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Article ; Online: Insight into Tyrosine-Containing Pharmaceuticals as Potential Inhibitors of SARS-CoV-2 3CL pro and NSP16

Mohamed R. Elamin / Tarek A. Yousef / Amin O. Elzupir

Chemistry, Vol 5, Iss 54, Pp 762-

Structural Analysis, Docking Studies, Molecular Dynamics Simulations, and Density Functional Theory Investigations

2023 Volume 777

Abstract: Tyrosine-containing pharmaceuticals’ (TPh) potential to inhibit SARS CoV-2 3-chymotrypsin-like proteases (3CL pro ) and nonstructural protein 16 (NSP16) has been explored using docking studies, molecular dynamics simulations, and density functional ... ...

Abstract	Tyrosine-containing pharmaceuticals’ (TPh) potential to inhibit SARS CoV-2 3-chymotrypsin-like proteases (3CL pro ) and nonstructural protein 16 (NSP16) has been explored using docking studies, molecular dynamics simulations, and density functional theory. The TPh with FDA approval showed excellent contact with the active site pockets of 3CLpro and NSP16. Their binding affinity scores ranged from −5.8 to −4.9 kcal/mol and −6.3 to −4.8 for 3CLpro and NSP16, respectively. A 100-ns molecular dynamics simulation confirmed the stability of the carbidopa/NSP16 complex and N-acetyl tyrosine with both target enzymes. Further, the HOMO-LUMO transitions, molecular orbitals, and dipole moments of carbidopa, droxidopa, and N-acetyl tyrosine were computed using density functional theory (DFT). Considering N-acetyl tyrosine and carbidopa’s substantial inhibitory activity, it is recommended to investigate them further in order to explore their application for the treatment of COVID-19 or any other coronaviruses in the future.
Keywords	coronavirus ; N-acetyl tyrosine ; nonstructural protein 16 ; chemical reactivity descriptors ; Chemistry ; QD1-999
Subject code	541
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Electrochemical Sensor Based on an Environmentally Friendly Synthesis of Magnetic Chitosan Nanocomposite Carbon Paste Electrode for the Determination of Diclofenac to Control Inflammation

Mohamed Abd-Elsabour / Mortaga M. Abou-Krisha / Sayed H. Kenawy / Tarek A. Yousef

Nanomaterials, Vol 13, Iss 1079, p

2023 Volume 1079

Abstract: A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, ... ...

Abstract	A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, surface area, and morphology. The produced electrode showed a high electrocatalytic activity to use the DIC in 0.1 M of the BR buffer (pH 3.0). The effect of scanning speed and pH on the DIC oxidation peak suggests that the DIC electrode process has a typical diffusion characteristic with two electrons and two protons. Furthermore, the peak current linearly proportional to the DIC concentration ranged from 0.025 M to 4.0 M with the correlation coefficient (r2). The sensitivity, limit of detection (LOD; 3σ), and the limit of quantification (LOQ; 10σ) were 0.993, 9.6 µA/µM cm 2 , 0.007 µM, and 0.024 µM, respectively. In the end, the proposed sensor enables the reliable and sensitive detection of DIC in biological and pharmaceutical samples.
Keywords	magnetic chitosan nanocomposite ; diclofenac ; cyclic voltammetry ; differential pulse voltammetry ; chronoamperometry ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Synthesis, Identification, Computer-Aided Docking Studies, and ADMET Prediction of Novel Benzimidazo-1,2,3-triazole Based Molecules as Potential Antimicrobial Agents

Huda R. M. Rashdan / Aboubakr H. Abdelmonsef / Mortaga M. Abou-Krisha / Tarek A. Yousef

Molecules, Vol 26, Iss 7119, p

2021 Volume 7119

Abstract: 2-azido-1 H -benzo[d]imidazole derivatives 1a , b were reacted with a β-ketoester such as acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a , b . The latter acted as a key molecule for the synthesis of new carbazone ... ...

