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Article ; Online: The Electric Field Modulation by Hemisphere Damage Sites in Fused Silica Subsurface

Shaobo He / Liang Yang / Li Li / Xiao-Tao Zu

Advances in Condensed Matter Physics, Vol

2014 Volume 2014

Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity

Barbara A Perez / Hannah K Shorrock / Monica Banez‐Coronel / Tao Zu / Lisa EL Romano / Lauren A Laboissonniere / Tammy Reid / Yoshio Ikeda / Kaalak Reddy / Christopher M Gomez / Thomas Bird / Tetsuo Ashizawa / Lawrence J Schut / Alfredo Brusco / J Andrew Berglund / Lis F Hasholt / Jorgen E Nielsen / SH Subramony / Laura PW Ranum

EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)

2021

Abstract: Abstract Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder caused by a CTG•CAG expansion, is unusual because most individuals that carry the mutation do not develop ataxia. To understand the variable penetrance of ... ...

Abstract	Abstract Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder caused by a CTG•CAG expansion, is unusual because most individuals that carry the mutation do not develop ataxia. To understand the variable penetrance of SCA8, we studied the molecular differences between highly penetrant families and more common sporadic cases (82%) using a large cohort of SCA8 families (n = 77). We show that repeat expansion mutations from individuals with multiple affected family members have CCG•CGG interruptions at a higher frequency than sporadic SCA8 cases and that the number of CCG•CGG interruptions correlates with age at onset. At the molecular level, CCG•CGG interruptions increase RNA hairpin stability, and in cell culture experiments, increase p‐eIF2α and polyAla and polySer RAN protein levels. Additionally, CCG•CGG interruptions, which encode arginine interruptions in the polyGln frame, increase toxicity of the resulting proteins. In summary, SCA8 CCG•CGG interruptions increase polyAla and polySer RAN protein levels, polyGln protein toxicity, and disease penetrance and provide novel insight into the molecular differences between SCA8 families with high vs. low disease penetrance.
Keywords	cis‐modifier ; RAN translation ; reduced penetrance ; sequence interruptions ; spinocerebellar ataxia type 8 ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of different aluminum salts on the photocatalytic properties of Al doped TiO2 nanoparticles towards the degradation of AO7 dye

Jin-ling Luo / Shi-fa Wang / Wei Liu / Cheng-xiang Tian / Ju-wei Wu / Xiao-tao Zu / Wei-lie Zhou / Xiao-dong Yuan / Xia Xiang

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 16

Abstract: Abstract Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of ... ...

Abstract	Abstract Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of anatase and photocatalytic properties of the as-prepared Al-TiO2 nanoparticles were studied. The energy gap (Eg) of Al-TiO2 nanoparticles decreases due to Al ion doping into TiO2. The photocatalytic activities of the Al-TiO2 samples were investigated by the degradation of acid orange 7 dye in aqueous solution under simulated solar irradiation. The Al-TiO2 nanoparticles prepared from Al(NO3)3∙9H2O exhibit the best photocatalytic activity among the four kinds of samples, followed in turn by the Al-TiO2 nanoparticles prepared with AlCl3, Al2(SO4)3∙18H2O and pure TiO2. The different performances are attributed to complex effects of Eg, particle size, surface morphology, phase purity and the defect sites of the Al-TiO2 nanoparticles.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.

Li, Hong / Chen, Juan / Zhang, Yan / Sun, ShuJin / Tao, ZuLai / Long, Mian

Science China. Life sciences

2010 Volume 53, Issue 9, Page(s) 1085–1091

Abstract: Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector- ... ...

Abstract	Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.
MeSH term(s)	Active Transport, Cell Nucleus ; Animals ; Cell Culture Techniques ; Cell Cycle/physiology ; Cell Line ; Cell Proliferation ; Cell Shape ; Cytoskeleton/physiology ; Gravitation ; Humans ; Osteoblasts/cytology ; Osteoblasts/physiology ; Rats
Language	English
Publishing date	2010-09
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1869-1889
ISSN (online)	1869-1889
DOI	10.1007/s11427-010-4057-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Micropatterning of biotin-avidin layers and cell location].

Hu, Jiang / Wang, Zhan-Hui / Tao, Zu-Lai

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2002 Volume 18, Issue 5, Page(s) 619–621

Abstract: The located culture of cells on patterned surfaces is useful for tissue engineering, biosensor development and fundamental research of cell biology. It is presented here a rapid fabrication method of Biotin-Avidin protein layers micropattern, which is ... ...

Abstract	The located culture of cells on patterned surfaces is useful for tissue engineering, biosensor development and fundamental research of cell biology. It is presented here a rapid fabrication method of Biotin-Avidin protein layers micropattern, which is based on soft-lithography technology. The bovine aortic endothelial cells are cultured on the micropatterned surface. It is found that cell location can be controlled on the scale of individual cell by this method.
MeSH term(s)	Animals ; Avidin/metabolism ; Biotin/metabolism ; Cattle ; Cells, Cultured/cytology ; Tissue Engineering
Chemical Substances	Avidin (1405-69-2) ; Biotin (6SO6U10H04)
Language	Chinese
Publishing date	2002-09
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042206-7
ISSN	1000-3061 ; 1042-749X
ISSN	1000-3061 ; 1042-749X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Th(IV) adsorption on alumina: effects of contact time, pH, ionic strength and phosphate.

