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Article: Réguler l’aide médicale des pays à revenu intermédiaire : le cas du Maroc.

Moustatraf, Abdellatif / Taoufik, Jamal

Sante publique (Vandoeuvre-les-Nancy, France)

2019 Volume Vol. 31, Issue 1, Page(s) 103–112

Abstract: Introduction: The sustainability of medical assistance, considered necessary in middle-income countries, requires permanent regulation. In Morocco, the medical assistance scheme (MAS) is confronted with the lack of regulation tools and the difficulty of ...

Title translation	Medical assistance in middle-income countries needs regulation to ensure its sustainability: Case of Morocco.
Abstract	Introduction: The sustainability of medical assistance, considered necessary in middle-income countries, requires permanent regulation. In Morocco, the medical assistance scheme (MAS) is confronted with the lack of regulation tools and the difficulty of affixing these tools effectively in the absence of a regulator. In this sense, the shortcomings of the current practice of its regulation should be identified in order to recommend actions and tools to improve its implementation and guarantee its continuity. Methods: The analysis and the proposed recommendations are based on the review of the available literature, the review of the legal texts framing the basic medical coverage and the analysis of the current practice of regulation of the MAS. Results: The regulation of the MAS was not treated in the same way as the compulsory health insurance. There is no proper regulator as the case of the compulsory health insurance. In substance, the planned measures remain very insufficient and scattered between several actors and sometimes difficult to apply. Based on a reference framework designed along four axes (resources, expenditures, health care offer and population), the analysis identified fifteen actions and tools to correct deficiencies and support its sustainability. Conclusion: The proposed recommendations need a durable commitment from all the actors who must trigger as quickly as possible urgent actions to optimize the implementation of the medical assistance scheme and improve its perception in the citizen.
MeSH term(s)	Delivery of Health Care/economics ; Health Expenditures ; Health Resources ; Healthcare Financing ; Humans ; Insurance, Health ; Medical Assistance/economics ; Morocco
Language	French
Publishing date	2019-06-15
Publishing country	France
Document type	Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.191.0103
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Article: Pour un financement pérenne du Régime d’assistance médicale au Maroc

Moustatraf, Abdellatif / Taoufik, Jamal

Sante publique (Vandoeuvre-les-Nancy, France)

2019 Volume 30, Issue 6, Page(s) 859–868

Abstract: Introduction: Five years after its implementation, the Medical Assistance scheme (Ramed) has been able to cover more than eleven million people. Nevertheless, its financing remains the main challenge. Its initial financial structure was exceeded after ... ...

Title translation	For sustainable financing of the Medical Assistance scheme in Morocco.
Abstract	Introduction: Five years after its implementation, the Medical Assistance scheme (Ramed) has been able to cover more than eleven million people. Nevertheless, its financing remains the main challenge. Its initial financial structure was exceeded after its implementation. A reconfiguration of the financial package has become a necessity in order to guarantee sustainable financing. Methods: A review of the literature and a situational analysis through disseminated reports and documents made it possible to identify the initial financial package and its limits in order to design a new financial package. Results: The current financing is out of step with the regulations, which has a negative impact on it. Funds are insufficient to cover needs and do not even exceed half of the planned funding, set at three billion dirhams, due to a partial collection of resources. In order to meet the needs of the beneficiaries and follow their growing rhythm, at least 4 billion dirhams annually must be collected. This amount can only be ensured with a revision of the contributions of the State and local authorities. Conclusion: The current funds do not meet the needs, which undermines the social acceptability of the regime and threatens its sustainability. It is essential to improve its funding through a diversity of resources and more commitment from stakeholders to ensure sustainable funding managed according to the principles of good governance.
MeSH term(s)	Delivery of Health Care/economics ; Health Resources ; Healthcare Financing ; Humans ; Medical Assistance/economics ; Morocco
Language	French
Publishing date	2019-04-16
Publishing country	France
Document type	Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.187.0859
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Article: Virtual docking screening and QSAR studies to explore AKT and mTOR inhibitors acting on PI3K in cancers.

