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  1. Book: Inflammatory bowel disease

    Targan, Stephan R.

    from bench to bedside

    2003  

    Author's details ed. by Stephan R. Targan
    Keywords Inflammatory Bowel Diseases ; Darmentzündung
    Subject Entzündliche Darmkrankheit
    Language English
    Size XV, 903 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Kluwer Acad
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT013674324
    ISBN 1-4020-0713-2 ; 978-1-4020-0713-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 1819 order for loan Magazin

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  2. Book: Inflammatory bowel disease

    Targan, Stephan R. / Shanahan, Fergus / Karp, Loren C.

    Translating basic science into clinical practice

    2010  

    Author's details ed. by Stephan R. Targan ; Fergus Shanahan ; Loren C. Karp
    Keywords Inflammatory Bowel Diseases
    Language English
    Size IX, 740 S., [2] Bl. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015762408
    ISBN 978-1-4051-5725-4 ; 1-4051-5725-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 2476 order for loan Magazin

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  3. Article: Therapeutic Targets for Emerging Biologic Therapies in IBD.

    Hanauer, Stephen B / Plevy, Scott E / Sands, Bruce E / Targan, Stephan R

    Gastroenterology & hepatology

    2023  Volume 5, Issue 7 Suppl 16, Page(s) 4–16

    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6543: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 517: Show issues

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  4. Book ; Online: Inflammatory Bowel Disease

    Karp, Loren C. / Shanahan, Fergus / Targan, Stephan R.

    From Bench to Bedside

    2005  

    Author's details edited by Loren C. Karp, Fergus Shanahan, Stephan R. Targan
    Keywords Biochemistry ; Gastroenterology ; Internal medicine
    Language English
    Publisher Springer Science+Business Media, Inc
    Publishing place Norwell
    Document type Book ; Online
    HBZ-ID TT050386809
    ISBN 978-0-387-25807-2 ; 978-0-387-25808-9 ; 0-387-25807-8 ; 0-387-25808-6
    DOI 10.1007/b136186
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Inflammatory bowel disease

    Targan, Stephan R. / Shanahan, Fergus

    from bench to bedside

    1994  

    Author's details Stephan R. Targan ; Fergus Shanahan
    Keywords Inflammatory Bowel Diseases ; Chronische Darmentzündung
    Subject Inflammatory bowel disease ; Irritable Bowel Syndrome ; Entzündliche Darmkrankheit ; Chronisch-entzündliche Darmerkrankung
    Size XIII, 795 S. : Ill., graph. Darst.
    Publisher Williams & Wilkins
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006307596
    ISBN 0-683-08110-1 ; 978-0-683-08110-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 2940 order for loan Magazin

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  6. Book: Immunology and immunopathology of the liver and gastrointestinal tract

    Shanahan, Fergus / Targan, Stephan R.

    1990  

    Title variant Immunology and immunopathology of the liver and gastrointestinal tract / Stephan R. Targan ; Fergus Shanahan
    Author's details ed. by Stephan R. Targan
    Keywords Gastrointestinal System / immunology ; Gastrointestinal System / pathology ; Liver / immunology ; Liver / pathology ; Gastrointestinaltrakt ; Immunologie ; Immunpathologie
    Subject Magen-Darm-Kanal ; Magen-Darm-Trakt ; Magen-Darmtrakt ; Immunopathologie ; Klinische Immunologie
    Size XVI, 656 S. : Ill., graph. Darst.
    Publisher Igaku-Shoin
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003541376
    ISBN 0-89640-168-5 ; 4-260-14168-6 ; 978-0-89640-168-6 ; 978-4-260-14168-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5541 order for loan Magazin

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  7. Article: Introductory words about TL1A/DR3.

    Targan, Stephan R

    Advances in experimental medicine and biology

    2011  Volume 691, Page(s) 271–274

    MeSH term(s) Animals ; Colitis/immunology ; Colitis/pathology ; Colitis/therapy ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/pathology ; Disease Models, Animal ; Humans ; Mice ; Receptors, Tumor Necrosis Factor, Member 25/metabolism ; Signal Transduction ; Tumor Necrosis Factor Ligand Superfamily Member 15/genetics ; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism
    Chemical Substances Receptors, Tumor Necrosis Factor, Member 25 ; Tumor Necrosis Factor Ligand Superfamily Member 15
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Introductory Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4419-6612-4_27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells.

    Estrada, Hannah Q / Patel, Shachi / Rabizadeh, Shervin / Casero, David / Targan, Stephan R / Barrett, Robert J

    Inflammatory bowel diseases

    2021  Volume 28, Issue 5, Page(s) 667–679

    Abstract: Background: Intestinal fibrosis is a serious complication of Crohn's disease. Numerous cell types including intestinal epithelial and mesenchymal cells are implicated in this process, yet studies are hampered by the lack of personalized in vitro models. ...

