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Article ; Online: Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells.

Zhou, Ying / Chen, Hanqiao / Zhong, Weiwei / Tao, Yizhi Jane

2024 Volume 20, Issue 1, Page(s) e1011366

Abstract: C. elegans is a free-living nematode that is widely used as a small animal model for studying fundamental biological processes and disease mechanisms. Since the discovery of the Orsay virus in 2011, C. elegans also holds the promise of dissecting virus- ... ...

Abstract	C. elegans is a free-living nematode that is widely used as a small animal model for studying fundamental biological processes and disease mechanisms. Since the discovery of the Orsay virus in 2011, C. elegans also holds the promise of dissecting virus-host interaction networks and innate antiviral immunity pathways in an intact animal. Orsay virus primarily targets the worm intestine, causing enlarged intestinal lumen as well as visible changes to infected cells such as liquefaction of cytoplasm and convoluted apical border. Previous studies of Orsay virus identified that C. elegans is able to mount antiviral responses by DRH-1/RIG-I mediated RNA interference and Intracellular Pathogen Response, a uridylyltransferase that destabilizes viral RNAs by 3' end uridylation, and ubiquitin protein modifications and turnover. To comprehensively search for novel antiviral pathways in C. elegans, we performed genome-wide RNAi screens by bacterial feeding using existing bacterial RNAi libraries covering 94% of the entire genome. Out of the 106 potential antiviral gene hits identified, we investigated those in three new pathways: collagens, actin remodelers, and epigenetic regulators. By characterizing Orsay virus infection in RNAi and mutant worms, our results indicate that collagens likely form a physical barrier in intestine cells to inhibit viral infection by preventing Orsay virus entry. Furthermore, evidence suggests that actin remodeling proteins (unc-34, wve-1 and wsp-1) and chromatin remodelers (nurf-1 and isw-1) exert their antiviral activities by regulating the intestinal actin (act-5), a critical component of the terminal web which likely function as another physical barrier to prevent Orsay infection.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Actins/metabolism ; RNA Interference ; Virus Diseases/genetics ; Collagen/genetics ; Collagen/metabolism ; Host-Pathogen Interactions ; Nerve Tissue Proteins/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; Actins ; Collagen (9007-34-5) ; unc-34 protein, C elegans ; Nerve Tissue Proteins
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011366
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Collagen and actin network mediate antiviral immunity against Orsay in C. elegans intestinal cells.

Zhou, Ying / Zhong, Weiwei / Tao, Yizhi Jane

bioRxiv : the preprint server for biology

2023

Abstract	C. elegans is a free-living nematode that is widely used as a small animal model for studying fundamental biological processes and disease mechanisms. Since the discovery of the Orsay virus in 2011, C. elegans also holds the promise of dissecting virus-host interaction networks and innate antiviral immunity pathways in an intact animal. Orsay primarily targets the worm intestine, causing enlarged intestinal lumen as well as visible changes to infected cells such as liquefaction of cytoplasm and rearrangement of the terminal web. Previous studies of Orsay identified that C. elegans is able to mount antiviral responses by DRH-1/RIG-I mediated RNA interference and Intracellular Pathogen Response, a uridylyltransferase that destabilizes viral RNAs by 3' end uridylation, and ubiquitin protein modifications and turnover. To comprehensively search for novel antiviral pathways in
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.20.537671
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Influenza

Wang, Qinghua / Tao, Yizhi Jane

current research

2016

Author's details	edited by Qinghua Wang and Yizhi Jane Tao
MeSH term(s)	Orthomyxoviridae ; Influenza, Human/virology
Language	English
Size	x, 164 p. :, ill. (some col.) ;, 23 cm.
Publisher	Caister Academic Press
Publishing place	Norfolk
Document type	Book
ISBN	9781910190432 ; 1910190438
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.