Kandoussi, Ilham / Benherrif, Oussama / Lakhlili, Wiame / Taoufik, Jamal / Ibrahimi, Azeddine

Contemporary oncology (Poznan, Poland)

2020 Volume 24, Issue 1, Page(s) 5–12

Abstract: The phosphoinositide 3-kinase (PI3K) pathway is an important regulator of cell proliferation and metabolism. PI3K activation initiates a signal transduction cascade, of which the major effectors are the kinases AKT and mTOR. Aberrant activation of the ... ...

Abstract	The phosphoinositide 3-kinase (PI3K) pathway is an important regulator of cell proliferation and metabolism. PI3K activation initiates a signal transduction cascade, of which the major effectors are the kinases AKT and mTOR. Aberrant activation of the PI3K/AKT/mTOR pathway is frequently observed in many human malignancies and the combination of compounds simultaneously targeting different related molecules in the PI3K/AKT/mTOR pathway leads to synergistic activity. To explore the competing common ATP inhibitors PI3K/AKT and PI3K/mTOR we developed a model PI3K-SAR 2D which made it possible to predict the bioactivity of inhibitors of AKT and mTOR towards PI3K; the interaction of the best inhibitors was evaluated by docking analysis and compared to that of dactolisib and pictilisib. A PI3K-SAR model with a correlation coefficient (R2) of 0.81706 and an RMSE of 0.16029 was obtained, which was validated and evaluated by a cross-validation method, LOO. The most predicted AKT and mTOR inhibitors present respectively pIC50 activities between 9.26-9.93 and 9.59-9.87. After docking and several comparisons, inhibitors with better predictions showed better affinity and interaction with PI3K compared to pictilisib and dactolisib, so we found that 4 inhibitors of AKT and 14 mTOR inhibitors met the criteria of Lipinski and Veber and could be future drugs.
Language	English
Publishing date	2020-02-26
Publishing country	Poland
Document type	Journal Article
ISSN	1428-2526
ISSN	1428-2526
DOI	10.5114/wo.2020.93334
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Article: Crystal structure and Hirshfeld surface analysis of (

Assila, Hamza / Zaoui, Younes / Ameziane El Hassani, Issam / El Ghammarti, Samira / Mague, Joel T / Taoufik, Jamal / Ramli, Youssef / Ansar, Mhammed

Acta crystallographica. Section E, Crystallographic communications

2022 Volume 78, Issue Pt 6, Page(s) 563–567

Abstract: The asymmetric unit of the title mol-ecule, ... ...

Abstract	The asymmetric unit of the title mol-ecule, C
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989022004789
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Article: La législation sur l'industrie pharmaceutique au Maroc durant le Protectorat français 1912-1956.

Nhaili, Hicham / Taoufik, Jamal

Revue d'histoire de la pharmacie

2015 Volume 63, Issue 386, Page(s) 237–254

Abstract: In Morocco, the pharmaceutical industry was born with the French protectorate. She knew a great evolution: from a limited production for local needs, it became an important activity, organized to export pharmaceutical patent medicines. This article ... ...

Title translation	Legislation on the pharmaceutical industry in Morocco during the French protectorate 1912 - 1956.
Abstract	In Morocco, the pharmaceutical industry was born with the French protectorate. She knew a great evolution: from a limited production for local needs, it became an important activity, organized to export pharmaceutical patent medicines. This article revisits the birth and history of this industry during the protectorate. It refers to the situation at the time by listing some examples of active establishments and some specialities marketed. It also aims to increase knowledge about the industry and provides an overview of the situation of practitioners remembering the texts governing the profession. Based on the available literature, we examined and analyzed the arrangements related to the establishment, organization and evolution of the pharmaceutical industry.
MeSH term(s)	Drug Industry/history ; France ; History, 20th Century ; Humans ; Legislation, Pharmacy/history ; Morocco
Language	French
Publishing date	2015-06
Publishing country	France
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	800880-2
ISSN	0035-2349
ISSN	0035-2349
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Article ; Online: Ethyl 2-[4-(4-meth-oxy-benz-yl)-3-methyl-6-oxopyridazin-1-yl]acetate.

