articular joints represents a response of local cells to persistent stress that leads to cell-cycle arrest and enhanced production of inflammatory cytokines, which in turn perpetuates joint damage and leads to significant morbidities in afflicted patients. It has been recently discovered that clearance of senescent cells by novel "senolytic" therapies can attenuate the chronic inflammatory microenvironment of RA and OA, preventing further disease progression and supporting healing processes. To identify patients who might benefit from these new senolytic therapies and monitor therapy response, there is an unmet need to identify and map senescent cells in articular joints and related musculoskeletal tissues. To fill this gap, new imaging biomarkers are being developed to detect and characterize senescent cells in human joints and musculoskeletal tissues. This review article will provide an overview of these efforts. New imaging biomarkers for senescence cells are expected to significantly improve the specificity of state-of-the-art imaging technologies for diagnosing musculoskeletal disorders.
Language	English
Publishing date	2024-02-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04585-8
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Zs.A 1304: Show issues

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Article: The Bigger the Better? Center Volume Dependent Effects on Procedural and Functional Outcome in Established Endovascular Stroke Centers.

Hahn, Marianne / Gröschel, Sonja / Tanyildizi, Yasemin / Brockmann, Marc A / Gröschel, Klaus / Uphaus, Timo

Frontiers in neurology

2022 Volume 13, Page(s) 828528

Abstract: Background: Mechanical thrombectomy (MT) rates for the treatment of acute ischaemic stroke due to large vessel occlusion are steadily increasing, but are delivered in heterogenic settings. We aim to investigate effects of procedural load in centers with ...

Abstract	Background: Mechanical thrombectomy (MT) rates for the treatment of acute ischaemic stroke due to large vessel occlusion are steadily increasing, but are delivered in heterogenic settings. We aim to investigate effects of procedural load in centers with established MT-structures by comparing high- vs. low-volume centers with regard to procedural characteristics and functional outcomes. Methods: Data from 5,379 patients enrolled in the German Stroke Registry Endovascular Treatment (GSR-ET) between June 2015 and December 2019 were compared between three groups: high volume: ≥180 MTs/year, 2,342 patients; medium volume: 135-179 MTs/year, 2,202 patients; low volume: <135 MTs/year, 835 patients. Univariate analysis and multiple linear and logistic regression analyses were performed to identify differences between high- and low-volume centers. Results: We identified high- vs. low-volume centers to be an independent predictor of shorter intra-hospital (admission to groin puncture: 60 vs. 82 min, β = -26.458; Conclusion: Differences in efficiency measured by procedural times call for analysis and optimization of in-house procedural workflows at regularly used but comparatively low procedural volume MT centers.
Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.828528
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Article ; Online: Apparent Swelling of the Tongue.

Engelbarts, Matthias / Helling, Kai / Tanyildizi, Yasemin

Deutsches Arzteblatt international

2017 Volume 114, Issue 43, Page(s) 738

MeSH term(s)	Anesthesia ; Carotid Artery, Internal, Dissection/complications ; Carotid Artery, Internal, Dissection/diagnosis ; Edema/etiology ; Face ; Humans ; Male ; Middle Aged ; Tongue/pathology
Language	English
Publishing date	2017-11-16
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.2017.0738b
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Article: Evaluation of Resection Margin after Image-Guided Dural Tail Resection in Convexity Meningiomas.

Kalasauskas, Darius / Tanyildizi, Yasemin / Renovanz, Mirjam / Brockmann, Marc A / Sommer, Clemens J / Ringel, Florian / Keric, Naureen

Journal of clinical medicine

2021 Volume 10, Issue 6

Abstract: Infiltration of adjacent dura with meningioma cells is a common phenomenon. Wide resection of the dural tail (DT) to achieve a gross total resection is a general recommendation. We aimed to investigate a tumor cell infiltration of the DT after image- ... ...

