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Article ; Online: Prognostic factors of patients with recurrent uterine malignancies undergoing secondary cytoreductive surgery

Chenyan Fang / Yingli Zhang / Ping Zhang / Tao Zhu

BMC Women's Health, Vol 24, Iss 1, Pp 1-

2024 Volume 14

Abstract: Abstract Background Several studies have demonstrated that secondary cytoreductive surgery (SCS) for patients with recurrent uterine malignancies may improve the survival. However, the selection criteria for SCS remain to be defined. This study aimed to ... ...

Abstract	Abstract Background Several studies have demonstrated that secondary cytoreductive surgery (SCS) for patients with recurrent uterine malignancies may improve the survival. However, the selection criteria for SCS remain to be defined. This study aimed to assess the outcome of SCS and to explore factors that may influence the prognosis. Methods Data of patients with recurrent uterine malignancies who received SCS in our hospital between January 2005 and January 2015 were retrospectively analyzed. Patients were assigned into endometrial carcinoma (EC) group and uterine sarcoma (US) group. Results 84 cases in total were involved in the study, including 47 cases with recurrent EC and 37 cases with recurrent US. The 5-year survival of cases with recurrent EC and recurrent US was 59.6% and 33.3%, respectively. Recurrent EC cases with a lower tumor grade (G1/G1-G2/G2), size of the largest tumor ≤ 6 cm, single recurrent tumor, a history of adjuvant therapy, as well as recurrent US cases with younger age, a longer disease-free interval (DFI) before SCS (≥ 12 months), no peritoneal dissemination, and a history of complete cytoreduction were associated with a longer survival. The number of recurrent tumors was found as an independent prognostic factor of SCS. Conclusion Recurrent EC cases with a lower tumor grade, smaller tumor size, single tumor, a history of adjuvant therapy, as well as recurrent US cases with younger age, a longer DFI before SCS, no peritoneal dissemination, and a history of complete cytoreduction were more likely to benefit from SCS.
Keywords	Recurrent uterine malignancy ; Secondary cytoreductive Surgery ; Prognosis ; Gynecology and obstetrics ; RG1-991 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of prognostic value of preoperative neutrophil-to-lymphocyte ratio for postoperative mortality and morbidity

Yingchao Zhu / Yaodan Bi / Bin Liu / Tao Zhu

Frontiers in Medicine, Vol

2023 Volume 10

Abstract: BackgroundThe preoperative elevated neutrophil-to-lymphocyte ratio (NLR) was reported to be associated with poorer outcomes after cancer and cardiovascular surgeries. It is unclear, however, if the predictive value is particular or if it may be applied ... ...

Abstract	BackgroundThe preoperative elevated neutrophil-to-lymphocyte ratio (NLR) was reported to be associated with poorer outcomes after cancer and cardiovascular surgeries. It is unclear, however, if the predictive value is particular or if it may be applied to other types of surgery. We aimed to assess the prognostic value of preoperative NLR levels for morbidity and mortality after various surgery and determine an optimal threshold for NLR.MethodsWe conducted a cohort analysis on patients receiving surgery at Sichuan University West China Hospital between 2018 and 2020. Multivariable piecewise regression analysis were used to determine the optimal cutoff value of NLR. Subgroup analysis were performed to verify the correlation. Sensitivity analysis was used to explore the effect of different thresholds.ResultsWe obtained data from 136,347 patients. The optimal cutoff of NLR was determined as 3.6 [95% CI (3.0, 4.1)] by piecewise regression method. After multivariable adjustment, preoperative high NLR remained significantly associated with increased in-hospital mortality (aOR, 2.19; 95% CI, 1.90–2.52; p < 0.001) and ICU admission after surgery (aOR, 1.69; 95% CI, 1.59–1.79; p < 0.001). Subgroup analyses confirmed the predictive value of high NLR in multiple surgical subgroups, including general, orthopedic, neurosurgical, and thoracic surgery subgroups, otorhinolaryngology, head and neck surgery, and burn plastic surgery. A NLR threshold of 3.6 gave excellent predictive value, whether employed alone or added in an extended model.ConclusionsIn conclusion, the association of elevated NLR with higher mortality and ICU admission can be extended to a wider range of procedures. NLR threshold of 3.6 could provide good prognostic value for the prognostic model.
Keywords	risk assessment ; serum biomarkers ; neutrophil-to-lymphocyte ratio ; surgery ; postoperative outcomes ; mortality ; Medicine (General) ; R5-920
Subject code	310
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of modified anterior and traditional posterior accesses for ultrasound-guided superior laryngeal nerve block in awake endotracheal intubation

Guo Chen / Tao Zhu / Yusi Hua / Qiyuan Huang

BMJ Open, Vol 13, Iss

study protocol for a randomised non-inferiority clinical trial

2023 Volume 2

Abstract: Introduction Awake tracheal intubation (ATI) involves placing a tracheal tube in an awake, spontaneously breathing patient. Superior laryngeal nerve block (SLNB) can effectively abolish the glottic closure reflex, and blunt the sensation of the ... ...

