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Article ; Online: A Case of Thoracic Perineural (Tarlov) Cyst.

Tariq, Asma / Majid, Adnan

American journal of respiratory and critical care medicine

2020 Volume 201, Issue 11, Page(s) e79

MeSH term(s)	Adult ; Humans ; Male ; Tarlov Cysts/diagnostic imaging ; Thorax ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-01-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201908-1574IM
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Article ; Online: Incidence and Nature of Respiratory Events in Patients Undergoing Bronchoscopy Under Conscious Sedation.

Tariq, Asma / Hill, Nicholas S / Price, Lori Lyn / Ismail, Khalid

Journal of bronchology & interventional pulmonology

2022 Volume 29, Issue 4, Page(s) 283–289

Abstract: Background: During diagnostic bronchoscopies, conscious sedation improves patient tolerance, but it can contribute to hypercapnia and hypoxia by various mechanisms including depression of ventilatory drive. This prospective study was undertaken to ... ...

Abstract	Background: During diagnostic bronchoscopies, conscious sedation improves patient tolerance, but it can contribute to hypercapnia and hypoxia by various mechanisms including depression of ventilatory drive. This prospective study was undertaken to determine the frequency of respiratory events and associated oxygen desaturations during bronchoscopy with conscious sedation. Patients and methods: The Nox-T3 monitoring system was placed before starting the bronchoscopy and remained in place for 30 minutes following the procedure. The primary endpoint was the occurrence of obstructive and central apneic events during bronchoscopy under conscious sedation. Results: Obstructive events (apnea and hypopnea) occurred in 100% of patients (n=31), and central apneas occurred in 58% of patients (n=18) during the procedure with a median of 9 and 2 events per patient, respectively. During recovery, a significant proportion of patients had detectable obstructive (86%) and central (36%) events. Higher body mass index was associated with oxygen desaturation to <90% and with the need for escalation of care. Furthermore, a conscious sedation regimen that included propofol was significantly associated with central apneic events. Conclusion: Respiratory events are common during and immediately postprocedure after conscious sedation for bronchoscopy. Most events are obstructive, and the use of propofol predisposes to central apneas during the procedure. Both types of events are associated with a higher body mass index. Oxygen desaturation to <90% triggers escalation of care. A further prospective study will be required to determine the clinical significance of these apneic events and whether alleviating these events will improve the safety and outcomes of bronchoscopic procedures performed under conscious sedation.
MeSH term(s)	Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Conscious Sedation/adverse effects ; Conscious Sedation/methods ; Humans ; Incidence ; Oxygen ; Propofol/adverse effects ; Prospective Studies ; Sleep Apnea, Central/chemically induced
Chemical Substances	Oxygen (S88TT14065) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000837
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Article ; Online: Crime scene investigation in Pakistan: A perspective.

Mateen, Rana Muhammad / Tariq, Asma

Forensic science international. Synergy

2019 Volume 1, Page(s) 285–287

Abstract: Crime scene investigation is an important tool in criminal investigation process. Proper processing of crime scene is a prerequisite for successfully solving a criminal case. In Pakistan, local policemen are not properly trained and equipped with the ... ...

Abstract	Crime scene investigation is an important tool in criminal investigation process. Proper processing of crime scene is a prerequisite for successfully solving a criminal case. In Pakistan, local policemen are not properly trained and equipped with the necessary items required for systematic processing of crime scene including proper identification and collection of evidence. Certain capacity building measures and improvements must be needed for proper processing of crime scene in Pakistan. This article focuses the current situation and strategies being practiced in Pakistan followed by suggestions for capacity building measures in this field.
Language	English
Publishing date	2019-07-19
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	424042-x
ISSN	2589-871X ; 1872-6283 ; 0379-0738
ISSN (online)	2589-871X ; 1872-6283
ISSN	0379-0738
DOI	10.1016/j.fsisyn.2019.06.046
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Article ; Online: In-silico analysis of potential anticancer drug for NEK7 and PPP1CA proteins overexpressed in pancreatic ductal adenocarcinoma.

