Article ; Online: Prophylactic Postoperative High Flow Nasal Oxygen Versus Conventional Oxygen Therapy in Obese Patients Undergoing Bariatric Surgery (OXYBAR Study): a Pilot Randomised Controlled Trial.
2021 Volume 31, Issue 11, Page(s) 4799–4807
Abstract: Background: Patients with obesity are predisposed to a reduction in end-expiratory lung volume (EELV) and atelectasis after anaesthesia. High flow nasal oxygen (HFNO) may increase EELV, reducing the likelihood of postoperative pulmonary complications ( ... ...
Abstract | Background: Patients with obesity are predisposed to a reduction in end-expiratory lung volume (EELV) and atelectasis after anaesthesia. High flow nasal oxygen (HFNO) may increase EELV, reducing the likelihood of postoperative pulmonary complications (PPC). We conducted a pilot randomised controlled trial (RCT) of conventional oxygen therapy versus HFNO after bariatric surgery. The aim was to investigate the feasibility of using electrical impedance tomography (EIT) as a means of assessing respiratory mechanics and to inform the design of a definitive RCT. Methods: We performed a single-centre, parallel-group, pilot RCT. Adult patients with obesity undergoing elective bariatric surgery were eligible for inclusion. We excluded patients with a known contraindication to HFNO or with chronic lung disease. Results: Fifty patients were randomised in equal proportions. One patient crossed over from conventional O Conclusions: These data suggest that a large-scale RCT of HFNO after bariatric surgery in an 'all-comers' population is likely infeasible. While EIT was an effective means of assessing respiratory mechanics, it was impractical over time. Similarly, the infrequency of PPC precludes its use as a primary outcome. Future studies should focus on identifying patients at the greatest risk of PPC. |
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MeSH term(s) | Adult ; Bariatric Surgery ; Humans ; Obesity/complications ; Obesity/surgery ; Obesity, Morbid/surgery ; Oxygen ; Pilot Projects |
Chemical Substances | Oxygen (S88TT14065) |
Language | English |
Publishing date | 2021-08-13 |
Publishing country | United States |
Document type | Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1070827-3 |
ISSN | 1708-0428 ; 0960-8923 |
ISSN (online) | 1708-0428 |
ISSN | 0960-8923 |
DOI | 10.1007/s11695-021-05644-y |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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