Abstract	Introduction Awake tracheal intubation (ATI) involves placing a tracheal tube in an awake, spontaneously breathing patient. Superior laryngeal nerve block (SLNB) can effectively abolish the glottic closure reflex, and blunt the sensation of the structures above the cords. A method that consists of SLNB along with translaryngeal injection (TLI) can provide satisfactory anaesthesia and intubating conditions. We present a novel modified access of SLNB, ultrasound (US)-guided anterior SLNB, to aid awake videolaryngoscopes-assisted endotracheal intubation in adult elective surgery patients, and we compare the effectiveness and safety to traditional US-guided posterior SLNB.Methods and analysis A total of 100 adult elective surgery patients requiring general endotracheal anaesthesia will be randomly assigned to the modified group (modified US-guided anterior SLNB) or the traditional group (traditional US-guided posterior SLNB). After SLNB, all participants will be performed with TLI. The primary outcome is the proportion of acceptable intubation conditions based on intubation scores. Secondary outcomes include: (a) the first-attempt intubation success rate, (b) haemodynamic changes during ATI, (c) time taken for airway anaesthesia and intubation, (d) recall of intubation, (e) participant perception of comfort during intubation, (f) perioperative complication rate. This report describes the study design of this randomised controlled trial.Ethics and dissemination The study protocol has been approved by an ethical committee of the West China Hospital (Sichuan University), and registered at the Chinese Clinical Trials Register (www.chictr.org.cn). Results will be published in a peer-reviewed journal.Trial registration number ChiCTR2200058086.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Orographic mechanical and surface thermal effects of the Tibetan–Iranian Plateau on extratropical intraseasonal waves in boreal summer

Tao Zhu / Jing Yang / Bian He

Environmental Research Letters, Vol 18, Iss 7, p

numerical experiments

2023 Volume 074008

Abstract: The intensity and location of boreal summer extratropical intraseasonal oscillations along the subtropical westerly jet (EISO-SJ) are crucial in triggering and distributing extreme events over Eurasia. Based on numerical experiments, this study ... ...

Abstract	The intensity and location of boreal summer extratropical intraseasonal oscillations along the subtropical westerly jet (EISO-SJ) are crucial in triggering and distributing extreme events over Eurasia. Based on numerical experiments, this study distinguishes the orographic mechanical and surface thermal forcing of the Tibetan–Iranian Plateau (i.e. TIP-MF and TIP-TF) on EISO-SJ. The TIP-MF primarily modulates the amplitude of EISO-SJ that strengthens over the upstream and weakens over the downstream. Comparatively, the TIP-TF not only reduces/increases the intensity of EISO-SJ over the TIP upstream/downstream, but also significantly migrates the track of EISO-SJ northward. Further analysis demonstrates that the changes of the westerly jet, eddy energy propagation and energy conversion are consistent with the track and amplitude changes of EISO-SJ. This study indicates the variations of the TIP surface sensible heating in interannual variation and global change, as well as the terrain uplift of the TIP in paleoclimate influence on the mid-latitude subseasonal variation.
Keywords	orographic mechanical effect ; thermal effect ; extratropical intraseasonal oscillation ; numerical experiment ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An extratropical window of opportunity for subseasonal prediction of East Asian summer surface air temperature

Jing Yang / Tao Zhu / Frederic Vitart

npj Climate and Atmospheric Science, Vol 6, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Previous studies suggest that boreal summer intraseasonal variations along the subtropical westerly jet (SJ), featuring quasi-biweekly periodicity, frequently modulate downstream subseasonal variations over East Asia (EA). Based on subseasonal ... ...