Adrees, Safa / Imtiaz, Anam / Yaseen, Aiman / Irfan Fareed, Muhammad / Anwar, Waqar / Ashraf, Asma / Shabbir, Rana Muhammad Kamran / Andlib, Shaista / Hussain, Mureed / Tariq, Asma / Mateen, Rana Muhammad / Saqib, Muhammad Arif Nadeem / Parveen, Rukhsana

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–17

Abstract: NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current ... ...

Abstract	NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current study was to identify a possible NEK7 and PPP1CA therapeutic inhibitor. For this investigation, 5000 compounds were retrieved from the IMPPAT library of phytochemicals, which were docked with our respective target proteins. Also, a reference compound, gemcitabine, which is a Food and Drug Administration (FDA) approved drug, was docked with the target proteins. The binding energy of the reference compound for both the targeted proteins was -6.5 kcal/mol. The common ligand with the lowest binding energy for both targets is boeravinone B (PubChem ID: 14018348) with -9.2 kcal/mol of NEK7 and -7.6 kcal/mol for PPP1CA. The compound was further investigated through density function theory (DFT) and molecular dynamic simulation analysis. The root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and hydrogen bonding analysis indicated the stability of the boeravinone B with the target proteins (NEK7 and PPP1CA).Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2318484
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Article: Persistence of Semen on five different fabric types in various water environments

Nabi, Ahmed Ghulam / Mateen, Rana Muhammad / Khalid, Aqsa / Tariq, Asma / Parveen, Rukhsana

Forensic science international. 2021 Oct., v. 327

2021

Abstract: Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual ... ...

Abstract	Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual assault. The water environments selected for this study are all related to the potential crime scenes from which there is a possibility of finding a dead body or clothing of a sexual assault victim. Tap water, River water, Swimming pool water, and Canal water were selected. Fabric types selected were khaddar, linen, silk, polyester, and chiffon. Detection of seminal stains was carried out by three methods; Alternate Light Source (ALS), Acid phosphatase (AP) testing, and Kernechtrot-Picro-indigo-carmine (KPIC) testing. These tests were performed for each fabric type in each water environment after regular intervals, 24 h, 48 h, 72 h, 4 days, 7 days, and 14 days. This study aimed to compare the ability of five types of fabrics to retain seminal material after immersion in four different types of water environments. Fluorescence was only detected in tap water-soaked silk fabric after 14 days of immersion. Seminal fluid was detected in khaddar, chiffon, silk, and polyester in samples immersed for 14 days in tap water. Spermatozoa were retained by khaddar and silk immersed in tap water, Polyester fabric in tap and river water, Chiffon in only river water and Linen in swimming pool water when immersed for 14 days. However, fluorescence, seminal fluid or spermatozoa were not detected in linen fabric regardless of all the afore mentioned variables.
Keywords	acid phosphatase ; crime ; fluorescence ; forensic sciences ; linen fabric ; polyesters ; river water ; silk ; silk fabric ; tap water
Language	English
Dates of publication	2021-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2021.110944
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Article ; Online: A Retrospective Observational Study of Domiciliary Oxygen Usage in a Subset of Veterans.

Savani, Ravi / Patil, Monali / Tariq, Asma / Mador, M Jeffery

Respiratory care

2020 Volume 65, Issue 11, Page(s) 1694–1701

Abstract: Background: Long-term oxygen therapy (LTOT) delivered continuously is known to decrease mortality in patients with COPD and who are hypoxemic; however, supportive data for LTOT use in patients without COPD is lacking. In addition, many patients may be ... ...