Abstract	Infiltration of adjacent dura with meningioma cells is a common phenomenon. Wide resection of the dural tail (DT) to achieve a gross total resection is a general recommendation. We aimed to investigate a tumor cell infiltration of the DT after image-guided resection of convexity meningiomas. The study's inclusion criteria were the diagnosis of convexity meningioma, planned Simpson I° resection, and an identifiable DT. Intraoperative image-guidance was applied to identify the outer edge of the DT and to guide resection. After resection, en-bloc specimen or four samples of outermost pieces of DT in case of piecemeal resection were sent for histological analysis. In addition to resection margin infiltration, the radiological extent of DT, radiomic characteristics (109 in total), histology, and demographic data were assessed. Hierarchical clustering was used to generate patient clusters for radiomic analysis. Twenty-two patients were included in the study, while 20 (91%) were female. The mean age was 54.2 (Standard deviation (SD) 13.9, range 30-85) years. En-bloc resection could be achieved in 4 patients. The remaining patients received piecemeal resection. 2 DT samples were omitted due to tumor infiltration of the superior sagittal sinus. None of the en-bloc resection samples demonstrated dural infiltration on the resection margin. Tumor cells were detected in 4 of 70 (5.7%) dural tail samples and could not be excluded in another 5 of 70 (7.1%). No tumor recurrences were detected at follow-up MRI examinations after a mean follow-up of 27.5 (SD 13.2, range 0 to 50.0) months. There was no significant association between DT infiltration and histological subtype or patient characteristics and between DT extent and tumor infiltration. Clustering according to radiomic characteristics was not associated with tumor infiltration (
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10061177
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Article ; Online: Systematic Analysis of Combined Thrombolysis Using Ultrasound and Different Fibrinolytic Drugs in an in Vitro Clot Model of Intracerebral Hemorrhage.

Masomi-Bornwasser, Julia / Fabrig, Oliver / Krenzlin, Harald / König, Jochem / Tanyildizi, Yasemin / Kempski, Oliver / Ringel, Florian / Keric, Naureen

Ultrasound in medicine & biology

2021 Volume 47, Issue 5, Page(s) 1334–1342

Abstract: Adequate removal of blood clots by minimally invasive surgery seems to correlate with a better clinical outcome in patients with intracerebral hemorrhages (ICHs). Moreover, neurotoxic effects of recombinant tissue plasminogen activator have been reported. ...

Abstract	Adequate removal of blood clots by minimally invasive surgery seems to correlate with a better clinical outcome in patients with intracerebral hemorrhages (ICHs). Moreover, neurotoxic effects of recombinant tissue plasminogen activator have been reported. The aim of this study was to improve fibrinolysis using an intra-clot ultrasound application with tenecteplase and urokinase in our established ICH clot model. One hundred thirty clots were produced from 25 or 50 mL of human blood, incubated for different periods and equipped with drainage, through which an ultrasound catheter was placed in 65 treatment clots for 1 h, randomly allocated into three groups: administration of ultrasound, administration of 60 IU of tenecteplase or administration of 30,000 IU urokinase. Relative end weights were compared. This study found a significant increase in thrombolysis caused by a combination of ultrasound and fibrinolytic drugs, whereas ultrasound and tenecteplase are significantly more effective in the treatment of larger and aged clots.
MeSH term(s)	Cerebral Hemorrhage/therapy ; Combined Modality Therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; In Vitro Techniques ; Mechanical Thrombolysis/methods ; Tenecteplase/therapeutic use ; Thrombolytic Therapy ; Thrombosis/therapy ; Ultrasonic Therapy ; Urokinase-Type Plasminogen Activator/therapeutic use
Chemical Substances	Fibrinolytic Agents ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73) ; Tenecteplase (WGD229O42W)
Language	English
Publishing date	2021-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2021.01.005
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Zs.A 963: Show issues

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Article ; Online: In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical thrombectomy.

Payne, Emily S / Krost-Reuhl, Samantha / Heimann, Axel / Keric, Naureen / Masomi-Bornwasser, Julia / Gerber, Tiemo / Seidman, Larissa / Kirschner, Stefanie / Brockmann, Marc A / Tanyildizi, Yasemin

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2022 Volume 29, Issue 6, Page(s) 637–647

Abstract: Background: Mechanical thrombectomy is the standard treatment for acute ischemic stroke in patients with large vessel occlusion and can be performed up to 24h after symptom onset. Despite high recanalization rates, embolism in new territories has been ... ...