Abstract	Abstract Previous studies suggest that boreal summer intraseasonal variations along the subtropical westerly jet (SJ), featuring quasi-biweekly periodicity, frequently modulate downstream subseasonal variations over East Asia (EA). Based on subseasonal hindcasts from six dynamical models, this study discovered that the leading two–three-week prediction skills for surface air temperature (SAT) are significantly higher in summer with stronger intraseasonal oscillation along the SJ, which are best demonstrated over the eastern Tibetan Plateau, Southwest Basin, and North China. The reasons are that the enhanced quasi-biweekly wave and its energy dispersion along the SJ cause more regular quasi-biweekly periodic variations of downstream SAT, which potentially increase regional predictability. This study suggests that the strengthened intraseasonal periodic signals along the SJ would enhance the subseasonal predictability in downstream regions, which could provide a window of opportunity for achieving better subseasonal prediction for EA SAT.
Keywords	Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
Subject code	551
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Knowledge, attitudes, and practices toward over-the-counter antipyretics among fever patients

Yan Zhang / Shuchang Liang / Tao Zhu

Frontiers in Public Health, Vol

a cross-sectional study in the context of a policy change KAP of OTC antipyretics

2023 Volume 11

Abstract: BackgroundOn January 8, 2023, a change in the control policy for COVID-19 was implemented in China, whereby patient self-management of fever typically entails the utilization of over-the-counter fever-reducing medications.ObjectiveThis study aimed to ... ...

Abstract	BackgroundOn January 8, 2023, a change in the control policy for COVID-19 was implemented in China, whereby patient self-management of fever typically entails the utilization of over-the-counter fever-reducing medications.ObjectiveThis study aimed to investigate the knowledge, attitudes, and practices (KAP) toward over-the-counter (OTC) antipyretics among fever patients.MethodsThis cross-sectional study was conducted between October 2022 and February 2023 at author’s hospital in Wuhan, China, among fever patients on OTC antipyretics, using a self-administered questionnaire.ResultsA total of 481 valid questionnaires were collected, with the age of 36.05 ± 12.10 years, including 240 (49.90%) males, and 209 (43.45%) collected before policy change. The knowledge, attitudes, precautions for medication administration and decision-making practices scores were 6.86 ± 3.30 (possible range: 0–12), 16.67 ± 2.46 (possible range: 7–35), 29.98 ± 5.41 (possible range: 7–35) and 27.87 ± 1.28 (possible range: 8–40), respectively. The multivariable logistic regression analysis showed that knowledge (OR = 0.83, 95%CI: 0.81–0.92, p < 0.001) was independently associated with positive attitude. Knowledge (OR = 1.41, 95%CI: 1.28–1.56, p < 0.001), attitude (OR = 0.87, 95%CI: 0.79–0.95, p = 0.004), suburban (OR = 0.45, 95%CI: 0.23–0.88, p = 0.019) were independently associated with proactive precautions for medication administration practices. Knowledge (OR = 1.14, 95%CI: 1.07–1.22, p < 0.001), attitude (OR = 0.90, 95%CI: 0.82–0.98, p = 0.018), responding after policy change, 2023 (OR = 1.70, 95%CI: 1.10–2.63, p = 0.016) were independently associated with proactive decision making practices.ConclusionFever patients had moderate knowledge, negative attitude, proactive precautions for medication administration practices, moderate decision-making practices. After the policy change, there was a significant increase in knowledge regarding medication administration precautions and decision-making.
Keywords	over-the-counter ; antipyretics ; fever patients ; knowledge ; attitudes ; practices ; cross-sectional study ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Double-cavity cucurbiturils: synthesis, structures, properties, and applications.

Li, Qing / Yu, Zhengwei / Redshaw, Carl / Xiao, Xin / Tao, Zhu

Chemical Society reviews

2024 Volume 53, Issue 7, Page(s) 3536–3560

Abstract: Double-cavity Q[ ...

Abstract	Double-cavity Q[
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d3cs00961k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Delayed diagnosis of abdominal Henoch-Schonlein purpura in children: A case report.

Guo, Hui / Wang, Zhi-Ling / Tao, Zhu

World journal of clinical cases

2023 Volume 11, Issue 26, Page(s) 6311–6317

Abstract: Background: For children with abdominal Henoch-Schonlein purpura presenting abdominal pain as an initial symptom and severe clinical manifestations, but without purpura appearance on the skin, the diagnosis and treatment are relatively difficult. This ... ...