Guo, Zhi-Jun / Yu, Xing-Min / Guo, Fei-Hu / Tao, Zu-Yi

Journal of colloid and interface science

2005 Volume 288, Issue 1, Page(s) 14–20

Abstract: Adsorption of Th(IV) (total concentration, 10(-5)-10(-4) mol/L) was studied by a batch technique. The effects of pH, ionic strength, contact time, and phosphate on the adsorption of Th(IV) onto alumina were investigated. Adsorption isotherms of Th(IV) on ...

Abstract	Adsorption of Th(IV) (total concentration, 10(-5)-10(-4) mol/L) was studied by a batch technique. The effects of pH, ionic strength, contact time, and phosphate on the adsorption of Th(IV) onto alumina were investigated. Adsorption isotherms of Th(IV) on alumina at approximately constant pH and three ionic strengths (0.05, 0.1, 0.5 mol/L KNO3) were determined. It was found that the pH values of aqueous solutions of both the Th(IV)-alumina and phosphate-alumina adsorption systems increase with increasing contact time, respectively. Adsorption of Th(IV) on alumina steeply increases with increasing pH from 1 to 4.5 and the adsorption edge consists of three regions. The phosphate added clearly enhances Th(IV) adsorption in the pH range 1-4. From the adsorption isotherms at approximately constant pH and three different ionic strengths, a reduced ionic strength effect was observed and is contradictory to the insensitive effect obtained from the adsorption edges on three oxides of Fe, Al, and Si at different ionic strengths. Compared with the adsorption edges at different ionic strengths, the adsorption isotherms at approximately constant pH and different ionic strengths are more advantageous in the investigation of ionic strength effect. The significantly positive effect of phosphate on Th(IV) adsorption onto alumina was attributed to strong surface binding of phosphate on alumina and the subsequent formation of ternary surface complexes involving Th(IV) and phosphate.
Language	English
Publishing date	2005-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2005.02.056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surface acoustic wave ammonia sensor based on ZnO/SiO2 composite film

Wang, Shuang-Yue / Jin-Yi Ma / Zhi-Jie Li / H.Q. Su / N.R. Alkurd / Wei-Lie Zhou / Lu Wang / Bo Du / Yong-Liang Tang / Dong-Yi Ao / Shou-Chao Zhang / Q.K. Yu / Xiao-Tao Zu

Journal of hazardous materials. 2015 Mar. 21, v. 285

2015

Abstract: A surface acoustic wave (SAW) resonator with ZnO/SiO2 (ZS) composite film was used as an ammonia sensor in this study. ZS composite films were deposited on the surface of SAW devices using the solâgel method, and were characterized using SEM, AFM, and ... ...

Abstract	A surface acoustic wave (SAW) resonator with ZnO/SiO2 (ZS) composite film was used as an ammonia sensor in this study. ZS composite films were deposited on the surface of SAW devices using the solâgel method, and were characterized using SEM, AFM, and XRD. The performance of the sensors under ammonia gas was optimized by adjusting the molar ratio of ZnO:SiO2 to 1:1, 1:2 and 1:3, and the sensor with the ratio of ZnO to SiO2 equaling to 1:2 was found to have the best performance. The response of sensor was 1.132kHz under 10ppm NH3, which was much higher than that of the sensor based on a pristine ZnO film. Moreover, the sensor has good selectivity, reversibility and stability at room temperature. These can be attributed to the enhanced absorption of ammonia and unique surface reaction on composite films due to the existence of silica.
Keywords	X-ray diffraction ; absorption ; acoustics ; ambient temperature ; ammonia ; atomic force microscopy ; composite materials ; films (materials) ; scanning electron microscopy ; silica ; sol-gel processing ; zinc oxide
Language	English
Dates of publication	2015-0321
Size	p. 368-374.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2014.12.014
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antisense RNA Sequences Modulating the Ataxin-1 Message

Youxin Gao / Tao Zu / Walter C. Low / Harry T. Orr / R. Scott Mcivor Ph.D.

Cell Transplantation, Vol

Molecular Model of Gene Therapy for Spinocerebellar Ataxia Type 1, a Dominant-Acting Unstable Trinucleotide Repeat Disease

2008 Volume 17

Abstract: Spinocerebellar ataxia type 1 (SCA1) is a dominant inherited disease caused by expanded trinucleotide repeats resulting in an increased polyglutamine tract in the gene product. As a potential therapeutic approach for SCA1, we tested antisense RNAs ... ...