Abstract	Background: Long-term oxygen therapy (LTOT) delivered continuously is known to decrease mortality in patients with COPD and who are hypoxemic; however, supportive data for LTOT use in patients without COPD is lacking. In addition, many patients may be prescribed LTOT without a definitive etiology for hypoxemia. First, we investigated the diagnoses for which oxygen was prescribed to a sample of veterans and whether each diagnosis was supported by confirmatory testing. Second, we looked at the proportion of subjects who were prescribed non-continuous therapy. Methods: We retrospectively studied subjects prescribed domiciliary oxygen at the Veterans Administration Western New York Healthcare System. The subjects who met inclusion criteria were identified by using a computerized patient record system; data were collected on subject characteristics, oxygen prescription information, diagnosis for hypoxia, and diagnostic workup. Descriptive data were presented as mean ± SD and median (range). Statistical analysis was performed by using the chi-square test and an unpaired Results: A total of 494 subjects were included: 96.8% men, mean ± SD ages 74.2 ± 10.8 y. Most of the subjects were prescribed oxygen as out-patients (68.5%). A total of 335 (67.8%) were prescribed oxygen for continuous therapy, 72 (14.1%) for nocturnal therapy, 50 (10.1%) for exertion, and 30 (6.1%) for both exertion and nocturnal use. At 3 months, 19.6% of the initial cohort had oxygen discontinued. In those subjects with oxygen continued at 3 months, COPD was the most common diagnosis (63.6%), of which 76.1% had pulmonary function tests (PFTs), with 85.7% showing obstruction on spirometry. Conclusions: Results of our study showed a 99.4% adherence to Medicare criteria for domiciliary oxygen prescription. Also, 30.3% of the subjects were prescribed LTOT for exertional or nocturnal desaturation or both. Repeated testing at 3 months identified subjects who no longer required oxygen. COPD was the most common etiology for domiciliary oxygen. A small proportion of the subjects (6.9%) were prescribed oxygen without underlying etiology for hypoxia. Exertional and/or nocturnal oxygen prescription was common, and further research to elucidate its utility is clearly warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Hypoxia/etiology ; Hypoxia/therapy ; Male ; Medicare ; Middle Aged ; New York ; Oxygen ; Oxygen Inhalation Therapy ; Pulmonary Disease, Chronic Obstructive/therapy ; Retrospective Studies ; United States ; Veterans
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.07179
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Article ; Online: Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19.

Tariq, Asma / Mateen, Rana Muhammad / Afzal, Muhammad Sohail / Saleem, Mahjabeen

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 98, Page(s) 166–175

Abstract: Objectives: With the increasing number of people suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a dire need to look for effective remedies against this pandemic. Drug ... ...

Abstract	Objectives: With the increasing number of people suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a dire need to look for effective remedies against this pandemic. Drug repurposing seems to be the solution for the current situation. Methods: In a quest to find a potential drug against this virus, 15 antimalarial drugs (including chloroquine) and 2413 US Food and Drug Administration-approved drugs were investigated for activity against both the protease and spike proteins of SARS-CoV-2 using an in silico approach. Molecular docking analysis followed by molecular dynamics simulation was performed to estimate the binding and stability of the complexes. Results: This study identified a single drug - paromomycin - with activity against two targets of SARS-CoV-2, i.e., spike protein (S1) and protease domain. Paromomycin was found to have strong binding affinity for both targets of coronavirus. The results also showed that no antimalarial drug exhibited effective binding for either S1 or protease. Conclusions: This study found that paromomycin may be an effective dual targeting drug against coronavirus, as it binds not only to the protease domain of the virion, but also to the spike domain, with high stability. Furthermore, none of the antimalarial drugs showed strong binding affinity for either protease or the receptor binding domain (RBD).
MeSH term(s)	Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; COVID-19 ; Computer Simulation ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; Pandemics ; Paromomycin/therapeutic use ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/metabolism ; Pneumonia, Viral/drug therapy ; Protease Inhibitors/therapeutic use ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; COVID-19 Drug Treatment
Chemical Substances	Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; Paromomycin (61JJC8N5ZK) ; Peptide Hydrolases (EC 3.4.-)
Keywords	covid19
Language	English
Publishing date	2020-06-21
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.06.063
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Article ; Online: Persistence of Semen on five different fabric types in various water environments.