Li, Sha / Li, Nan / He, Jie / Zhou, Runxin / Lu, Zhimin / Tao, Yizhi Jane / Guo, Yusong R / Wang, Yugang

Research (Washington, D.C.)

2023 Volume 6, Page(s) 109

Abstract: Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA) ...

Abstract	Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA) substrates for histone modification is less known. We here report that lysine acetyltransferase 2A (KAT2A) as an illustrative instance of HATs can selectively utilize acetyl-CoA, propionyl-CoA, butyryl-CoA, and succinyl-CoA to directly deposit 18 histone acylation hallmarks in nucleosome. By analyzing the co-crystal structures of the catalytic domain of KAT2A in complex with acetyl-CoA, propionyl-CoA, butyryl-CoA, malonyl-CoA, succinyl-CoA, and glutaryl-CoA, we conclude that the alternative substrate-binding pocket of KAT2A and the length and electrostatic features of the acyl chain cooperatively determine the selection of the acyl-CoA substrates by KAT2A. This study reveals the molecular basis underlying the pluripotency of HATs that selectively install acylation hallmarks in nucleosomes, which might serve as instrumental mechanism to precisely regulate histone acylation profiles in cells.
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/research.0109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Human astrovirus capsid protein releases a membrane lytic peptide upon trypsin maturation.

Ykema, Matthew / Ye, Kai / Xun, Meng / Harper, Justin / Betancourt-Solis, Miguel A / Arias, Carlos F / McNew, James A / Tao, Yizhi Jane

Journal of virology

2023 Volume 97, Issue 8, Page(s) e0080223

Abstract: The human astrovirus (HAstV) is a non-enveloped, single-stranded RNA virus that is a common cause of gastroenteritis. Most non-enveloped viruses use membrane disruption to deliver the viral genome into a host cell after virus uptake. The virus-host ... ...

Abstract	The human astrovirus (HAstV) is a non-enveloped, single-stranded RNA virus that is a common cause of gastroenteritis. Most non-enveloped viruses use membrane disruption to deliver the viral genome into a host cell after virus uptake. The virus-host factors that allow for HAstV cell entry are currently unknown but thought to be associated with the host-protease-mediated viral maturation. Using
MeSH term(s)	Humans ; Capsid Proteins/genetics ; Capsid Proteins/chemistry ; Mamastrovirus/genetics ; Trypsin ; Liposomes ; Peptides/genetics ; Gastroenteritis ; Lipids ; Astroviridae Infections ; Phylogeny
Chemical Substances	Capsid Proteins ; Trypsin (EC 3.4.21.4) ; Liposomes ; Peptides ; Lipids
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00802-23
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Article ; Online: Rapid In Situ Thermal Decontamination of Wearable Composite Textile Materials.

Bell, Marquise D / Ye, Kai / Yap, Te Faye / Rajappan, Anoop / Liu, Zhen / Tao, Yizhi Jane / Preston, Daniel J

ACS applied materials & interfaces

2023 Volume 15, Issue 37, Page(s) 44521–44532

Abstract: Pandemics stress supply lines and generate shortages of personal protective equipment (PPE), in part because most PPE is single-use and disposable, resulting in a need for constant replenishment to cope with high-volume usage. To better prepare for the ... ...

Abstract	Pandemics stress supply lines and generate shortages of personal protective equipment (PPE), in part because most PPE is single-use and disposable, resulting in a need for constant replenishment to cope with high-volume usage. To better prepare for the next pandemic and to reduce waste associated with disposable PPE, we present a composite textile material capable of thermally decontaminating its surface via Joule heating. This material can achieve high surface temperatures (>100 °C) and inactivate viruses quickly (<5 s of heating), as evidenced experimentally with the surrogate virus HCoV-OC43 and in agreement with analytical modeling for both HCoV-OC43 and SARS-CoV-2. Furthermore, it does not require doffing because it remains relatively cool near the skin (<40 °C). The material can be easily integrated into clothing and provides a rapid, reusable, in situ decontamination method capable of reducing PPE waste and mitigating the risk of supply line disruptions in times of need.
MeSH term(s)	Humans ; COVID-19/prevention & control ; Decontamination ; SARS-CoV-2 ; Textiles ; Wearable Electronic Devices
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c09063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MAIVeSS: streamlined selection of antigenically matched, high-yield viruses for seasonal influenza vaccine production.