Abstract	2-azido-1 H -benzo[d]imidazole derivatives 1a , b were reacted with a β-ketoester such as acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a , b . The latter acted as a key molecule for the synthesis of new carbazone derivatives 4a , b that were submitted to react with 2-oxo- N -phenyl-2-(phenylamino)acetohydrazonoyl chloride to obtain the target thiadiazole derivatives 6a , b . The structures of the newly synthesized compounds were inferred from correct spectral and microanalytical data. Moreover, the newly prepared compounds were subjected to molecular docking studies with DNA gyrase B and exhibited binding energy that extended from −9.8 to −6.4 kcal/mol, which confirmed their excellent potency. The compounds 6a , b were found to be with the minimum binding energy (−9.7 and −9.8 kcal/mol) as compared to the standard drug ciprofloxacin (−7.4 kcal/mol) against the target enzyme DNA gyrase B. In addition, the newly synthesized compounds were also examined and screened for their in vitro antimicrobial activity against pathogenic microorganisms Staphylococcus aureus , E. coli, Pseudomonas aeruginosa , Aspergillus niger , and Candida albicans . Among the newly synthesized molecules, significant antimicrobial activity against all the tested microorganisms was obtained for the compounds 6a , b . The in silico and in vitro findings showed that compounds 6a , b were the most active against bacterial strains, and could serve as potential antimicrobial agents.
Keywords	benzimidazole ; 1,3,4-thiadiazole ; 1,2,3-triazoles ; antimicrobial activity ; docking study ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: A Competition between Hydrogen, Stacking, and Halogen Bonding in N -(4-((3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)selanyl)phenyl)acetamide

Mohamed Gouda / Hela Ferjani / Hany M. Abd El-Lateef / Mai M. Khalaf / Saad Shaaban / Tarek A. Yousef

International Journal of Molecular Sciences, Vol 23, Iss 2716, p

Structure, Hirshfeld Surface Analysis, 3D Energy Framework Approach, and DFT Calculation

2022 Volume 2716

Abstract: N -(4-((3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)selanyl)phenyl)acetamide (5), C 19 H 15 NO 3 Se, was prepared in two steps from 4,4′-diselanediyldianiline (3) via reduction and subsequent nucleophilic reaction with 2-methyl-3-bromo-1,4- ... ...

Abstract	N -(4-((3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)selanyl)phenyl)acetamide (5), C 19 H 15 NO 3 Se, was prepared in two steps from 4,4′-diselanediyldianiline (3) via reduction and subsequent nucleophilic reaction with 2-methyl-3-bromo-1,4-naphthalenedione, followed by acetylation with acetic anhydride. The cytotoxicity was estimated against 158N and 158JP oligodendrocytes and the redox profile was also evaluated using different in vitro assays. The technique of single-crystal X-ray diffraction is used to confirm the structure of compound 5. The enantiopure 5 crystallizes in space group P21 with Flack parameter 0.017 (8), exhibiting a chiral layered absolute structure. Molecular structural studies showed that the crystal structure is foremost stabilized by N-H···O and relatively weak C-H···O contacts between molecules, and additionally stabilized by weak C-H···π and Se···N interactions. Hirshfeld surface analysis is used to quantitatively investigate the noncovalent interactions that stabilize crystal packing. Framework energy diagrams were used to graphically represent the stabilizing interaction energies for crystal packing. The analysis of the energy framework shows that the interactions energies of and C-H···π and C-O···π are primarily dispersive and are the crystal’s main important forces. Density functional theory (DFT) calculations were used to determine the compound’s stability, chemical reactivity, and other parameters by determining the HOMO-LUMO energy differences. The determination of its optimized surface of the molecular electrostatic potential (MEP) was also carried out. This study was conducted to demonstrate both the electron-rich and electron-poor sites.
Keywords	crystal structure ; organoselenium ; antioxidant ; cytoprotective ; Hirshfeld surface analysis ; DFT calculations ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unexpected kinetically controlled organoselenium-based isomaleimide

Saad Shaaban / Hela Ferjani / Hany M. Abd El-Lateef / Mai M. Khalaf / Mohamed Gouda / Mohamed Alaasar / Tarek A. Yousef

Frontiers in Chemistry, Vol

X-ray structure, hirshfeld surface analysis, 3D energy framework approach, and density functional theory calculation

2022 Volume 10

Abstract: Reduction of 4,4′-diselanediyldianiline (1) followed by the reaction with bromo-4-(bromomethyl)benzene afforded the corresponding 4-((4-bromobenzyl)selanyl)aniline (2) in 85% yield. N-Maleanilic acid 3 was obtained in 94% yield via the reaction of ... ...