Abstract	Background: Mechanical thrombectomy is the standard treatment for acute ischemic stroke in patients with large vessel occlusion and can be performed up to 24h after symptom onset. Despite high recanalization rates, embolism in new territories has been reported in 8.6% of the cases. Causes for this could be clot abruption during stent retrieval into the smaller opening of a standard distal access catheter, and antegrade blood flow via collaterals despite proximal balloon protection. A funnel-shaped tip with a larger internal diameter was developed to increase the rate of first-pass recanalization and to improve the safety and efficacy of mechanical thrombectomy. Methods: This in vitro study compared the efficacy of a funnel-shaped tip with a standard tip in combination with different clot compositions. Mechanical thrombectomy was performed 80 times for each tip, using two stent retrievers (Trevo XP ProVue 3/20 mm, 4/20 mm) and four different clot types (hard vs. soft clots, 0-24h vs. 72h aged clots). Results: Significantly higher first-pass recanalization rates (mTICI 3) were observed for the funnel-shaped tip, 70.0% versus 30.0% for the standard tip (absolute difference, 32; relative difference 57.1%; P < .001), regardless of the clot type and stent retriever. Recanalization could be increased using harder Chandler loop clots versus softer statically generated clots, as well as 0-24h versus 72h aged clots, respectively. Conclusion: The funnel-shaped tip achieved higher first-pass recanalization rates than the smaller standard tip and lower rates of clot abruption at the tip. Clot compositions and aging times impacted recanalization rates.
MeSH term(s)	Humans ; Aged ; Stroke/diagnostic imaging ; Stroke/surgery ; Thrombectomy/methods ; Ischemic Stroke ; Treatment Outcome ; Thrombosis/surgery ; Catheters ; Stents ; In Vitro Techniques
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199221122843
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Article ; Online: Multivariable non-invasive association of isocitrate dehydrogenase mutational status in World Health Organization grade II and III gliomas with advanced magnetic resonance imaging T2 mapping techniques.

Kern, Maike / Auer, Timo A / Fehrenbach, Uli / Tanyildizi, Yasemin / Picht, Thomas / Misch, Martin / Wiener, Edzard

The neuroradiology journal

2020 Volume 33, Issue 2, Page(s) 160–168

Abstract: Aim: To investigate multivariable analyses for noninvasive association of the isocitrate dehydrogenase (IDH) mutational status in grade II and III gliomas including evaluation of T2 mapping-sequences.: Methods: Magnetic resonance imaging (MRI) ... ...

Abstract	Aim: To investigate multivariable analyses for noninvasive association of the isocitrate dehydrogenase (IDH) mutational status in grade II and III gliomas including evaluation of T2 mapping-sequences. Methods: Magnetic resonance imaging (MRI) examinations with histopathologically proven World Health Organization grade II and III gliomas were retrospectively enrolled. Multivariate receiver operating characteristics (ROC) analyses to associate IDH mutational status were performed containing quantitative T2 mapping analyses and qualitative characteristics (sex, age, localization, heterogeneity, oedema, necrosis and diameter). Relaxation times were calculated pixelwise by means of standardized ROI analyses. Interobserver variability also was tested. Results: Out of 32 patients (mean age: 50.7 years; range: 32-83), nine had grade II gliomas and 24 grade III, while 59.5% showed a positive IDH mutated state (IDHm) and 40.5% were wildtype (IDHw). Multivariable ROC analyses were calculated for relaxation time and range, localization and age with a cumulative 0.955 area under the curve (AUC) ( Conclusions: This is the first study evaluating quantitative T2 mapping sequences for association of the IDH mutational status in grade II and III gliomas demonstrating an association between relaxation time and mutational status. Analyses of T2 mapping relaxation times may even be suitable for predicting the correct IDH mutational state. Prognostic accuracy increases significantly in predicting the correct mutational state when combing T2 relaxation time characteristics and the qualitative MRI features age and localization.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Female ; Glioma/diagnostic imaging ; Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mutation ; Neoplasm Grading ; Prognosis ; Retrospective Studies ; World Health Organization
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2020-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/1971400919890099
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Article ; Online: Survival prediction for patients with non-resectable intrahepatic cholangiocarcinoma undergoing chemotherapy: a retrospective analysis comparing the tumor marker CA 19-9 with cross-sectional imaging.