Zaoui, Younes / Assila, Hamza / Mague, Joel T / Alsubari, Abdulsalam / Taoufik, Jamal / Ramli, Youssef / Ansar, Mhammed

IUCrData

2022 Volume 7, Issue Pt 6, Page(s) x220582

Abstract: In the title mol-ecule, ... ...

Abstract	In the title mol-ecule, C
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Journal Article
ISSN	2414-3146
ISSN (online)	2414-3146
DOI	10.1107/S241431462200582X
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Article ; Online: Assessment of the medical expenditure of the basic health insurance in Morocco.

Yassine, Amal / Hangouche, Abdelkader Jalil / El Malhouf, Naoufel / Maarouf, Siham / Taoufik, Jamal

The Pan African medical journal

2020 Volume 35, Page(s) 115

Abstract: Introduction: The health care consumption for the population insured by the Basic Health Insurance in Morocco are paid directly to the care providers for the health care or health products from the health insurance funds. The level of expenditure ... ...

Abstract	Introduction: The health care consumption for the population insured by the Basic Health Insurance in Morocco are paid directly to the care providers for the health care or health products from the health insurance funds. The level of expenditure recorded is changing at an accelerated rate than the financial resources. The objective of this study is to evaluate the health care consumption care by the insured population under the Basic Health Insurance. Methods: This is a cross-sectional study analysis of the economic data collected by the National Moroccan Health Insurance Agency Related to the expenditures from the health insurance fund for both public and private sectors to identify the behavior of the consumption of health care by the insured population under the Basic Health Insurance. Results: The medical expenditure of the covered population by the basic Health Insurance in Morocco has almost doubled from 354800 to 652500 US Dollars between 2009 and 2014 with significant increase in the public sector than the private sector. The share of expenditures in the public ambulatory care sector under Basic Health Insurance is higher relative to the hospital care. Although in the private sector the share of expenditures for both types of care varies. In 2014, the drug item expenditure accounted for 33% of Health Insurance expenses for both sectors. The level of health care consumption among the population in Long-Term Illness (LTI) represents 49,29% of the total expenditure by the Health Insurance whereas its insured covered population does not exceed 2,78%. Conclusion: Controlling the medical expenditure of the health insurance requires strengthening and the development of regulatory measures that contribute to the health reforms. For chronic diseases, it is necessary to put in place prevention actions.
MeSH term(s)	Cross-Sectional Studies ; Delivery of Health Care/economics ; Health Expenditures/trends ; Humans ; Insurance, Health/economics ; Insurance, Health/trends ; Morocco ; Private Sector/economics ; Private Sector/trends ; Public Sector/economics ; Public Sector/trends
Language	English
Publishing date	2020-04-14
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2020.35.115.13076
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Article ; Online: Impact of clinical pharmacy services in a hematology/oncology ward in Morocco.

Moukafih, Badreddine / Abahssain, Halima / Mrabti, Hind / Errihani, Hassan / Rahali, Younes / Taoufik, Jamal / Chaibi, Aicha

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2020 Volume 27, Issue 2, Page(s) 305–311

Abstract: Background: Clinical pharmacists are contributing to safe medication use by providing comprehensive management to patients and medical staff. The aim of this study is to document and evaluate the role of clinical pharmacy services in oncology department. ...