Abstract	Reduction of 4,4′-diselanediyldianiline (1) followed by the reaction with bromo-4-(bromomethyl)benzene afforded the corresponding 4-((4-bromobenzyl)selanyl)aniline (2) in 85% yield. N-Maleanilic acid 3 was obtained in 94% yield via the reaction of selenoamine 2 with toxilic anhydride. Subsequent dehydration of N-maleanilic acid 3 using acetic anhydride furnished the unexpected isomaleimide 5-((4-((4-bromophenyl)selanyl)phenyl)imino)furan-2(5H)-one (4) instead of the maleimide 5. The molecular structure of compound 4 was confirmed by mass spectrometry, 1H- and 13C-NMR spectroscopy, and X-ray diffraction analysis. Their cytotoxicity was assessed against two oligodendrocytes, and their respective redox properties were evaluated using 2′,7′-dichlorodihydrofluorescein diacetate (H2-DCFDA) assay. Furthermore, their antiapoptotic potential was also evaluated by flow cytometry. The compound crystallizes in triclinic P-1 space group with unit cell parameters a = 5.7880 (4) Å, b = 9.8913 (6) Å, c = 14.5951 (9) Å, V = 1731.0 (3) Å3 and Z = 2. The crystal packing is stabilized by intermolecular hydrogen bonding, π···π, C-Br···π stacking interactions, and other non-covalent interactions. The mapping of different Hirshfeld surfaces and 2D-fingerprint were used to investigate intermolecular interactions. The interaction energies that stabilize the crystal packing were calculated and graphically represented as framework energy diagrams. We present a computational investigation of compound 4’s molecular structure at the Density Functional Theory level using the B3LYP method and the 6-31G ++ basis set in this paper. The optimized structure matches the experimental outcome. The global reactivity descriptors and molecular electrostatic potential (M.E.P.) map emphasize the molecule’s reactive locations, allowing reactivity prediction. The charge transfer properties of molecules can be estimated by examining Frontier molecular orbitals.
Keywords	isomaleimide ; organoselenium ; crystal structure ; antioxidant ; hirshfeld surface analysis ; DFT calculations ; Chemistry ; QD1-999
Subject code	540 ; 541
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
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Article ; Online: Cd(II) and Pd(II) Mixed Ligand Complexes of Dithiocarbamate and Tertiary Phosphine Ligands—Spectroscopic, Anti-Microbial, and Computational Studies

Tohama B. Abdullah / Reza Behjatmanesh-Ardakani / Ahmed S. Faihan / Hayfa M. Jirjes / Mortaga M. Abou-Krisha / Tarek A. Yousef / Sayed H. Kenawy / Ahmed S. M. Al-Janabi

Molecules, Vol 28, Iss 2305, p

2023 Volume 2305

Abstract: Mixed ligand complexes of Pd(II) and Cd(II) with N -picolyl-amine dithiocarbamate (PAC-dtc) as primary ligand and tertiary phosphine ligand as secondary ligands have been synthesized and characterized via elemental analysis, molar conductance, NMR ( 1 H ... ...

Abstract	Mixed ligand complexes of Pd(II) and Cd(II) with N -picolyl-amine dithiocarbamate (PAC-dtc) as primary ligand and tertiary phosphine ligand as secondary ligands have been synthesized and characterized via elemental analysis, molar conductance, NMR ( 1 H and 31 P), and IR techniques. The PAC-dtc ligand displayed in a monodentate fashion via sulfur atom whereas diphosphine ligands coordinated as a bidentate mode to afford a square planner around the Pd(II) ion or tetrahedral around the Cd(II) ion. Except for complexes [Cd(PAC-dtc) 2 (dppe)] and [Cd(PAC-dtc) 2 (PPh 3 ) 2 ], the prepared complexes showed significant antimicrobial activity when evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. Moreover, DFT calculations were performed to investigate three complexes {[Pd(PAC-dtc) 2 (dppe)](1), [Cd(PAC-dtc) 2 (dppe)](2), [Cd(PAC-dtc) 2 (PPh 3 ) 2 ](7)}, and their quantum parameters were evaluated using the Gaussian 09 program at the B3LYP/Lanl2dz theoretical level. The optimized structures of the three complexes were square planar and tetrahedral geometry. The calculated bond lengths and bond angles showed a slightly distorted tetrahedral geometry for [Cd(PAC-dtc) 2 (dppe)](2) compared to [Cd(PAC-dtc) 2 (PPh 3 ) 2 ](7) due to the ring constrain in the dppe ligand. Moreover, the [Pd(PAC-dtc) 2 (dppe)](1) complex showed higher stability compared to Cd(2) and Cd(7) complexes which can be attributed to the higher back-donation of Pd(1) complex.
Keywords	picolylamine ; dithiocarbamate ; single-pot reaction ; DFT ; complexes ; Organic chemistry ; QD241-441
Subject code	290
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors

Tarek A. Yousef / Abdulrahman G. Alhamzani / Mortaga M. Abou-Krisha / G. Kanthimathi / M.S. Raghu / K. Yogesh Kumar / M.K. Prashanth / Byong-Hun Jeon

Heliyon, Vol 9, Iss 2, Pp e13460- (2023)

2023

Abstract: The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the ... ...