Abstract	Background: For children with abdominal Henoch-Schonlein purpura presenting abdominal pain as an initial symptom and severe clinical manifestations, but without purpura appearance on the skin, the diagnosis and treatment are relatively difficult. This study summarized the characteristics of this group of patients by literature review and provided additional references for further refinement of glucocorticoid therapy in this vasculitis. Case summary: A 6-year-old girl presented mainly with repeated abdominal pain and had received short-term out-of-hospital treatment with hydrocortisone. On day 7 after onset, gastroscopy revealed chronic non-atrophic gastritis and erosive duodenitis without purpuric rash, and no obvious resolution of the abdominal pain was found after treatment against infection and for protection of gastric mucosa. On day 14 the inflammatory indices continued to rise and the pain was relieved after enhanced anti-infective therapy, but without complete resolution. On day 19, the patient presented with aggravated abdominal pain with purplish-red dots on the lower limbs, by which Henoch-Schonlein purpura was confirmed. After 5 d of sequential treatment with methylprednisolone and prednisone, abdominal pain disappeared and she was discharged. Conclusion: Henoch-Schonlein purpura-related rash may appear after long-term abdominal pain, and should be distinguished from acute and chronic gastrointestinal diseases at the early stage without typical rash. For bacterial infection-induced Henoch-Schonlein purpura, glucocorticoid therapy alone without clearing the infection may not relieve symptoms.
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i26.6311
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tool Failure Analysis and Multi-Objective Optimization of a Cutting-Type Energy-Absorbing Structure for Subway Vehicles

Qianchen Gao / Shoune Xiao / Xiaorui Wang / Mingmeng Wang / Tao Zhu

Applied Sciences, Vol 13, Iss 1619, p

2023 Volume 1619

Abstract: This paper aims to provide essential guidance for the crashworthiness design of cutting energy-absorbing structures for subway vehicles. By investigating tool failure with experiment and numerical approaches, a new energy-absorbing tube structure was ... ...

Abstract	This paper aims to provide essential guidance for the crashworthiness design of cutting energy-absorbing structures for subway vehicles. By investigating tool failure with experiment and numerical approaches, a new energy-absorbing tube structure was proposed and optimized to improve the crashworthiness and reliability of the cutting energy-absorption structure. The impact test results revealed that multiple failure modes occurred in the tool. Mechanical wear occurs mainly in the middle of the cutting edge, while the tool’s tip failure is primarily due to thermal wear. Impact forces were no longer stable due to tool failure. The simulation results of the established tool-tube thermal–structural coupling finite element model were consistent with the tests. The temperature distribution indirectly validated the failure modes in different tool areas. By eliminating the tearing-type fracture mode, the proposed new structure effectively reduced the high temperature of the tool’s tip, better maintained the uniform temperature of the cutting edge, and smoothed changing of the cutting force. Finally, the Kriging surrogate model and NSGA-II algorithm were utilized to obtain the tool’s minimum steady-state temperature ( STT ) and maximum mean average cutting force ( MCF ). The optimal solution determined by the minimum distance method is STT = 514 K, MCF = 131 kN.
Keywords	tool failure ; crashworthiness ; energy-absorbing structure ; finite element analysis ; thermal–structural coupling ; multi-objective optimization ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The perspective of hypertension and salt intake in Chinese population

Kexin Jiang / Tingting He / Yongzhi Ji / Tao Zhu / Enshe Jiang

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: Salt intake is too high nowadays. It has been widely recognized that there is a close relationship between hypertension (HTN) and dietary salt intake. Investigations reveal that long-term high salt intake, mainly sodium intake, induces a relevant ... ...

Abstract	Salt intake is too high nowadays. It has been widely recognized that there is a close relationship between hypertension (HTN) and dietary salt intake. Investigations reveal that long-term high salt intake, mainly sodium intake, induces a relevant increase in blood pressure in hypertensive and normotensive individuals. According to most scientific evidence, a diet with high salt intake in public increases cardiovascular risk, salted-related HTN, and other HTN-associated outcomes. Given the clinical importance, this review aims to present the prevalence of HTN and trends in salt intake in the Chinese population and will comprehensively discuss the risk factors, causes, and mechanisms of the association between salt intake and HTN. The review also highlights the education of Chinese people regarding salt intake and the cost-effectiveness of salt reduction from a global perspective. Finally, the review will emphasize the need to customize the unique Chinese practices to reduce salt intake and how awareness changes people's eating lifestyle and helps adopt diet salt reduction strategies.
Keywords	hypertension ; salt intake ; dietary ; salt reduction ; Chinese population ; Public aspects of medicine ; RA1-1270
Subject code	333
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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