Hahn, Felix / Müller, Lukas / Jungmann, Florian / Mähringer-Kunz, Aline / Tanyildizi, Yasemin / Düber, Christoph / Galle, Peter R / Weinmann, Arndt / Kloeckner, Roman

Journal of cancer research and clinical oncology

2020 Volume 146, Issue 7, Page(s) 1883–1890

Abstract: Purpose: Carbohydrate antigen (CA) 19-9 has been established as the main serum marker for patients with intrahepatic cholangiocarcinoma (ICC). The aim of this study was to compare the prognostic value of CA 19-9 changes versus response determined by ... ...

Abstract	Purpose: Carbohydrate antigen (CA) 19-9 has been established as the main serum marker for patients with intrahepatic cholangiocarcinoma (ICC). The aim of this study was to compare the prognostic value of CA 19-9 changes versus response determined by imaging in patients with ICC undergoing chemotherapy. Methods: Between 2003 and 2018, 151 patients with histopathologically confirmed ICC underwent chemotherapy at our tertiary care center for non-resectable or recurrent ICC, of whom 121 were included in this study. Serum CA 19-9 levels and imaging were retrospectively evaluated during chemotherapy. Log-rank testing and optimal stratification were used to classify patients into risk groups. Results: Prior to chemotherapy, baseline serum CA 19-9 levels above the previously published cut-off of 37 U/ml were associated with poor survival (median OS 8.7 vs. 12.4 months, p = 0.003). After the beginning of chemotherapy, an increase in CA 19-9 of more than 40 U/ml resulted in impaired residual survival (median OS 5.0 vs. 12.1 months, p < 0.001). However, progressive disease at the first follow-up imaging proved the strongest predictor for poor outcome (median OS 4.6 vs. 15.5 months, p < 0.001). In contrast to prior studies, our data did not show statistically relevant differences in survival time with respect to absolute or relative decreases in serum CA 19-9 levels. Conclusion: In our study, the disease control rate-that is, the absence of progressive disease-was the strongest predictor of prolonged residual OS. To this end, both CA 19-9 changes and progressive disease on initial follow-up showed remarkable discriminatory power, with the latter slightly outperforming the former. Therefore, imaging should remain the mainstay of patient evaluation during follow-up.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/mortality ; Biomarkers, Tumor ; CA-19-9 Antigen ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; ROC Curve ; Retrospective Studies
Chemical Substances	Biomarkers, Tumor ; CA-19-9 Antigen
Language	English
Publishing date	2020-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-020-03200-2
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Article ; Online: Longitudinal imaging and evaluation of SAH-associated cerebral large artery vasospasm in mice using micro-CT and angiography.

Weyer, Vanessa / Maros, Máté E / Kronfeld, Andrea / Kirschner, Stefanie / Groden, Christoph / Sommer, Clemens / Tanyildizi, Yasemin / Kramer, Martin / Brockmann, Marc A

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2019 Volume 40, Issue 11, Page(s) 2265–2277

Abstract: Longitudinal in vivo imaging studies characterizing subarachnoid hemorrhage (SAH)-induced large artery vasospasm (LAV) in mice are lacking. We developed a SAH-scoring system to assess SAH severity in mice using micro CT and longitudinally analysed LAV by ...

Abstract	Longitudinal in vivo imaging studies characterizing subarachnoid hemorrhage (SAH)-induced large artery vasospasm (LAV) in mice are lacking. We developed a SAH-scoring system to assess SAH severity in mice using micro CT and longitudinally analysed LAV by intravenous digital subtraction angiography (i.v. DSA). Thirty female C57Bl/6J-mice (7 sham, 23 SAH) were implanted with central venous ports for repetitive contrast agent administration. SAH was induced by filament perforation. LAV was assessed up to 14 days after induction of SAH by i.v. DSA. SAH-score and neuroscore showed a highly significant positive correlation (r
MeSH term(s)	Animals ; Biomarkers ; Biopsy ; Cerebral Angiography/methods ; Cerebral Arteries/diagnostic imaging ; Cerebral Arteries/physiopathology ; Disease Models, Animal ; Female ; Immunohistochemistry ; Mice ; Severity of Illness Index ; Subarachnoid Hemorrhage/diagnosis ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/mortality ; Vasospasm, Intracranial/diagnosis ; X-Ray Microtomography/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X19887052
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