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  1. Article ; Online: Anatomical and physiological considerations in short bowel syndrome: Emphasis on intestinal adaptation and the role of enterohormones.

    Tappenden, Kelly A

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2023  Volume 38 Suppl 1, Page(s) S27–S34

    Abstract: Short bowel syndrome (SBS)-associated intestinal failure (IF) is a complex, life-threatening condition that requires complex care of multiple factors impacting the patient's long-term prognosis. Various etiologies result in SBS-IF, with three primary ... ...

    Abstract Short bowel syndrome (SBS)-associated intestinal failure (IF) is a complex, life-threatening condition that requires complex care of multiple factors impacting the patient's long-term prognosis. Various etiologies result in SBS-IF, with three primary anatomical subtypes occurring following intestinal resection. Depending on the extent and segment(s) of the intestine resected, malabsorption can be nutrient specific or sweeping; however, such issues and the associated prognosis for the patient can be predicted with analysis of the residual intestine, along with baseline nutrient and fluid deficits and extent of malabsorption. The provision of parenteral nutrition/intravenous (PN-IV) fluids and antisymptomatic agents is fundamental; however, optimal management should focus on intestinal rehabilitation, wherein intestinal adaptation is prioritized and PN-IV fluids are weaned over time. Key strategies to maximize intestinal adaptation include hyperphagic consumption of an individualized SBS diet and the appropriate use of trophic agents, such as a glucagon-like peptide 2 analog.
    MeSH term(s) Humans ; Short Bowel Syndrome/therapy ; Short Bowel Syndrome/complications ; Intestines ; Glucagon-Like Peptide 2 ; Parenteral Nutrition/adverse effects ; Nutritional Status ; Adaptation, Physiological
    Chemical Substances Glucagon-Like Peptide 2
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2451: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Anatomical and physiological considerations in short bowel syndrome: Emphasis on intestinal adaptation and the role of enterohormones

    Tappenden, Kelly A.

    Nutrition in Clinical Practice. 2023 May, v. 38 Suppl S1 p.S27-S34

    2023  

    Abstract: Short bowel syndrome (SBS)–associated intestinal failure (IF) is a complex, life‐threatening condition that requires complex care of multiple factors impacting the patient's long‐term prognosis. Various etiologies result in SBS‐IF, with three primary ... ...

    Abstract Short bowel syndrome (SBS)–associated intestinal failure (IF) is a complex, life‐threatening condition that requires complex care of multiple factors impacting the patient's long‐term prognosis. Various etiologies result in SBS‐IF, with three primary anatomical subtypes occurring following intestinal resection. Depending on the extent and segment(s) of the intestine resected, malabsorption can be nutrient specific or sweeping; however, such issues and the associated prognosis for the patient can be predicted with analysis of the residual intestine, along with baseline nutrient and fluid deficits and extent of malabsorption. The provision of parenteral nutrition/intravenous (PN‐IV) fluids and antisymptomatic agents is fundamental; however, optimal management should focus on intestinal rehabilitation, wherein intestinal adaptation is prioritized and PN‐IV fluids are weaned over time. Key strategies to maximize intestinal adaptation include hyperphagic consumption of an individualized SBS diet and the appropriate use of trophic agents, such as a glucagon‐like peptide 2 analog.
    Keywords diet ; glucagon-like peptide 2 ; intestines ; intravenous injection ; malabsorption ; parenteral feeding ; patients ; prognosis ; resection
    Language English
    Dates of publication 2023-05
    Size p. S27-S34.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10991
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Conference proceedings: Intestinal failure: current and emerging therapies including transplantation

    Tappenden, Kelly A.

    proceedings of the NIH-sponsored Workshop on Intestinal Failure, February 7 - 8, 2004, A.S.P.E.N.'s Nutrition Week 2004, Las Vegas, Nevada

    (Gastroenterology ; 130,2, Suppl. 1)

    2006  

    Institution National Institutes of Health
    American Society of Parenteral and Enteral Nutrition
    Event/congress Workshop on Intestinal Failure (2004, LasVegasNev.) ; Clinical Nutrition Week (2004, LasVegasNev.)
    Series title Gastroenterology ; 130,2, Suppl. 1
    Collection
    Language English
    Size S169 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014673880
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ui V Zs 44 -130,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Article: Notice of Redundant Publication.

    Tappenden, Kelly A

    JPEN. Journal of parenteral and enteral nutrition

    2016  Volume 40, Issue 2, Page(s) 290

    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607115616967
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  5. Article: A unifying vision for scientific decision making: the Academy of Nutrition and Dietetics' Scientific Integrity Principles.