Abstract	The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the conventional medicine colchicine, compounds 8e and 8f demonstrated stronger sensitivity and improved IC50 values in the range of 3.19–8.21 μM against breast MCF-7, colorectal HCT116, and liver HepG2 cancer cell lines. The target compounds were tested for enzymatic activity against the tubulin enzyme. Compounds 8e and 8f were shown to have the most effective inhibitory action among the new compounds, with IC50 values of 7.95 and 9.81 nM, respectively. As compared to the reference drug, molecular docking investigations of the developed compounds revealed the crucial hydrogen bonding in addition to the hydrophobic interaction at the binding site, assisting in the prediction of the structural requirements for the found anticancer activity. These findings indicate that the 1,3,4-oxadizole scaffold has the potential for future research into new anticancer medicines.
Keywords	1,3,4-Oxadiazole ; Anticancer ; Tubulin inhibitors ; Molecular docking ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	540
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Spectroscopic, Anti-Cancer Activity, and DFT Computational Studies of Pt(II) Complexes with 1-Benzyl-3-phenylthiourea and Phosphine/Diamine Ligands

Dina Saadi Mohamed / Subhi A. Al-Jibori / Reza Behjatmanesh-Ardakani / Ahmed S. Faihan / Tarek A. Yousef / Abdulrahman G. Alhamzani / Mortaga M. Abou-Krisha / Ahmed S. M. Al-Janabi / Benjamin S. Hsiao

Inorganics, Vol 11, Iss 125, p

2023 Volume 125

Abstract: The reaction between [PtCl 2 (L-L)] (L-L = dppe, dppp, dppb, dppf, Phen and Bipy) or [PtCl 2 (PPh 3 ) 2 ] with 1-benzyl-3-phenylthiourea (H 2 BPT) in a basic medium (CHCl 3 /EtOH) created new coordinated square planner Pt(II) complexes with [Pt(BPT)(L-L)] ...

Abstract	The reaction between [PtCl 2 (L-L)] (L-L = dppe, dppp, dppb, dppf, Phen and Bipy) or [PtCl 2 (PPh 3 ) 2 ] with 1-benzyl-3-phenylthiourea (H 2 BPT) in a basic medium (CHCl 3 /EtOH) created new coordinated square planner Pt(II) complexes with [Pt(BPT)(L-L)] ( 1 – 4 , 6 , 7 ) and [Pt(BPT)(PPh 3 ) 2 ] ( 5 ) types. These complexes were fully characterized by analytical and spectroscopic techniques (i.e., IR, UV. Vis., 1 H, and 31 P NMR). The results indicated that the thiourea derivative ligand act as a dianion ligand bonded through both S and N atoms in a chelating mode or as a mono-anion ligand coordinated through a sulfur atom with Pt(II) ion. Cytotoxicity activity was performed by the MTT assay to determine anti-cancer activities against MCF-7 breast cancer cells. The study indicated that IC 50 values for MCF-7 cells were 10.96–78.90 µM. Additionally, the complexes [Pt(BPT)(dppe)] ( 1 ), [Pt(BPT)(PPh 3 ) 2 ] ( 5 ), and [Pt(BPT) 2 (Bipy)] ( 7 ) were investigated theoretically, where their quantum parameters were evaluated using the Gaussian 09 program using the theory of B3LYP/Def2TZVP//B3LYP/Lanl2dz. The calculation results confirmed the optimized structures of the complexes square planar geometry. However, the calculated bond lengths and angles showed a slightly distorted square planar geometry due to the trans influence of the sulfur atom. Additionally, complexes of [Pt(BPT)(dppe)] ( 1 ) and [Pt(BPT)(PPh 3 ) 2 ] ( 5 ) showed higher stability compared to [Pt(BPT) 2 (Bipy)] ( 7 ), which can be attributed to the higher back-donation of ( 1 ) and ( 5 ) complexes. Furthermore, among the three complexes, the [Pt(BPT) 2 (Bipy)] ( 7 ) complex possessed the lowest HOMO–LUMO gap, which may be a good candidate as the photo-catalyst material.
Keywords	thiourea ; phosphine ; computational ; DFT ; platinum ; Inorganic chemistry ; QD146-197
Subject code	290
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quinine Charge Transfer Complexes with 2,3-Dichloro-5,6-Dicyano-Benzoquinone and 7,7,8,8-Tetracyanoquinodimethane