Nabi, Ahmed Ghulam / Mateen, Rana Muhammad / Khalid, Aqsa / Tariq, Asma / Parveen, Rukhsana

Forensic science international

2021 Volume 327, Page(s) 110944

Abstract	Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual assault. The water environments selected for this study are all related to the potential crime scenes from which there is a possibility of finding a dead body or clothing of a sexual assault victim. Tap water, River water, Swimming pool water, and Canal water were selected. Fabric types selected were khaddar, linen, silk, polyester, and chiffon. Detection of seminal stains was carried out by three methods; Alternate Light Source (ALS), Acid phosphatase (AP) testing, and Kernechtrot-Picro-indigo-carmine (KPIC) testing. These tests were performed for each fabric type in each water environment after regular intervals, 24 h, 48 h, 72 h, 4 days, 7 days, and 14 days. This study aimed to compare the ability of five types of fabrics to retain seminal material after immersion in four different types of water environments. Fluorescence was only detected in tap water-soaked silk fabric after 14 days of immersion. Seminal fluid was detected in khaddar, chiffon, silk, and polyester in samples immersed for 14 days in tap water. Spermatozoa were retained by khaddar and silk immersed in tap water, Polyester fabric in tap and river water, Chiffon in only river water and Linen in swimming pool water when immersed for 14 days. However, fluorescence, seminal fluid or spermatozoa were not detected in linen fabric regardless of all the afore mentioned variables.
MeSH term(s)	Clothing ; Fluorescence ; Humans ; Immersion ; Male ; Rivers ; Semen ; Spermatozoa ; Swimming Pools ; Textiles/classification ; Time Factors ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2021-08-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2021.110944
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Article ; Online: TULP3 NLS inhibition: an

Mateen, Rana Muhammad / Tariq, Asma / Afzal, Muhammad Sohail / Ali, Muhammad / Tipu, Imran / Hussain, Mureed / Saleem, Mahjabeen / Naveed, Muhammad

Journal of biomolecular structure & dynamics

2022 Volume 41, Issue 10, Page(s) 4641–4649

Abstract: TULP3 is involved in cell regulation pathways including transcription and signal transduction. In some pathological states like in cancers, increased level of TULP3 has been observed so it can serve as a potential target to hamper the activation of those ...

Abstract	TULP3 is involved in cell regulation pathways including transcription and signal transduction. In some pathological states like in cancers, increased level of TULP3 has been observed so it can serve as a potential target to hamper the activation of those pathways. We propose a novel idea of inhibiting nuclear localization signal (NLS) to interrupt nuclear translocation of TULP3 so that the downstream activations of pathways are blocked. In current
MeSH term(s)	Nuclear Localization Signals/chemistry ; alpha Karyopherins/chemistry ; Ligands ; Protein Binding ; Cell Nucleus/metabolism ; Active Transport, Cell Nucleus
Chemical Substances	Nuclear Localization Signals ; alpha Karyopherins ; Ligands
Language	English
Publishing date	2022-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2070283
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Article ; Online: Paromomycin

Tariq, Asma / Sohail Afza, Muhammad / Mateen, Rana Muhammad

reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano

a potential dual targeted drug effectively inhibits both Spike (S1) and Main Protease of COVID-19

2020

Abstract: Objectives: With increase in number of people suffering from COVID-19, there is a dire need to look for effective remedies against this pandemic. Drug repurposing seems to be the solution for current situation. Methods: In our quest for finding potential ...

Abstract	Objectives: With increase in number of people suffering from COVID-19, there is a dire need to look for effective remedies against this pandemic. Drug repurposing seems to be the solution for current situation. Methods: In our quest for finding potential drug against this virus, 15 anti-malarial drugs including chloroquine, and 2413 FDA approved drugs were investigated against both protease and spike proteins of COVID-19 using in-silico approach. Molecular docking analysis followed by MD simulation was carried out to estimate the binding and stability of the complexes. Results: In this study, we found a single drug Paromomycin against two targets of COVID-19 i.e. Spike protein (S1) and protease domain. Paromomycin was found to have strong binding affinity against both the targets of coronavirus. The results also showed that no anti-malarial drug exhibited effective binding against either S1 or protease. Conclusions: Current study concluded that Paromomycin is an effective dual targeting drug against coronavirus, as it binds not only to the protease domain of the virion but also with the spike domain with high stability. Furthermore, none of the anti-malarial drugs showed strong binding affinity for either protease or receptor binding domain (RBD).
Keywords	COVID-19 ; Drug repurposing ; Chloroquine ; Protease ; Spike ; MD simulation ; Síndrome respiratorio agudo grave ; SARS-CoV-2 ; Coronavirus ; covid19
Publisher	Science Direct
Publishing country	co
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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