    Tappenden, Kelly A

    Journal of the Academy of Nutrition and Dietetics

    2015  Volume 115, Issue 9, Page(s) 1486–1490

    Abstract: In 2014, recognizing the need to have a single document to guide scientific decision making at the Academy of Nutrition and Dietetics (Academy), the Council on Research was charged with developing a scientific integrity policy for the organization. From ... ...

    Abstract In 2014, recognizing the need to have a single document to guide scientific decision making at the Academy of Nutrition and Dietetics (Academy), the Council on Research was charged with developing a scientific integrity policy for the organization. From the Council on Research, four members volunteered to lead this workgroup, which reviewed the literature and best practices for scientific integrity from well-respected organizations, including federal funders of research. It became clear that the scope of this document would be quite broad, given the many scientific activities the Academy is involved in, and that it would be unreasonable to set policy for each of these many situations. Therefore, the workgroup set about defining the scope of scientific activities to be covered and envisioned a set of guiding principles, to which policies from every organizational unit of the Academy could be compared to ensure they were in alignment. While many relevant policies exist already, such as the requirement of a signed conflict of interest disclosure for Food & Nutrition Conference & Expo speakers, the Evidence Analysis Library funding policy, and the Academy's sponsorship policy, the scientific integrity principals are unique in that they provide a unifying vision to which future policies can be compared and approved based on their alignment with the principles. The six principles outlined in this article were approved by the full Council on Research in January 2015 and approved by the Academy's Board of Directors in March 2015. This article covers the scope of the principles, presents the principles and existing related resources, and outlines next steps for the Academy to review and revise current policies and create new ones in alignment with these principles.
    MeSH term(s) Conflict of Interest ; Decision Making, Organizational ; Decision Support Techniques ; Evidence-Based Medicine ; Human Experimentation/ethics ; Human Experimentation/standards ; Humans ; Information Dissemination ; Nutritional Sciences/economics ; Nutritional Sciences/education ; Nutritional Sciences/manpower ; Nutritional Sciences/methods ; Practice Guidelines as Topic ; Publishing/ethics ; Publishing/standards ; Research Support as Topic/ethics ; Research Support as Topic/standards ; Scientific Misconduct ; Societies, Scientific ; United States
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Guideline ; Journal Article
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2015.06.372
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  6. Article: Resolving to ensure the data lead the way.

    Tappenden, Kelly A

    JPEN. Journal of parenteral and enteral nutrition

    2014  Volume 38, Issue 1, Page(s) 10

    MeSH term(s) Editorial Policies ; Peer Review ; Periodicals as Topic
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607113519062
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
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  7. Article: Pathophysiology of short bowel syndrome: considerations of resected and residual anatomy.

    Tappenden, Kelly A

    JPEN. Journal of parenteral and enteral nutrition

    2014  Volume 38, Issue 1 Suppl, Page(s) 14S–22S

    Abstract: The human small intestine is organized with a proximal-to-distal gradient of mucosal structure and nutrient processing capacity. However, certain nutrients undergo site-specific digestion and absorption, such as iron and folate in the duodenum/jejunum vs ...

    Abstract The human small intestine is organized with a proximal-to-distal gradient of mucosal structure and nutrient processing capacity. However, certain nutrients undergo site-specific digestion and absorption, such as iron and folate in the duodenum/jejunum vs vitamin B12 and bile salts in the ileum. Intestinal resection can result in short bowel syndrome (SBS) due to reduction of total and/or site-specific nutrient processing areas. Depending on the segment(s) of intestine resected, malabsorption can be nutrient specific (eg, vitamin B12 or fat) or sweeping, with deficiencies in energy, protein, and various micronutrients. Jejunal resections are generally better tolerated than ileal resections because of greater postresection adaptive capacity than that of the jejunum. Following intestinal resection, energy scavenging and fluid absorption become particularly important in the colon owing to loss of digestive and absorptive surface area in the resection portion. Resection-induced alterations in enteroendocrine cell abundance can further disrupt intestinal function. For example, patients with end jejunostomy have depressed circulating peptide YY and glucagon-like peptide 2 concentrations, which likely contribute to the rapid intestinal transit and blunted intestinal adaptation observed in this population. SBS-associated pathophysiology often extends beyond the gastrointestinal tract, with hepatobiliary disease, metabolic bone disease, D-lactic acidosis, and kidney stone formation being chronic complications. Clinical management of SBS must be individualized to account for the specific nutrient processing deficit within the remnant bowel and to mitigate potential complications, both inside and outside the gastrointestinal tract.
    MeSH term(s) Adaptation, Physiological ; Digestive System Surgical Procedures/methods ; Glucagon-Like Peptide 2/blood ; Humans ; Intestine, Small/physiopathology ; Peptide YY/blood ; Short Bowel Syndrome/physiopathology ; Short Bowel Syndrome/therapy
    Chemical Substances Glucagon-Like Peptide 2 ; Peptide YY (106388-42-5)
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607113520005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
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  8. Article: Intestinal adaptation following resection.