Gao, Cheng / Wen, Feng / Guan, Minhui / Hatuwal, Bijaya / Li, Lei / Praena, Beatriz / Tang, Cynthia Y / Zhang, Jieze / Luo, Feng / Xie, Hang / Webby, Richard / Tao, Yizhi Jane / Wan, Xiu-Feng

Nature communications

2024 Volume 15, Issue 1, Page(s) 1128

Abstract: Vaccines are the main pharmaceutical intervention used against the global public health threat posed by influenza viruses. Timely selection of optimal seed viruses with matched antigenicity between vaccine antigen and circulating viruses and with high ... ...

Abstract	Vaccines are the main pharmaceutical intervention used against the global public health threat posed by influenza viruses. Timely selection of optimal seed viruses with matched antigenicity between vaccine antigen and circulating viruses and with high yield underscore vaccine efficacy and supply, respectively. Current methods for selecting influenza seed vaccines are labor intensive and time-consuming. Here, we report the Machine-learning Assisted Influenza VaccinE Strain Selection framework, MAIVeSS, that enables streamlined selection of naturally circulating, antigenically matched, and high-yield influenza vaccine strains directly from clinical samples by using molecular signatures of antigenicity and yield to support optimal candidate vaccine virus selection. We apply our framework on publicly available sequences to select A(H1N1)pdm09 vaccine candidates and experimentally confirm that these candidates have optimal antigenicity and growth in cells and eggs. Our framework can potentially reduce the optimal vaccine candidate selection time from months to days and thus facilitate timely supply of seasonal vaccines.
MeSH term(s)	Humans ; Influenza, Human ; Influenza Vaccines ; Influenza A Virus, H1N1 Subtype ; Seasons ; Orthomyxoviridae Infections
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45145-x
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Article ; Online: Editorial overview: Virus structure and expression.

Jan, Eric / Tao, Yizhi Jane

Current opinion in virology

2015 Volume 12, Page(s) ix–x

MeSH term(s)	Viral Structures/physiology ; Virus Physiological Phenomena ; Viruses/chemistry ; Viruses/genetics ; Viruses/ultrastructure
Language	English
Publishing date	2015-06
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2611378-8
ISSN	1879-6265 ; 1879-6257
ISSN (online)	1879-6265
ISSN	1879-6257
DOI	10.1016/j.coviro.2015.05.005
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Article: Neu5Gc binding loss of subtype H7 influenza A virus facilitates adaptation to gallinaceous poultry following transmission from waterbirds but restricts spillback.

Guan, Minhui / Deliberto, Thomas J / Feng, Aijing / Zhang, Jieze / Li, Tao / Wang, Shuaishuai / Li, Lei / Killian, Mary Lea / Praena, Beatriz / Giri, Emily / Deliberto, Shelagh T / Hang, Jun / Olivier, Alicia / Torchetti, Mia Kim / Tao, Yizhi Jane / Parrish, Colin / Wan, Xiu-Feng

bioRxiv : the preprint server for biology

2024

Abstract: Migratory waterfowl, gulls, and shorebirds serve as natural reservoirs for influenza A viruses, with potential spillovers to domestic poultry and humans. The intricacies of interspecies adaptation among avian species, particularly from wild birds to ... ...