Gamal A. E. Mostafa / Tarek A. Yousef / Samir T. Gaballah / Atef M. Homoda / Rashad Al-Salahi / Haya I. Aljohar / Haitham AlRabiah

Applied Sciences, Vol 12, Iss 978, p

Spectroscopic Characterization and Theoretical Study

2022 Volume 978

Abstract: The molecular charge transfer reactions of quinine (Q) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-acceptor to form charge transfer (CT) complexes have been studied. The CT complexes were ... ...

Abstract	The molecular charge transfer reactions of quinine (Q) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-acceptor to form charge transfer (CT) complexes have been studied. The CT complexes were characterized by infrared spectra, NMR, mass spectrometry, conductometry and spectrometry. The Q-DDQ and Q-TCNQ charge transfer complexes were monitored at 480 and 843 nm, respectively. The results confirm the formation of CT complexes. The molar ratio of Q:DDQ and Q: TCNQ assessed using Job’s method was 1:1, which agrees with the results obtained by the Benesi-Hildebrand equation. The stability of the formed CT complexes was assessed by measuring different spectroscopic parameters such as oscillator strength, transition dipole moment, ionization potential, the energy of CT complex, resonance energy, dissociation energy and standard free energy change. The DFT geometry optimization of quinine, DDQ and TCNQ, its charge transfer complex, and UV theoretical vs. experimental comparative study were carried out. The theoretical and experimental results agreed. DFT/B3LYP/6-311++G(d,p) level of theory was used for the investigation of charge transfer between quinine as electron donor and (DDQ and TNCQ) as electron acceptors. The geometric structures, orbital energies, HOMO, LUMO and energy gaps were determined. The transition energies of the charge transfer complexes were computed using the TD-DFT/B3LYP/6-311++G(d,p) level of theory. The computed parameters were comparable to the experimental parameters, and the computational results aided in the analysis of the data.
Keywords	Quinine ; DDQ ; TCNQ ; charge transfer complex ; spectroscopy ; density functional theory (DFT) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	541
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and characterization of new HgS nanoparticles prepared by Hg(II)-triazole-3-thiol as precursor

Ahmed S. Al-Janabi / Omar D.H. Al-Mouqdady / Mohammad E.A. Al-Doori / Hela Ferjani / O.K. Al Duaij / Zeid A. ALOthman / Tarek A. Yousef

Journal of Saudi Chemical Society, Vol 26, Iss 4, Pp 101507- (2022)

2022

Abstract: Nine Hg(II) complexes, [Hg(DiphtS)2(L-L)](2–7) {where, HDiphtS = 4,5-diphenyl-1,2,4-triazole-3-thiol; L-L = bis(diphenylphosphino)ethane (dppe) (2); 1,3-bis(diphenylphosphino)propane (dppp)(3); 1,4-bis(diphenylphosphino)butane (dppb)(4); 1,1′-bis( ... ...

Abstract	Nine Hg(II) complexes, [Hg(DiphtS)2(L-L)](2–7) {where, HDiphtS = 4,5-diphenyl-1,2,4-triazole-3-thiol; L-L = bis(diphenylphosphino)ethane (dppe) (2); 1,3-bis(diphenylphosphino)propane (dppp)(3); 1,4-bis(diphenylphosphino)butane (dppb)(4); 1,1′-bis(diphenylphosphino)ferrocene (dppf)(5); 2,2′-bipyridine (Bipy)(6) and 1,10-phenanthroline (Phen)(7) } or [Hg(DiphtS)2(L)2] (8–9) {where L = triphenylphosphine (Ph3P) (8) and triphenylphosphine sulphide (Ph3PS) (9)}, have been prepared form the reaction of [Hg(DiphtS)2](1) with phosphine or amine as co-ligands. Then characterized by the IR, NMR (1H and 31P) spectroscopy, elemental analysis, molar conductivity. The results supported the monodentate behaviour of HDiphtS ligand in all complexes (1–9) in anion form through the sulfur atom. Complexes 1, 2 and 6 have been used as single source precursors for the preparation of ethylene-diamine capped HgS-nanoparticles. Powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM), have been used to characterize the HgS nanoparticles.
Keywords	Thiol ; Triazole ; HgS nanoparticle ; Phosphine ; Hg(II) ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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