Abstract	Background: Clinical pharmacists are contributing to safe medication use by providing comprehensive management to patients and medical staff. The aim of this study is to document and evaluate the role of clinical pharmacy services in oncology department. Patients and methods: A prospective, descriptive, observational study was carried out from July 2018 through June 2019 at the Department of Medical Oncology at the National Institute of Oncology, Morocco. Medication reviews concerning hospitalized adult cancer patients were performed every day by the clinical pharmacist assigned to the department. Results: A total of 3542 prescriptions of 526 adult cancer patients were analyzed. The pharmacist identified 450 drug-related problems (12.7% of the prescriptions) primarily related to the analgesics (31.5%). Medication problems included mostly untreated indications (31.3%), overdosing (17.1%), drug-drug interactions (12.4%), underdosing (11.1%), administration omissions (6.7%), drug not indicated (6.0%), and contraindication (5.3%). Interventions ( Conclusion: This work highlights the positive clinical relevance of pharmacists' interventions in oncology and the importance of medicopharmaceutical collaboration to prevent medication error.
MeSH term(s)	Drug Interactions ; Drug Monitoring ; Drug Prescriptions/standards ; Female ; Hematology ; Humans ; Male ; Medical Oncology ; Medication Errors/prevention & control ; Medication Errors/statistics & numerical data ; Middle Aged ; Morocco ; Neoplasms/drug therapy ; Pharmacists ; Pharmacy Service, Hospital ; Professional Role ; Prospective Studies
Language	English
Publishing date	2020-04-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155220919169
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Article: Docking analysis of verteporfin with YAP WW domain.

Kandoussi, Ilham / Lakhlili, Wiame / Taoufik, Jamal / Ibrahimi, Azeddine

Bioinformation

2017 Volume 13, Issue 7, Page(s) 237–240

Abstract: The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular ... ...

Abstract	The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular degeneration) as a potential WW domain-ligand modulator by inhibition. A homology protein SWISS MODEL of the human YAP protein was constructed to dock (using AutoDock vina) with the PubChem verteporfin structure for interaction analysis. The docking result shows the possibilities of verteporfin interaction with the oncogenic transcription cofactor YAP having WW1 and WW2 domains. Thus, the ability of verteporfin to bind with the YAP WW domain having modulator activity is implied in this analysis.
Language	English
Publishing date	2017-07-31
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630013237
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Article ; Online: Assessment of iodine concentration in dietary salt at household level in Morocco.

Zahidi, Ahmed / Zahidi, Meriem / Taoufik, Jamal

BMC public health

2016 Volume 16, Page(s) 418

Abstract: Background: Following WHO recommendations, Morocco adopted in 1995 the universal salt iodization (USI) as a strategy to prevent and control iodine deficiency disorders. In 2009, the standard salt iodine concentration was adjusted to 15-40 mg/kg. The ... ...

Abstract	Background: Following WHO recommendations, Morocco adopted in 1995 the universal salt iodization (USI) as a strategy to prevent and control iodine deficiency disorders. In 2009, the standard salt iodine concentration was adjusted to 15-40 mg/kg. The success of USI for the control of iodine deficiency disorders requires an evaluation of iodine concentration in salt prior to assessing the iodine nutritional status of a population. Methods: In our study we refer to the anterior studies that were made in Morocco in 1993 and 1998. 178 salt samples from households were tested for iodine using spot-testing kits. The iodometric titration method was used to analyze accurately the concentration of iodine in the 178 household salt samples. An empiric polling method was adopted, using a non-probability sampling method; across the different twelve regions in the country. Results: The median and interquartile range iodine concentration in salt was 2.9 mg/kg (IQR: 2.4-3.7). The results show that only 25 % of households use iodized salt. The recommended iodine concentration in salt of 15-40 mg/kg was met only in 4.5 % of salt samples. The bulk salt is used by 8 % of households. All samples of this bulk salt were found in rural areas. According to nonparametric appropriate tests used, there is no significant difference in iodine concentrations between regions, between urban and rural areas and between packaged and bulk salt. Conclusions: Two decades since introducing legislation on Universal Salt Iodization, our survey shows that generalization of iodized salt is far from being reached. In 2015, only a quarter of Moroccan households use the iodized salt and only 4.5 % of salt is in conformity with regulations. The use of bulk salt by households in rural areas constitutes a major obstacle to the success of USI. The National Iodine Deficiency Disorders Control Program can only be achieved if an internal follow-up and a control of external quality of program is put in place.
MeSH term(s)	Cross-Sectional Studies ; Humans ; Iodine/chemistry ; Iodine/deficiency ; Morocco ; Nutritional Status ; Sodium Chloride, Dietary
Chemical Substances	Sodium Chloride, Dietary ; iodized salt ; Iodine (9679TC07X4)
Language	English
Publishing date	2016-05-20
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-016-3108-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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