Abstract	Migratory waterfowl, gulls, and shorebirds serve as natural reservoirs for influenza A viruses, with potential spillovers to domestic poultry and humans. The intricacies of interspecies adaptation among avian species, particularly from wild birds to domestic poultry, are not fully elucidated. In this study, we investigated the molecular mechanisms underlying avian species barriers in H7 transmission, particularly the factors responsible for the disproportionate distribution of poultry infected with A/Anhui/1/2013 (AH/13)-lineage H7N9 viruses. We hypothesized that the differential expression of N-glycolylneuraminic acid (Neu5Gc) among avian species exerts selective pressure on H7 viruses, shaping their evolution and enabling them to replicate and transmit efficiently among gallinaceous poultry, particularly chickens. Our glycan microarray and biolayer interferometry experiments showed that AH/13-lineage H7N9 viruses exclusively bind to Neu5Ac, in contrast to wild waterbird H7 viruses that bind both Neu5Ac and Neu5Gc. Significantly, reverting the V179 amino acid in AH/13-lineage back to the I179, predominantly found in wild waterbirds, expanded the binding affinity of AH/13-lineage H7 viruses from exclusively Neu5Ac to both Neu5Ac and Neu5Gc. When cultivating H7 viruses in cell lines with varied Neu5Gc levels, we observed that Neu5Gc expression impairs the replication of Neu5Ac-specific H7 viruses and facilitates adaptive mutations. Conversely, Neu5Gc deficiency triggers adaptive changes in H7 viruses capable of binding to both Neu5Ac and Neu5Gc. Additionally, we assessed Neu5Gc expression in the respiratory and gastrointestinal tissues of seven avian species, including chickens, Canada geese, and various dabbling ducks. Neu5Gc was absent in chicken and Canada goose, but its expression varied in the duck species. In summary, our findings reveal the crucial role of Neu5Gc in shaping the host range and interspecies transmission of H7 viruses. This understanding of virus-host interactions is crucial for developing strategies to manage and prevent influenza virus outbreaks in diverse avian populations.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.02.573990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Exposure in Norway Rats (Rattus norvegicus) from New York City.

Wang, Yang / Lenoch, Julianna / Kohler, Dennis / DeLiberto, Thomas J / Tang, Cynthia Y / Li, Tao / Tao, Yizhi Jane / Guan, Minhui / Compton, Susan / Zeiss, Caroline / Hang, Jun / Wan, Xiu-Feng

mBio

2023 Volume 14, Issue 2, Page(s) e0362122

Abstract: Millions of Norway rats (Rattus norvegicus) inhabit New York City (NYC), presenting the potential for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to rats. We evaluated SARS-CoV-2 exposure among 79 rats ... ...

Abstract	Millions of Norway rats (Rattus norvegicus) inhabit New York City (NYC), presenting the potential for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to rats. We evaluated SARS-CoV-2 exposure among 79 rats captured from NYC during the fall of 2021. Our results showed that 13 of the 79 rats (16.5%) tested IgG- or IgM-positive, and partial SARS-CoV-2 genomes were recovered from all 4 rats that were qRT-PCR (reverse transcription-quantitative PCR)-positive. Genomic analyses suggest these viruses were associated with genetic lineage B, which was predominant in NYC in the spring of 2020 during the early pandemic period. To further investigate rat susceptibility to SARS-CoV-2 variants, we conducted a virus challenge study and showed that Alpha, Delta, and Omicron variants can cause infections in wild-type Sprague Dawley (SD) rats, including high replication levels in the upper and lower respiratory tracts and induction of both innate and adaptive immune responses. Additionally, the Delta variant resulted in the highest infectivity. In summary, our results indicate that rats are susceptible to infection with Alpha, Delta, and Omicron variants, and wild Norway rats in the NYC municipal sewer systems have been exposed to SARS-CoV-2. Our findings highlight the need for further monitoring of SARS-CoV-2 in urban rat populations and for evaluating the potential risk of secondary zoonotic transmission from these rat populations back to humans.
MeSH term(s)	Humans ; Rats ; Animals ; Rats, Sprague-Dawley ; COVID-19 ; New York City/epidemiology ; SARS-CoV-2/genetics
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.03621-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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