    Abstract Background: Intestinal fibrosis is a serious complication of Crohn's disease. Numerous cell types including intestinal epithelial and mesenchymal cells are implicated in this process, yet studies are hampered by the lack of personalized in vitro models. Human intestinal organoids (HIOs) derived from induced pluripotent stem cells (iPSCs) contain these cell types, and our goal was to determine the feasibility of utilizing these to develop a personalized intestinal fibrosis model.
    Methods: iPSCs from 2 control individuals and 2 very early onset inflammatory bowel disease patients with stricturing complications were obtained and directed to form HIOs. Purified populations of epithelial and mesenchymal cells were derived from HIOs, and both types were treated with the profibrogenic cytokine transforming growth factor β (TGFβ). Quantitative polymerase chain reaction and RNA sequencing analysis were used to assay their responses.
    Results: In iPSC-derived mesenchymal cells, there was a significant increase in the expression of profibrotic genes (Col1a1, Col5a1, and TIMP1) in response to TGFβ. RNA sequencing analysis identified further profibrotic genes and demonstrated differential responses to this cytokine in each of the 4 lines. Increases in profibrotic gene expression (Col1a1, FN, TIMP1) along with genes associated with epithelial-mesenchymal transition (vimentin and N-cadherin) were observed in TGFβ -treated epithelial cells.
    Conclusions: We demonstrate the feasibility of utilizing iPSC-HIO technology to model intestinal fibrotic responses in vitro. This now permits the generation of near unlimited quantities of patient-specific cells that could be used to reveal cell- and environmental-specific mechanisms underpinning intestinal fibrosis.
    MeSH term(s) Fibrosis ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Intestines ; Organoids/metabolism ; Transforming Growth Factor beta/metabolism
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2021-12-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izab292
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion.

    Biener-Ramanujan, Eva / Rosier, Florian / Coetzee, Simon G / McGovern, Dermot D P / Hazelett, Dennis / Targan, Stephan R / Gonsky, Rivkah

    Frontiers in immunology

    2022  Volume 13, Page(s) 999155

    Abstract: Ribonuclease T2 gene (RNASET2) variants are associated in genome wide association studies (GWAS) with risk for several autoimmune diseases, including Crohn's disease (CD). In T cells, a functional and biological relationship exists between TNFSF15- ... ...

    Abstract Ribonuclease T2 gene (RNASET2) variants are associated in genome wide association studies (GWAS) with risk for several autoimmune diseases, including Crohn's disease (CD). In T cells, a functional and biological relationship exists between TNFSF15-mediated enhancement of IFN-γ production, mucosal inflammation and RNASET2. Disease risk variants are associated with decreased mRNA expression and clinical characteristics of severe CD; however, functional classifications of variants and underlying molecular mechanisms contributing to pathogenesis remain largely unknown. In this study we demonstrate that allelic imbalance of RNASET2 disease risk variant rs2149092 is associated with transcriptional and post-transcriptional mechanisms regulating transcription factor binding, promoter-transactivation and allele-specific expression. RNASET2 mRNA expression decreases in response to multiple modes of T cell activation and recovers following elimination of activator. In CD patients with severe disease necessitating surgical intervention, preoperative circulating RNASET2 protein levels were decreased compared to non-IBD subjects and rebounded post-operatively following removal of the inflamed region, with levels associated with allelic carriage. Furthermore, overexpression or treatment with recombinant RNASET2 significantly reduced IFN-γ secretion. These findings reveal that RNASET2 cis- and trans-acting variation contributed regulatory complexity and determined expression and provide a basis for linking genetic variation with CD pathobiology. These data may ultimately identify RNASET2 as an effective therapeutic target in a subset of CD patients with severe disease.
    MeSH term(s) Humans ; Crohn Disease/genetics ; Genome-Wide Association Study ; Allelic Imbalance ; Polymorphism, Genetic ; RNA, Messenger ; Tumor Necrosis Factor Ligand Superfamily Member 15 ; Ribonucleases ; Tumor Suppressor Proteins
    Chemical Substances RNA, Messenger ; TNFSF15 protein, human ; Tumor Necrosis Factor Ligand Superfamily Member 15 ; RNASET2 protein, human (EC 3.1.27.-) ; Ribonucleases (EC 3.1.-) ; Tumor Suppressor Proteins
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.999155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Inflammatory Bowel disease

    Targan, Stephan R

    translating basic science into clinical practice

    2010  

    Author's details ed. by Stephan R. Targan
    Keywords Inflammatory bowel diseases ; Inflammatory bowel diseases/Pathophysiology
    Language English
    Size Online-Ressource (XIV, 740 S.), graph. Darst.
    Edition 1. Aufl.
    Publisher Wiley-Blackwell
    Publishing place Chichester, UK u.a.
    Document type Book ; Online
    Note Literaturangaben
    ISBN 1405157259 ; 1444318411 ; 8781405157254 ; 9781405157254 ; 9781444318418 ; 9781444318418
    DOI 10.1002/9781444318418
    Database Former special subject collection: coastal and deep sea fishing

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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