    Tappenden, Kelly A

    JPEN. Journal of parenteral and enteral nutrition

    2014  Volume 38, Issue 1 Suppl, Page(s) 23S–31S

    Abstract: Intestinal adaptation is a natural compensatory process that occurs following extensive intestinal resection, whereby structural and functional changes in the intestine improve nutrient and fluid absorption in the remnant bowel. In animal studies, ... ...

    Abstract Intestinal adaptation is a natural compensatory process that occurs following extensive intestinal resection, whereby structural and functional changes in the intestine improve nutrient and fluid absorption in the remnant bowel. In animal studies, postresection structural adaptations include bowel lengthening and thickening and increases in villus height and crypt depth. Functional changes include increased nutrient transporter expression, accelerated crypt cell differentiation, and slowed transit time. In adult humans, data regarding adaptive changes are sparse, and the mechanisms underlying intestinal adaptation remain to be fully elucidated. Several factors influence the degree of intestinal adaptation that occurs post resection, including site and extent of resection, luminal stimulation with enteral nutrients, and intestinotrophic factors. Two intestinotrophic growth factors, the glucagon-like peptide 2 analog teduglutide and recombinant growth hormone (somatropin), are now approved for clinical use in patients with short bowel syndrome (SBS). Both agents enhance fluid absorption and decrease requirements for parenteral nutrition (PN) and/or intravenous fluid. Intestinal adaptation has been thought to be limited to the first 1-2 years following resection in humans. However, recent data suggest that a significant proportion of adult patients with SBS can achieve enteral autonomy, even after many years of PN dependence, particularly with trophic stimulation.
    MeSH term(s) Adaptation, Physiological ; Animals ; Disease Models, Animal ; Glucagon-Like Peptide 2/metabolism ; Humans ; Intestinal Mucosa/metabolism ; Intestine, Small/physiopathology ; Parenteral Nutrition ; Peptides/metabolism ; Randomized Controlled Trials as Topic ; Short Bowel Syndrome/physiopathology ; Short Bowel Syndrome/surgery
    Chemical Substances Glucagon-Like Peptide 2 ; Peptides ; teduglutide (7M19191IKG)
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607114525210
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
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  9. Article ; Online: Learn Intestinal Failure Tele-ECHO Project: An innovative online telementoring and case-based learning clinic.

    Winkler, Marion F / Tappenden, Kelly A / Spangenburg, Michelle / Iyer, Kishore

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2021  Volume 36, Issue 4, Page(s) 785–792

    Abstract: Intestinal failure (IF) is a rare chronic disease requiring intravenous (IV) fluids or parenteral nutrition (PN) dependency for optimal patient health and sustenance. The complex care is best managed by specialized multidisciplinary teams. Patients who ... ...

    Abstract Intestinal failure (IF) is a rare chronic disease requiring intravenous (IV) fluids or parenteral nutrition (PN) dependency for optimal patient health and sustenance. The complex care is best managed by specialized multidisciplinary teams. Patients who have limited access to intestinal rehabilitation centers often receive IV/PN care from clinicians lacking specialty expertise. An innovative videoconferencing project was launched in May 2019 to provide online telementoring and case-based learning in IF. The Extension for Community Healthcare Outcomes (ECHO) model was adopted to provide education and virtual support via the Learn Intestinal Failure Tele-ECHO (LIFT-ECHO) project. Online clinics include patient case presentations, moderated discussion, best-practice recommendations, and didactic continuing education lectures on IF- and PN-related topics. Participation is interprofessional and international. Via knowledge dissemination and specialty mentorship, LIFT-ECHO is expected to improve healthcare for patients with IF and transform care delivery by overcoming the limitations in access to expertise.
    MeSH term(s) Humans ; Videoconferencing
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The value of nutrition intervention.

    Tappenden, Kelly A

    JPEN. Journal of parenteral and enteral nutrition

    2013  Volume 37, Issue 2, Page(s) 160

    MeSH term(s) Dietary Supplements ; Hospitalization ; Humans ; Malnutrition/therapy ; Nutrition Therapy
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607113477813
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