Abstract	Spinocerebellar ataxia type 1 (SCA1) is a dominant inherited disease caused by expanded trinucleotide repeats resulting in an increased polyglutamine tract in the gene product. As a potential therapeutic approach for SCA1, we tested antisense RNAs targeting two regions of the ataxin-1 message. Single-stranded regions around the translational initiation site and the intron 8 splice donor site of the ataxin-1 message were identified by computer-assisted RNA secondary structure prediction. Plasmids were generated to contain a 254-bp antisense sequence spanning the translation initiation site (pLasBDini) or a 317-bp sequence spanning the intron 8 splice donor site (pLasBDei) of the ataxin-1 message. These plasmids were transfected into Chinese hamster ovary cells engineered to express either expanded or unexpanded ataxin-1 message and protein. Reduced levels of mutant ataxin-1 message (82 CAG repeats), wild-type ataxin-1 message (30 CAG repeats), and ataxin-1 protein were observed by Northern and Western blot analyses in pLasBDini-transfected clones. pLasBDei-transfected 293 cells exhibited a shift in ataxin-1 message to a size several kilobases longer than that of the natural message. Reverse transcriptase/polymerase chain reaction assays demonstrated the retention of message spanning the intron 8 splice acceptor and the inability to amplify sequences between exons 8 and 9, implying that normal splicing of intron 8 had been interrupted. We conclude that antisense RNAs were effective in reducing or modifying ataxin-1 messages in transfected cells, and may be an effective genetic strategy for therapy of SCA1 and similar dominant-acting neurological disorders.
Keywords	Medicine ; R
Subject code	572
Language	English
Publishing date	2008-07-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Highly sensitive room-temperature surface acoustic wave (SAW) ammonia sensors based on Co3O4/SiO2 composite films

Tang, Yong-Liang / Bo Du / Hai-Qiao Su / Jia-Jun Chen / Jin-Yi Ma / Lu Wang / Qing-Kai Yu / Weilie Zhou / Xiao-Tao Zu / Yuan-Jun Guo / Zhi-Jie Li

Journal of hazardous materials. 2014 Sept. 15, v. 280

2014

Abstract: Surface acoustic wave (SAW) sensors based on Co3O4/SiO2 composite sensing films for ammonia detection were investigated at room temperature. The Co3O4/SiO2 composite films were deposited onto ST-cut quartz SAW resonators by a solâgel method. SEM and ... ...

Abstract	Surface acoustic wave (SAW) sensors based on Co3O4/SiO2 composite sensing films for ammonia detection were investigated at room temperature. The Co3O4/SiO2 composite films were deposited onto ST-cut quartz SAW resonators by a solâgel method. SEM and AFM characterizations showed that the films had porous structures.Â The existence of SiO2 was found to enhance the ammonia sensing property of the sensor significantly. The sensor based on a Co3O4/SiO2 composite film, with 50% Co3O4 loading, which had the highest RMS value (3.72), showed the best sensing property. It exhibited a positive frequency shift of 3500Hz to 1ppm ammonia as well as excellent selectivity, stability and reproducibility at room temperature. Moreover, a 37% decrease in the conductance of the composite film as well as a positive frequency shift of 12,500Hz were observed when the sensor was exposed to 20ppm ammonia, indicating the positive frequency shift was derived from the decrease in film conductance.
Keywords	acoustics ; ambient temperature ; ammonia ; atomic force microscopy ; composite materials ; films (materials) ; quartz ; scanning electron microscopy ; silica ; sol-gel processing
Language	English
Dates of publication	2014-0915
Size	p. 127-133.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2014.08.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of dilute acid-intensified hydrolysis on fermentative biohydrogen production capacity of maize stalk

Sun Xuexi, Zhengzhou University, Zhengzhou (China), School of Chemical Engineering and Energy / Li Junfeng, Zhengzhou University, Zhengzhou (China), School of Chemical Engineering and Energy / Li Tao, Zhengzhou University, Zhengzhou (China), School of Chemical Engineering and Energy

Agricultural Science and Technology

Jan. 2011 , Issue (8)

Abstract: Objective] This study was to explore the effects of dilute acid hydrolysis on fermentative biohydrogen production capacity of maize stalk. [Method] Using maize stalks subjected to mechanical disintegration, steam explosion and dilute acid hydrolysis as ... ...

Abstract	[Objective] This study was to explore the effects of dilute acid hydrolysis on fermentative biohydrogen production capacity of maize stalk. [Method] Using maize stalks subjected to mechanical disintegration, steam explosion and dilute acid hydrolysis as experimental materials, we measured and analyzed the effects of different treatments and particle size of maize stalk were analyzed. [Result] The optimal fermentative biohydrogen production was found under following parameters: pretreatment of 0.8% dilute H2SO4 following steam explosion, particle size of maize stalk of 0.425-0.850 mm, liquid-solid ratio [0.8% H2SO4 (M) : stalk (W)] of 10:1. [Conclusion] Post steam explosion, dilute 0.8% dilute H2SO4 intensified hydrolysis on maize stalk could produce fermentative biohydrogen production capacity.
Keywords	MAIZE ; STRAW ; BIOGAS ; MAIS ; PAILLE ; BIOGAZ ; MAIZ ; PAJA ; BIOGAS ; http://www.fao.org/aos/agrovoc#c_12332 ; http://www.fao.org/aos/agrovoc#c_7441 ; http://www.fao.org/aos/agrovoc#c_9262
Language	zho
Document type	Article
ISSN	1009-4229
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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